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移植受者
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  transplantation recipients
    Alveolar damage of pneumocystis carinii pneumonia in renal transplantation recipients
    肾移植受者卡氏肺囊虫肺炎的肺泡损伤
短句来源
    Pneumocystis carinii pneumonia in renal transplantation recipients: a clinical and pathologic analysis
    肾移植受者卡氏肺孢子肺炎12例临床病理分析
短句来源
    Objective To study the clinical and pathological characteristics of pneumocystis carinii pneumonia in renal transplantation recipients.
    目的探讨肾移植受者卡氏肺孢子肺炎的临床病理特点。
短句来源
    Methods We reviewed the clinical and pathological data in 12 renal transplantation recipients with pneumocystis carinii pneumonia, and analysed systematically their histopathological and histochemical characteristics.
    方法复习12例肾移植受者卡氏肺孢子肺炎的临床病理资料,并对其组织病理学、组织化学进行观察分析。
短句来源
  “移植受者”译为未确定词的双语例句
    Methods: Analysis was made of 255 patients of recipients of allo-HSCT from 1998 to 2001. Results: Seventy-two episodes of pneumonia occurred in 66 patients with the morbidity of 25.9%;
    方法:总结北京大学血液病研究所1998至 2001连续 4年中 255例异基因造血干细胞移植受者中发生移植后肺炎的资料。 结果: 66例发生移植后肺炎的患者累计发病 72例次,总发病率 25. 9%;
短句来源
    CONCLUSION: The key points of successful treatment for severe pneumonia are the combination of early aggressive reduction of the immunosuppressive therapy, early detection of responsible pathogen and effective control of severe hypoxemia.
    结论:及早调整免疫抑制方案、及时明确病原和有效纠正低氧血症是治疗移植受者严重肺部感染的关键。
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  transplantation recipients
The records of 471 bone marrow transplantation recipients over 11 years at the Hadassah University Hospital Bone Marrow Transplantation Department were reviewed.
      
We compared results using Neoral versus Sandimmune, each in combination with steroid and azathioprine immunosuppression, in primary liver transplantation recipients.
      
Invasive central nervous system aspergillosis in bone marrow transplantation recipients: an overview
      
The BARIGA LDLT (biliary anastomosis in right graft for adult living donor liver transplantation recipients) with end-to-side or end-to-end hepatico-hepaticostomy was used in five recipients of right grafts (segments 5-8).
      
Cytomegaloviral virus infection in bone marrow transplantation recipients: strategies for prevention and treatment
      
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Objective To study the alveolar ultrastructural changes and the interaction between Pneumocystis carinii (PC) and alveoli in Pneumocystis carinii pneumonia(PCP) patients after renal transplantation Methods Twenty seven patients with suspected PCP after renal transplantation were examinated by bronchoscopy with bronchoalveolar lavage(BAL) and transbronchial lung biopsy(TBLB) The BAL fluid was centrifuged and the sediments were stained for PC Cases for which electron microscope showed alveolar...

Objective To study the alveolar ultrastructural changes and the interaction between Pneumocystis carinii (PC) and alveoli in Pneumocystis carinii pneumonia(PCP) patients after renal transplantation Methods Twenty seven patients with suspected PCP after renal transplantation were examinated by bronchoscopy with bronchoalveolar lavage(BAL) and transbronchial lung biopsy(TBLB) The BAL fluid was centrifuged and the sediments were stained for PC Cases for which electron microscope showed alveolar tissue in TBLB specimen were included Then the clinical features,PC,alveolar epithelial damage,exudate in alveolar space,inflammatory cell infiltration,and fibrous tissue in the interstitial space were analyzed and evaluated Results Twenty three cases were studied The mean time from renal transplantation to onset of illness was 5 6 months,and that from onset of illness to hospitalization was 5 5 days Clinical features included fever,dyspnea,unproductive cough,and scanty chest signs,to hypoxemic respiratory failure Chest CT showed diffuse lung interstitial changes in 22 of the 23 cases,9 with consolidation After treatment with SMZco,the fever resolved in 1 5 days,and the general state of the patients became better,and 19 patients were dischaged within 1 month PC in BAL fluid was found by special staining in 18 patients ,while PC was found by electron microscope in 14 patients In most cases PC was few in the lung tissue, but in 3 cases abundant PC filled the alveolar space PC was seen in two forms,the cyst and the trophozoite Electron and light microscopes showed alveolar exudate,inflammation in interstitium and alveolar space, interstitial fibrosis,and alveolar epithelial damage in all patients Conclusion In PCP patients after renal transplantation there was marked alveolar damage, which was the major pathological change in the lung

