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阿尔茨海默病模型     
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  alzheimer disease models
     Influence of tiantai No. 1 recipe on learning and memory function of spontaneous Alzheimer disease models
     天泰1号对自发阿尔茨海默病模型学习记忆功能的影响(英文)
短句来源
     Rats in saline group were injected with 2 μ L model saline, which rats in other three groups were injected with 2 μ L(5 g/L)β amyloid1 42 injection into hippocampus to induce Alzheimer disease models.
     生理盐水组大鼠海马注入2μL生理盐水,其他3组大鼠缓慢注入2μL淀粉样β蛋白1~42(5g/L),复制阿尔茨海默病模型
短句来源
     OBJECTIVE To investigate the effect of No. 1 recipe on learning and memory function of spontaneous Alzheimer disease models.
     目的:观察天泰1号对自发阿尔茨海默病模型学习记忆功能的影响。
短句来源
     A total of 56 Alzheimer disease models were divided into training group(n =40) and control group(n=16),and the un Alzheimer disease models were selected as normal control group(n=16).
     选取86只大鼠运用淀粉样β蛋白双侧海马注射建立大鼠阿尔茨海默病模型,随机抽取造模成功大鼠56只分为阿尔茨海默病训练组40只、阿尔茨海默病对照组16只。
短句来源
     OBJECTIVE To investigate the effect of tiantai No. 1 recipe on learning and memory function and synaptic plasticity of spontaneous Alzheimer disease models.
     目的押观察天泰1号对自发阿尔茨海默病模型学习记忆功能及神经突触可塑性的影响。
短句来源
  alzheimer disease model
     EXPLORATION OF CENTRAL DOPAMINE D_2 RECEPTOR IN ALZHEIMER DISEASE MODEL RATS
     阿尔茨海默病模型小鼠脑多巴胺D_2受体的研究
短句来源
     Mechanisms of Shen-wu capsule inhibiting β-amyloid production in brain of Alzheimer disease model mice
     参乌胶囊抑制阿尔茨海默病模型小鼠脑内β-淀粉样肽生成的机制研究
短句来源
     The stain of synaptophysin in polymorpic layer and molecular layer of CA1 region was lighter in the Alzheimer disease model group than normal control group.
     阿尔茨海默病模型组海马CA1区多形层和分子层突触素染色较正常对照组浅。
短句来源
     ③The abilities of learning and memory of rats in the Alzheimer disease model group obviously worsened, and the trying times of learning and memory was markedly higher than normal control group and sham-operation group P < 0.05, moreover, the rate of correct reaction in the whole process was significantly lower than normal control group and sham-operation group P < 0.05.
     ③阿尔茨海默病模型组大鼠学习能力和记忆能力均显著下降,学习记忆获得尝试次数显著高于正常组和假手术组(P<0.05),并且在整个过程中正确反应率明显低于正常组和假手术组(P<0.05)。
短句来源
     ②The absorptances of synaptophysin in hippocampus of rats in sham-operation group and control group were similar, and the differences were not significant 0.268±0.01,(0.270±0.01),t=1.549, P > 0.05, while that in the Alzheimer disease model group was significantly lower than the control group with remarkable differences 0.176±0.01,(0.270±0.01),t=2.875, P < 0.05.
     ②假手术组大鼠海马结构内突触素吸光度值与对照组接近,差异无显著性意义[(0.268±0.01),(0.270±0.01),t=1.549,P>0.05]; 阿尔茨海默病模型组大鼠海马结构内突触素吸光度值明显低于对照组,差异有显著性意义[(0.176±0.01),(0.270±0.01),t=2.875,P<0.05]。
短句来源
  models of alzheimer disease
     ②Model group:2 μL βamyloid 142(5 g/L) was slowly injected into cerebral hippocampus, models of Alzheimer disease were replicated,and the rats were treated with gastric perfusion of double distilled water(3 mL) 3 days after model establishment;
     ②模型组:脑海马缓慢注入2μL淀粉样β蛋白1~42(5g/L),复制拟阿尔茨海默病模型,造模后3d灌胃3mL的双蒸水。
短句来源
     CONCLUSION:Acidic peptide of 30 and 60 mg/kg can obviously ameliorate the learning and memory abilities in rat models of Alzheimer disease,which may be realized mainly through up-regulating the NGF content in basal forebrain and down-regulating the NMDAR and β-amyloid contents in cerebral cortex.
     结论:30,60mg/kg的酸性肽能明显改善阿尔茨海默病模型大鼠的学习记忆能力,其治疗作用途径可能是通过上调基底前脑中的神经生长因子水平,下调大脑皮质中N-甲基-D-天冬氨酸受体和β淀粉样蛋白的水平实现的。
短句来源
     Effect of Dihuang Yinzi on expression of brain monoamine B gene in rat models of Alzheimer disease
     地黄饮子影响阿尔茨海默病模型大鼠大脑单胺氧化酶B基因的表达
短句来源
     Effects of basic fibroblast growth factor on rat models of Alzheimer disease
     碱性成纤维细胞生长因子对阿尔茨海默病模型大鼠的影响
短句来源
     Effect of rehmanniae decoction on the neuron apoptosis and ultrastructure in rat models of Alzheimer disease
     地黄饮子对阿尔茨海默病模型鼠脑神经元细胞凋亡及超微结构的影响
短句来源
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  model of alzheimer ' s disease
     Effect of Ziheche on β-amyloid,β-amyloid precursor protein mRNA in brain tissue of rat model of Alzheimer's disease
     紫河车对阿尔茨海默病模型大鼠脑组织内β淀粉样蛋白及β淀粉样前体蛋白mRNA表达的影响
短句来源
     Molecular mechanism of Replenishing Kidney Recipe on preventing the deteriation of learning and memory in rats model of Alzheimer's disease
     补肾填精方防治阿尔茨海默病模型大鼠学习记忆损害的分子机制
短句来源
     Effects of acidic oligose on differentially expressed genes in the mice model of Alzheimer's disease by microarray
     酸性寡糖对阿尔茨海默病模型小鼠脑内基因表达的影响
短句来源
     Objective To observe the changes of β-Amyloid,β-Amyloid precursor protein mRNA in brain tissue of rat model of Alzheimer's Disease(AD) after intervention with Ziheche and investigate the mechanisms of enhancing learning and memory in rat model of Alzheimer's Disease by Ziheche.
     目的观察用紫河车干预后的阿尔茨海默病(AD)模型大鼠的脑组织内β样淀粉蛋白(Aβ)、β类淀粉前体蛋白信使核糖核酸(βAPPmRNA)表达改变,探讨紫河车改善阿尔茨海默病模型大鼠症状的部分机制。
短句来源
     Effects of Tiantai No.1 on RBC Immunological Function in Mice Model of Alzheimer's Disease
     天泰1号对阿尔茨海默病模型红细胞免疫功能的影响
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  alzheimer disease models
Alzheimer disease models and human neuropathology: similarities and differences
      
