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细胞信号途径
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  cell signal transduction pathway
     This paper summarized the toxicology studies of adverse effects on carcinogenisis, reproductive system,neural system and immune system and described the potential mechanism, such as combining to the specific receptors,competing serum hormone binding protein with natural hormone,altered post-receptor activation,regulation of cell signal transduction pathway and inhibition of microtube cumulation.
     该文对近年来环境内分泌干扰物毒理学研究进行综述,包括致癌、损伤生殖功能、导致神经系统和免疫系统异常等毒性作用,并对其与受体直接结合、与天然激素竞争血浆激素结合蛋白、影响激素的受体后效应、直接调节细胞信号途径产生应答、抑制微管聚合等生物学机制进行了初步的阐述。
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  cellular signal transduction pathways
     The ras family of proto-oncogenes are upstream mediators of several essential cellular signal transduction pathways involved in cell proliferation and survival.
     原癌基因ras家族编码是与细胞增殖和生长有关的一些重要细胞信号途径的上游产物。
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  “细胞信号途径”译为未确定词的双语例句
     Numerous studies imply that the process of embryo implantation requires participation of numerous molecular and cellular factors, including endocrine, paracrine, autocrine, and juxtacrine modulators, to induce multifaceted cellular signaling pathways that, presumably, are regulated in a spatiotemporal manner both in the embryo and in the uterus.
     目前认为有多种分子和细胞水平的调控分子如内分泌、旁分泌、邻分泌调节因子参与胚胎的着床过程,并通过多种细胞信号途径从时间和空间上对胚胎和子宫进行精细调控。 但是子宫内膜仅在某一特定时期允许胚胎着床,这一时期时间很短,代表着子宫内膜对胚胎具有容受性,称为“着床窗口期”。
短句来源
     For understanding the function of tonoplast protein in plant cell signal pathway, we have identified an integral protein kinase activity from the highly purified tonoplast isolated from maize ( Zea mays L.) root by a new nonradioactive method in which a color labeled peptide was used as substrate.
     为了解液泡膜蛋白在植物细胞信号途径中的功能 ,用新型的非放射性同位素方法从玉米根细胞的高纯度液泡膜上鉴定出一种膜内在的蛋白激酶。
短句来源
     The molecular mechanisms of capacitation are too complex,but many reports have documented that the capacitation is regulated by the activation of cellular signaling pathways.
     精子获能的分子机制相当复杂,许多报道表明精子获能受到多种细胞信号途径的调控。
短句来源
     Lipid second messengers,particularly phosphoinositides,play a pivotal role in several cell signaling networks. Specific inositol lipids such as PtdIns(3,4)P_(2) and PtdIns(3,4,5)P_(3) which are generated by phosphoinositide 3-kinases(PI3Ks) are specific activators to the serine/threonine protein kinase Akt that have been implicated in a plethora of cell functions.
     脂质第二信使尤其磷酸肌醇在细胞信号途径网络中具有重要作用,3-磷酸肌醇激酶(PI3K)产生的特异肌醇脂质3,4,5-三磷酸肌醇和3,4-二磷酸肌醇是调节Akt活性的重要作用分子,与多种细胞功能有关。
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     It was stem cell that makes it possible to treat cancer radically and prevent it from relapsing and metastasizing by specifically killing targeted cancer stem cells and even some old concepts such as tumorigenesis mechanism, cell signaling pathways etc may need to be reevaluated, that raised great challenge to traditional oncotherapy.
     肿瘤干细胞的提出,可靶向性杀伤肿瘤干细胞从而使根治肿瘤和防止肿瘤复发和转移成为可能,且先前诸多关于肿瘤发生发展机制、细胞信号途径等研究成果可能需要重新评价,对传统的肿瘤治疗方式提出了巨大挑战。
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  相似匹配句对
     The Signaling Pathways Triggering Cellular Senescence
     细胞老化相关信号途径
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     Signal Regulation of B Cell Homeostasis
     B细胞稳态的信号调节
短句来源
     Cellular signal transduction and cancer
     细胞信号传导和肿瘤
短句来源
     GA Signal Transduction Pathway
     赤霉素的信号转导途径
短句来源
     Notch signal pathway in determining glial cell fates
     神经胶质细胞命运与Notch信号途径的决定作用
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  cellular signal transduction pathways
Cadmium is a toxic transition heavy metal of continuing occupational and environmental concern, with a wide variety of adverse effects on regulation of gene expression and cellular signal transduction pathways.
      
This article reviews how these KSHV proteins modulate cellular signal transduction pathways.
      
Tyrosine phosphorylation events are key components of several cellular signal transduction pathways.
      
There is an upsurge of interest in the chemistry and biochemistry of phosphoinotides, their analogues and the related enzymes due to their involvement in the inositol phosphates mediated cellular signal transduction pathways.
      
MAPKs may be one of the important cellular signal transduction pathways affected by various environmental pollutants, including heavy metals.
      
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For understanding the function of tonoplast protein in plant cell signal pathway, we have identified an integral protein kinase activity from the highly purified tonoplast isolated from maize ( Zea mays L.) root by a new nonradioactive method in which a color labeled peptide was used as substrate. The protein kinase was Ca 2+ _dependent and CaM and phosphatidylserine_independent, like the calmodulin_like domain protein kinase (CDPK) in many plants. The optimal pH value and Ca 2+ concentration were...

