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实验性心力衰竭
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  experimental heart failure
     [Objective] To observe the expression of β3-adrenoceptors (β3-AR) of left ventricle and the effect on heart function by stimulating β3-AR in rats with experimental heart failure.
     【目的】观察实验性心力衰竭大鼠左心室β3-肾上腺素能受体(AR)表达水平的变化及β3-AR激动时对心功能的影响。
短句来源
     Methods Model of experimental heart failure was established in anesthetized cats. MPG(100 mg·kg-1,200 mg·kg-1,iv) was administered by intravenous infusion and cardiac hemodynamics parameters were measured by using polygraph and electromagnetic flowmeter.
     方法用戊巴比妥钠造成猫实验性心力衰竭动物模型 ,分别静脉注射甲基葡萄糖苷100mg·kg-1、200mg·kg-1,用多导生理记录仪和电磁流量计记录猫的心脏血流动力学参数。
短句来源
     Effect and Mechanism of Xinshuaikang(心衰康) on Experimental Heart Failure in Dogs
     心衰康对实验性心力衰竭的影响及作用机理的研究
短句来源
     Objective To study the effects of Aralosides (As) on cardiac function in rats with experimental heart failure.
     目的 :观察龙牙葱木皂苷 (Aralosides,As)对实验性心力衰竭大鼠血流动力学的影响。
短句来源
     The Effect of ACE Inhibitor on Central Aortic Reflective Wave Pressure Augmentation Index in Rats with Experimental Heart Failure
     ACE抑制剂对实验性心力衰竭大鼠中心动脉反射波增强指数的影响
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  experimental cardiac failure
     Comparative Effects of Common Vasodilators on Experimental Cardiac Failure
     常用血管扩张剂对实验性心力衰竭的作用比较
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  “实验性心力衰竭”译为未确定词的双语例句
     AIM: To observe the effect of β3-adrenoceptor (AR) on ventricle fibrillation threshold (VFT) and effective refractory period (ERP) in rats with heart failure.
     目的:观察实验性心力衰竭大鼠左心室β3-肾上腺素能受体(AR)表达水平的变化及β3-AR激动时对心脏室颤阈值(VFT)和心室有效不应期(ERP)的影响。
短句来源
     Expression of intercellular adhesion molecule-1 in myocardial cells of experimental rats with congestive heart failure
     实验性心力衰竭大鼠心肌细胞细胞间黏附分子1的表达
短句来源
     The molecular mechanism of protective effect of PPARγ ligand rosglitazone for left ventricular remodelingand dysfunction in experimental congestive heart failure rat
     PPARγ配体罗格列酮防治实验性心力衰竭大鼠左室重构改善心功能的分子机制研究
短句来源
     Objective:To investigate the effects of Shenmai injection (SMI,参麦注射液) on the plasma angiotensin(AngⅡ),endothelin(ET),atrial natriuretic polypeptide(ANP) and the myocardial contractility and relaxation of left ventricular in experimental rats with heart failure(HF).
     目的 :研究参麦注射液对实验性心力衰竭 (心衰 )大鼠左室舒缩功能及血浆血管紧张素 (Ang )、内皮素 (ET)和心钠素 (ANP)的影响。
短句来源
     The effect of "anti-heart-failure Ⅱ oral liquid" (AC Ⅱ) on experimental models of heart failure and cardiogenic shock in anesthetized cat was studied.
     采用麻醉猫实验性心力衰竭和心源性休克的模型观察了抗心衰Ⅱ号口服液(ACⅡ)的作 用。
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  experimental heart failure
We investigated MC density in the pericardium and myocardium of rats in intact and experimental heart failure (HF) 24 h and 14, 28, and 60 days after two (at 24 h intervals) injections of Isoproterenol (IP) inducing necrosises in the myocardium.
      
Plasma exudation in conscious dogs with experimental heart failure
      
The arterial baroreflex has been shown to be depressed in both clinical and experimental heart failure.
      
Central hypercapnic chemoreflex modulation of renal sympathetic nerve activity in experimental heart failure
      
Role of the natriuretic peptides in the cardiorenal and humoral actions of omapatrilat: Insights from experimental heart failure
      
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  experimental cardiac failure
Effect of dithiothreitol on cardiomyocyte ultrastructure in the prooxidant zone of rat heart in experimental cardiac failure
      
In rats with experimental cardiac failure treated with dithiothreitol, compensatory and repair changes predominate in the prooxidant zone cardiomyocytes.
      


The natriuretic and diuretic effectsof atrium extracts of rabbits with con-gestive heart failure were found to begreatly decreasing as compared with con-trols (P<0.01), and observation fromelectron microscope indicated that thenumber of atrial specific granules,whichcontain cardionatrin,in congestive heartfailure rabbits also decreased as comparedwith that in normal rabbits.Both resultsanggest that in congestive heart failurethere is a decrease of cardionatrin inatrial tissue,and this may be due toits greatly...

