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   药物吸收 的翻译结果: 查询用时:0.522秒
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药物吸收
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  drug absorption
     Results The equations are derived to calculate the values of drug absorption fraction (F),the mean absorption time(MAT) and their percent errors △F% and △MAT%. △F% of oral administration of acyclovir is between 0.41% and 2.55%,△MAT% is between 2.45% and 9.39%.
     结果推导出计算药物吸收分数F和平均吸收时间MAT及其百分误差△F%和△MAT%的公式,口服阿昔洛韦的△F%在0.41%~2.55%之间,△MAT%在2.45%~9.39%之间。
短句来源
     Caco-2 cell model——an effective tool for the research of drug absorption
     Caco-2细胞模型——药物吸收研究的有效“工具”
短句来源
     The application of Caco-2 cell model in the research of natural drug absorption
     Caco-2细胞模型在天然药物吸收研究中的应用
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     The results showed that perfusion flow rate could significantly affect the drug absorption constant(Ka) and apparent absorption coefficient(Papp) (P<0.01).
     结果表明,灌流速度对药物吸收速率常数(Ka)和表观吸收系数(Papp)有极显著影响(P<0.01);
短句来源
     A simple method for computing drug absorption rate constant k_a has been suggested.
     本文提出了一种计算药物吸收速率常数k_a的简便算法。
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  “药物吸收”译为未确定词的双语例句
     After oral administration of 250 mg cefaclor, the drug concentration quickly reached peak concentration of 4.95 mg/L±2.41 mg/L and the eliminative half time was 0.69 h±0.6 h;
     药代动力学研究表明 ,口服头孢克洛 2 5 0mg后药物吸收较快 ,血药峰浓度为 4 95mg/L± 2 4 1mg/L ,消除半衰期 0 6 9h± 0 6h ;
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     Enhancement Effect of Nano TiO_2 on the Drug Uptake of Tumor Cells
     纳米TiO_2在提高肿瘤细胞药物吸收及抗耐药性中的作用
     Results The concentrations of safflow yellow from 5μg·ml~-1 to 20μg·ml~-1 and the pH of drug solution from pH 7.8 to pH5.4 had no distinctive effect on the absorption kinetics.
     结果在5~20μg·ml-1浓度范围内药物浓度对吸收速率常数无影响; 在pH7.8~5.4内药物吸收不受pH值影响;
短句来源
     When a single oral dose of 200 mg of lomefloxacin was gaven to the patiens before and after breakfast, the absorption was slightly decreased. The T1/2 k. was 0. 39±0.18 and 0.47±0.20 h, the Tmax was 1.3±0.3 and 1.6±0.4 h respectively, but the Cmax had no significant difference between before and after food.
     空腹和餐后口服洛美沙星 200 mg后,显示食物可使该药物吸收过程明显延长,T1/2ka分别为 0.39± 0.18和0.47±0.20 h,Tmax分别为1.3±0.3和1.6±0.4h,但Cmax下降不明显。
短句来源
     The results showed that perfusion flow rate could significantly affect the values of K_a and P_(app);
     结果表明灌流速度对药物吸收速度常数(K_a)和药物表观吸收系数(P_(app))值有显著影响;
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  相似匹配句对
     The Models of Drug Absorption and Transit
     药物吸收和转运的研究模型
短句来源
     Application of Chitosan in Drug Absorption Enhancement
     几丁聚糖在促进药物吸收中的应用
短句来源
     Drug Patches
     药物贴片
短句来源
     Drug Addiction
     药物成瘾性
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     K uptake by spring maize is significantly improved by potassium fertilizer and established the dynamic model of N.
     K的吸收。 建立了N.
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  drug absorption
Rapid Screening of Drug Absorption Potential Using the Immobilized Artificial Membrane Phosphatidylcholine Column and Molar Volu
      
Prediction of Human Drug Absorption Using Liposome Electrokinetic Chromatography
      
Recent advances and issues in the characterization and prediction of drug absorption from the small intestine are reviewed.
      
Pharmacokinetic study revealed that the targeting of the microcapsules markedly enhanced the drug absorption into the surrounding tissues for a prolonged period of time.
      
These molecules influence drug absorption and distribution, and play key roles in drug therapeutic effects.
      
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A sensitive and specific method was developed for the isolation of puerarin from biological specimens and its quantitative determination by the application of polyamide thin layer chromatography and ultraviolet spectrophotometry. This method was adopted for the study of the metabolic fate of puerarin and its pharmacokinetics in rats, and also for the evaluation of drug elimination in humans.The blood level of puerarin following intravenous administration in rats was found to decrease in two phases, the distribution...

