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外科学
肿瘤学
内分泌腺及全身性疾病
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  125 iodine
     Results The intensity of radioactivity of 125 Iodine in the sciatic nerve of the injection side in the control group was 30 times of that in other tissues.
     结果 对照组 ,注射侧坐骨神经干的12 5碘放射性强度是其它组织的 3 0倍以上。
短句来源
     Objective To study the feasibility of tracing axoplasmic flow by 125 Iodine horseradish paroxidase ( 125 I HRP) in order to provide the experimental basis for study of nerve regeneration using radioisotope.
     目的 研究12 5碘 辣根过氧化物酶 ( 12 5I HRP)追踪术后神经轴浆流的可行性 ; 为临床应用放射性同位素研究神经再生提供实验依据。
短句来源
     Conclusion; The therapy of radioactive 125Iodine seed implantation is safe and resultful.
     结论:放射性125碘粒子插植治疗晚期癌症安全可行。
短句来源
     In the experimental group, the 125 Iodine radioactivity of the sciatic nerve of the injection side was 6 times of that in the muscles around the nerve and 7 times of that in the left sciatic nerve.
     实验组 ,注射侧坐骨神经的12 5碘放射性强度是其周围肌肉和对侧坐骨神经的 6倍和 7倍。
短句来源
     Methods; From the system of TPS and image guided,125Iodine seeds were implanted in 54 comfirmed terminal cancer. The seeds were evenly scattered in all patients' tumors.
     方法:54例确诊的晚期恶性肿瘤患者,由放射治疗计划系统(TPS)通过影像引导植入放射性核素125碘粒子,均采用均一方式布源。
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  “125碘”译为未确定词的双语例句
     Objective To summarize the effect of ~(125)I seeds interstitial brachytherapy on the malignant tumor.
     目的总结125碘(125I)粒子近距离治疗恶性肿瘤的疗效。
短句来源
     Among them,a male and 6 female,their age ranging from 38 to 67. 5. 66 seeds were implanted with an average of 38 seeds per case.
     年龄 :38~ 6 7岁 ,共植入12 5碘粒 5 6 6粒 ,平均每例 38粒。
短句来源
     Methods: Serum level of Epo in 114 hemopathic patients and 30 normal controls was determined by 125 I-RIA.
     方法:用放射免疫125碘标记法检测114例血液病性贫血患者血清中Epo水平,并将同期正常人30例为对照进行统计学分析。
短句来源
     Biodistribution of 125 I labeled 17α vinyestradiol 3 acetate ( 125 I VE 2A)in nude mice bearing human breast cancer containing different estrogen receptor (ER) content was studied to understand the relation between this compound and ER and, consequently, to develop the ER imaging.
     为探讨测定乳腺癌细胞内雌激素受体( E R),以判断肿瘤对内分泌治疗的敏感性和预后,利用1 25 碘标记 17α乙烯雌二醇3醋酸酯(1 2 5 I V E2 A)在不同 E R 含量的荷人乳腺癌裸鼠体内进行生物学分布研究,观察其与受体含量的关系,为进一步进行肿瘤 E R 显像奠定基础。
短句来源
     (3) By the outcome of animal investigation in vivo,small 125I seeds’ dosage is in effect.
     (3)根据动物实验的结果,125碘低剂量有效。
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  相似匹配句对
     Study on Iodine-25 Production Technique
     125生产工艺研究
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     THE PREPARATION OF ~(125)I-POLYVINYLPYRROLIDONE
     ~(125)——聚乙烯吡咯烷酮的制备
短句来源
     ~(125)I-SOD was purified by columnchromatography.
     ~(125)I-B.H.
短句来源
     125, T.
     125和T.
短句来源
     Identification of Iodine in Salt
     盐的检验
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  ~ 125 iodine
Zinc status was determined and, for each group, blood was pooled, and LDL were isolated and labeled with125Iodine.
      
Radio-immunoconjugates produced with125Iodine (125I) have been used for biodistribution studies following administration directly into rat bladder.
      
The AB57-F(ab')2 fragment conjugated to a bacterial enzyme, carboxypeptidase G2 (CPG2), and, radiolabeled with125iodine, also localized in the xenografts.
      
This study evaluates prognostic factors influencing survival outcomes for 50 patients with permanent125 iodine-125 implants in the primary treatment of non-GBM high-grade gliomas.
      
As part of this study, antibodies of differing isotypes with specificity for either HSN or MC24 sarcoma were labelled with125iodine and injected intravenously into normal rats or those bearing paired tumours in contralateral flanks.
      
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  125 iodine
Zinc status was determined and, for each group, blood was pooled, and LDL were isolated and labeled with125Iodine.
      
