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抗弥散
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     Intervention with anti-H.
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     Anti-H.
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     The Diffusion MR Images
     磁共振弥散成像
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     骨髓弥散加权成像
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  anti-blooming
We present a new observational technique based on the use of an anti-blooming CCD in order to directly image this zone.
      
A charge sink drain removes charge from the circuit on subtraction and also acts as an anti-blooming stop.
      
A higher VNS-voltage leads to better anti-blooming performance, but decreases the well capacity and slightly decreases the light sensitivity.
      
Anti-blooming capabilities can be incorporated in the detectors, which may reduce the full well capacity.
      
All Philips CCD sensors are buried channel devices combined with an anti-blooming feature.
      
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In many applications, the more electrons are generated in the parts of photosites that can be stored in the CCD shift register, they tend to "bloom" or "spill over" to neighboring pixels along the shift register, thus "smearing" the information. In this paper, a CCD with functions of anti-blooming and integration control is introduced, the time orders of driving designed with CPLD are also expounded. In the end, the output waveforms are measured in the same illumination and different integration time....

In many applications, the more electrons are generated in the parts of photosites that can be stored in the CCD shift register, they tend to "bloom" or "spill over" to neighboring pixels along the shift register, thus "smearing" the information. In this paper, a CCD with functions of anti-blooming and integration control is introduced, the time orders of driving designed with CPLD are also expounded. In the end, the output waveforms are measured in the same illumination and different integration time. It is proved the problem is resolved perfectly with the functions.

在许多CCD应用场合中,当局部像元产生转移寄存器难以容纳的电荷时,会弥散到相邻的像元中,破坏图像原有的信息。介绍了一款能够实现反弥散、积分时间可调的CCD芯片,详细叙述了利用CPLD产生CCD各种驱动时序的方法。最后,在光照强度不变的条件下,利用示波器测试了不同积分时间的信号输出。实验证明:设计的电路能够驱动CCD正常工作,实现了其积分控制和抗弥散功能。

AIM: To investigate the anti-DIC effect of the domestic recombinant hirudin (rH) in order to provide preclinical pharmacological basis for its new drug application. METHODS: DIC was induced by constant iv infusion of thrombin (100 U·kg -1 ·h -1 ×1 h) plus PAMBA (50 mg·kg -1 ·h -1 ×1 h). Platelet count (PLT), PT and fibrinogen (FIB) determination as well as plasmaprotamine paracoagulation (3P) test served as diagnostic indexes of DIC, while pathlogical examination of microthrombosis of lungs and kidneys was...

AIM: To investigate the anti-DIC effect of the domestic recombinant hirudin (rH) in order to provide preclinical pharmacological basis for its new drug application. METHODS: DIC was induced by constant iv infusion of thrombin (100 U·kg -1 ·h -1 ×1 h) plus PAMBA (50 mg·kg -1 ·h -1 ×1 h). Platelet count (PLT), PT and fibrinogen (FIB) determination as well as plasmaprotamine paracoagulation (3P) test served as diagnostic indexes of DIC, while pathlogical examination of microthrombosis of lungs and kidneys was followed. RESULTS: rH 125,62.5,31.25 and 15.625 μg·kg -1 iv. gtt demonstrated a dose-dependant inhibitory effect on DIC. The inhibitory effects on DIC of rH(%) were 89.38%, 52.60%, 49.71% and 25.58% for PT, and 100.01% , 61.86%, 58.40% and 32.68% for PLT, and 85.22%, 73.01%, 33.60% and 14.86% for FIB respectively at the descending order of rH doses. CONCLUSION: Domestic rH being tested has powerful anti-DIC effect which is comparable with refludan—an r-hirudin product approved by European Community for marketing.

目的:研究重组水蛭素(recombinanthirudin,rH)的抗弥散性血管内凝血(DIC)的作用。方法:♂大耳白兔,采用凝血酶(100U·kg-1·1h)和氨基已酸(50mg·kg-1·h-1×1h)静脉滴注造成急性DIC模型,观察rH对凝血酶原时间(PT)、血小板计数(PLT)、纤维蛋白原(FIB)含量和血浆鱼精蛋白副凝固(3P)试验以及肺、肾微血栓形成的影响。结果:4个剂量的rH(125、62.5、31.25和15.625μg·kg-1)对于DIC的抑制率:用PT表示分别为89.38、52.60、49.71和25.58;用PLT表示分别为100.01、61.86、58.40和32.68;用FIB表示分别为85.22、73.01、33.60和14.86。各剂量组的肺、肾病理切片均未见微血栓形成。当rH剂量为125μg·kg-1时,试验中各项指标均与生理盐水空白对照组一致。结论:国产rH具有强大的抗DIC作用,其作用强度与已被欧共体批准上市的产品重组水蛭素Refludan相同。

 
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