A sensitive and specific method was developed for the isolation of puerarin from biological specimens and its quantitative determination by the application of polyamide thin layer chromatography and ultraviolet spectrophotometry. This method was adopted for the study of the metabolic fate of puerarin and its pharmacokinetics in rats, and also for the evaluation of drug elimination in humans.The blood level of puerarin following intravenous administration in rats was found to decrease in two phases, the distribution phase and the elimination phase, with halflives of 3 and 18 min respectively. The pharmacokinetic parameters calculated according to the 2-compartment open model were as follows:α=0.23/min β=0.04/minK_(12)=0.08/min V_1=19.9 mlK_(21)=0.09/min V_2=33.7 mlK_e(K_2)=0.1/min V_d=53.7 mlClearance=2.0 ml/minThese results imply that puerarin is distributed widely in the body and eliminated in a fairly rapid rate which prevelits its serious accumulation in the body.Determination. of the drug in various organs revealed that drug levels were highest in the kidney, moderate in plasma, liver and spleen and lowest in the brain, indicating the existence of a partial blood-brain barrier.Absorption of the drug from the gastrointestinal tract was found to be fairly rapid but incomplete, 37.7% of the close could still be recovered from the gastrointestinal content and the faeces 24 hours after administration:In rate, the amount excreted in urine and faeces within 24 hours was about 1.85% and 35.7% respectively of the dose. administered orally, as compared with 37.6% and 7.39% administered intravenously. In normal human volunteers, however, only 0.78% of the dose was found in urine in 36 hrs, and 73.3% of the dose was present in the faeces collected for 72 hrs after oral administration.In vitro experiments provided evidence that puerarin was rather stable in the gastrointestinal tract, and might be metabolized by blood and various tissues such as liver, lung and kidney. The drug-plasma binding rate was found to be 24.6%.The metabolic characteristics of puerarin and daidzein were compared.

本文建立了一个用薄层及紫外光分光光度法分离并测定生物样品中葛根素的方法,并用该法研究了葛根素在大鼠体内的代谢,分析了其药代动力学特点,并观察了口服后在人体的排泄情况。 大鼠静脉注射后药物在肾脏含量较高,血浆、肝、脾次之,药物可通过血脑屏障进入脑组织,但脑中含量较低。血浆药-时曲线分快、慢两个时期。根据开放形二室模型数学公式计算葛根素各药代动力学参数为:t_(1/2)(α)=3.0分,t_(1/2)(β)=18.0分,V_1=19.9 ml,V_2=33.7ml,V_d=53.7ml,α=0.23/分,β=0.04/分,K_(12)=0.08/分,K_(21)=0.09/分,K_0=0.10/分,清除率=2.0 ml/分。此结果表明葛根素在体内分布广、消除快、不易积畜。体外实验证明,葛根素可被大鼠血及肝、肾等组织所代谢,且可与肝、肾、肺及血浆蛋白相结合,其与血浆蛋白的结合率达24.6%。 大鼠灌胃葛根素后药物吸收较快,但吸收程度较差,灌胃后24小时自粪及胃肠道内容物回收的药物为剂量的37.3%。体外实验证明,葛根素在胃肠道内破坏很少。 大鼠灌胃葛根素后24小时自尿及粪分别排出1.85%及35.70%...

本文建立了一个用薄层及紫外光分光光度法分离并测定生物样品中葛根素的方法,并用该法研究了葛根素在大鼠体内的代谢,分析了其药代动力学特点,并观察了口服后在人体的排泄情况。 大鼠静脉注射后药物在肾脏含量较高,血浆、肝、脾次之,药物可通过血脑屏障进入脑组织,但脑中含量较低。血浆药-时曲线分快、慢两个时期。根据开放形二室模型数学公式计算葛根素各药代动力学参数为:t_(1/2)(α)=3.0分,t_(1/2)(β)=18.0分,V_1=19.9 ml,V_2=33.7ml,V_d=53.7ml,α=0.23/分,β=0.04/分,K_(12)=0.08/分,K_(21)=0.09/分,K_0=0.10/分,清除率=2.0 ml/分。此结果表明葛根素在体内分布广、消除快、不易积畜。体外实验证明,葛根素可被大鼠血及肝、肾等组织所代谢,且可与肝、肾、肺及血浆蛋白相结合,其与血浆蛋白的结合率达24.6%。 大鼠灌胃葛根素后药物吸收较快,但吸收程度较差,灌胃后24小时自粪及胃肠道内容物回收的药物为剂量的37.3%。体外实验证明,葛根素在胃肠道内破坏很少。 大鼠灌胃葛根素后24小时自尿及粪分别排出1.85%及35.70%,静脉注射后分别自尿、粪及胆汁排出剂量的37.62%,7.39%及3.65%。正常成人口服葛根素后36小时仅有0.78%自尿排出,72小时自粪排出剂量的73.3%。 本文对葛根素及黄豆甙元的代谢特点进行了讨论。