目的 通过观察肾移植后卡氏肺囊虫肺炎 (PCP)患者的肺泡超微结构改变 ,探讨其与病原学的关系。方法 对可疑PCP的肾移植受者 ,进行支气管肺泡灌洗 (BAL)和 (或 )经支气管肺组织活检 (TBLB) ,以发现卡氏肺囊虫为确诊依据 ,通过光镜和电镜下的观察 ,结合其临床特点 ,分析病原体与宿主肺泡病理反应的关系。结果 确诊PCP 2 3例 ,发病距肾移植时间平均 5 6个月 ,发病至就诊时间平均 5 5d ;临床以发热、呼吸困难为主要症状 ,胸部CT表现为两肺弥漫性肺间质及肺泡改变。通过BAL检查发现卡氏肺囊虫者 18例 ,通过TBLB电镜检查发现卡氏肺囊虫者 14例 ,虫体以滋养体与包囊两种形式存在。肺组织光、电镜检查 :可见Ⅰ型上皮细胞变性、Ⅱ型细胞增生、Ⅰ型和Ⅱ型上皮细胞脱落、上皮细胞脱落后其下的基底膜暴露于肺泡腔等 ;肺间质及肺泡内出现少量炎症细胞 ;肺泡腔内见少量蛋白样物质渗出 ,部分可见空泡样细胞及泡沫样组织 ;肺间质中可见不同程度胶原纤维增生 ,肺泡间隔增宽。结论 肾移植后PCP患者存在明显的肺泡损伤 ,以肺泡内渗出、炎症细胞浸润、上皮细胞受损及间质纤维组织增生为特征 ,为其...

目的 通过观察肾移植后卡氏肺囊虫肺炎 (PCP)患者的肺泡超微结构改变 ,探讨其与病原学的关系。方法 对可疑PCP的肾移植受者 ,进行支气管肺泡灌洗 (BAL)和 (或 )经支气管肺组织活检 (TBLB) ,以发现卡氏肺囊虫为确诊依据 ,通过光镜和电镜下的观察 ,结合其临床特点 ,分析病原体与宿主肺泡病理反应的关系。结果 确诊PCP 2 3例 ,发病距肾移植时间平均 5 6个月 ,发病至就诊时间平均 5 5d ;临床以发热、呼吸困难为主要症状 ,胸部CT表现为两肺弥漫性肺间质及肺泡改变。通过BAL检查发现卡氏肺囊虫者 18例 ,通过TBLB电镜检查发现卡氏肺囊虫者 14例 ,虫体以滋养体与包囊两种形式存在。肺组织光、电镜检查 :可见Ⅰ型上皮细胞变性、Ⅱ型细胞增生、Ⅰ型和Ⅱ型上皮细胞脱落、上皮细胞脱落后其下的基底膜暴露于肺泡腔等 ;肺间质及肺泡内出现少量炎症细胞 ;肺泡腔内见少量蛋白样物质渗出 ,部分可见空泡样细胞及泡沫样组织 ;肺间质中可见不同程度胶原纤维增生 ,肺泡间隔增宽。结论 肾移植后PCP患者存在明显的肺泡损伤 ,以肺泡内渗出、炎症细胞浸润、上皮细胞受损及间质纤维组织增生为特征 ,为其发病的主要病理基础

Objective: To analyse the clinical features and pathogenesis of pneumonia post allogeneic hematopoietic stem cell transplantation (HSCT). Methods: Analysis was made of 255 patients of recipients of allo-HSCT from 1998 to 2001. Results: Seventy-two episodes of pneumonia occurred in 66 patients with the morbidity of 25.9%; 50 (75%) patients were cured. Twelve episodes (16.7%) were caused by mixed infection of bacteria and fungi;22 episodes (30.6%) were caused by cytomegalovirus infection and 36 episodes (50.0%)...