Radio-immunoconjugates produced with125Iodine (125I) have been used for biodistribution studies following administration directly into rat bladder.
      
The AB57-F(ab')2 fragment conjugated to a bacterial enzyme, carboxypeptidase G2 (CPG2), and, radiolabeled with125iodine, also localized in the xenografts.
      
This study evaluates prognostic factors influencing survival outcomes for 50 patients with permanent125 iodine-125 implants in the primary treatment of non-GBM high-grade gliomas.
      
As part of this study, antibodies of differing isotypes with specificity for either HSN or MC24 sarcoma were labelled with125iodine and injected intravenously into normal rats or those bearing paired tumours in contralateral flanks.
      
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  (125) ~-iodine
The toxicity of 5-iodo-2'-deoxyuridine (I-UdR) was assayed in male C57 BL/6J mice bearing the syngeneic mammary adenocarcinoma EO 771 by injecting different doses of 'cold' I-UdR or 125-iodine labelled I-UdR.
      
Dilutions of sera were incubated on these antigens and bound anti-viral antibodies were monitored by the addition of 125-iodine labeled anti-human-IgG or anti-human-IgM antibody.
      
Interstitial radiotherapie of prostate carcinomas with 125-iodine seeds
      
Interstitial radiotherapy with 125-iodine seeds in the treatment of prostate carcinomas
      
Interstitial 125-iodine radiosurgery of low-grade gliomas of the insula of Reil
      
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4-Methyl-5-ethyl-2-thiouracil,m.p.211°,was prepared according to the direc- tions of Johnson and Baily.4-Methyl-5-ethyl-uracil,m.p.236°,was formed in a 81% yield from 4-methyl-5-ethyl-2-thiouracil by boiling the latter with an aqueous solution of monochloroacetic acid.4-Methyl-5-ethyl-uracil reacted with phosphorous oxychloride and phosphorous pentachloride,giving 4-methyl-5-ethyl-2,6-dichloropy- rimidine in a 79% yield.This dichloropyrimidine boiled at 145° at 23mm,at 120° at 9mm,at 130° at 10mm,or at 130°...

4-Methyl-5-ethyl-2-thiouracil,m.p.211°,was prepared according to the direc- tions of Johnson and Baily.4-Methyl-5-ethyl-uracil,m.p.236°,was formed in a 81% yield from 4-methyl-5-ethyl-2-thiouracil by boiling the latter with an aqueous solution of monochloroacetic acid.4-Methyl-5-ethyl-uracil reacted with phosphorous oxychloride and phosphorous pentachloride,giving 4-methyl-5-ethyl-2,6-dichloropy- rimidine in a 79% yield.This dichloropyrimidine boiled at 145° at 23mm,at 120° at 9mm,at 130° at 10mm,or at 130° at 11mm;and melted at 33°.This dichloropyrimidine reacted with sodium methoxide in methyl alcohol,with sodium ethoxide in ethyl alcohol,with sodium n-propoxide in n-propyl alcohol,with sodium isopropoxide in isopropyl alcohol,with sodium n-butoxide in n-butyl alcohol,with sodium isobutoxide in isobutyl alcohol,with sodium isopentoxide in isoamyl alcohol and with sodium benzoxide in benzyl alcohol,giving the corresponding 2,6-dimethoxy-pyrimidine(b.p.113°/13mm,107°/7mm,115°/15mm,or 125°/ 18mm,),2,6-diethoxy-pyrimidine(b.p. 143°/20mm),2,6-di-n-propoxy-pyrimidine (b.p.131°/5mm),2,6-di-isopropoxy-pyrimidine(b.p.114°/5mm),2,6-di-n-butoxy- pyrimidine(b.p.175°/7mm),2,6-di-isobutoxy-pyrimidine(b.p.155°/5mm),2,6-di- isopentoxy-pyrimidine(b.p.170°/5mm)and 2,6-di-benzoxy-pyrimidine (b.p.221°/ 3mm)respectively. 4-Methyl-5-ethyl-2,6-dimethoxy pyrimidine rearranged partially in the pre- sence of methyl iodide at room temperature into 2-oxy-3,4-dimethyl-5-ethyl-6- methoxy-pyrimidine, m.p.81°,the structure of which was established by its be- havior on hydrolysis in the presence of concentrated hydrochloric acid,giving 3,4-dimethyl-5-ethyl-uracil,m.p.170-171°.Nevertheless,4-methyl-5-ethyl-2,6-di- methoxy-pyrimidine rearranged with ease into the isomeric and stable configura- tion,1,3,4-trimethyl-5-ethyI-uracil(b.p.190°/7mm,m.p.99-100°)by merely heat- ing at 280°-290° for six hours.Furthermore,the partially rearranged configura- tion,like 2-oxy-3,4-dimethyl-5-ethyl-6-methoxy-pyrimidine,was only stable,however, at this lower temperature;and further transformation into the isomeric and com- pletely rearranged modification took place by heating at 335-350° for six hours. In this case,1,3,4-trimethyl-5-ethyl-uracil(m.p.99-100°)was similarly isolated.

