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膀胱移行细胞肿瘤     
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  bladder transitional cell carcinoma
     [Objective] To investigate the expression of Cyclooxygenase (COX-2) and its clinical value in Bladder transitional cell carcinoma (BTCC).
     目的探讨Cyclooxygenase(COX-2)在膀胱移行细胞肿瘤中的表达及临床意义。
短句来源
     Objective To investigate the express and clinical significance of fragile histidine triad(FHIT) in bladder transitional cell carcinoma.
     目的研究脆性组氨酸三联体基因(FHIT)在膀胱移行细胞肿瘤中的表达及其临床意义。
短句来源
  transitional cell carcinoma of bladder
     bcl 2 expression in transitional cell carcinoma of bladder
     bcl-2基因蛋白在膀胱移行细胞肿瘤中的表达及意义
短句来源
     The effect of colleganase A(MMP-2) in judging the progress of transitional cell carcinoma of bladder
     明胶酶A(MMP-2)蛋白在评估膀胱移行细胞肿瘤进展期的作用
短句来源
     Objective To study on the expression of Colleganase A (MMP-2) in different grade and stage transitional cell carcinoma of bladder(TCCB), and to find the possibility and method to judge the progress of TCCB through MMP-2. Method Immunohistochemistry and zymography were used to study the content of MMP-2 in 47 surgically resected specimens from patients with TCCB, and 5 normal bladder tissue were obtained as control,then statistical methods were used to analyse the data.
     目的 研究明胶酶A(MMP 2 )在不同病理分期、分级的膀胱移行细胞肿瘤 (TCCB)中的表达规律 ,并探讨以MMP 2来判断TCCB进展情况的可能性及方法。 方法 通过免疫组织化学和明胶酶谱等方法对 4 7例手术切除的TC CB组织中MMP 2蛋白进行定量检测 ,同时取 5例正常膀胱组织作为对照。
短句来源
  transitional cell tumors
     the expression of FHIT protein in different grade bladder transitional cell tumors had marked statistical significance(P<0.01).
     FHIT蛋白在膀胱移行细胞肿瘤不同分级中随恶性程度的增高,表达减少,有显著的统计学意义(Spearman相关分析,P<0.01);
短句来源
     Methods The expression of FHIT was studied by S-P immunohistochemisty in 20 cases of non-tumor tissues and 60 bladder transitional cell tumors,patients with which had not been treated by chemotherapy,radiotherapy and immunotherapy before surgery.
     方法用免疫组化法检测60例术前未经化疗、放疗和免疫治疗的膀胱移行细胞肿瘤和20例膀胱非肿瘤性病变的FHIT蛋白的表达。
短句来源
  bladder transitional cell tumors
     the expression of FHIT protein in different grade bladder transitional cell tumors had marked statistical significance(P<0.01).
     FHIT蛋白在膀胱移行细胞肿瘤不同分级中随恶性程度的增高,表达减少,有显著的统计学意义(Spearman相关分析,P<0.01);
短句来源
     Methods The expression of FHIT was studied by S-P immunohistochemisty in 20 cases of non-tumor tissues and 60 bladder transitional cell tumors,patients with which had not been treated by chemotherapy,radiotherapy and immunotherapy before surgery.
     方法用免疫组化法检测60例术前未经化疗、放疗和免疫治疗的膀胱移行细胞肿瘤和20例膀胱非肿瘤性病变的FHIT蛋白的表达。
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      bladder transitional cell carcinoma
    The expression and significance of KAI1 and Ki67 in bladder transitional cell carcinoma
          
    MDR1/P-glycoprotein overexpression in bladder transitional cell carcinoma and its correlation with expression of survivin and Fa
          
    OBJECTIVE To explore the expression of the MDR1/P-glycoprotein, Fas and survivin and to examine their correlation with the biologic behavior of bladder transitional cell carcinoma (BTCC).
          
    To our knowledge, this HPV type has not been previously described in multifocal bladder transitional cell carcinoma in transplanted patients.
          
    Using colony formation technique and KK-47 cell line established from a human bladder transitional cell carcinoma, the effects of 6 anticancer drugs, thio-TEPA, Bleomycin, mitomycin C, carbazilquinone, Adriamycin and cis-Platinum, were compared.
          
