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肝纤维化     
相关语句
  liver fibrosis
    Changes of Th-2 Cytokines Expression in Liver of Mice Infected with Schistosomiasis Japonica and Its Relationship with Liver Fibrosis
    Th_2细胞因子在日本血吸虫小鼠肝脏中的变化及其与肝纤维化的比较
短句来源
    Effects of truncated type Ⅱ receptor of TGF-β_1 expressing plasmid on rat liver fibrosis
    TGF-β_1Ⅱ型受体部分基因表达质粒对实验性大鼠肝纤维化的影响
短句来源
    The Survey of Research on Animal Model of Liver Fibrosis
    肝纤维化动物模型的研究进展
短句来源
    Effects of antisense TIMP-1 eukaryotic expressing plasmids on TIMP-1 and MMP-13 expression in rat liver fibrosis
    反义TIMP-1对实验性肝纤维化中TIMP-1及MMP-13表达的影响
短句来源
    In order to investigate the effect of tissue inhibitor of metalloproteinase-1 (TIMP 1) transcript on experimental hepatic fibrogenesis, the expression of TIMP 1 was studied during early and late stages of liver fibrosis induced by carbon tetrachloride in rats by using digoxigenin-labeled in situ hybridization.
    为了解组织金属蛋白酶抑制因子1(TIMP-1)基因在实验性肝纤维化形成中的作用,我们应用地高辛原位杂交技术对大鼠肝组织在四氯化碳(CCl4)诱发肝纤维化形成过程中TIMP-1mR-NA的表达进行了研究。
短句来源
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  hepatic fibrosis
    Intrahepatic Expression of Transforming Growth Factor-β_1 and Its Receptor in Rat Hepatic fibrosis
    转化生长因子-β_1及其受体的表达与大鼠肝纤维化关系的研究
短句来源
    Effects of Anti Idiotypic Antibody NP30 on Modulation of Egg Granuloma Formation and Hepatic Fibrosis of Schistosomiasis *
    抗独特型抗体NP30对血吸虫病虫卵肉芽肿及肝纤维化的调节作用
短句来源
    The fluctuation of cytokine mRNA expression level of a novel T-cell-mediated immune hepatic fibrosis model in Balb/c mice
    T细胞介导的小鼠免疫性肝纤维化形成过程中细胞因子mRNA表达水平
短句来源
    2. Fat store cells were one of main cell sources when extracellular matrix excessive was deposited on hepatic fibrosis.
    (2)贮脂细胞是肝纤维化中细胞外基质过度沉积的重要细胞来源之一;
短句来源
    Objective:To study the effects of TGF β 1 and TGF β RⅡ changes on collagen production during pathogenesis of hepatic fibrosis in rats.
    目的 :探讨肝纤维化形成过程转化生长因子 -β1(TGF-β1)及其受体的表达对胶原合成的影响。
短句来源
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  fibrosis
    Changes of Th-2 Cytokines Expression in Liver of Mice Infected with Schistosomiasis Japonica and Its Relationship with Liver Fibrosis
    Th_2细胞因子在日本血吸虫小鼠肝脏中的变化及其与肝纤维化的比较
短句来源
    Intrahepatic Expression of Transforming Growth Factor-β_1 and Its Receptor in Rat Hepatic fibrosis
    转化生长因子-β_1及其受体的表达与大鼠肝纤维化关系的研究
短句来源
    Effects of Anti Idiotypic Antibody NP30 on Modulation of Egg Granuloma Formation and Hepatic Fibrosis of Schistosomiasis *
    抗独特型抗体NP30对血吸虫病虫卵肉芽肿及肝纤维化的调节作用
短句来源
    The fluctuation of cytokine mRNA expression level of a novel T-cell-mediated immune hepatic fibrosis model in Balb/c mice
    T细胞介导的小鼠免疫性肝纤维化形成过程中细胞因子mRNA表达水平
短句来源
    Effects of truncated type Ⅱ receptor of TGF-β_1 expressing plasmid on rat liver fibrosis
    TGF-β_1Ⅱ型受体部分基因表达质粒对实验性大鼠肝纤维化的影响
短句来源
更多       
  liver fibrogenesis
    The data obtained indicate that mesenchymal cells including fat storing cell and endothelial cell in liver may be the mian cell source of TIMP 1. The abnormal expression of TIMP 1 mRNA in liver fibrogenesis is not only an earlier molecule event which may relate to the pathogenesis of liver fibrosis, but also a promoting factor which plays an important role in progression of liver fibrosis.
    TIMP-1的异常表达是大鼠肝纤维化过程中较早出现的分子变化,与肝纤维化发生有关; 纤维化晚期持续高表达的TIMP-1通过抑制胶原酶而在肝纤维化持续进展中起重要作用。
短句来源
    This modal clearly presented the dynamic changes of ECMs and their relation to the producing cells, therefore it might be more applicable for studying the mechanism of liver fibrogenesis.
    提示ECM生成细胞可能来自细胞骨架表型不同的PMC和HSC,本模型由于能清晰地显示ECM及其生成细胞而更适用于肝纤维化机制及防治的研究。
短句来源

 

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      liver fibrosis
    Conversely, HAART-related hepatotoxicity may enhance the progression of liver fibrosis.
          