(1)4-甲基5-乙基-2,6-二氯代嘧啶曾用磷醯氯和五氯化磷与其相应的2,6-二羟基嘧啶作用制取。(2)4-甲基-5-乙基-2,6-二氯代嘧啶与醇钠作用,极易转变成4-甲基-5-乙基-2,6-二烷氧基嘧啶。(3)4-甲基-5-乙基-2,6-二甲氧基嘧啶和2-氧代-3,4-二甲基-5-乙基-6-甲氧基嘧啶在高温时重排成其稳定构型的(或称内醯胺)的异构体:1,3,4-三甲基-5-乙基-2,6-二氧代嘧啶。另一方面,4-甲基-5-乙基-2,6-二甲氧基嘧啶用代甲烷处理并长久放置则仅仅发生部分重排作用,得到2-氧代-3,4-二甲基-5-乙基-6-甲氧基嘧啶。

4-Methyl-2,6-dichloropyrimidine was prepared by heating 4-methyl-uracil with phosphorous oxychloride in the presence of phosphorous pentachloride; and it boiled at 97° at 7 mm, at 102° at 10 mm, or at 113° at 13 mm. 4-Methyl-2,6- dichloropyrimidine reacted with sodium methoxide in anhydrous methyl alcohol, forming 4-methyl-2,6- dimethoxy-pyrimidine, which was isolated by ether extraction and pnrified by vacuum distillation. Pure 4-methyl-2,6-dimethoxy-pyrimidine boiled at 85-87° at 7 mm, or at 103° at 13 mm,...

4-Methyl-2,6-dichloropyrimidine was prepared by heating 4-methyl-uracil with phosphorous oxychloride in the presence of phosphorous pentachloride; and it boiled at 97° at 7 mm, at 102° at 10 mm, or at 113° at 13 mm. 4-Methyl-2,6- dichloropyrimidine reacted with sodium methoxide in anhydrous methyl alcohol, forming 4-methyl-2,6- dimethoxy-pyrimidine, which was isolated by ether extraction and pnrified by vacuum distillation. Pure 4-methyl-2,6-dimethoxy-pyrimidine boiled at 85-87° at 7 mm, or at 103° at 13 mm, and melted at 62-65°. It was recrystallized from petroleum ether, m.p. 65-66°. In the above reaction, there was isolated a white solid, suspending in the ethereal solution and being collected separately. This white solid, considered as a by-product, was dissolved in hot water and acidified with acetic acid, whereupon it separated in needles. After recrystallization from water, it melted at 201-202°. It was tentatively assigned to be 4-methyl-2-methoxy- uracil. Further, 2,6-dialkoxy-pyrimidines were prepared similarly as 4-methyl-2,6-dimethoxy- pyrimidine: 4-Methyl-2,6-dichloropyrimidine reacted with sodium ethylate in anhydrous ethyl alcohol, forming 4-methyl-2,6-diethoxy-pyrimidine, which boiled at 110°/11 ram. 4-Methyl- 2,6-dichloropyrimidine was treated with sodium n-propoxide in normal propyl alcohol, forming 4-methyl-2,6-di-n-propoxy-pyrimidine, which boiled at 120°/5 mm. 4-Methyl- 2,6-dichloropyrimidine reacted with sodium iso-propoxide in isopropyl alcohol, forming 4-methyl-2,6-di-isopropoxy-pyrimidine, which boiled at 103°/3 mm. The action of sodium n-butoxide in normal butyl alcohoI upon 4-methyl-2,6-dichloropyrimidnie gave 4-methyl- 2,6-di-n-butoxy-pyrimidine, which boiled at 147-148°/5 mm. The action of sodium isobutoxide in isobutyl alcohol upon 4-methyl-2,6-dichloropyrimidine gave 4-methyl-2,6- isobutoxy-pyrimidine, which boiled at 132-133°/6 mm. The action of sodium isopentoxide in isopentyl alcohol upon 4-methyl-2,6-dichloropyrimidine gave 4 methyl-2,6-di-isopentoxy- pyrimidine, which boiled at 145-146°/3 mm. 4-Methyl-2,6-dichloropyrimidine reacted with sodium benzoxide in benzyl alcohol, giving 4-methyl-2,6-dibenzoxy-pyrimidine, which boiled at 231°/6 mm. 4-Methyl-2,6-dimethoxy-pyrimidine was heated in a sealed tube at 330-350°, giving the completely rearranged isomeric compound, 1,3,4-trimethyl-uracil, which was purified by vacuum sublimation at 130° at 10 mm and then by recrystallization from 95% alcohol. The latter melted at 107-109°. Nevertheless, 4-methyl-2,6-dimethoxy-pyrimidine was dis- solved in methyl iodide, and kept at room temperature in the dark with occasional shaking; whereupon the partially rearranged product, 2-oxy-3,4-dimethyl-6-methoxy-pyrimidine, gradually separated out. After recrystallization from absolutealcohol, it melted at 134-135.5°. Its structure was established as follows: Pure 2-oxy-3,4-dimethyl-6-methoxy-pyrimidine was heated with dilute hydrochloric acid for one hour; whereupon 3,4-dimethyl-uracil, m.p. 220-221°, separated out. This partially rearranged product, 2-oxy-3,4-dimethyl-6-methoxy- pyrimidine was heated at 335-350° and was again transformed into its stable and completely rearranged modification, 1,3,4-trimethyl-uracil, which was purified by vacuum sublimation and then recrystallization from 95% alcohol. The latter melted at 109-110°.