  alzheimer disease model
Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model.
      
  model of alzheimer ' s disease
Impaired Processes of Working Memory in the Monkey Model of Alzheimer's Disease
      
Alterations of the Sensory and Cognitive Components of Operative Memory in a Monkey Model of Alzheimer's Disease
      
These studies, which provide in vitro support for the hypothesis, are being pursued in an animal model of Alzheimer's disease.
      
Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease
      
We have switched to mice so that we can prepare to perform our experiments in a transgenic animal model of Alzheimer's disease.
      
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Morris water maze was used to observe preventive effect of Bushen Yizhi Decoction (BYD)on learning and memory in rat model with Alzheimer's disease(AD),and AD rat model was established by intraperitoneral injection of D_galactose combined with ibotenic acid injection into bilateral nucleus basalis of Meynert.The results showed that BYD improved learning and memory in AD rat model.Escape latency of AD rat model in Morris water maze was shortened (P<0.01) and distance of swimming in the platform quadrant was...

Morris water maze was used to observe preventive effect of Bushen Yizhi Decoction (BYD)on learning and memory in rat model with Alzheimer's disease(AD),and AD rat model was established by intraperitoneral injection of D_galactose combined with ibotenic acid injection into bilateral nucleus basalis of Meynert.The results showed that BYD improved learning and memory in AD rat model.Escape latency of AD rat model in Morris water maze was shortened (P<0.01) and distance of swimming in the platform quadrant was prolonged (P<0.05) .It is suggested that BYD possesses a certain preventive effect on learning and memory in AD rat model.

为寻求防治老年性痴呆的有效措施 ,运用Morris水迷宫评价了中药补肾益智方 (由蛇床子、枸杞子、女贞子、人参等组成 )对由D_半乳糖致亚急性衰老加上Meynert核损毁所致阿尔茨海默病模型大鼠的学习记忆能力的保护作用。结果表明 :补肾益智方能够改善模型大鼠的学习记忆成绩 ,包括缩短模型大鼠在Morris水迷宫中寻找到平台的逃避潜伏期 (P <0 .0 1) ,延长其在原平台象限游泳的距离 (P <0 .0 5)。提示补肾益智方对阿尔茨海默病模型大鼠的学习记忆能力有一定的保护作用

Objective To study the effects of basic fibroblast growth factor (bFGF) on the praxiology and cerebral acetylcholinesterase (AchE) fiber density of kainic acid-lesioned rat models of Alzheimer disease (AD). Methods AD models were induced in 30 normal adult rats by damaging the rat nucleus basalis of Meynert (NBM) with kainic acid, and the models were then assigned into 3 groups to receive cerebroventricular infusion with bFGF, saline or nothing for treatment, serving respectively as the treatment...