    Objective: To study the effect of Xuesaitong soft capsule (XST) on liver fibrosis criteria in patients with post-hepatitis fibrosis.Methods: Sixty-four patients with such fibrosis were randomly divided into the treated group and control group.
          
    Their liver fibrosis criteria were examined before and after treatment.Results: The levels of serum procollagen III, hyaluronic acid, collagen IV, laminin in the two groups were significantly lower (P>amp;lt;0.
          
    The differences between the two groups were insignificant (P>amp;gt;0.05).Conclusion: XST could recover liver dysfunction and had anti-liver fibrosis function.
          
    However, response rates are much lower in patients who are difficult to treat, such as those infected with hepatitis C virus genotype 1, high viral load, or advanced liver fibrosis.
          
    更多          
      hepatic fibrosis
    The Ile50Val polymorphism of the IL4RA gene was tested for association with chronic viral hepatitis and the character of its progression (the stage of hepatic fibrosis).
          
    However, a significant difference in genotype frequency distribution was observed for the patients with different stages of hepatic fibrosis.
          
    In hepatic fibrosis, the connective tissue biomatrix of the liver changes from the normal matrix, rich in basement membrane collagens, to a matrix enriched in interstitial fibrillar collagens.
          
    Viral hepatitis, hepatic fibrosis and hepatocirrhosis etc.
          
    Clinical study of Dahuang Zhechong pill in treating posthepatitis B hepatic fibrosis
          
    更多          
      fibrosis
    Hepatic steatosis, lobular inflammation, hepatocytic ballooning and fibrosis were presented widespread in NAFLD liver tissues.
          
    Mild perisinusoidal fibrosis and periportal fibrosis were often observed in stage 1 cases.
          
    According to the statistic analysis, hepatic steatosis was positively correlated with lobular inflammation, hepatocytic ballooning and fibrosis (r = 0.587, 0.488, 0.374, respectively, all P value >amp;lt; 0.01).
          
    The number of microgranulomas, lipogranulomas and apoptotic bodies increased following severity of steatosis, lobular inflammation and fibrosis.
          
    We suggest that the role of portal inflammation should be emphasized besides hepatic steatosis, lobular inflammation, hepatocyte ballooning and fibrosis in diagnosis and evaluation of NAFLD.
          
    更多          
      liver fibrogenesis
    The liver fibrogenesis was assessed using a digital image analysis instrument of Masson's trichrome stained sections.
          
    Exciting new data are expanding our understanding of the mechanisms of steatogenesis in HCV infection and providing potential links between insulin resistance or hyperglycemic states and liver fibrogenesis.
          
    The expression of basic fibroblast growth factor (bFGF) in rat liver fibrosis and hepatic stellate cells (HSCs) and the relationship between the expression of bFGF and rat liver fibrogenesis were studied.
          
    bFGF possibly regulates liver fibrogenesis through regulating metabolism of extracellular matrix (ECM) by autocrine and paracrine stimulation.
          
    At present, liver fibrogenesis is referred to as a dynamic process involving complex cellular and molecular mechanisms, resulting from the chronic activation of the tissue repair mechanisms that follows reiterated liver tissue injury.
          
    更多          


    The activity of tumor necrosis factor (TNF) in both the culture supernatant of pheripheral blood mononuclear cells (PBMC) and the serum was examined in 20 patients of advanced schisto-somiasis at 8th week after pyquiton treatment,and 6 rabbits infected with S.japonicum cercariae at 8th and 16th weeks post-infection and using L929 cell cytotoxic assay.The results showed that the capacity of PBMC to produce TNF in response to LPS from patients with late schistosomiasis was significantly lower than that from normal...

    The activity of tumor necrosis factor (TNF) in both the culture supernatant of pheripheral blood mononuclear cells (PBMC) and the serum was examined in 20 patients of advanced schisto-somiasis at 8th week after pyquiton treatment,and 6 rabbits infected with S.japonicum cercariae at 8th and 16th weeks post-infection and using L929 cell cytotoxic assay.The results showed that the capacity of PBMC to produce TNF in response to LPS from patients with late schistosomiasis was significantly lower than that from normal subjects (P<0.01),whereas the activity of TNF in serum was significantly elevated (P<0.01).The capacity of PBMC to produce TNF and the TNF activity in serum of infected rabbits showed sharp rise at 8th week post-infection (P<0.01),and remained high at 16th week,then returned to normal level 8 weeks after treatment.The persistent rise of TNF in the circulation indicate that TNF might take part in the formation of hepatic fibrosis.