The natriuretic and diuretic effectsof atrium extracts of rabbits with con-gestive heart failure were found to begreatly decreasing as compared with con-trols (P<0.01), and observation fromelectron microscope indicated that thenumber of atrial specific granules,whichcontain cardionatrin,in congestive heartfailure rabbits also decreased as comparedwith that in normal rabbits.Both resultsanggest that in congestive heart failurethere is a decrease of cardionatrin inatrial tissue,and this may be due toits greatly compensative excretion intocirculation.The present study also introducesa conventent method for producing chroniccongestive heart failure.By use of aconstricting operation on pulmonary arteryto produce pulmonary hypertention,therabbits develop right-sided congestive heartfailure within several days.

采用手术方法造成家兔慢性充血性有心衰竭,发现心衰兔心房提取物的利钠利尿活性明显降低(与对照相比,P<0.01)。电镜观察发现,心衰兔心房肌细胞含心钠素的特殊颗粒数显减少。生物学活性检测与形态学观察结果一致。在家兔实验性心力衰竭时,心房肌内心钠素的减少可能系大量心钠素排入血液的结果。

The myocardium of 20 chronic heart fa(?)ure (CHF) rabbits caused by adriamycin was studied by electron microscopy. The main morphological alterations of CHF heart were as follows: changes in biological membrane, including seperation of intercalated disks, degeneration of mitochondria, dilatation of sarcoplasmic reticulum; atrophy, disruption and lysis of myofibrils; edema of cardiomycytes and interstitial fibrosis.Compensated and decompensated CHF were classified according to the general manifestations of the...

The myocardium of 20 chronic heart fa(?)ure (CHF) rabbits caused by adriamycin was studied by electron microscopy. The main morphological alterations of CHF heart were as follows: changes in biological membrane, including seperation of intercalated disks, degeneration of mitochondria, dilatation of sarcoplasmic reticulum; atrophy, disruption and lysis of myofibrils; edema of cardiomycytes and interstitial fibrosis.Compensated and decompensated CHF were classified according to the general manifestations of the rabbits. The main morphologic differences of myocardium between them were that in the former, the lesions were focal and mitochondriosis was appeared, in the later, the lesions were more diffuse and severe. A close relationship bettween morphologic alterations and heart function was observed.

本文用电镜观察实验性心力衰竭时心肌组织的超微结构改变,分析了心功能代偿与失代偿阶段病理形态的差异,认为心功能状态与心肌受损的程度和范围有关。

Neriperside is a mixed glycoside containing mainly peruvoside, neriifolin and cerberin. The cardiac hemodynamics of peruvoside and neriifolin in anesthetized dogs, the biological activity and the safety margin of neriperside and its constituents in cats and guinea pigs were studied and compared with those of ouabain, digoxin and desJanoside. Their pharmacokinetics were studied by ra-dioimmunoassay. The results indicated that the cardiac performance was improved during intravenous injection of neriifolin and...

Neriperside is a mixed glycoside containing mainly peruvoside, neriifolin and cerberin. The cardiac hemodynamics of peruvoside and neriifolin in anesthetized dogs, the biological activity and the safety margin of neriperside and its constituents in cats and guinea pigs were studied and compared with those of ouabain, digoxin and desJanoside. Their pharmacokinetics were studied by ra-dioimmunoassay. The results indicated that the cardiac performance was improved during intravenous injection of neriifolin and peruvoside or intravenous infusion of neriperside, peruvoside, neriifolin, cerberin, digoxin,deslanoside, ouabain and strophan-thin K. According to therapeutic dose in guinea pig, the sequence of potency of their cardiotonie effect was peruvoside neriifolin neriperside deslanoside digoxin. The cardiotonic potency of cerberin was only a quarter of that of neriifolin.After intravenous injection of peruvoside or neriifolin, the plasma concentration curve was shown to fit a two compartment open model with the following pharma-cokinerie parameters :neriifolin T1/2α=11 min, T1/2β=6.79 h, Vd = 6.78 L/kg and CL = 0.69 L/h/kg; peruvoside T1/2α = 8 min, T1/2=2.13 h, Vd = 3.94 L/kg and CL=1.28 L/h/kg. After oral administration of peruvoside, neriifolin and neriperside, absorption was shown to be rapid with peak blood levels at 52 min, 34 min and 15 min respectively. The bioavailability of peruvoside, neriifolin and neriperside was found to be 29.5%, 35.6% and 27.1% respectively.

本文报告了黄夹甙、次甙甲和次甙乙对麻醉犬的血流动力学和器官血流量的作用,比较了黄夹甙成分和洋地黄制剂对实验性心力衰竭猫和豚鼠的强心效力和安全范围。结果表明,这些强心甙均有正性肌力作用,次甙乙收缩血管的作用不明显。以心力衰竭豚鼠治疗量为指标,强心作用顺序为黄夹次甙甲>次甙乙>黄夹甙>西地兰>地高辛。次甙甲的安全范围比洋地黄制剂大。用放射免疫法测定了心衰豚鼠静脉滴注黄夹甙、次甙甲和次甙乙达到治疗效力、中毒反应(心律失常)和死亡时的血药浓度,表明次甙甲的治疗和中毒浓度交叉很小。黄夹甙、次甙甲和次甙乙口服吸收快,生物利用度相似,次甙甲消除快(T 1/2 2.13 h,次甙乙除消较慢(T 1/2 6.79)。

 
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