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宫颈鳞癌scc
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  “宫颈鳞癌(scc)”译为未确定词的双语例句
     Objective To study the expression of a novel inhibitor gene of apoptosis survivin in cervical carcinoma and its association with the expression of HPV16-E6 and p53 genes.
     目的:研究凋亡抑制基因survivin在宫颈鳞癌(SCC)组织中的表达及其与p53基因表达和HPV16感染的相关性,探讨survivin基因在SCC发生发展中的意义。
短句来源
     Objective:To study the expressions and clinical significances of p16INK4A and p14ARF proteins in squamous carcinoma of the cervix(SCC),cervical intraepithelial neoplasia(CIN) and normal cervix samples.
     目的:研究p16INK4A和p14ARF蛋白在宫颈鳞癌(SCC)、宫颈上皮内瘤样病变(CIN)及正常宫颈组织标本中的表达特征和临床意义。
短句来源
     Methods The expression of MDM2 and p53 protein in normal cervical epithelium,cervical intra-epithelial neoplasm(CIN) and invasive cervical squamous-cell carcinoma(SCC) were detected with immunohistochemical SP methods in 76 cases.
     方法 用免疫组化SP法检测MDM2及p53蛋白在正常宫颈上皮、宫颈上皮内瘤样病变 (CIN)、宫颈鳞癌 (SCC)中的表达 ,共 76例。
短句来源
     However, in ICC subgroups the frequencies of Arg/Arg genotype were significantly higher than that in the control group(Z=2.43, P=0.01, OR=1.28; Z=2.44, (P=0.01), OR=1.45).
     亚洲人群宫颈鳞癌(SCC)亚组合并OR=1.28,95%CI=1.05~1.55。
短句来源
     Objective To investigate the relationship between HPV infection and the expression of P16~(INK4A) in cervical intraepithelial neoplasia(CIN) and cervical squamous cell carcinomas(SCC).
     目的探讨HPV(16/18型)感染和P16INK4A蛋白表达在人类宫颈鳞癌(SCC)及其癌前病变(CIN)中的关系。
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  相似匹配句对
     CHEMOTHERAPY IN RECURRENT AND ADVANCED CERVICAL CANCER
     晚期及复发宫颈的化疗
短句来源
     The Expressions of Cathepsin B and Its Significance in Squamous Carcinoma of Uterine Cervix
     组织蛋白酶B在宫颈组织中的表达
短句来源
     Clinical Analysis of Low Differentiative Cervical Squamous Cell Carcinoma
     宫颈低分化的临床分析
短句来源
     Expression of PTEN and P53 in Squamous Carcinoma of Cervix and Its Relationship with Occurrence and Development
     PTEN和P53在宫颈中的表达
短句来源
     Expression of Cyclin D 1 in Cervical Squamous Cell Carcinoma
     宫颈中细胞周期蛋白D_1的表达
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Objective To disclose the correlation between human papillomavirus (HPV ) type and grade of cervical intraepithelial lesion (CIN). Methods PCR and in situ hybridization (ISH) techniques were used to detect the presence of HPV 6B/11, 16, 18 in 61 cases of CIN and 12 cases of cervical squamous cell carcinoma (SCC). Results PCR showed HPV 6, 11 distributing mainly in low grade squamous intraepithelial lesion (LSIL, 61.9%) and partly in CINII (20%), but not in CINIII and SCC. The frequency of HPV 16, 18 increased...

Objective To disclose the correlation between human papillomavirus (HPV ) type and grade of cervical intraepithelial lesion (CIN). Methods PCR and in situ hybridization (ISH) techniques were used to detect the presence of HPV 6B/11, 16, 18 in 61 cases of CIN and 12 cases of cervical squamous cell carcinoma (SCC). Results PCR showed HPV 6, 11 distributing mainly in low grade squamous intraepithelial lesion (LSIL, 61.9%) and partly in CINII (20%), but not in CINIII and SCC. The frequency of HPV 16, 18 increased corresponding to the increasing of CIN grading and up to 83.3% in SCC. ISH showed HPV 6b/11, 16,18 DNA hybridization intranuclear signal were diffusely distributed in LSIL and granular in appearance in episomal HPV. Similar signal were also seen in CINII infected by HPV 6b/11 and partly by HPV 16, 18, anyhow, CINIII, SCC and partly CINII HPV 16, 18 DNA hybridization were nongranular in appearance. Conclusion low grade SIL associated with "low risk" types of HPV 6, 11 belonged to productive infection. CINIII and SCC associated with “high risk” types of HPV 16, 18 belonged to integrated infection, while CINII belonged to either productive or integrated infection.

