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儿童iga肾病
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  childhood iga nephropathy
     Discussiion on the correlation of the clinical characteristics with histopathologic features in childhood IgA nephropathy
     儿童IgA肾病临床与病理的关系
短句来源
     To observe the clinical effects of "Yishen Liangxue Kangmin Decoction" in treating childhood IgA nephropathy, 54 children were treated with this Decoction.
     目的探究益肾凉血抗敏汤治疗儿童IgA肾病疗效。
短句来源
  pediatric iga nephropathy
     The relationship of the clinical and pathologic factors of pediatric IgA nephropathy
     儿童IgA肾病临床与病理关系的探讨
短句来源
     Results The mainly clinical manifestations of pediatric IgA nephropathy were hematuria and proteinuria. The mainly pathological change was II~III classification. The immunologic complex included IgA,IgG,and IgM,especially IgA.
     结果儿童IgA肾病临床表现以血尿合并蛋白尿最多,病理改变以II~III级为主,免疫物质以IgA沉积为主,IgG、IgM也有部分沉积。
短句来源
     Conclusion Pediatric IgA nephropathy should be detected and treated early.
     结论儿童IgA肾病应尽早发现,尽早治疗。
短句来源
  “儿童iga肾病”译为未确定词的双语例句
     Clinical and Pathological Analysis of 256 Children with IgA Nephrosis
     儿童IgA肾病256例临床与病理分析
短句来源
     Clinical and pathological features of 37 children with IgA nephropathy
     37例儿童IgA肾病临床与病理分析
短句来源
     Clinical and Pathological Analysis of IgA Nephropathy with Manifestations of Nephritic Syndrome in Children
     肾病综合征表现的儿童IgA肾病临床和病理分析
短句来源
     The deposits included IgA+M+G(+C_3)in 14 cases,IgA in 13,IgA+M(+C_3)in10.Conclusion IgAN is common in school-aged children,boys far more than girls.
     沉积类型为IgA+M+G(+C3)型14例(37.84%),IgA型13例(35.14%),IgA+M(+C3)型10例(27.03%)。 结论儿童IgA肾病以学龄期儿童多见,男性明显多于女性。
短句来源
     Treament of 54 Cases of IgA Nephrosis in Children with "Yishen Liangxue Kangmin" Decoction
     益肾凉血抗敏汤治疗儿童IgA肾病54例
短句来源
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     With antibiotic-resistant H.pylori strains increasing, in vivo efficacy of anti-H.
     儿童H.
短句来源
     Helicobacter pylori gastritis in children can be diagnosed by obtaining antral biopsy specimens for culture and histologic study during upper gastrointestinal endoscopy.
     儿童H.
短句来源
     Discussiion on the correlation of the clinical characteristics with histopathologic features in childhood IgA nephropathy
     儿童IgA肾病临床与病理的关系
短句来源
     Analysis of clinicopathological features of IgA nephropathy in 37 children
     儿童IgA肾病的临床与病理分析
短句来源
     Relationship between Clinical and Histological Features in Children with Immunoglobulin A Nephropathy
     儿童IgA肾病临床与病理的关系
短句来源
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  childhood iga nephropathy
Glomerular electron-dense deposits in childhood IgA nephropathy
      
Immunoelectron microscopic study of childhood IgA nephropathy and Henoch-Sch?nlein nephritis
      
A histopathological study on the prognosis of childhood IgA nephropathy and glomerular basement membrane lesions
      
Follow-up of renal function and urinary protein excretion in childhood IgA nephropathy
      
Thus, IgA abnormality in childhood IgA nephropathy would be better represented by an increase in macromolecular IgA1 of >amp;gt;11.4s than by an increase in IgA1 in fractions of 11.4-9.3s or >amp;lt;9.3s.
      
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  pediatric iga nephropathy
Angiotensin-converting enzyme genotype and outcome in pediatric IgA nephropathy
      
Use of mizoribine as a rescue drug for steroid-resistant pediatric IgA nephropathy
      
Recent clinical trials have shown a beneficial effect of mizoribine (Miz), an immunosuppressive drug, in the treatment of new-onset pediatric IgA nephropathy (IgAN).
      


To investigate the relationship between HLA-DR gene frequencies and primary nephrot-ic syndrome (NS) in children (age range: 2~14 years), we used polymerase chain reaction (PCR) anda set of 30 sequence-specific oligonucleotide (SSO) probes to determine the HLA-DR gene frequencies.Of the 36 children, nine were diagnosed as IgA nephropathy (IgAN) and the other 27 were non-IgAmesangial proliferative glomerulonephritis (MsPGN). DNA samples extracted from peripheral bloodlymphocytes digested with proteinase K were...

To investigate the relationship between HLA-DR gene frequencies and primary nephrot-ic syndrome (NS) in children (age range: 2~14 years), we used polymerase chain reaction (PCR) anda set of 30 sequence-specific oligonucleotide (SSO) probes to determine the HLA-DR gene frequencies.Of the 36 children, nine were diagnosed as IgA nephropathy (IgAN) and the other 27 were non-IgAmesangial proliferative glomerulonephritis (MsPGN). DNA samples extracted from peripheral bloodlymphocytes digested with proteinase K were subjected to PCR for 30 cycles and then to dot-blot hy-bridization with 30 probes labelled with Y-32 P-ATP. We found that there was a higher gene frequencyof DR4 in IgAN children with NS as compared with normal control (19. 4%vs9. 0%, Pc= 0. 02,RR=2. 98), and a higher gene frequency of DR12 (5) in non-IgA MsPGN children with NS (13. 9 %vs3. 9 %,Pc= 0. 006, RR = 4. 52). In conclusion, the association of HLA-DR4 and DR12 (5) with primary NS inchildren suggested that some immunogenetic situation be responsible for the immunological mechanism inChinese children with primary NS.

