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早期预适应
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  early preconditioning
     (2)PGEi early preconditioning protrection ( EPP ) group rats were injected 20 min PGE1 (1.25Mg-kg-1.min-1) 40 min before I/R;
     ②早期预适应保护(EPP)组:结扎LAn前4omin推注PoEI(1 .25陀·kg一’·min一’)Zomin;
短句来源
     To test the hypothesis that early preconditioning and late preconditioning can yield additive cardiac protection.
     探讨心肌早期预适应与晚期预适应之间是否存在协同作用 .
短句来源
  “早期预适应”译为未确定词的双语例句
     Normal saline (NS) was infused intravenously with the same volume of NG and BU in Sham group. Ischemia/preconditioning (IP) was performed by three cycles of 5 min I/R in EIP group. BU (1 0 mg·kg -1 ) and NG (0 3 mg·kg -1 ) was administered intravenously alone in BU and NG group or given together in B+N group to mimic the effects of IP, respectively.
     各组手术之前行不同处理 ,Sham组静注等容积NS ,早期预适应 (EIP)组行 3个循环5min缺血 / 5min再灌预处理 ,BU组静注盐酸丁丙诺啡 1 0mg·kg-1,NG组静注NG 0 3mg·kg-1,B +N组分别给上述剂量BU和NG。
短句来源
     Early Proconditioning and Late Proconditioning Can Yield Additive Cardiac Protection
     心肌早期预适应与晚期预适应的协同作用
短句来源
     Ischemic preconditioning (IPC ), a phenomenon in which brief episodes of ischemia and reperfusion before a prolonged ischemic event limit myocardial injury, has been classified into two phases: an early phase and a delayed phase of cardioprotection.
     心肌缺血预适应(ischemic preconditioning,IPC)指反复几次短暂的心肌缺血再灌注,可对抗随后的较长时间持续缺血所造成的心肌损伤,它包括早期预适应和延迟预适应两个阶段。
短句来源
     Conclusion: We draw the conclusion that EP and DP can yield additive cardiac protection since they have differential mechanisms.
     结论 :心肌早期预适应与晚期预适应可产生协同作用 ,从而加强预适应的心肌保护程度
短句来源
  相似匹配句对
     Early Proconditioning and Late Proconditioning Can Yield Additive Cardiac Protection
     心肌早期预适应与晚期预适应的协同作用
短句来源
     Transient ischemia (preconditioning stimulus) not only triggers early preconditioning, but also induces delayed protection.
     缺血预适应表现为早期和延迟心肌保护 .
短句来源
     PREMATURE MENOPAUSE
     早期绝经
短句来源
     Early Osteoporosis
     早期骨质疏松
短句来源
     Ischemic preconditioning of myocardium
     心肌局部缺血的预适应(英文)
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  early preconditioning
This suggests that the early preconditioning effect is rather weak.
      
Furthermore, when early preconditioning occurs, the protection is limited to only few ischemic episodes (probably three to five).
      
Previous investigations have demonstrated that early preconditioning induced by nitroglycerin is mediated by calcitonin gene-related peptide (CGRP).
      
We investigated whether a combination of ischaemic late preconditioning (LPC) and ischaemic early preconditioning (EPC) induces additive myocardial protection in vivo, and the role of ATP-sensitive K (KATP) channels in ischaemic LPC and in LPC+EPC.
      


To test the hypothesis that early preconditioning and late preconditioning can yield additive cardiac protection. Method: All rats were divided into four groups. Myocardial infarction was achieved by isoprenaline(ip). EP or DP was achieved by morphine injection or heat stress. Results: EP and DP group′s heart function were better than controls. EP+DP group′s heart funtion was better than control, EP or DP groups. Conclusion: We draw the conclusion that EP and DP can yield additive cardiac protection since they...

To test the hypothesis that early preconditioning and late preconditioning can yield additive cardiac protection. Method: All rats were divided into four groups. Myocardial infarction was achieved by isoprenaline(ip). EP or DP was achieved by morphine injection or heat stress. Results: EP and DP group′s heart function were better than controls. EP+DP group′s heart funtion was better than control, EP or DP groups. Conclusion: We draw the conclusion that EP and DP can yield additive cardiac protection since they have differential mechanisms.

探讨心肌早期预适应与晚期预适应之间是否存在协同作用 .方法 :采用热处理方法诱导晚期预适应 ,吗啡静脉注射诱导早期预适应 ,腹腔注射异丙基肾上腺素复制在体心肌梗死模型 .结果 :热处理和吗啡分别可诱导晚期与早期预适应 ,改善心肌梗死后的心功能 .热处理后再予吗啡预适应可进一步改善心肌梗死后的心功能 .结论 :心肌早期预适应与晚期预适应可产生协同作用 ,从而加强预适应的心肌保护程度

AIM To study the early cardioprotective effects of pharmacological preconditioning of nitroglycerin (NG) and buprenorphine (BU) used alone and in combination on myocardial ischemia in rats. METHODS Male Wistar rats were randomized to 5 groups. The ischemia and reperfusion injury was induced by ligation of the left arterior descending coronary arrery for 30 min and followed reperfusion for 2 h. The rats were subjected to different treatments before I/R. Normal saline (NS) was infused intravenously with the...

