The Expression of Efflux Pumps Related to Resistance to Anticancer Drugs(Pgp, MRP, LRP) in Human SCLC Cancer Specimens and Modulation of Multidrug Resistance in Human SCLC Cell Line GLC4/ADR by Inhibition of MRP with Antisense MRP RNA
The MVD in the cases with the high expression of MMP-2 was significantly higher than in those with the low expression of MMP-2 in cancer tissues and paracancerous tissues (30.71±7.41 vs 26.15±4.82,t=2.11,P< 0.05; 15.31±5.23 vs 9.61±2.17,t=3.98, P < 0.01 ).
Results:VEGF121,165 mRNA were all detected in malignant and benign ovarian tissues, with higher level(0.452±0.134 and 0.301±0.096 respectively)in epithelial ovarian cancer tissues than in benign ovarian tissues [0.195±0.066(P=0.000)and 0.204±0.059(P=0.001)respectively].
Results The positive rates and the scores of Arom and Surv in cancer tissues were significantly higher than those of the para-tumor tissues 〔Arom: 40.43% vs 21.28% (P<0.05), 1.53±1.69 vs 0.79±1.41 (P<0.05);
Results:The count means of MV and MC in the cancer tissues were significantly higher than that in the peri-cancerous tissues(MV,67.30±13.68/HP vs.37.20±10.58 /HP,p<0.01;MC,15.64±4.54/HP vs 8.08±2.03 /HP,p<0.01);
Guanidine-like compounds have been investigated since the first observations of their therapeutic potential some 30 years ago in fields of cancer and virology.
Epidermal Growth Factor Receptor (EGFR) is among the growth factor receptor kinases that have been implicated in as being important in cancer.
Inhibitive Effect of Prodigiosin on the Proliferation of Human Malignant Pancreatic Cancer Cells
Pancreatic cancer is not only common, but also extremely difficult to treat, for which it has been called "the challenge of the twenty-first century".
In this study, we find that prodigiosin could effectively inhibit the proliferation of human pancreatic cancer cells H8898 in a dose-and-time-dependent manner, with an IC50 of 75μmol according to the results of MTT and cell proliferation assays.
To determine the correlation of Sef with human diseases, Sef expression patterns were observed in cell lines and human cancer tissues.
Results demonstrated that Sef might be up-regulated in the cancer tissues suggesting a possible role of Sef in pathophysiology of human diseases.
LOH and MSI of the FHIT were detected by using PCR at 4 microsatellite loci: D3S 1300, D3S 4103, D3S 1481, D3S 1234 in cancer tissues from 50 patients with primary GC, with normal mucosa acting as matched controls.
Our results showed over expression of EMMPRIN in advanced stages of breast cancer tissues compared with benign tumor tissue samples.
The expression level of Pescadillo was increased significantly in breast cancer tissues compared with their paired margin tissues.
Immunohistochemical analysis revealed a high expression level of hSef in kidney, testis, and the corresponding carcinoma tissues.
Western blot analysis showed HCR2 to be notably depressed in carcinoma tissues in 3 out of 4 HCC patients.
The aim of the present study was to investigate the genetic instability in cervical carcinoma tissues and provide evidence for discovering new tumor suppressor genes and screening diagnostic molecular marker of cervical carcinoma.
Methods: cDNA probes were prepared by labeling mRNA from samples of four pancreatic carcinoma tissues with Cy5-dUTP and mRNA from adjacent normal tissues with Cy3-dUTP respectively through reverse transcription.
Relationship among COX-2 protein expression, PGs levels and biologic behavior in ovarian carcinoma tissues