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      transitional cell carcinoma of bladder
    Recurrence risk factors in patients with transitional cell carcinoma of bladder
          
    Cloning of human Uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expres
          
    Expression of KAI1/CD82 and MRP-1/CD9 in transitional cell carcinoma of bladder
          
    The expression of KAI1/CD82 and MRP-1/CD9 in transitional cell carcinoma of bladder (TCCB) and its clinical significance were investigated.
          
    The immunocytochemical demonstration of basement membrane deposition in transitional cell carcinoma of bladder
          
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      transitional cell tumors
    Karyometry in recurrent superficial transitional cell tumors of the bladder
          
    Karyometric analysis of recurrent superficial transitional cell tumors can be useful in selecting patients who need a more aggressive therapy.
          
    Two of three patients with non-transitional cell tumors attained a partial remission for 1-7 months.
          
    A case of Rathke's cleft cyst within a pituitary adenoma presenting with acromegaly - do "transitional cell tumors of the pituit
          
    We found that the proliferating basal layers of the transitional cell carcinomas were undergoing squamous metaplasia, which indicates that squamous carcinomas in the organ may arise from pre-existing transitional cell tumors.
          
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    bcl 2 expression was detected in 6 normal bladder mucosa,6 hyperplastic inflammatory bladder mucosa,6 papiloma of bladder and 45 transitional cell carcinoma of bladder by means of flow cytometry and cytoimmunofluorescence staining using anti bcl 2 polyclonal antibody bcl 2(N 19).The positive expression rate in these 4 groups was 33.3%,50.0%,83.3% and 100.0% respectively.It was significantly higher in the tumor groups ( P <0.001) but was not related to the tumor grade and stage and prognosis ( P >0.05)...

    bcl 2 expression was detected in 6 normal bladder mucosa,6 hyperplastic inflammatory bladder mucosa,6 papiloma of bladder and 45 transitional cell carcinoma of bladder by means of flow cytometry and cytoimmunofluorescence staining using anti bcl 2 polyclonal antibody bcl 2(N 19).The positive expression rate in these 4 groups was 33.3%,50.0%,83.3% and 100.0% respectively.It was significantly higher in the tumor groups ( P <0.001) but was not related to the tumor grade and stage and prognosis ( P >0.05) denoting that abnormal bcl 2 expression might play a promotive role in the tumorigenesis and tumor development of bladder tumors.

    为探讨bcl2基因蛋白在膀胱移行细胞和移行细胞肿瘤中表达程度的差异及该蛋白表达与移行细胞癌病理分级、临床分期和预后的关系,用抗体bcl2(N19)及流式免疫学技术对6例正常膀胱粘膜、6例炎性增生粘膜、6例乳头状瘤和45例移行细胞癌的bcl2蛋白表达进行了定量分析。结果表明:bcl2蛋白在4种组织标本中均表达,阳性率分别为33.3%、50.0%、83.3%、100.0%。FI值呈移行细胞癌>乳头状瘤>炎性增生粘膜>正常粘膜。肿瘤组bcl2蛋白表达显著高于非肿瘤组(P<0.001)。在膀胱移行细胞癌中bcl2蛋白的表达程度与肿瘤病理分级、临床分期和预后无关(P>0.05)。提示bcl2蛋白的异常表达可能在膀胱移行细胞肿瘤发生、发展中起着促进作用。

    Objective To study the relationship between the expression of Ki-67, Bcl-2 and EMA and biological behavior of bladder tumor. Method Using an immunohistochemical method (LSAB), the expression of Ki-67, BcL-2 and EMA in formalin-fixed paraffin-embedded sections of tumor tissues were detected in 49 patients with bladder cancer. Result Ki-67 labeling index was associated with the proliferation of tumor cells in grade 0, Ⅰ,Ⅱ but in grade Ⅲ (P < 0. 01 ). It is unreliable to represent the proliferation of tumor by...