目的探讨人乳头状瘤病毒(HPV)不同型别与宫颈病变性质的关系。方法应用PCR技术和原位杂交方法对61例宫颈上皮内瘤(CervicalintraepithelialNeoplasiaCIN)和12例宫颈鳞癌(SCC)进行HPV6B/11、16、18DNA检测。结果PCR检测结果显示HPV6、11主要分布于低度鳞状上皮内病变(619%)和一部分CINⅡ中(20%),而在CINⅢ和SCC中检测不到;HPV16、18的检出率随CIN级别增高而增加,在SCC中高达833%。原位杂交结果显示在低度鳞状上皮内病变中,地高辛(Dig)标记的HPV6B/11、16、18DNA杂交物质在核中均呈细颗粒状,为“游离型”。上述杂交阳性信号形态亦出现于CINⅡ的所有HPV6B/11及部分HPV16、18型感染中,而CINⅢ和宫颈鳞癌及部分CINⅡ中,其杂交阳性信号均为非颗粒状的“整合型”。结论低度鳞状上皮内病变是以HPV6、11低危型为主的多型别病毒的繁殖性感染,CINⅢ和宫颈鳞癌为HPV16、18高危型病毒的整合型感染,而在CINⅡ中存在着HPV6,11和HPV16,18的繁殖性感染及HPV16,18的整合型感染

Objective To study the roles of MDM2 and p53 protein playing in the pathogenesis and development of cervical carcinoma.Methods The expression of MDM2 and p53 protein in normal cervical epithelium,cervical intra-epithelial neoplasm(CIN) and invasive cervical squamous-cell carcinoma(SCC) were detected with immunohistochemical SP methods in 76 cases.Results 1.The expression rates of MDM2 and p53 were gradually increased with cervical lessions progress.The positive rates of MDM2 and p53 in normal cervical epithelium,CIN...

Objective To study the roles of MDM2 and p53 protein playing in the pathogenesis and development of cervical carcinoma.Methods The expression of MDM2 and p53 protein in normal cervical epithelium,cervical intra-epithelial neoplasm(CIN) and invasive cervical squamous-cell carcinoma(SCC) were detected with immunohistochemical SP methods in 76 cases.Results 1.The expression rates of MDM2 and p53 were gradually increased with cervical lessions progress.The positive rates of MDM2 and p53 in normal cervical epithelium,CIN and invasive carcinoma were,0,13.64%,44.12%;5.00%,18.18%,47.06%;respectively.The positive rates of MDM2 and p53 in invasive cervical carcinoma group were obviously highier than those of normal cervical epithelium group and CIN group.2.The frequence of MDM2 did not show correlation with accumulation of p53 in statistics. Conclusion MDM2 and p53 may be involved in the pathogenesis and development in cervical carcinoma,and be valualble in diagnosis and treatment in cervical carcinoma.

目的 探讨MDM2、p53蛋白在宫颈癌发生、发展中的作用。方法 用免疫组化SP法检测MDM2及p53蛋白在正常宫颈上皮、宫颈上皮内瘤样病变 (CIN)、宫颈鳞癌 (SCC)中的表达 ,共 76例。结果  1.随着宫颈病变加重 ,MDM2、p53表达率均渐增高 ,二者在正常宫颈、CIN、SCC的表达率分别为 :MDM2的表达为 0、 13 64%、 4 4 12 %;p53的表达为 5 0 0 %、18 18%、 4 7 0 6%。MDM2、p53在浸润癌组较CIN及正常宫颈组明显增高。 2 .MDM2的表达与p53的聚积在统计学上未显示出有相关性。结论 MDM2、p53可能参与宫颈癌的发生、发展 ,对宫颈癌的诊断和治疗具有一定意义。

Objectives: To investigate the clinical value of the serum levels of cancer antigen 125 (CA125), carbohydrate antigen 19 9 (CA19 9), cytokeratin 19 fragments (CYFRA21 1), squamous cell carcinoma antigen (SCC) and carcinoembryonic antigen (CEA) in patients with cervical cancer. Methods: CA125, CA19 9 and CYFRA21 1 were measured by immunoradiometric assay, SCC and CEA were measured by enzyme linked immunosorbent assay. Twenty eight healthy females, 16 cervical intraepithelial neoplasia and 63 patients...

