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膀胱癌
相关语句
  bladder cancer
    An immunotoxin using VH-PE for urinary bladder cancer
    抗人膀胱癌VH-PE在大肠杆菌的表达及初步鉴定
短句来源
    PREPARATION OF THE PHAGE SINGLE CHAIN ANTIBODY OF ANTI HUMAN BLADDER CANCER
    抗人膀胱癌噬菌体单链抗体的初步制备
短句来源
    METHODS: Human bladder cancer cell line T24 was inoculated into the bladders of 25 BALB/c nude mice to establish orthotopic bladder cancer model.
    方法:直视下经尿道机械损伤BALB/c裸鼠膀胱粘膜,将人膀胱癌细胞T24经尿道种植于25只裸鼠膀胱,建立荷人膀胱癌原位动物模型。
短句来源
    Establishment of Balb/c nude mice orthotopic transplantation tumor model with human bladder cancer
    荷人膀胱癌原位移植瘤Balb/c裸小鼠动物模型的建立
短句来源
    Establishment and Application of An Orthotopic Murine Bladder Cancer Model
    原位膀胱癌动物模型的建立及应用
短句来源
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  “膀胱癌”译为未确定词的双语例句
    Humanization of Mouse Anti-bladder Cancer McAb by CDR3 Directed Phage Antibody Library
    CDR3导向抗体库技术人源化抗膀胱癌单抗BDI
短句来源
    We partially purified and characterized bone resorption factor (BRF) from human transitional cell carcinoma (TCC) , rat Walker 256 carcinoma and mouse 7,12 dimethyl benz (a) anthracene (DMBA) induced squamous carcinoma.
    我们从人膀胱癌、大鼠乳腺癌(Walker 256)及7.12-Dimethyl Benz[α]anthracene诱发的小鼠鳞癌的提取液中初步分离鉴定了一种溶骨因子。
短句来源
    Urinary contents of hEGF of pregnent womenand patients of urinary baldder cancer were higher and lower than that of the normal groups respectively.
    测定了正常人、孕妇及膀胱癌病人尿中hEGF的含量,孕妇尿中hEGF含量明显高于正常女性,膀胱癌患者尿中hEGF含量明显低于正常人。
短句来源
    RESULTS: The luciferase activities in T24 and EJ cells treated with Tw were much higher than that in COS-7 and fibrocytes cells treated with Tw, as well as higher than that in T24 and EJ cells treated with Td, respectively.
    结果:在膀胱癌T24和EJ细胞中,Tw组转录活性显著高于对照组,亦高于Td组。
短句来源
    Combined with c-myc and [STBX]mad1, down-regulation of Tw expression was observed.
    c-myc和mad1联合可下调膀胱癌细胞Tw的转录。
短句来源
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  bladder cancer
Study of recombinant human IFN-α-2b bacilli calmette-guerin activated killer cells and against bladder cancer cell in vitro
      
Presently, one of the most potent immunotherapies is the application of bacillus Calmette Guerin (BCG) to prevent recurrences of the superficial bladder cancer.
      
We conclude that the recombinant BCG can activate more PBMCs to anti-bladder cancer in vitro than wild-type BCG does.
      
Radiotherapy is an Effective Treatment for High-Risk T1-Bladder Cancer
      
We have evaluated the efficacy of adjuvant radiotherapy or radiochemotherapy on local control, bladder preservation, recurrence rate and long-term survival after TURB of high-risk T1-bladder cancer.
      
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Marked hypercalcemia would be caused by ectodermic solid tumor remote from the bone and Without any indication of bone invasion. It suggested that certain humoral factor secreted by the tumor may contribute to the pathogenesis.We partially purified and characterized bone resorption factor (BRF) from human transitional cell carcinoma (TCC) , rat Walker 256 carcinoma and mouse 7,12 dimethyl benz (a) anthracene (DMBA) induced squamous carcinoma. Gel filtration chromatography of tumor extract demonstrates a single...

Marked hypercalcemia would be caused by ectodermic solid tumor remote from the bone and Without any indication of bone invasion. It suggested that certain humoral factor secreted by the tumor may contribute to the pathogenesis.We partially purified and characterized bone resorption factor (BRF) from human transitional cell carcinoma (TCC) , rat Walker 256 carcinoma and mouse 7,12 dimethyl benz (a) anthracene (DMBA) induced squamous carcinoma. Gel filtration chromatography of tumor extract demonstrates a single major peak of bone resorption activity (BRA, 45Ca release from calvarial bone) that elutes with an apparent MW of about 15,000 dalton. The BRA is associated with increased release of immunoreactive PGE 2 and both can be inhibited by indomethacin and boiling. In TCC and DMBA, the BRA were co-eluted with an activity of stimulating aden-ylate cyclase in rat osteosarcoma cells ROS 17/2.8. It appears that these factors are unique BRF, which are different from other known factors that can cause bone resorption.

