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   人前列腺癌细胞株pc3 的翻译结果: 查询用时:0.01秒
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人前列腺癌细胞株pc
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  “人前列腺癌细胞株pc3”译为未确定词的双语例句
     Objective: To evaluate the effect of arsenic trioxide (As 2 O 3 ) on the growth of human androgen independent prostate cancer PC 3 cell lines.
     目的 :探讨三氧化二砷 (As2 O3 )对雄激素非依赖性人前列腺癌细胞株PC 3生长的影响及其机制。
短句来源
     Objective:To investigate the role of TFPI-2 in human prostate cancer cells invasion in vitro and in vivo.
     目的:探讨人组织因子途径抑制物2(TFPI2)对基因转染入人前列腺癌细胞株PC3M体外和体内侵袭转移能力的影响。
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     CONCLUSIONCisplatin can enhance antiproliferative effect of curcumin to hunman prostate cancer cell line PC-3.
     结论:姜黄素可与顺铂协同抑制人前列腺癌细胞株PC3的增殖。
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  相似匹配句对
     EFFECT OF RhoA AND cAMP ON MORPHOLOGICAL CHANGES IN HUMAN PROSTATE CANCER CELL LINE PC-3
     RhoA蛋白和cAMP对前列腺癌细胞PC-3形态的影响(简报)
短句来源
     Effect of hyperthermia on growth of human prostatic carcinoma cell lines PC-3m and LNCaP in vitro
     高温对前列腺癌细胞PC-3m和LNCaP生长影响的体外研究
短句来源
     Suppression of Recombinant Secreted Human Prostate Secretory Protein of 94 Amino Acids (rsHPSP94) on Prostate Cancer Cell PC-3
     重组分泌型PSP94对前列腺癌细胞PC-3抑制作用的研究
短句来源
     CONCLUSIONCisplatin can enhance antiproliferative effect of curcumin to hunman prostate cancer cell line PC-3.
     结论:姜黄素可与顺铂协同抑制前列腺癌细胞PC3的增殖。
短句来源
     Effect of sodium selenate on the viability and proliferation of PC-3 cell line, a kind of human prostate cancer cell
     硒酸钠对前列腺癌细胞PC-3细胞活力和增殖的影响
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Nude mice bearing transplanted human prostate cancer cell line PC-3M were treated with male sex hormone. Results demonstrated that low dose of testosterone propionate (TP)(50mg/kg wt.)stimulated the tumor growth,and the androgen receptor(AR)levels and protein kinase C (PKC) activity were elevated in the tumor tissue.On the contrary higher dose of TP(400mg/kg wt.) inhibited the tumor growth,and the AR level and PKC activity in tumor tissue were reduced significantly.These results showed that TP has a biphasic...

Nude mice bearing transplanted human prostate cancer cell line PC-3M were treated with male sex hormone. Results demonstrated that low dose of testosterone propionate (TP)(50mg/kg wt.)stimulated the tumor growth,and the androgen receptor(AR)levels and protein kinase C (PKC) activity were elevated in the tumor tissue.On the contrary higher dose of TP(400mg/kg wt.) inhibited the tumor growth,and the AR level and PKC activity in tumor tissue were reduced significantly.These results showed that TP has a biphasic effect on the growth of human prostate cancer PC-3M cell line. The mechanism of the biphasic effect and its relationship between AR and PKC levels are also discussed.

采用雄性激素治疗移植人前列腺癌细胞株(PC—3M)所复制的裸鼠模型.结果表明,低剂量丙酸睾丸素(50mg/kg体重)明显促进肿瘤生长,同时肿瘤组织中雄激素受体(AR)水平及蛋白激酶C(PKC)活性均明显增高;而高剂量丙酸睾丸素(400mg/kg体重)则明显抑制肿瘤生长,且肿瘤组织中AR水平及PKC活性明显降低.显示雄激素对人前列腺癌(PC-3M)细胞株具有双相效应.讨论了这种双相效应与AR和PKC变化的关系.

Human prostate secretory protein of 94 amino acids (PSP94) cDNA including signal and mature peptide has been successfully obtained by reverse transcription polymerase chain reaction (RT PCR) from human hypertrophic prostate mRNA.Sequence analysis indicated that the sequence of human PSP94 cDNA was the same as that of human natural PSP cDNA.The hPSP94 cDNA and human TNFα mutant (TNF Δ) gene were fused by an artificial linker SAPGTP.The chimeric gene coding for 5′PSP SAPGTP TNF Δ fusion protein under control...

