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剂量-时间-效应关系
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  “剂量-时间-效应关系”译为未确定词的双语例句
     Conclusion It was suggested th at gene expression of MT-1F,MT-1G ,MT-1H and 1X in HPBLs could be used as potential exposure biomarker.
     结论 镉可诱导人外周血淋巴细胞MT-1F、MT -1G、MT- 1H、MT- 1XmRNA表达增加 ,并表现出剂量 -时间 -效应关系 ,可作为潜在的镉接触生物标志物。
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     Results The proliferation rate of FL cells reached its peak on the third day at EGF concentration of 10μg/L(42. 4% ,P<0. 01). Expression of p-Erkl/2 protein was markedly elevated when concentrations of EGF were 10-60μg/L, In the therapy groups, the gastric glands were rearranged in order and the inflammatory cells were less.
     结果剂量-时间-效应关系示EGF浓度10μg/L第3天时促细胞增殖率最高(42.4%,P<0.01),Western blot结果示EGF浓度10~60μg/L时磷酸化Erk1/2活性显著升高;
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     Objective To investigate the relationship of dose-duration-effect of proliferation inhibition and apoptosis induction when treated HL-60 with different dose of Ara-C and different duration of administration in vitro.
     目的  研究阿糖胞苷 (Ara -C)在体外对人白血病细胞株HL - 6 0增殖抑制和诱导凋亡的剂量 -时间 -效应关系。
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     Methods Following treat the HL-60 cell with designed concentration and duration, the MTT survey was used to detect the relationship of dose-duration-effect in inhibiting the proliferation of HL-60. Then the morphology of HL-60 and the DNA Ladder were observed through luminescent dyes-Hoechst 33258 and agar electrophoresis respectively. Furthermore, the cell cycle distribution and apoptosis rate were determined through FCM.
     方法  在体外设定的浓度梯度和作用时间下应用Ara -C处理人白血病HL - 6 0细胞 ,采用四氮唑盐还原法 (MTT法 )检测Ara -C对HL - 6 0细胞增殖抑制的剂量 -时间 -效应关系 ,荧光染色观察凋亡细胞形态学改变 ,琼脂糖凝胶电泳测定DNA梯带 (DNA ,Lad der) ,流式细胞仪检测细胞凋亡率和细胞周期变化。
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     Methods K562 cells were treated with 17-AAG. The cell viability was evaluated by MTT assay and cell morphology was observed with Wright-Giemsa staining. The cell cycle and apoptosis were detected by flow cytometry.
     方法用17-AAG处理K562细胞,用四氮唑盐还原法(MTT法)检测17-AAG对K562细胞增殖抑制的剂量-时间-效应关系,瑞特-姬姆萨染色观察细胞形态学变化,Hoechst 33342荧光染色观察凋亡细胞核的变化,流式细胞仪检测细胞凋亡率和细胞周期变化,Western blot检测相关蛋白分子的变化。
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     The dose response relationships between
     显的剂量-效应关系
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     A dose - effect relationship was observed in the animal.
     动物实验有剂量-效应关系;
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     The relationships of dose-effect and inhibition-time will be found.
     并建立了剂量效应关系、抑制率—时间关系
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     Furthermore,the time-dosage dependentrelationship existed in the nhibition rate of tumor cells.
     癌细胞抑制率呈现出时间剂量依赖性效应关系
     Furthermore, the time-dosage dependent relationship existed in the inhibition rate of tumor cells.
     癌细胞抑制率呈现出时间剂量依赖性效应关系
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The effects of trinitrotoluene(TNT) on Ca2+-ATPase and protein-thiol of rat hepatocyte plasma membrane were studied in two experimental models. When TNT was directly incubated with the plasma membrane isolated by Percoll density centrifugation in the presence of NADPH at 37℃ for 30 or 60 min, no obvious changes of Ca2+-ATPase and protein-thiol were shown. In the dose- and time-dependent manners, however, the marked reduces of Ca2+-ATPase and protein-thiol in the plasma mem-brane isolated from Affi-Gel 731 polycation...

The effects of trinitrotoluene(TNT) on Ca2+-ATPase and protein-thiol of rat hepatocyte plasma membrane were studied in two experimental models. When TNT was directly incubated with the plasma membrane isolated by Percoll density centrifugation in the presence of NADPH at 37℃ for 30 or 60 min, no obvious changes of Ca2+-ATPase and protein-thiol were shown. In the dose- and time-dependent manners, however, the marked reduces of Ca2+-ATPase and protein-thiol in the plasma mem-brane isolated from Affi-Gel 731 polycation -coated bead after preincubation of TNT with intact hepatocyte in same conditions were observed, with significant relationship (r =0.905, p<0.01) between two indices. An addition of dithiothreit in the incubation system protected the plasma membrane against TNT-induced Ca2+-ATPase inhibition.

