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移植受者
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  transplantation recipients
    METHODS The lowest CsA concentration(ρ0) and the highest CsA concentration(ρ2) in blood of 136 kidney transplantation recipients were detected by fluorescence polarization immunoassay(FPIA).
    方法采用荧光偏振免疫(FPIA)法,对136例肾移植受者进行全血中CsA谷浓度(ρ0)及服药后2 h血药浓度(ρ2)监测,并对数据进行归纳分析。
短句来源
    Comparing steady-state pharmacokinetics of ciclosporin in kidney and liver transplantation recipients,the elimination rate constant (β) in liver transplantation recipients was significantly decreased,T_(1/2β),T_(1/2α),t_(max) and the time of reaching average steady concentration (t_(css)) in liver transplantation recipients were significantly extended.
    肝移植受者较肾移植β显著减小,T1/2β、T1/2α延长,t_(max)和达平均稳态血药浓度的时间(tcss)后移。
短句来源
    Comparison of steady-state pharmacokinetics of ciclosporin in kidney and liver transplantation recipients
    肝肾移植受者环孢素稳态药动学比较
短句来源
    The MEIA and ELISA was used to detect ta crolimus valley point concentrations in heart,liver,small intestine and kidney transplantation recipients at different postoperative periods.
    以他克莫司谷浓度测定结果结合器官移植受者的临床情况 ,比较MEIA法和ELISA法在心脏、肝脏、小肠和肾脏移植患者全血他克莫司谷浓度治疗窗的范围。
短句来源
    Objective To study the pharmacokinetics of cyclosporin A (CsA) with or without combination of berberine hy-drochloride (Ber) in renal transplantation recipients.
    目的:研究盐酸黄连素对肾移植受者使用环孢素A增效作用的体内动力学过程。
短句来源
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  transplanted recipients
    Clinical Study on Coadministration of Cyclosporin A and Berberin Hydrochloride in Renal Transplanted Recipients
    肾移植受者环孢素A与盐酸小檗碱合用的临床研究
短句来源
    Gender difference of pharmacokinetics of oral cyclosporin A in renal transplanted recipients
    肾移植受者口服环孢素A药代动力学的性别差异
短句来源
    The Pharmacokinetics of Enhancement of Cyclosporin A by Berberine Chloride Coadministrated in Renal Transplanted Recipients
    盐酸黄连素对肾移植受者环孢素A增效作用的临床药代动力学研究
短句来源
    METHODS:The bloodconcentrations of CsA were detected with FPIA method in 132 renal transplanted recipients. The liver function and so on that mightaffect the blood concentration of CsA were observed.
    方法:采用FPIA法测定132例肾移植受者的CsA血药浓度,观察肝功能等对CsA血药浓度的影响。
短句来源
    METHODS:Blood concentration of CsA was detected by FPIA in 40 renal transplanted recipients. The influence of the red blood cells and hemoglobin for the blood concentration of CsA was analysed.
    方法 :应用FPIA法测定 40例肾移植受者术后CsA血药浓度 ,分析术后不同时间RBC数及HGB含量对CsA血药浓度的影响。
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  transplant patients
    METHODS: Twenty_five renal transplant patients (M 19, F 16; age 34 a±s 12 a) with gingival hyperplasia were treated with metronidazole 400 mg, po, tid, 7 d for a course.
    方法:肾移植受者患牙龈增生25例(男性19例,女性6例,年龄34a±s12a),采用甲硝唑400mg,po,tid,7d为一个疗程。
短句来源
    OBJECTIVE To develop an RP-HPLC method for determining the C_(0) and C_(2)of_()cyclosporine A(CsA) in renal transplant patients whole blood.
    目的:建立全血中环孢素A(CsA)的RP-HPLC测定法,监测肾移植受者全血中CsA的C0、C2值。
短句来源
    Determination of C_0、C_2 of cyclosporine A in renal transplant patients whole blood by RP-HPLC
    高效液相色谱法测定肾移植受者环孢素A的血药谷值及两小时浓度
短句来源
  “移植受者”译为未确定词的双语例句
    Efficacy/Cost Analysis of Domestic and Imported Cyclosporine inKidney-Transplanted Recipients
    肾移植受者应用国产与进口环孢素的疗效/费用分析
短句来源
    CONCLUSION This limited sampling strategy provides an effective approach for estimation of full MPA AUC0-12 in renal recipients.
    结论本研究中建立的有限取样方法为估算肾移植受者口服MMF后完整的MPA AUC0-12h 值提供了一种具有实用价值的方法。
    The results showed that anisodamine could attenuate the abnormalities in serum GCA,bilirubin,albumin,liver LPO,GSH and P450.49 patients with liver damage caused by CsA hepatoxicity were treated with anisodamine,The results showed that 35 cases(71.4%)were cured with SGPT and serum bilirubin returning to normal,6 cases(12.2%)were improved and 8 cases failed to respond to the therapy(16.3%).
    结果表明山莨菪碱可减轻CsA引起血甘氨胆酸、胆红素、白蛋白,肝匀浆LPO、GSH及P_(450)的异常变化。 49例CsA肝损害的肾移植受者经山莨菪碱治疗,其中35例(71.4%)治愈,6例(12.2%)好转,无效8例(16.3%)。
短句来源
    Methods The whole blood CsA concentrations were assayed 7 days after oral admi- nistration with a dosage of 6 mg/kg daily in 47 recipients. The blood samples drawn just prior to ingestion of the dose and subsequently at 1, 2, 3, 4, 5, 6, 8, 10, 12 h later were monitored with TDX.
    方法  4 7例肾移植受者术后服用CsA 6mg·kg-1·d-1,7d后留取服药即刻及服药后 1、2、3、4、5、6、8、10及 12h的血样 ,测定全血CsA浓度 ,计算各自的药代动力学参数。
短句来源
    Methods The whole blood CsA concentrations were assayed 7 days after oral administration of a dosage of 6mg·kg-1·d-1 in 47 recipients .
    方法:47例肾移植受者术后服用环孢素A(CsA)6mg·kg-1·d-17d后,常规留取服药即刻及服药后1,2,3,4,5,6,8,10,12h血样测全血环孢素浓度,计算各自的药动学参数。
短句来源
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  transplantation recipients
The records of 471 bone marrow transplantation recipients over 11 years at the Hadassah University Hospital Bone Marrow Transplantation Department were reviewed.
      
