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选择性细胞毒
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  selective cytotoxicity
     Compounds 17, 25, 26, 28, and 31 showed somewhat selective cytotoxicity against the SK-MEL-2 skin cancer.
     化合物17,19,25,26,28,和31对皮肤癌(SK一MEL一2)有不同程度的选择性细胞毒活性。
短句来源
     Results indicated that the immunoconjugate exhibited selective cytotoxicity to target cells.
     结果提示,这种免疫结合物对靶细胞具有选择性细胞毒作用。
短句来源
     In vitro study indicated that MGb2-Dex-PYM conjugate retained substantailly the original immunological activity of the MGb2 and showed stronger selective cytotoxicity against gastric cancer cell line (SGC-7901) (IC 5086μg/ml) than free PYMand the normal mouse IgG-Dex-PYM conjugate (IC50>600μg/ml).
     任制备过程中结合物中抗体活性无损失,结合物对靶细胞具有较强的选择性细胞毒作用(IC_(50)为86μg/ml),优干游离平阳霉素及无关机体结合物(IC_(50)>600μg/ml)。
短句来源
     SELECTIVE CYTOTOXICITY OF CEA McAb-METHOTREXATE CONJUGATE
     CEA单抗-MTX结合物的选择性细胞毒作用
短句来源
     The immunoconjugate showed highiy selective cytotoxicity to target cells.
     表明此偶合物在体外具有较好的选择性细胞毒作用。
短句来源
  “选择性细胞毒”译为未确定词的双语例句
     Also, HWSP had significant promoting proliferationof splenic lymphocytes and selective tumoricidal effect on liver cancer cells of Bel-7402 invitro.
     体外对脾淋巴细胞具有显著地促增殖作用,对肿瘤细胞具有选择性细胞毒作用,对肝癌Bel-7402生长具有显著的抑制作用。
短句来源
     Conclusions 35 S McAb SZ39 has a strong selective cytotoxic effect against glioma cells and is of good prospect as an immunoradiotherapeutic agent.
     结论35S-McAbSZ39具有高效的靶选择性细胞毒效应,作为一种免疫放疗制剂具有良好的应用前景。
短句来源
     The IC50 values of the total polypeptides of Viscum coloratum in the lung cancer cell A549,the cervical carcinoma cell Hela and the cerebral cancer cell SF126 of human beings are 3.7μg/mL,1.5μg/mL and 2.1μg/mL. respectively.
     B4 KSCCPNTTGR NIYNTCRFAG ASRERCAKLS GCKIISASTC PSDYPK。 它们对不同肿瘤细胞系具有选择性细胞毒活性,槲寄生总肽对于人肺癌细胞A549、人宫颈癌细胞Hela、人脑瘤细胞SF126的IC50值分别为:3.7、1.5、2.1μg/mL;
短句来源
     Results (1) The effect of IHW2 is specific for leukemia.
     结果①IHW_2体外有选择性细胞毒作用;
短句来源
     Some benzofuraxans and quinoxaline di-N-oxides were synthesized. The relationships of hypoxia-selective cytotoxicity, and radiosensitization in vitro with their chemical structure were discussed.
     本文合成了一些苯并呋咱N-氧化物类(2a~2c)及喹喔啉双N-氧化物类(3a~3e)化合物,初步探讨了体外乏氧选择性细胞毒及放射增敏作用与化学结构的关系。
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  相似匹配句对
     Cytochalasin B
     细胞B
短句来源
     Cytotoxic T Cell
     细胞T细胞
短句来源
     SELECTIVE CYTOTOXICITY OF CEA McAb-METHOTREXATE CONJUGATE
     CEA单抗-MTX结合物的选择性细胞作用
短句来源
     Selective inhibition effect of China cobra venom active factor on endothelial cells
     中华眼镜蛇活性组分选择性抑制内皮细胞增殖
短句来源
     The immunoconjugate showed highiy selective cytotoxicity to target cells.
     表明此偶合物在体外具有较好的选择性细胞作用。
短句来源
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  selective cytotoxicity
We report here an improved method for isolation of highly purified hepatic stellate cells, using dichloromethylene diphosphate (CL2MDP), which has selective cytotoxicity of Kupffer cells.
      
Panaxydol (3) and panaxyne (6) showed significant and selective cytotoxicity against SK-OV-3 with ED50 values 2.93 and 1.40 μM, respectively.
      
Inhibitors of histone deacetylases induce tumor-selective cytotoxicity through modulating Aurora-A kinase
      
Selective cytotoxicity of MIA Pa Ca-2 conditioned medium to acinar cells: a novel approach to reduce acinar cell contaminants i
      
No significant selective cytotoxicity was discernible with any unabsorbed antisera.
      
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Monoclonal antibody(Anti-C CT2) directed against human T cells was co -valently linked to bleomycin A6. By immunofluorescent assay, anti-CCT2-bleomycin A6 was found binding to human leukemia CEM cells, mouse le-ukeia L1210 and P388 cells, but not to mouse myeloma SP 2/0 cells.Cytoto-xicity of anti-C C T2-bleomycin A6 conjugate was studied. The growth of CEM cells was inhibited much stronger by the immunoconjugate than by free bleomycin A6, the IC50s being 0.14 and 1.56μmol/L, respectively.For SP 2/0 cells no...