Objective: To analyse the clinical features and pathogenesis of pneumonia post allogeneic hematopoietic stem cell transplantation (HSCT). Methods: Analysis was made of 255 patients of recipients of allo-HSCT from 1998 to 2001. Results: Seventy-two episodes of pneumonia occurred in 66 patients with the morbidity of 25.9%; 50 (75%) patients were cured. Twelve episodes (16.7%) were caused by mixed infection of bacteria and fungi;22 episodes (30.6%) were caused by cytomegalovirus infection and 36 episodes (50.0%) were classified as idiopathic pneumonia syndrome. The total mortility of pneumonia post allo-HSCT in our institute was 22.7%. The occurrence of chronic graft-versus-host disease was significantly high in idiopathic pneumonia syndrome, in which good response to immune suppressive therapy was observed. Conclusion: Pneumonia post allo-HSCT is a common complication, of which pathogenesis includes infection and non-infection. Its clinical outcome could be improved by specific therapy.

目的:分析异基因造血干细胞移植后肺炎的临床特点和病因谱。方法:总结北京大学血液病研究所1998至 2001连续 4年中 255例异基因造血干细胞移植受者中发生移植后肺炎的资料。结果: 66例发生移植后肺炎的患者累计发病 72例次,总发病率 25. 9%; 50例患者的移植后肺炎被治愈,占 75%。病因分析显示,细 /真菌感染性移植后肺炎 12例次(16. 7% ),巨细胞病毒性肺炎 22例次(30. 6% ),特发性肺炎综合征 36例次(50. 0% )。总死亡率为 22. 7%。发生特发性肺炎综合征的患者较多伴发慢性移植物抗宿主病,免疫抑制剂治疗有效。结论:异基因造血干细胞移植后肺炎是移植后常见的合并症,其病因学包括感染和非感染因素,针对病因的治疗可以改善预后。

Objective To study the clinical and pathological characteristics of pneumocystis carinii pneumonia in renal transplantation recipients. Methods We reviewed the clinical and pathological data in 12 renal transplantation recipients with pneumocystis carinii pneumonia, and analysed systematically their histopathological and histochemical characteristics. Results Among the 12 cases, all were identified as interstitial pneumonia. Pathological features showed foamy or protein exudates filled in alveolar cavity with...

Objective To study the clinical and pathological characteristics of pneumocystis carinii pneumonia in renal transplantation recipients. Methods We reviewed the clinical and pathological data in 12 renal transplantation recipients with pneumocystis carinii pneumonia, and analysed systematically their histopathological and histochemical characteristics. Results Among the 12 cases, all were identified as interstitial pneumonia. Pathological features showed foamy or protein exudates filled in alveolar cavity with interstice between the alveolar wall and exudates, proliferation of alveolar cuboidal epithelium, and black circular or semilunar pathogens with 4~5μm diameter presented by Gomori's methnanime silvernitrate staining. Conclusions Pneumocystis carinii pneumonia presents as interstitial pneumonia. Foamy exudates and visible pathogens in pathological examination are important features for accurate diagnosis.

目的探讨肾移植受者卡氏肺孢子肺炎的临床病理特点。方法复习12例肾移植受者卡氏肺孢子肺炎的临床病理资料,并对其组织病理学、组织化学进行观察分析。结果12例均表现为间质性肺炎以及肺泡腔内出现泡沫状或絮状蛋白样渗出物,渗出物与肺泡壁存在明显的空隙,肺泡立方上皮明显增生;六胺银染色见病原体呈黑色圆形或半月形,大小约4~5μm。结论卡氏肺孢子肺炎是一种间质性肺炎,泡沫状渗出物及查见病原体是其确诊的重要依据。

 
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