Human prostate secretory protein of 94 amino acids (PSP94) cDNA including signal and mature peptide has been successfully obtained by reverse transcription polymerase chain reaction (RT PCR) from human hypertrophic prostate mRNA.Sequence analysis indicated that the sequence of human PSP94 cDNA was the same as that of human natural PSP cDNA.The hPSP94 cDNA and human TNFα mutant (TNF Δ) gene were fused by an artificial linker SAPGTP.The chimeric gene coding for 5′PSP SAPGTP TNF Δ fusion protein under control of the phage P RP L promoter was constructed.The expression was assayed by SDS PAGE,which showed that the amount of the expressed the protein was about 35% of total bacterial proteins.Western blot indicated that the molecular weight of 5′PSP SAPGTP TNF Δ was in accordance with the estimated value of 31 kD.Through biological activity analysis,the fusion protein has cytotoxicity activity of L929 and PC 3 cell.

利用RT-PCR从人肥大前列腺组织钓取94个氨基酸的人前列腺分泌蛋白(PSP94)全长cDNA,序列分析结果与文献报道的完全一致.将PSP94成熟肽与人TNFα衍生物(TNFΔ)通过Linker-SAPGTP在基因水平上融合成5′PSP94-TNFΔ,融合基因DNA序列分析结果与设计的相符合.5′PSP94-TNFΔ在大肠杆菌中表达产物分子量约为31kD,表达量约占菌体总蛋白量的35%.以L929细胞和人前列腺癌细胞株PC-3为靶细胞进行细胞毒分析结果表明,5′PSP94-TNFΔ融合蛋白既具有TNF的细胞毒活性,又具有对前列腺癌细胞PC-3的杀伤作用

Objectives: To explore whether gene transfer of TNFR can enhance the TNFR expression on tumor cell membrane and its influence on tumorcidal activity of TNF. Methods:The retroviral expression vector of TNFR and was constructed and transfected into package cell PA317 to produce virus that can transfer TNFR. The virus was used to infect human androgen insensitive prostate cancer cell line PC 3m and renal cancer cell line Renca. The TNFR number on tumor cell membrane,the tumorcidal activity in vitro and tumor...

Objectives: To explore whether gene transfer of TNFR can enhance the TNFR expression on tumor cell membrane and its influence on tumorcidal activity of TNF. Methods:The retroviral expression vector of TNFR and was constructed and transfected into package cell PA317 to produce virus that can transfer TNFR. The virus was used to infect human androgen insensitive prostate cancer cell line PC 3m and renal cancer cell line Renca. The TNFR number on tumor cell membrane,the tumorcidal activity in vitro and tumor inhibition rate in vivo of TNF was detected. Results: The number of TNFR on human androgen insensitive prostate cancer cell line PC 3 m and renal cancer cell line Renca was elevated and the tumorcidal activity in vitro and tumor inhibition rate in vivo of TNF was enhanced. Conclusions:Gene transfer can enhance the TNFR expression on tumor cell membrane The tumorcidal and tumor inhibition activity of TNF can also be improved.

目的 :探讨肿瘤坏死因子受体 (TNFR)基因转移对肿瘤细胞表面 TNFR表达量的影响 ,进而观察其对TNF杀伤肿瘤细胞作用的影响。 方法 :建立 TNFR的逆转录病毒表达载体 ,通过转染包装细胞 PA 317产生完整病毒颗粒 ;人前列腺癌细胞株 PC- 3m和小鼠 Renca肾腺癌细胞株经病毒感染后 ,检测其细胞表面 TNFR数量及TNF在体内外对其杀伤作用的变化。 结果 :TNFR基因转移前后 PC- 3m细胞表面与 TNF结合的位点数量分别为 2 912个 /细胞和 8872个 /细胞 (P<0 .0 5 ) ,Renca细胞表面与 TNF结合的位点数分别为 783个 /细胞和 36 78个 /细胞 (P<0 .0 5 )。 TNFR基因转染后 ,TNF在裸鼠体内对 PC- 3m和 Renca的肿瘤抑制率分别增强 1.8和 2 .1倍。 结论 :以逆转录病毒为载体的基因转移方法 ,可以提高肿瘤细胞表面 TNFR的表达量 ,从而增强 TNF对肿瘤细胞的体外杀伤作用和体内抑制作用

 
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