We compared results using Neoral versus Sandimmune, each in combination with steroid and azathioprine immunosuppression, in primary liver transplantation recipients.
      
Invasive central nervous system aspergillosis in bone marrow transplantation recipients: an overview
      
The BARIGA LDLT (biliary anastomosis in right graft for adult living donor liver transplantation recipients) with end-to-side or end-to-end hepatico-hepaticostomy was used in five recipients of right grafts (segments 5-8).
      
Cytomegaloviral virus infection in bone marrow transplantation recipients: strategies for prevention and treatment
      
更多          
  transplanted recipients
Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic
      
Furthermore, Smad4lox/lox-Mx1Cre bone marrow transplanted recipients did not develop a wasting syndrome.
      
Nonvascularized islets neither engrafted nor controlled blood glucose levels in transplanted recipients.
      
Representative samples of liver and colon were obtained from transplanted recipients and fixed in 10% neutral-buffered formalin.
      
  transplant patients
Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients
      
The diagnosis of urinary tract infection in renal transplant patients is important because unrecognized bacterial infection may lead - in the worst case - to graft loss.
      
Due to the high incidence of skin tumors, transplant patients should undergo dermatological examinations on a regular basis.
      
Although renal transplant patients are notoriously susceptible to bacteriaemic infection caused by enteric commensals and pathogens, there has been only one previous report ofY.
      
Single-dose treatment also proved very effective against urinary tract infections in renal transplant patients whose infection is almost always located in the lower urinary tract.
      
更多          


SD rats were divided into 4 groups:control,CsA,CsA+anisodamine(5mg/kg·d)and CsA+anisodamine(20mg/kg·d)groups.The serum glycocholic acid(GCA),bilirubin(Bil),albumin,ALT,AST,ALP were measured before and 1,2 weeks after the administration.The triglyceride(Trig),LPO,GSH,SOD,and P450 of liver homogenate were assayed 2 weeks after the beginning of the administration.The results showed that anisodamine could attenuate the abnormalities in serum GCA,bilirubin,albumin,liver LPO,GSH and P450.49 patients with liver damage...

