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   类固醇合成 的翻译结果: 查询用时:0.865秒
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类固醇合成
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  steroidogenesis
     [Methods] Based on the primary Leydig cell culture model, MEHP exposure groups involved control (0μmol/L), 62.5, 125,250, 500 and 1000μmol/L. We observed mitochondria activity with MTT method, measured testosterone level with RIA and determined steroidogenesis acute regulatory protein (StAR) mRNA expression with RT-PCR.
     [方法]建立SD大鼠睾丸Leydig细胞体外原代培养模型,MEHP染毒剂量组分为对照(0μmol/L)、62.5、125、250、500和1000μmol/L,通过噻唑蓝(MTT)法观察线粒体活性,放射免疫法测定睾酮浓度、RT-PCR法测定Leydig细胞类固醇合成急性调节蛋白(StAR)mRNA表达。
     PRL alone had no effect on steroidogenesis of theca cells, but when add together with FSH (100 μg/L) or LH (50 μg/L) it effectively suppressed the production of E 2 or E 2 and T which were stimulated by FSH or LH.
     PRL单独对膜细胞类固醇合成无明显作用,但可抑制LH诱导的T和E2合成,以及FSH刺激的E2合成。
短句来源
     Methods: Based on the primary Leydig cell culture model, MEHP exposure groups involved control (0 μmol/L), (62.5), 125, 250, 500 and 1 000 μmol/L. We observed mitochondria activity with the MTT method, measured the testosterone level with RIA and determined steroidogenesis acute regulatory protein(StAR) mRNA expression with RT-PCR.
     方法:建立SD大鼠睾丸Leydig细胞体外原代培养模型,MEHP染毒剂量组分为对照(0μmol/L)、62.5、125、250、500、1000μmol/L,通过噻唑蓝(MTT)法观察线粒体活性,放射免疫法测定睾酮浓度,RTPCR法测定Leydig细胞类固醇合成急性调节蛋白(StAR)mRNA表达。
短句来源
     The development and differentiation of follicles are closely associated with the ability of steroidogenesis, which depends on the expression and activity of steroidogenetic enzyme cytochrome P450 superfamily.
     卵泡的发育和分化与类固醇合成能力的增加密切相关,而类固醇的合成能力依赖于类固醇生成酶细胞色素P450超家族成员的表达和活性。
短句来源
     IP-10can be used as gene therapy for prostate cancer due to its antiangiogenic effects and its inhibitory effects on steroidogenesis.
     结论:过量表达的IP_10基因对MA_10小鼠Leydig肿瘤细胞的类固醇合成及生长具有显著的抑制作用,此结果提示我们可以考虑使用转入IP_10基因的?
短句来源
  steroidogenic
     The expressions of StAR (steroidogenic acute regulatory protein) mRNA in testes from 7,14,23 and 37 day-old piglets were studied by tissue in situ hybridization. The results indicated that in the testes of piglets, StARmRNA was expressed in Leydig cells of pig testes.
     类固醇合成快速调节蛋白(steroidogenic acute regulatory protein,StAR)在调节类固醇合成中发挥了重要作用,为了认识StAR蛋白在仔猪性腺发育早期中的表达,以7、14、23、37日龄的仔猪睾丸为研究对象,采用组织原位杂交方法研究了StARmRNA在仔猪睾丸中的表达水平。
短句来源
     The results were as followed: (1) In all periods, the expression of cholesterol side chain decomposition enzyme (P450scc) , 3 beta-hydroxysteroid dehydrogenase(3β-HSD),steroidogenic acute regulatory protein (StAR) mRNA and protein had no significant change.
     结果显示:(1)在不同年龄阶段,P450scc(胆固醇支链裂解酶)mRNA、3β-HSD(3β-羟胆固醇脱氢酶)mRNA、StAR(类固醇合成快速调节蛋白)mRNA和蛋白的水平无明显变化;
短句来源
     OBJECTIVE:To study the effect of electromagnetic irradiation on steroidogenic acute regulatory protein(StAR) and cytochrome P450 cholesterol side-chain cleavage(P450scc) in the tissues of the testis of the adult rats,and to preliminarily reveal the molecular mechanism of electromagnetic radiation that affects the synthesis of testosterone.
     目的:探讨电磁辐射对成年大鼠睾丸组织中类固醇合成急性调节蛋白(StAR)、细胞色素P450胆固醇侧链裂解酶(P450scc)的作用,初步揭示电磁辐射影响睾酮合成的分子机制。
短句来源
     Objective To study the effect of electromagnetic irradiation on steroidogenic acute regulatory protein (StAR) and cytochrome P450 cholesterol side chain clevage enzyme (P450 scc) in adult rat testis tissue.
     目的探讨电磁辐射对成年大鼠睾丸组织中类固醇合成急性调节蛋白 (StAR)、细胞色素P4 5 0胆固醇侧链裂解酶 (P4 5 0scc)的作用。
