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代谢物指纹图谱
相关语句
  metabolite fingerprint
     Metabolite Fingerprint and Biomarkers Identification of Rat Urine after Dosed with Ginsenoside Rg3 Based on Ultra High Performance Liquid Chromatography/Time-of-FlightMass Spectrometry (UPLC/TOF-MS)
     超高效液相色谱/飞行时间质谱用于人参皂甙Rg3作用后大鼠尿液代谢物指纹图谱分析及标记物的鉴定
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  相似匹配句对
     Application of fingerprint of traditional Chinese medicine
     中药指纹图谱的应用
短句来源
     Studies on Fingerprint of Radix Curcumae
     郁金的指纹图谱研究
短句来源
     (2) secondary metabolite synthesis;
     (2)次生代谢物的合成;
短句来源
     Advances in the Research of Resveratrol Metabolins
     白藜芦醇代谢物的研究进展
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Metabolites in urine can illustrate the physical condition of an individual as a whole.Ultra high performance liquid chromatography/time of flight mass spectrometry(UPLC/TOF-MS) is a relative new technique for the separation of complex samples.The aim of this study is to assess the feasibility of metabonomics in gender difference in unrestricted conditions,i.e.for healthy volunteers there are no strict controls such as food,life style and the collection of urine samples.In this work,31 spontaneous urine samples...

Metabolites in urine can illustrate the physical condition of an individual as a whole.Ultra high performance liquid chromatography/time of flight mass spectrometry(UPLC/TOF-MS) is a relative new technique for the separation of complex samples.The aim of this study is to assess the feasibility of metabonomics in gender difference in unrestricted conditions,i.e.for healthy volunteers there are no strict controls such as food,life style and the collection of urine samples.In this work,31 spontaneous urine samples were collected and analyzed by using UPLC/TOF-MS.Principal components analysis(PCA) and partial least squares discriminant analysis(PLS-DA) models were tested and compared in samples classification.The gender discrimination was highly improved and some gender related biomarkers were found by PLS-DA.These preliminary results(suggested) that UPLC/MS-based approaches coupled with pattern recognition show promise for metabonomics.

尿中的代谢产物可以反映生命个体的生理状态。为了考察在非严格控制条件下(即对志愿者的饮食、生活方式以及样品采集时间等诸多条件不加以控制)基于尿中代谢物的指纹图谱对男女性别进行区分的可行性,采用超高效液相色谱/飞行时间质谱(UPLC/TO F-M S)联用技术分析了31个随机尿样,并用主成分分析法(PCA)和偏最小二乘法判别分析(PLS-DA)两种数据处理方法对数据进行处理,与PCA法比较,PLS-DA法能提高分类效果,并筛选出4种可能的与性别相关的生物标记物。研究结果表明,UPLC/M S联用技术通量高,数据量丰富;模式识别数据处理方法适合于从大量数据中提取信息,两者的结合有利于代谢组学的研究。

 
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