SD rats were divided into 4 groups:control,CsA,CsA+anisodamine(5mg/kg·d)and CsA+anisodamine(20mg/kg·d)groups.The serum glycocholic acid(GCA),bilirubin(Bil),albumin,ALT,AST,ALP were measured before and 1,2 weeks after the administration.The triglyceride(Trig),LPO,GSH,SOD,and P450 of liver homogenate were assayed 2 weeks after the beginning of the administration.The results showed that anisodamine could attenuate the abnormalities in serum GCA,bilirubin,albumin,liver LPO,GSH and P450.49 patients with liver damage caused by CsA hepatoxicity were treated with anisodamine,The results showed that 35 cases(71.4%)were cured with SGPT and serum bilirubin returning to normal,6 cases(12.2%)were improved and 8 cases failed to respond to the therapy(16.3%).

SD大鼠分4组,即对照组、环孢素(CsA)组、CsA+小剂量山莨菪碱组、CsA+大剂量山莨菪碱组。用药前、用药1周及2周分别检测血甘氨胆酸、胆红素、白蛋白、丙氨酸转氨酶、天冬氨酸转氨酶及碱性磷酸酶。用药2周后检测肝组织甘油三酯、脂质过氧化产物(LPO)、超氧化物歧化酶、还原性谷胱甘肽(GSH)及细胞色素P450(P450)。结果表明山莨菪碱可减轻CsA引起血甘氨胆酸、胆红素、白蛋白,肝匀浆LPO、GSH及P_(450)的异常变化。49例CsA肝损害的肾移植受者经山莨菪碱治疗,其中35例(71.4%)治愈,6例(12.2%)好转,无效8例(16.3%)。

The efficacy/cost of domestic and imported cyclosporine was analyzed in 50kidney-transplanted recipients with stable renal function. The results showed that the immun-osuppressive efficacy of domestic cyclosporine was well-matched to that of imported cyclosprine. The incidence of adverse drug reaction of domestic cyclosporine was 44% while the incidence of ADR of imported cyclosporine was 36%. Most of whole blood cyclosprine concentrations were maintained in the idealtherapeutic range. Ding cost of domestic...

The efficacy/cost of domestic and imported cyclosporine was analyzed in 50kidney-transplanted recipients with stable renal function. The results showed that the immun-osuppressive efficacy of domestic cyclosporine was well-matched to that of imported cyclosprine. The incidence of adverse drug reaction of domestic cyclosporine was 44% while the incidence of ADR of imported cyclosporine was 36%. Most of whole blood cyclosprine concentrations were maintained in the idealtherapeutic range. Ding cost of domestic cyclosporine, however, was significant lower than that of imported cyclosporine.

通过比较分析50例具有稳定的移植肾功能的肾移植受者应用国产与进口环孢素的疗效/费用分析,发现两者的免疫抑制疗效相当,国产环孢素的不良反应发生率为44%,进口环孢素的不良反应发生率为36%。血药浓度基本上都维持在拟定的理想范围内。但在药物费用上国产环孢素显著低于进口环孢素。

A survey of 127 renal graft recipients surviving more than 5 years with long term oral cyclosporin has been made.Preoperative promotion of general health,better typing and graft of high quality were important.Whereas,chronic rejection was a primary factor affecting long-term survival.Early diagnosis of the chronic rejection and readjustment of the immunosuppressives with in the first week might increase the reverse rate.Attention should be paid to pulmonary infection and cyclosporin A hepatotoxicity.Sequencial...

A survey of 127 renal graft recipients surviving more than 5 years with long term oral cyclosporin has been made.Preoperative promotion of general health,better typing and graft of high quality were important.Whereas,chronic rejection was a primary factor affecting long-term survival.Early diagnosis of the chronic rejection and readjustment of the immunosuppressives with in the first week might increase the reverse rate.Attention should be paid to pulmonary infection and cyclosporin A hepatotoxicity.Sequencial use of cyclosporin A has been effective and regular periodic follow-up was essential to long-term survival.

1977年4月至1993年12月间共做肾移植801例,人/肾5年存活率74.64%/53.02%,对其中127例长期应用CsA康复5年以上的肾移植受者作了临床研究,所有患者保持定期随访。研究表明:应改善病人术前全身状况,提高组织配型和取肾质量。慢性排斥是影响移植肾长期存活的主要因素,早期明确诊断,一周内及时调整免疫抑制剂用量是提高逆转率的关键。认为应重视肺部感染和CsA肝毒性的防治。CsA序贯性用药疗效可靠。强调定期随访是提高长期康复率的保证。

 
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