Objective To study the effects of basic fibroblast growth factor (bFGF) on the praxiology and cerebral acetylcholinesterase (AchE) fiber density of kainic acid-lesioned rat models of Alzheimer disease (AD). Methods AD models were induced in 30 normal adult rats by damaging the rat nucleus basalis of Meynert (NBM) with kainic acid, and the models were then assigned into 3 groups to receive cerebroventricular infusion with bFGF, saline or nothing for treatment, serving respectively as the treatment group at 30 min, 1, 3 and 7 d after the injury, sham treatment group or injury group. Another 10 rats were used as control group, which received saline injections into the NBM without further treatment. The learning and memory abilities of the rats were measured through Y-maze test 30 d after the operations, and AchE cytochemical study was conducted to calculate the density of the AchE fibers in the hippocampus and forebrain of the rats. Results In comparison with the injury group, improvement was noted in the memory ability of rats with bFGF treatment and the density of AchE fiber was also significantly increased (P<0.01), but the improvement in both respects failed to reach the normal level (P<0.01). Conclusions AD model can be successfully established by damaging the NBM with kainic acid, and bFGF is beneficial in improving the impaired learning and memory abilities and increasing the density of AchE fibers in the basal forebrain cortex and hippocampus in the models.

目的探讨碱性成纤维细胞生长因子(bFGF)对红藻氨酸损毁Meynert基底核致阿尔茨海默病模型大鼠学习和记忆能力的影响及脑内胆碱能纤维密度的变化。方法痴呆组、痴呆治疗组及痴呆对照组大鼠前脑Meynert基底核注射红藻氨酸制造阿尔茨海默病模型;正常对照组注射生理盐水。痴呆治疗组造模后30 min、1、3、5、7 d右侧侧脑室注射bFGF;痴呆对照组同时间注射生理盐水。30 d后Y迷宫测试正常对照组、痴呆组、痴呆对照组及痴呆治疗组大鼠学习和记忆能力;AchE细胞化学染色,并测量基底前脑皮层及海马区AchE纤维密度。结果痴呆组大鼠Y迷宫学习及记忆能力较正常对照组下降(P<0.01),AchE纤维密度减低(P<0.01)。治疗组Y迷宫学习及记忆能力较痴呆对照组有改善(P<0.01),AchE纤维密度亦有所增加(P<0.01),但没有达到正常对照组水平(P<0.01)。结论红藻氨酸前脑Meynert基底核可成功制造阿尔茨海默病模型;bFGF可提高阿尔茨海默病模型大鼠基底前脑皮层及海马区AchE纤维密度,改善其Y迷宫记忆能力。

Objective To study the effect of basic fibroblast growth factor on neurogenesis in brain of rat Alzhermer disease(AD) model with NBM lesion induced by kainic acid. Methods AD model was established by inducing through leisioning NBM lesions with kainic acid. AD rats received bFGF or saline infusion into the cerebroventricular space daily after the induction of AP. After 7 days bFGF infusion, 5-BrdU was used to label the neural progenitors and the survival of newborn cells after bFGF infusion. TUNEL...

Objective To study the effect of basic fibroblast growth factor on neurogenesis in brain of rat Alzhermer disease(AD) model with NBM lesion induced by kainic acid. Methods AD model was established by inducing through leisioning NBM lesions with kainic acid. AD rats received bFGF or saline infusion into the cerebroventricular space daily after the induction of AP. After 7 days bFGF infusion, 5-BrdU was used to label the neural progenitors and the survival of newborn cells after bFGF infusion. TUNEL was used to label the apoptotic cell. Positive cells labeled for 5-BrdU or TUNEL in the subventicular zone and the dentate gyrus were counted.Results When compared to AD group, the number of 5-BrdU positive cells in bFGF treatment group significantly increased. But the number of TUNEL positive cells was not significantly different from that of the AD group. The number of 5-BrdU positive cells and the number of TUNEL positive cells was not significantly different from that of the nomal control group.Conclusion bFGF can acceleration the proliferation of neural progenitors in the subventicular zone and the dentate gyrus in AD rat.

目的 探讨碱性成纤维细胞生长因子 (bFGF)对红藻氨酸损毁Meynert基底核造成的阿尔茨海默病 (AD)模型大鼠室管膜下层及海马齿状回神经细胞增殖的影响。方法 AD处理组及AD对照组大鼠前脑Meynert基底核注射红藻氨酸制造阿尔茨海默病模型 ;正常对照组注射生理盐水。AD处理组造模后每天侧脑室注射bFGF共 7d ;AD对照组及正常对照组同时间注射生理盐水。BrdU标记增殖细胞。TUNEL方法标记DNA片段 ,原位检测凋亡细胞。计数室管膜下层和海马齿状回BrdU阳性细胞与凋亡细胞数。结果 AD处理组大鼠与AD对照组大鼠相比 ,室管膜下区及海马齿状回BrdU阳性细胞明显增加 (P <0 0 1) ,而凋亡细胞无明显差异 (P >0 0 5 )。AD对照组大鼠与正常对照组大鼠相比 ,室管膜下区与海马齿状回BrdU阳性细胞数及凋亡细胞均没明显差别 (P >0 0 5 )。结论 bFGF可促进AD模型大鼠脑内神经细胞的增殖 ,是治疗AD等神经缺损性疾病有希望的一种神经生长因子

 
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