AIM To study the early cardioprotective effects of pharmacological preconditioning of nitroglycerin (NG) and buprenorphine (BU) used alone and in combination on myocardial ischemia in rats. METHODS Male Wistar rats were randomized to 5 groups. The ischemia and reperfusion injury was induced by ligation of the left arterior descending coronary arrery for 30 min and followed reperfusion for 2 h. The rats were subjected to different treatments before I/R. Normal saline (NS) was infused intravenously with the same volume of NG and BU in Sham group. Ischemia/preconditioning (IP) was performed by three cycles of 5 min I/R in EIP group. BU (1 0 mg·kg -1 ) and NG (0 3 mg·kg -1 ) was administered intravenously alone in BU and NG group or given together in B+N group to mimic the effects of IP, respectively. Heart rate, blood pressure, ST segment and arrhythmias were recorded continuously throughout the whole test. Plasma LDH and CK were measured on 30 min after ischemia and 2 h after reperfusion, HE and TTC staining were performed to determine myocardial necrosis at the end of test. RESULTS Compared with Sham group the onset of arrhythmias was delayed and the duration of ventricular premature contraction (VPC) was shortened remarkably ( P <0 01). The incidence of bigeminy and ventricular tachycardia (VT) decreased as well. The plasma LDH and infarct size reduced, respectively ( P <0 01). Compared with Sham group, the elevation of ST segment corresponding to ischemic injury decreased and the duration of ventricular arrhythmias (VA) shortened in NG group significantly ( P <0 01). Plasma LDH ( P <0 01), CK ( P <0 05) and infarct size ( P <0 01) were also lowered than Sham group. Morphology observation by HE staining showed that the I/R injury on myocytes was attenuated by NG. ST segment elevation, plasma concentration of LDH and CK, the onset and the duration of VA, the infarct size of heart were all better than those of NG or BU alone in B+N group ( P <0 05). CONCLUSION The mimic early cardiaprotective effects of IP by NG and BU were confirmed on I/R model. Furthermore, combined used NG and BU used in combination were more effectively than used them alone.

目的 研究硝酸甘油 (nitroglycerin ,NG)和丁丙诺啡(buprenorphine,BU)两药单用及合用抗心肌缺血的药理性预适应的早期保护作用。方法 ♂Wistar大鼠分为 5组 ,行 30min冠脉结扎缺血 / 2h再灌。各组手术之前行不同处理 ,Sham组静注等容积NS ,早期预适应 (EIP)组行 3个循环5min缺血 / 5min再灌预处理 ,BU组静注盐酸丁丙诺啡 1 0mg·kg-1,NG组静注NG 0 3mg·kg-1,B +N组分别给上述剂量BU和NG。各组均于给药前、后及缺血和再灌期连续监测心率、血压、ST 段和心律失常情况 ;测定缺血 30min和再灌 2h血浆LDH、CK ;再灌 2h后行心肌HE染色与TTC染色定性和定量测定心肌坏死情况。结果 与Sham组比较 ,BU组明显推迟缺血期心律失常出现时间 ,缩短室早持续时间 (P <0 0 1) ,降低二联律和室速发生率 ;降低缺血期血LDH(P <0 0 5 )水平 ,缩小心肌坏死面积 (P <0 0 1) ,但未降低血CK水平和缺血期ST 段抬高。与Sham组比较 ,NG组明显降低缺血和再灌期ST段 (...

目的 研究硝酸甘油 (nitroglycerin ,NG)和丁丙诺啡(buprenorphine,BU)两药单用及合用抗心肌缺血的药理性预适应的早期保护作用。方法 ♂Wistar大鼠分为 5组 ,行 30min冠脉结扎缺血 / 2h再灌。各组手术之前行不同处理 ,Sham组静注等容积NS ,早期预适应 (EIP)组行 3个循环5min缺血 / 5min再灌预处理 ,BU组静注盐酸丁丙诺啡 1 0mg·kg-1,NG组静注NG 0 3mg·kg-1,B +N组分别给上述剂量BU和NG。各组均于给药前、后及缺血和再灌期连续监测心率、血压、ST 段和心律失常情况 ;测定缺血 30min和再灌 2h血浆LDH、CK ;再灌 2h后行心肌HE染色与TTC染色定性和定量测定心肌坏死情况。结果 与Sham组比较 ,BU组明显推迟缺血期心律失常出现时间 ,缩短室早持续时间 (P <0 0 1) ,降低二联律和室速发生率 ;降低缺血期血LDH(P <0 0 5 )水平 ,缩小心肌坏死面积 (P <0 0 1) ,但未降低血CK水平和缺血期ST 段抬高。与Sham组比较 ,NG组明显降低缺血和再灌期ST段 (P <0 0 1)、降低缺血期血LDH(P <0 0 1)和CK(P <0 0 5 )水平 ,缩小心肌坏死面积 (P <0 0 1) ,减轻HE染色心肌坏死程度 ,缩短心律失常持续时间。药物合用后与Sham组比较 ,不仅明显降低缺血和再灌期ST段、血LDH和CK水平 ,缩小心肌坏死面积 (P <0 0 1) ,减轻HE

 
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