Objectives: To investigate the clinical value of the serum levels of cancer antigen 125 (CA125), carbohydrate antigen 19 9 (CA19 9), cytokeratin 19 fragments (CYFRA21 1), squamous cell carcinoma antigen (SCC) and carcinoembryonic antigen (CEA) in patients with cervical cancer. Methods: CA125, CA19 9 and CYFRA21 1 were measured by immunoradiometric assay, SCC and CEA were measured by enzyme linked immunosorbent assay. Twenty eight healthy females, 16 cervical intraepithelial neoplasia and 63 patients with cervical cancer were detected. Results: The levels of CYFRA21 1 and SCC in cervical cancer were significantly higher than that of healthy females and cervical intraepithelial neoplasia(P< 0.05 ). The positive rate of CYFRA21 1, SCC and CEA in patients with cervical cancer increased with advance of the clinical stages (P< 0.05 ). The positive rates of CYFRA21 1 and SCC were different with histological differentiation. The positive rate of CA125 and CA19 9 were found significantly higher among patients with adenocarcinoma than those with squamous cell carcinoma. The sensitivity and utility can be increased with combination of CYFRA21 1+SCC+CA19 9 in diagnosis of cervical cancer.Conclusions: These five tumor markers can be detected in patients with cervical cancer, there are specifically clinical application value of CYFRA21 1 and SCC for diagnosis and monitoring the progress of the disease.

目的: 鳞状上皮细胞癌抗原( SCC)、癌胚抗原( CEA)、细胞角质素19 ( CYFRA21 1)、癌抗原125(CA125)、糖链抗原19-9(CA19 9)在宫颈癌检测中的信息提示和临床应用价值。方法:本组107 例,分为3 组,宫颈癌组63例,宫颈上皮内瘤变(CIN)组16 例,正常对照组28 例,采用放射免疫分析法检测3 组的血清CA125、CA19-9和CYFRA21-1水平,并采用酶联免疫吸附法检测血清SCC、CEA水平。结果:(1)宫颈癌组CYFRA21-1、SCC水平高于CIN组和正常对照组,差异有统计学意义(P<0.05)。(2)宫颈癌组CYFRA21 1、SCC、CEA阳性检出率随临床分期进展增高,Ⅱ期、Ⅲ/Ⅳ期与Ⅰ期比较差异有统计学意义(P<0.05)。CA19-9、SCC和CEA阳性检出率随分化程度增高而降低,高分化与低分化比较差异有统计学意义(P<0.05)。宫颈腺癌CA125、CA19 9阳性检出率高于鳞癌(P<0.05),宫颈鳞癌SCC阳性检出率高于腺癌(P<0.05),CYFRA21 1+SCC+CA19-9联合检测可提高宫颈癌的检出率。结论:5 种肿瘤标志物在...

目的: 鳞状上皮细胞癌抗原( SCC)、癌胚抗原( CEA)、细胞角质素19 ( CYFRA21 1)、癌抗原125(CA125)、糖链抗原19-9(CA19 9)在宫颈癌检测中的信息提示和临床应用价值。方法:本组107 例,分为3 组,宫颈癌组63例,宫颈上皮内瘤变(CIN)组16 例,正常对照组28 例,采用放射免疫分析法检测3 组的血清CA125、CA19-9和CYFRA21-1水平,并采用酶联免疫吸附法检测血清SCC、CEA水平。结果:(1)宫颈癌组CYFRA21-1、SCC水平高于CIN组和正常对照组,差异有统计学意义(P<0.05)。(2)宫颈癌组CYFRA21 1、SCC、CEA阳性检出率随临床分期进展增高,Ⅱ期、Ⅲ/Ⅳ期与Ⅰ期比较差异有统计学意义(P<0.05)。CA19-9、SCC和CEA阳性检出率随分化程度增高而降低,高分化与低分化比较差异有统计学意义(P<0.05)。宫颈腺癌CA125、CA19 9阳性检出率高于鳞癌(P<0.05),宫颈鳞癌SCC阳性检出率高于腺癌(P<0.05),CYFRA21 1+SCC+CA19-9联合检测可提高宫颈癌的检出率。结论:5 种肿瘤标志物在宫颈癌患者血清中均有阳性分布,其中CYFRA21-1和SCC对宫颈癌患者的辅助诊断、病情估计具有较高的临床价值。

 
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