用两种实验模型观察三硝基甲苯(TNT)对大鼠肝细胞质膜Ca~(2+)-ATP酶和蛋白巯基含量的影响。结果表明:当TNT直接与Percoll密度梯度离心分离的质膜及NADPH在37℃温育30或60min后,上述两项指标均未见明显改变;但若将TNT与胶原灌注分离的肝细胞在37℃温育同样的时间,然后用Affi-Gel 731聚阳离子凝胶颗粒吸附法分离质膜,则质膜Ca~(2+)-ATP酶活性和蛋白巯基含量均见明显下降,且呈剂量时间效应关系,两项观察指标之间密切相关。若在肝细胞的温育介质中加入二硫苏糖醇或GSH,则前者对Ca~(2+)-ATP酶活性具有明显的保护作用,而GSH作用不明显。

onoclonal antibody (McAb) and polyclonal antibody (PcAb) to surface antigen of duck hepatitis B virus (DHBsAg) were used to study the efficacy of inactivation and removal by specific adsorption of DHBV in duck plasma.The results indicated that neutralization with McAb or PcAb could block the antigen of the virus and the inhibition rate increased with increasing dosage. The immunoadsorption method could remove DHBV from plasma and the effect was also enhanced with increasing antibody content. Repeated treatment...

onoclonal antibody (McAb) and polyclonal antibody (PcAb) to surface antigen of duck hepatitis B virus (DHBsAg) were used to study the efficacy of inactivation and removal by specific adsorption of DHBV in duck plasma.The results indicated that neutralization with McAb or PcAb could block the antigen of the virus and the inhibition rate increased with increasing dosage. The immunoadsorption method could remove DHBV from plasma and the effect was also enhanced with increasing antibody content. Repeated treatment with addition of 5 mg of antibody adsorbent to each milliliter of plasma containing DHBV for 4 times resulted in negative conversion of various DHBV markers examined.

研究发现,单抗与多抗中和法可使病毒抗原得到封闭,抑制率随剂量的增加而增加。免疫吸附法可清除血浆中的鸭乙型肝炎病毒(DHBV),并有剂量时间效应关系。每毫升含DHBV血浆中加入5mg抗体吸附剂,反复处理4次,所测各种DHBV标志物均转为阴性。

Objective In order to explain the toxic mechanism of organic extract and cyanobacteria extract from water body.Methods The cytotoxicity of these two substances to mouse BALB/c 3T3 cell line in culture was investigated from multi-endpoint. The MTT and neutral red intake microassays and microscopic observation were used respectively.Results The rate of viability decreased, which was dose-time-dependent effect relationship on organic extracts concentration.The cell concentration increased following exposure...

Objective In order to explain the toxic mechanism of organic extract and cyanobacteria extract from water body.Methods The cytotoxicity of these two substances to mouse BALB/c 3T3 cell line in culture was investigated from multi-endpoint. The MTT and neutral red intake microassays and microscopic observation were used respectively.Results The rate of viability decreased, which was dose-time-dependent effect relationship on organic extracts concentration.The cell concentration increased following exposure to cyanobacteria extract at low concentration and short time. In contrary, it decreased at high concentration and long time exposure. Morphological alteration was observed when cell was treated with two substances at comparatively high concentration.Conclusions Toxicity of organic extracts and cyanobacteria extract on 3T3 cell was assessed sensitively by two microassays. Organic extract was harmful on cell membrane and mitochondrion. Cyanobacteria extract can injure the cell membrane, and it had dual role on mitochondrion, one was irritated, and the other was injury.

目的 研究水体有机物和蓝藻提取物的毒作用机理。方法 通过形态学观察、MTT法和中性红摄入法 ,从多个终点检测二者对BALB/c 3T3细胞的毒性作用。结果 二者达一定浓度时 ,可引起细胞形态改变 ;有机物在各个浓度、各个培养时相均可引起细胞的存活率下降 ,有明显的剂量 -时间 -效应关系 ;而藻毒素在低浓度短时间染毒下可引起细胞数目的增加 ,在高浓度或长时间作用下 ,细胞存活率却明显下降。结论 两种比色法可敏感检测有机物及藻毒素对BALB/c 3T3细胞的毒性作用 ,两者对细胞膜均有损伤作用 ;有机物对线粒体有损伤作用 ,而藻毒素对线粒体具有刺激和损伤的双重作用。

 
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