利用寡核苷酸探针杂交技术及聚合酶链反应技术,检测了临床表现为肾病综合征的36例患儿人类白细胞抗原(HLA)-DR基因频率的分布;其中9例为IgA肾病,27例为非IgA系膜增殖性肾炎。分别与255例正常汉族人HLA-DR基因频率进行比较,发现IgA肾病患儿HLA-DR4基因频率明显高于正常人[DR4:19.4%vs9.0%,Pc<0.05,相对危险系数(OR)=2.98];而非IgA系膜增殖性肾炎HLA-DR12(5)基因频率明显高于正常人[DR12(5):13.9%vs3.9%,Pc<0.01,OR=4.52]。提示HLA-DR4、HLA-DR12(5)分别与临床表现为肾病综合征的儿童IgA肾病和非IgA系膜增殖性肾炎具有明显相关性。

Objective:To evaluate correlation of the clinical characteristics with pathologic features and prognosis in children IgA nephmpathy.Methods:The clinical cliaracteristics and histopathologic features of 52 cases with IgA nephropa-thy were analysed. Results: The incidence of IgA nephropathy is 13. 6% in ail the renal biopsies in our department of nephrology. The male-to-female ratio is 2.05:1. Asymptomatic hematuria is the most frequent presentation, Renal disfunction or hypertension are rare. The histopathologic...

Objective:To evaluate correlation of the clinical characteristics with pathologic features and prognosis in children IgA nephmpathy.Methods:The clinical cliaracteristics and histopathologic features of 52 cases with IgA nephropa-thy were analysed. Results: The incidence of IgA nephropathy is 13. 6% in ail the renal biopsies in our department of nephrology. The male-to-female ratio is 2.05:1. Asymptomatic hematuria is the most frequent presentation, Renal disfunction or hypertension are rare. The histopathologic expression showed that more severe lesion in patients with proteinuria with or witliout the presence, of hematuria than in ones with asymptomatic hematuria. Moreover,immunofluorescence microscopy demonstrated tliat the staining in the former ca.se is usually predominandy for the complex pattern of immunoglobulins containing IgM. Conclusion:There is a relative relationship between the clinical characteristics and pathologic features.

目的:探讨儿童IgA肾病(IgA nephropathy)临床特点、预后及其与病理的关系。方法:对肾活检病理诊断为IgA肾病52例儿童病例进行临床与病理分析。结果:本组儿童IgA肾病发生率占同期肾活检的13.6%,男性多于女性,临床表现以单纯血尿最常见,其次为蛋白尿伴血尿、肾病综合征,肾功能不全、高血压少见。蛋白尿伴或不伴血尿较单纯血尿光镜下病理改变严重,且免疫球蛋白的沉积以复合型为主,IgM沉积的比率高。结论:儿童IgA肾病临床特征与病理有一定的关系,单纯血尿者病理改变轻微,预后良好,蛋白尿者病理改变严重,应加强随访。

Objective To compare the clinical and pathological characte ri stic of cases with IgA nephropathy presenting with hematuria or nephrotic syndro me respectively after summarizing all cases of IgA nephropathy hospitalized in o ur department in the last6years retrospectively. Methods The clinical index inc luding edema,hematuria,proteinuria,renal function,hypertension and pathologi cal examination by light microscopy and immunofluoresˉcence were analyzed in27c ases with hematuria(group A)and18cases with...

Objective To compare the clinical and pathological characte ri stic of cases with IgA nephropathy presenting with hematuria or nephrotic syndro me respectively after summarizing all cases of IgA nephropathy hospitalized in o ur department in the last6years retrospectively. Methods The clinical index inc luding edema,hematuria,proteinuria,renal function,hypertension and pathologi cal examination by light microscopy and immunofluoresˉcence were analyzed in27c ases with hematuria(group A)and18cases with nephrotic syndrome(group B). Res ults The renal pathological changes in group A are manifested in the1-2stages m ainly(89%)and those in group B are manifested in3-4stages(74%).Simple IgA is the predominant deposits by immunofluorescence in group A(74%),and complex a re the main deposits in group B(83%).Meanwhile Ig A deposited at the mesangial and capillary vessel in group B are more than those in group A evidently.There a re significant difference between the two groups(p<0.05). Conclusion The clin ical representation and tissue damage of IgA nephropathy presenting with nephrot ic syndrome are more serious than those with single hematuria,and the prognosis is much worse in former.

目的 回顾性地总结我科6年来所收治的儿童IgA肾病资料 ,对其中分别表现为单纯性血尿和肾病综合征的病例进行临床及病理特点比较。方法 将IgA肾病单纯性血尿组 (A组 )27例和肾病综合征 (B组 )18例进行临床 (水肿、血尿、蛋白尿、肾功能、高血压 )和病理 (光镜、免疫荧光 )分析。 结果 A组肾脏病理改变以Ⅰ~Ⅱ级为主 (89% ) ,B组多表现Ⅲ~Ⅳ级 (78% ) ,两组对比差异有显著性 (P<0.01) ;免疫荧光A组以单纯IgA沉积为主 (74% ) ,B组以复合沉积为主 (83 % ) ,且B组IgA于系膜 +毛细血管区沉积明显多于A组 ,差异均有显著性 (P<0.01)。 结论 IgA肾病表现为肾病综合征者临床及组织损伤均重于表现为单纯血尿者 ,其预后较差

 
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