某些源自外胚层的骨外实体瘤,它们并未浸润至骨组织,但可引起血钙显著增高,提示这些肿瘤可能分泌体液因子作用于骨导致溶骨。我们从人膀胱癌、大鼠乳腺癌(Walker 256)及7.12-Dimethyl Benz[α]anthracene诱发的小鼠鳞癌的提取液中初步分离鉴定了一种溶骨因子。肿瘤提取液经ultrogel层析,发观仅有一溶骨活性峰(~(45)Ca自乳鼠顶骨培养中的释出率),相当于表观分子量15,000道尔顿。此溶骨活性峰与PGE2生成的活性峰相平行,两者均能被Indomethacin及煮沸所抑制。在膀胱癌及鳞癌中,溶骨活性峰还与刺激大鼠成骨肉瘤细胞腺苷酸环化酶的活性相平行。实验结果表明此溶骨因子不同于其它已知能引起溶骨的因子。

The active ester of chlorambu(?) (CBL) was attached to a monoclonal antibody 5OH·19, against human colorectal cancer cell line (LOVO) to constitute a immunoconjugate CBL-5OH·19. which has a high ratio of CBL per molecule of McAb (25~30: 1) and (?)xcellent targeting activity. The results of (?)0-minute assay and 24-hour assay indicated that CBL-5OH·19 had strong in vitro killing activity to LOVO cells, which was more effective than free CBL. Meanwhile, CBL-5OH·19 was found to have no effect on human bladder tumor...

The active ester of chlorambu(?) (CBL) was attached to a monoclonal antibody 5OH·19, against human colorectal cancer cell line (LOVO) to constitute a immunoconjugate CBL-5OH·19. which has a high ratio of CBL per molecule of McAb (25~30: 1) and (?)xcellent targeting activity. The results of (?)0-minute assay and 24-hour assay indicated that CBL-5OH·19 had strong in vitro killing activity to LOVO cells, which was more effective than free CBL. Meanwhile, CBL-5OH·19 was found to have no effect on human bladder tumor cell line (E-J) and the conjugate CBLOIgG had no killing effect on both of LOVO and E-J cells. These results indicated that CBL-5OH·19was not only effective but also specific in killing the human colorectal cancer cells.

苯丁酸氮芥(CBL)的活性酯通过共价联接的方式与抗人直肠癌单克隆抗体5OH.19偶联,形成的免疫偶联物CBL一5OH.19具有较高的药物/抗体比率(25~30∶1)以及很好的导向活性。在体外30分钟试验和24小时试验中,CBL—50H.19对人直肠癌LoVo细胞均具有很强的体外杀伤活性.其效果比游离的CBL强。CBL—50H.19对人膀胱癌E—J细胞无杀伤活性;CBL与正常小鼠IgG偶联组成的免疫偶联物对LoVo细胞和E—J细胞均无杀伤作用。这表明CBL—50H.19对人直肠癌细胞不但具有较强的杀伤能力.而且具有好的杀伤特异性.

The synergistic effect of combinations of killing agents on tumor cells has long been recognized. Fodstad et al, reported that the combinations of Ricin and Adriamycin have a strong, syn ergistic effect on the L1210 leukemia cells. In this report, a novel immunotoxin containing Ricin and Adriamycin, BDI-l-Ricin-Adriamycin, was described.Ricin and Adriamycin were chemically coupled onto one monoclonal antibody molecule against human bladder cancer, BDI-1, to construct the two-killing-agent containing immunotoxin....

The synergistic effect of combinations of killing agents on tumor cells has long been recognized. Fodstad et al, reported that the combinations of Ricin and Adriamycin have a strong, syn ergistic effect on the L1210 leukemia cells. In this report, a novel immunotoxin containing Ricin and Adriamycin, BDI-l-Ricin-Adriamycin, was described.Ricin and Adriamycin were chemically coupled onto one monoclonal antibody molecule against human bladder cancer, BDI-1, to construct the two-killing-agent containing immunotoxin. The results of indirect immunofluorescence test and competiton bindig assay showed that the retention of 70% of the antibody binding activity in this immunotoxin was obtained. The in vitro cytotoxicity assay indicated that the immunotoxin in the presence of 0.1M galactose is 30,000 times more cytotoxic than BDI-1-Adriamycin conjugate and 10 times more cytotoxic than BDI-1-Ricin immunotoxin in the bladder cancer-specific killing, but has no cytotoxic effect on the LOVO colon carcinoma cells. This two-killing-agent containing immunotoxin may lead to the development of a new kind of immunotoxins which have strong cytotoxic activity to target cells.

本文用化学偶联方法,将篦麻毒素(RiCin)及阿霉素(Adriamycin,Adr)同时偶联到抗人膀胱癌单克隆抗体分子上,构建了第一个具有“双单头”的抗肿瘤导向药物。经间接免疫荧光检测以及放射竞争结合试验证明,这个免疫毒素保持了原抗体活性的70%。体外杀伤试验的结果表明,这个双单头免疫毒素在0.1M半乳糖存在的条件下,对膀胱癌细胞BIU-87的体外杀伤作用比单抗-阿霉索强30000倍;比单抗-篦麻毒素强10倍。对无关的人直肠癌LoVo细胞无明显的杀伤作用。

 
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