Monoclonal antibody(Anti-C CT2) directed against human T cells was co -valently linked to bleomycin A6. By immunofluorescent assay, anti-CCT2-bleomycin A6 was found binding to human leukemia CEM cells, mouse le-ukeia L1210 and P388 cells, but not to mouse myeloma SP 2/0 cells.Cytoto-xicity of anti-C C T2-bleomycin A6 conjugate was studied. The growth of CEM cells was inhibited much stronger by the immunoconjugate than by free bleomycin A6, the IC50s being 0.14 and 1.56μmol/L, respectively.For SP 2/0 cells no significant difference in cytotoxicity between the immunoconjugate and free blomycin A6 was found. Results indicated that the immunoconjugate exhibited selective cytotoxicity to target cells.Since bleomycin A6 is less toxic to hemopoiesis and immune function, this conjugate might be more safer for leukemia chemotherapy.

应用N-琥珀酰胺-3-(2-二硫吡啶)丙酸与T淋巴细胞分化抗原的单克隆抗体(CCT_2McAb)和争光霉素A_6交连制备抗CCT_2 McAb-争光霉素A_6结合物。此结合物经免疫荧光测定与人白血病CEM细胞,小鼠白血病L_(1210)和P_(388)细胞呈特异性结合,但不与小鼠SP 2/0骨髓瘤细胞结合。此结合物在体外培养中对CEM细胞显示很强的抑制作用,约为游离争光霉素A_6的12倍。结果提示,这种免疫结合物对靶细胞具有选择性细胞毒作用。争光霉素A-6对造血和免疫功能毒性很低,这种结合物可能较安全地用于白血病化疗。

We prepared an immunoconjugate consisting of an anti-human glioma monoclonal antibody, SZ-39, and the anticancer agent adriamycin linked covalently via a dextran T-40 bridge. 48 molecules of the drug were bound per molecule of antibody. The cytotoxic activity of the immunoconjugate was tested in vitro by use of inhibition of ~3H-TdR and demonstrated highly potent and target-selective killing effect on cells derived from human glioma. The immunoconjugate was superior to adriamycin alone, SZ-39 alone and adriamycin...

We prepared an immunoconjugate consisting of an anti-human glioma monoclonal antibody, SZ-39, and the anticancer agent adriamycin linked covalently via a dextran T-40 bridge. 48 molecules of the drug were bound per molecule of antibody. The cytotoxic activity of the immunoconjugate was tested in vitro by use of inhibition of ~3H-TdR and demonstrated highly potent and target-selective killing effect on cells derived from human glioma. The immunoconjugate was superior to adriamycin alone, SZ-39 alone and adriamycin plus SZ-39 in the cytotoxicity to target cells. It showed less cytotoxicity to non-target cells than that to target cells, its cytotoxicity to non-target cells was less than that of the free drug. 50% inhibitory concentration(IC_(50)) for the immunoconjugate to target cells was 1.75×10~(-8)M。

采用DextranT-40桥联法将抗人脑胶质瘤单克隆抗体SZ-39与抗肿瘤药物阿霉素进行化学交联,制备成免疫交联物。SZ-39单抗和阿霉素的摩尔结合比为1:48。~3H-TdR掺入细胞毒性试验表明,免疫交联物对靶细胞SHG-44的细胞毒作用显著优于游离药物、游离抗体及药物和抗体的混合物。其半数抑制剂量IC_(50)为1.75×10~(-8)mol/L。免疫交联物对非靶细胞SP_2/O的细胞毒作用不及游离药物。实验显示免疫交联物有良好的靶选择性细胞毒作用。

Pingyangmycin(PYM) was linked covalently to the murinemonoclonal antibody (MGb2), specific for human gastric cancer, via a dextran (Dex) bridge. The molar ratio of MGb2:Dex:PYMwas 1 : 3 : 65 μ5 in the conjugate. In vitro study indicated that MGb2-Dex-PYM conjugate retained substantailly the original immunological activity of the MGb2 and showed stronger selective cytotoxicity against gastric cancer cell line (SGC-7901) (IC 5086μg/ml) than free PYMand the normal mouse IgG-Dex-PYM conjugate (IC50>600μg/ml). MGb2-Dex-PYM...

Pingyangmycin(PYM) was linked covalently to the murinemonoclonal antibody (MGb2), specific for human gastric cancer, via a dextran (Dex) bridge. The molar ratio of MGb2:Dex:PYMwas 1 : 3 : 65 μ5 in the conjugate. In vitro study indicated that MGb2-Dex-PYM conjugate retained substantailly the original immunological activity of the MGb2 and showed stronger selective cytotoxicity against gastric cancer cell line (SGC-7901) (IC 5086μg/ml) than free PYMand the normal mouse IgG-Dex-PYM conjugate (IC50>600μg/ml). MGb2-Dex-PYM conjugate showed less cytotoxicity against non-traget cell line (Hep2) than free PYM in the same experiment. The radioimmunoimaging and distribution of the conjugate labelled by 125I in nude mice bearing human gastric cancer xenograft indicated that 125I-MGb2-Dex-PYM had good localization in the xenog-rafted gastric cancer. The result suggested that MGb2-Dex-PYM conjugate was an better antibody-guided agent.

本文报道用葡聚糖为中间体制备鼠抗人胃癌单克隆抗体MGb_2与平阳霉素的结合物。经测算结合物中MGb_2:葡聚糖:平阳霉素的克分子比为1:3:65±5。任制备过程中结合物中抗体活性无损失,结合物对靶细胞具有较强的选择性细胞毒作用(IC_(50)为86μg/ml),优干游离平阳霉素及无关机体结合物(IC_(50)>600μg/ml)。对非靶细胞则毒性很弱(IC_(50)>600μg/ml)。在荷瘤裸鼠体内放射免疫显像及生物学分布研究表明,该结合物能选择性地定位于肿瘤部位,在局部达到较高浓度。提示该结合物是一种较好的导向药物。

 
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