    Objective To study the relationship between the expression of Ki-67, Bcl-2 and EMA and biological behavior of bladder tumor. Method Using an immunohistochemical method (LSAB), the expression of Ki-67, BcL-2 and EMA in formalin-fixed paraffin-embedded sections of tumor tissues were detected in 49 patients with bladder cancer. Result Ki-67 labeling index was associated with the proliferation of tumor cells in grade 0, Ⅰ,Ⅱ but in grade Ⅲ (P < 0. 01 ). It is unreliable to represent the proliferation of tumor by the Ki-67-positive incidence in grade Ⅲ. Statistical correlation existed between age factor and the level of Bcl-2 expression except for the other tumor background parameters (P < 0. 05). The frequency of EMA-positive cells was decreased with the increase of the tumor grades and stage (P < 0. 01 and P < 0. 05, respectively). Conclusion The expression of the three antigens can show the biological behavior of bladder turmor in some aspects. EMA is closely related to the biological behavior of bladder tumor. It is an essential marker for judging the malignancy and prognosis of bladder tumor.

    目的研究Ki-67、Bcl-2和EMA在膀胱肿瘤细胞中的表达及其与肿瘤细胞生物学行为的关系。方法用免疫组化技术(ISAB法)检测Ki-67、Bcl-2和EMA在膀胱移行细胞肿瘤标本中的表达。结果Ki-67标记表达率与肿瘤细胞的增殖率有关(除Ⅲ级肿瘤),P<0.01。在Ⅲ级肿瘤中用Ki-67标记率代表肿瘤的增殖活性不可靠。各种肿瘤参数中只有年龄因素与Bcl-2的表达水平有统计学上的相关性,P<0.05。EMA的表达率随着膀胱肿瘤组织学分级和分期的增加而降低(P<0.01,P<005)。在复发和多发肿瘤中EMA的表达率亦较低(P<0.01)。结论三种抗原均可从某些方面反映出膀胱肿瘤的生物学行为。但只有EMA与膀胱肿瘤的生物学行为关系密切,可作为判定膀胱肿瘤的恶性程度和愈后的重要标记物。

    Objective To evaluate some nuclear parameters in diagnosis and didfferential diagnosis in order to establish a computer diagnosing system.Methods With the image analysis system,cells were studied for their nuclear area,nuclear perimeter,nuclear regular form factor,nuclear equivalent diameter,nuclear darkness and the ratio of nuclear area to cytoplasmic area in five cases of chronic cystitis,inverted papilloma,transitional cell papilloms,transitional cell carcinoma Ⅰ,Ⅱ,Ⅲ grade and two cases of nomal transitional...

    Objective To evaluate some nuclear parameters in diagnosis and didfferential diagnosis in order to establish a computer diagnosing system.Methods With the image analysis system,cells were studied for their nuclear area,nuclear perimeter,nuclear regular form factor,nuclear equivalent diameter,nuclear darkness and the ratio of nuclear area to cytoplasmic area in five cases of chronic cystitis,inverted papilloma,transitional cell papilloms,transitional cell carcinoma Ⅰ,Ⅱ,Ⅲ grade and two cases of nomal transitional epithelium.Results Highly significant statistical difference was detected in four parameters between benign and malignant cases.Conclusion Nuclear area,nuclear perimeter,nuclear equivalent diameter and the ratio of nuclear area to cytoplasmic area are more valuable in diagnosis and differential diagnosis.The higher the morphologic grade of malignancy is,the bigger the nuclei is.Morphometric analysis provides datas for the study of quantitaive histopathology

    目的 探讨核的形态参数在膀胱移行细胞肿瘤诊断与鉴别诊断中的作用,为计算机辅助病理诊断积累资料。方法 采用图像分析系统对膀胱慢性炎、内翻性乳头状瘤、移行细胞乳头状瘤(以上称非癌性病变)、移行细胞癌(TCC)Ⅰ级、Ⅱ级、Ⅲ级各5 例及尸检正常移行上皮2 例的核形态参数,(包括核面积、核周长、核形状因子、等效核直径、核质比和核黑度)进行测量。结果 核面积、核周长、等效核直径和核质比四项指标,良恶之间比较均有高度显著性差异,且TCCⅢ> TCCⅡ> TCCⅠ> 非癌性病变。结论 这些参数在良恶鉴别和移行细胞癌的分级中有一定价值;移行细胞癌恶性程序的增高主要表现为细胞核的增大和大小悬殊;图像分析为移行细胞肿瘤的数学病理学研究提供了一定资料。

     
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