A simple method for computing drug absorption rate constant k_a has been suggested. The method utilizes characteristic values of drug blood concentration-tlme curve (the peak value, the time needed to reach the peak value and the inflectional value) to calculate k_a directly. The formula for calculation is as follows:(1) where K is the drug elimination rate constant.Theoretically, for one-compartment open model, use formula (1) to calculate k_a is correct, while for two-compartment model, it only gives a rough...

A simple method for computing drug absorption rate constant k_a has been suggested. The method utilizes characteristic values of drug blood concentration-tlme curve (the peak value, the time needed to reach the peak value and the inflectional value) to calculate k_a directly. The formula for calculation is as follows:(1) where K is the drug elimination rate constant.Theoretically, for one-compartment open model, use formula (1) to calculate k_a is correct, while for two-compartment model, it only gives a rough estimate of k_a. Actually, accuracy of k_a calculated according to formula (1), is not only dependent on compartmental model but also dependent on other parameters involved.

本文提出了一种计算药物吸收速率常数k_a的简便算法。该法利用血药浓度-时间曲线的特征值(峰值c_(mar)、达峰时t_m及转折值c_1)来直接计算k_a。计算公式如下:式中K为药物消除速率常数。 理论上,对于一室开放形模型,按(1)式计算k_a是精确的;对于二室模型则仅提供k_a的一个初步估计。实践上,按(1)式计算k_a,其精确程度不仅依赖于所用的模型,而且依赖于该式中所含的各个参数的估计。

Quantitative relationships between the structure and estrogenic activity of 28 derivatives of 1,3,5(10) estratriene series have been examined by multiple variable regression analysis. The results indicate that the estrogenic activity of a derivative may be regarded as the total sum of the activity contributed by the unsubstituented parent structure [1,3,5(10)estra-triene] on the one hand and that by the substituents on the other. Since the correlation coefficient is equal to 0.98, the additivity model can be...

Quantitative relationships between the structure and estrogenic activity of 28 derivatives of 1,3,5(10) estratriene series have been examined by multiple variable regression analysis. The results indicate that the estrogenic activity of a derivative may be regarded as the total sum of the activity contributed by the unsubstituented parent structure [1,3,5(10)estra-triene] on the one hand and that by the substituents on the other. Since the correlation coefficient is equal to 0.98, the additivity model can be accepted. The effective value of a given substituent is a constant. The contributions elicited by hydroxy, methoxy, cyclopetoxy and other oxygen containing groups at C-3 and C-17β positions are unanimously positive i.e. to enhance the biological activity. On the contrary, contributions elicited by groups at C-2, C-6, C-13, C-16 and C-17α positions, except the 17α ethynyl group, are negative. Since the group contribution of a substituent varies with different positions attached, it seems reasonable to infer that the steric effects may play an important role inestrogenic activity.

对32个雌甾衍生物和9个雄甾和孕甾衍生物进行了结构和雌活性相互关系的定量分析(QSAR)。其结果表明雌甾化合物的雌活性作用可用Fujita-Ban的数学模型来表示。即每个衍生物的雌活性作用是甾核1,3,5(10)雌甾三烯的雌活性作用和各碳原子上各种取代基对雌活性的贡献之和。借助于多元回归和电子计算机计算出了甾核结构和各取代基对活性贡献的数值。计算值与实测值非常相近,相关系数R等于0.98。这些数值对于预测由这些位置的取代基所组成的,在化学上可能合成的药物的生物活性有一定参考价值。QSAR分析表明甾体母体、甾核的立体结构及取代基的位置对生物活性均有重要的影响;C-3环戊氧基增强灌服条件下的雌活性,可能与改变药物的吸收分布过程有关。作者认为对整体动物药理活性的QSAR分析要与药物物化性质研究、体外药物受体结合试验及药物代谢研究等多方面结合才能得到正确的认识。

 
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