For understanding the function of tonoplast protein in plant cell signal pathway, we have identified an integral protein kinase activity from the highly purified tonoplast isolated from maize ( Zea mays L.) root by a new nonradioactive method in which a color labeled peptide was used as substrate. The protein kinase was Ca 2+ _dependent and CaM and phosphatidylserine_independent, like the calmodulin_like domain protein kinase (CDPK) in many plants. The optimal pH value and Ca 2+ concentration were 6.5 and 10 μmol/L, respectively. According to the optimal pH value and the effect of detergent, it could be inferred that the active site of this protein kinase is oriented toward the cytoplasm. Zn 2+ had no obvious effect on its activity, indicating that this protein kinase has no zinc_finger domain that exists in some mammalian protein kinases. At the same time, when tonoplast proteins were prephosphorylated in the presence of Ca 2+ and ATP, both the ATP_hydrolysis and the proton_transport activity of vacuolar H +_ATPase were stimulated. This stimulation could be reversed by an alkaline_phosphatase. These results indicate that a Ca 2+ _dependent protein kinase was located in the tonoplast, and a Ca 2+ _dependent phosphorylation, probably caused by this kinase, activated the vacuolar H +_ATPase activity. These results are helpful for further research on the function of CDPK in the course of signal transduction in plants.

为了解液泡膜蛋白在植物细胞信号途径中的功能 ,用新型的非放射性同位素方法从玉米根细胞的高纯度液泡膜上鉴定出一种膜内在的蛋白激酶。这种蛋白激酶具有Ca2 +依赖、CaM和磷脂酰丝氨酸不依赖等特性 ,与已在多种植物中报道的含有类似钙调素结构域的蛋白激酶CDPK相似。离体实验表明其活性的最适pH值为 6 .5 ,最适Ca2 +浓度为 1 0 μmol/L。从最适pH值和去污剂的影响可以推测出其活性位点朝向胞质一侧。Zn2 +对其活性没有明显的抑制作用 ,说明该激酶缺少某些哺乳动物的蛋白激酶常含有的锌指结构。当液泡膜蛋白在Ca2 +和ATP存在的条件下被预磷酸化后 ,液泡膜H+_ATPase的ATP水解和质子转运过程均被激活。激活的活性可以被碱性磷酸酶逆转。以上结果说明玉米根尖细胞的液泡膜中存在一种可能是CDPK的蛋白激酶。由它造成的Ca2 +依赖的磷酸化作用激活了液泡膜H+_ATPase的活性。这些结果将有助于深入研究CDPK在植物细胞信号转导中的功能。

Edothelial cells in the heart play an obligatory role in regulating an maintaining cardiac normal development. With the development of targeted gene manipulation, more and more results have indicated that endothelialcardiomyocytal interaction is a prerequisite for normal cardiac development and growth. Some of the molecular mechanisms and cellular signals governing this interaction, such as neuregulin, angiopoietin, NO,TGFβ,endothelin and so on. The role of endothelialmyocardial signaling during heart development...

Edothelial cells in the heart play an obligatory role in regulating an maintaining cardiac normal development. With the development of targeted gene manipulation, more and more results have indicated that endothelialcardiomyocytal interaction is a prerequisite for normal cardiac development and growth. Some of the molecular mechanisms and cellular signals governing this interaction, such as neuregulin, angiopoietin, NO,TGFβ,endothelin and so on. The role of endothelialmyocardial signaling during heart development is discussed.

内皮细胞对于调节和维持心脏发育起着十分重要的作用.随着基因功能研究技术的发展,已有越来越多的资料表明内皮 心肌细胞相互作用对于心脏生长和发育是必须的.目前已经发现包括神经调节蛋白、血管紧张素、NO、TGF β、内皮素等在内的很多细胞信号途径均参与了此过程.就在心脏发育过程中心肌 内皮细胞相互作用的重要信号途径作一综述.

More and more attention was paid to the adverse effects of environmental endocrine disruptors on human and animals. But the biologic mechanism is currently not well known. This paper summarized the toxicology studies of adverse effects on carcinogenisis, reproductive system,neural system and immune system and described the potential mechanism, such as combining to the specific receptors,competing serum hormone binding protein with natural hormone,altered post-receptor activation,regulation of cell signal transduction...

More and more attention was paid to the adverse effects of environmental endocrine disruptors on human and animals. But the biologic mechanism is currently not well known. This paper summarized the toxicology studies of adverse effects on carcinogenisis, reproductive system,neural system and immune system and described the potential mechanism, such as combining to the specific receptors,competing serum hormone binding protein with natural hormone,altered post-receptor activation,regulation of cell signal transduction pathway and inhibition of microtube cumulation.

环境内分泌干扰物对人类、家畜、野生动物的健康和繁衍的不良影响愈来愈受到重视,但其毒理学机制尚未阐明。该文对近年来环境内分泌干扰物毒理学研究进行综述,包括致癌、损伤生殖功能、导致神经系统和免疫系统异常等毒性作用,并对其与受体直接结合、与天然激素竞争血浆激素结合蛋白、影响激素的受体后效应、直接调节细胞信号途径产生应答、抑制微管聚合等生物学机制进行了初步的阐述。

 
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