(1)4-甲基-2,6-二氯代嘧啶與鈉醇和醇的溶液作用,可以形成相應的2,6-二烴氧基嘧啶。 (2)4-甲基-2,6-二甲氧基嘧啶加熱至高温度即可轉變成其穩定結構的異構體1,3,4-三甲基-2,6-二羥基嘧啶。另一方面,在代甲烷催化劑的影響下,部份轉變成2-氧代-3,4-二甲基-6-甲氧基嘧啶;此化合物加熱卽可發生完全的轉變作用而形成其異構體1,3,4-三甲基-2,6-二羥基嘧啶。

From the Chinese drug, Chin-kuo-lan, there have been isolated a new crystalline alkaloid and a neutral principle. The new alkaloid, which is provisionally named calystigine, crystallized from a mixture of acetone and ether in brownish prisms, with a m.p. of 203°. It has a molecular formula of C_(25)H_(23)O_6N, according to analyses of its crystalline salts, which are (1) picrate, C_(25)H_(23)O_6N·C_6H_3N_3O_7, brownish needles, m.p. 220°; (2) nitrate, C_(25)H_(23)O_6N·HNO_3, yellow needles, m.p. 233-234°; (3)hydrochloride,...

From the Chinese drug, Chin-kuo-lan, there have been isolated a new crystalline alkaloid and a neutral principle. The new alkaloid, which is provisionally named calystigine, crystallized from a mixture of acetone and ether in brownish prisms, with a m.p. of 203°. It has a molecular formula of C_(25)H_(23)O_6N, according to analyses of its crystalline salts, which are (1) picrate, C_(25)H_(23)O_6N·C_6H_3N_3O_7, brownish needles, m.p. 220°; (2) nitrate, C_(25)H_(23)O_6N·HNO_3, yellow needles, m.p. 233-234°; (3)hydrochloride, prisms, m.p. 230°; (4) hydrobromide, yellow needles, m.p. 232°; (5) perchlorate, C_(25)H_(23)O_6N·HClO_4, yellow needles, m.p. 268°; (6) methyliodide, C_(25)H_(23)O_6N·CH_3I, bright reddish needles, m.p. 238°. The neutral principle crystallized from a mixture of chloroform and ethanol in fine soft needles, having a molecular formula of C_(14)H_(16)O_4, m.p. of 191°, and a specific rotation of +32° in chloroform. It does not contain methoxyt and carbonyl groups, but reacts with bromine in acetic-acid solution to form a monobromide C_(14)H_(15)O_4Br, m.p. 214°.

從中藥金果欖(Calystigia hydraceae)中分得新植物鹼及中性物質各一種。新植物鹼暫時命名為金果欖鹼(calystigine),其分子式為C_(25)H_(23)O_(6)N,熔點202-203°,含量0.07%。此新植物鹼是一種叔胺鹼,極易與甲烷生成黄色結形的甲基季銨鹽,熔點238°。現已製得下列各種結晶鹽質:硝酸鹽,熔點233-234°;鹽酸鹽,熔點230°;氫溴酸鹽,熔點232°;高氯酸鹽,熔點268°;苦味酸鹽,熔點202°。 從金果欖中分得的中性物質,為白色針狀晶體,其分子式為C_(14)H_(16)O_4,熔點191°,[α]_D~(15)=+32°。產量約為0.92%。此中性物質對於醋酸酐和苯肼均無反應,但與溴液在醋酸中反應稜,生成一溴化物,C_(14)H_(15)O_(4)Br,熔點214°。

 
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