    采用L929细胞杀伤法,对晚期日本血吸虫病(晚血)患者和感染日本血吸虫尾蚴8wk、16wk及杀虫后8wk的新西兰兔,进行了外周血单核细胞(PBMC)的肿瘤坏死因子(TNF)诱生能力和血清TNF活性测定。晚血患者PBMC的TNF诱生能力明显低于正常人,而血清中TNF活性明显增高(P<0.01)。感染8wk和16wk兔PBMC的TNF诱生能力较正常兔显著增高,尤以感染8wk时为甚,血清TNF活性亦相应增高(P<0.01);在杀虫治疗后8wk,其PBMC的TNF诱生能力和血清TNF活性均降至正常。晚血患者血清TNF活性的增高可能参与肝纤维化过程。

    By means of routine technique and several itntnunohistochemical methods, we studied the pathological changes in rat livers which were locally irradiated with 60Co γ-rays of 0, 10, 30, 50 and 60 Gy. The results showed that the liver lesions induced by single γ irradiation were more serious and occurred earlier than those by fractional radiation. Radiation hepatic fibrosis occurred in 30 Gy group with single irradiation in which Kupffer cells obviously increased in the early phase, whereas fat-storing cells did...

    By means of routine technique and several itntnunohistochemical methods, we studied the pathological changes in rat livers which were locally irradiated with 60Co γ-rays of 0, 10, 30, 50 and 60 Gy. The results showed that the liver lesions induced by single γ irradiation were more serious and occurred earlier than those by fractional radiation. Radiation hepatic fibrosis occurred in 30 Gy group with single irradiation in which Kupffer cells obviously increased in the early phase, whereas fat-storing cells did later.The type Ⅳ collagen was strongly positive and fibronectin increased in the earll fibrosis, while it was replaced by collagen in the late phase.Much more laminin and type Ⅳ collagen deposited in sinusoids,which were completely enclosed by base membrane and developed capillary vascularizat ion. Fibronectin type Ⅲ and Ⅳ collagens also increased in the hepatocytes. The significance of the changes in strorna in radiation hepatic fibrosis is discussed.

    60Coγ射线照射大鼠肝区后,不同时间分批活杀,进行肝脏病理(常规及多种免疫组化染色)研究。结果表明:单次照射病变明显重于分次照射且发生时间早;照后早期枯否细胞增多为显著,而晚期贮脂细胞增多为明显,胞浆内Ⅳ型胶原呈强阳性;纤维连接蛋白在肝纤维化早期明显增多,晚期则为胶原所取代;层粘连蛋白及Ⅳ型胶原在窦壁沉积进行性增多,可见完整基膜包绕肝窦,使之呈毛细血管化;肝细胞浆内纤维连接蛋白、Ⅲ及Ⅳ型胶原增多.最后,作者对上述肝间质成分变化在放射性肝纤维化中的作用进行了讨论.

    specimens of human liver tissues with different liver diseases were studied immunohistochemically to demonstrate the relationship among α-smooth-muscle-actin(α-SMA),a marker of myofibroblast,collagen typeⅠ、Ⅲ(col Ⅰ、Ⅲ)and inflammatory cells.The results showed that the proliferation and distribution of α-SMA(+)cells were closely related to that of the inflammatory cells.In chronic liver diseases,the amount of α-SMA-positive cells,colⅠand col Ⅲ was much more greater than that in control group. Particularly in the...

    specimens of human liver tissues with different liver diseases were studied immunohistochemically to demonstrate the relationship among α-smooth-muscle-actin(α-SMA),a marker of myofibroblast,collagen typeⅠ、Ⅲ(col Ⅰ、Ⅲ)and inflammatory cells.The results showed that the proliferation and distribution of α-SMA(+)cells were closely related to that of the inflammatory cells.In chronic liver diseases,the amount of α-SMA-positive cells,colⅠand col Ⅲ was much more greater than that in control group. Particularly in the chronic active diseases,the quantity of col Ⅲ was more than that of col Ⅰ as well.However,in chronic nonactie disease. the of colⅠis more than that of col Ⅲ The variations of distibution and the quantity of α-SMA(+)cells among different groups were basically similar to those col Ⅲ.It suggests that detection of MFb,marked with α-SMA in human liver,is a reliable creterion to indicate the progressing of fibrogenesis.

    本文以α-平滑肌肌动蛋白(α-SMA)作为肌纤维母细胞(MFb)的标志,对73例人肝组织作免疫组化研究,观察α-SMA阳性细胞与Ⅰ、Ⅲ型胶原以及炎症细胞的关系。发现在各种慢性肝病的肝组织中α-SMA、Ⅰ、Ⅲ型胶原阳性率均明显高于对照组;尤其在慢性活动性病变时,α-SMA阳性细胞数与Ⅲ型胶原量均多,而在慢性非活动性病例中Ⅰ型胶原量较多;且各组显示α-SMA阳性细胞量的曲线与Ⅲ型胶原基本一致。α-SMA阳性细胞的增生及分布与炎症细胞的浸润也密切相关。因此,可籍MFb(α-SMA阳性)的定位检测来判断人肝纤维化的进展情况。

     
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