短句来源
     Objective To investigate the possible mechanisms of decreasing steroidogenic function in the aged rat testes through determining the effects of aging on the steady-state levels of the mRNAs of testicular steroidogenic acute regulatory protein (StAR) and 17β-hydroxysteroid dehydrogenase(17β-HSD), and observing the morphology of the testes in the aged male rats.
     目的通过测定老年雄性SD大鼠睾丸类固醇合成急性调节蛋白(StAR)、17β-羟类固醇脱氢酶(17β- HSD)表达,观察睾丸间质和Leydig细胞结构的变化,探讨老年大鼠性腺功能减退的机制。
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  “类固醇合成”译为未确定词的双语例句
     Expression of enzymes associated with steroid biosynthesis in different tissues of mice
     类固醇合成相关酶在小鼠不同组织中的表达
短句来源
     Effects of Overexpression of IP-10Gene on MA-10 Mouse Leydig Tumor Cell Steroidoge-nesis and Cell Proliferation
     IP-10基因过量表达对MA-10小鼠Leydig肿瘤细胞类固醇合成及细胞增殖的影响
短句来源
     ③Effect of infrasound exposure on expression levels of SF-1,StAR,P450scc: Compared with the control group,expressions of all the indexes in the 90 dB group were decreased with prolonged exposure (P < 0.05).
     ③次声暴露对大鼠睾丸类固醇合成因子1、类固醇激素合成急性调节蛋白、细胞色素P450胆固醇侧链裂解酶mRNA表达水平的影响:与空白对照组比较,强度为8Hz、130dB次声作用的大鼠各指标表达水平随着暴露时间的延长而下降(P<0.05);
短句来源
     For the 90 dB group,the expressions of StAR,P450scc were decreased on day 1 and 7 (P < 0.05),while increased on day 14 and 21; although there were changes of the mRNA expression levels of SF-1,it had no significant difference at each time point.
     强度为8Hz、90dB次声作用的大鼠类固醇激素合成急性调节蛋白、细胞色素P450胆固醇侧链裂解酶mRNA表达水平于1,7d降低(P<0.05),而14,21d略有回升(P>0.05),各时间点类固醇合成因子1mRNA表达水平虽有波动,但差异无显著性意义。
短句来源
     cAMP (0.2 mmol/L) induced StAR Dl mRNA expression but this StAR Dl mRNA expression induced by cAMP (0.2 mmol/L) was decreased 30-40% by transfection with IP-10, indicating that progesterone synthesis inhibition by IP-10 may be through decreasing StAR Dl expression.
     实验结果证实,转染的IP一10基因在袱一10细胞中的过量表达可显著抑制c胡P(0.Zlnlnol/L)诱导的孕酮生成(P<0 .01),其抑制作用可能是通过减少类固醇合成急性调节蛋白StAR(DI)基因的表达而实现;
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  steroidogenesis
Binding Sites for Transcription Factor SF-1 in Promoter Regions of Genes Encoding Mouse Steroidogenesis Enzymes 3βHSDI and P450c
      
Steroidogenesis in Patients with Various Adrenal Cortex Diseases as Studied by Reversed-Phase High-Performance Liquid Chromatogr
      
At present, GeneNet contains the data on 16 gene networks which are arranged in six sections according to the subject concerned: lipid metabolism, steroidogenesis, erythropoiesis, antiviral response, plant seed development, and heat shock.
      
Experimental verification of 18 putative SF-1 sites predicted for the regulatory regions of the steroidogenesis genes showed that 15 (83%) of them did indeed interact with SF-1.
      
Influence of prenatal stress on steroidogenesis in gonads of blue foxes
      
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  steroidogenic
Thus, a high level of corticosterone during the period of elevated activity of the hypothalamic-pituitary-adrenal axis in 3-week old mice is determined by enhanced steroidogenic function of the adrenals.
      
MMP-9,-14 and TIMP-1,-2,-3 were mainly localized in the cytoplasm of the steroidogenic cells.
      
Expression of steroidogenic acute regulatory protein and its regulation by interferon-gamma in rat corpus luteum
      
Human chorionic gonadotropin (hCG) regulates the expression of Steroidogenic acute regulatory protein (StAR) via the ERK1/2 path
      
The scavenger receptor class B type I (SR-BI) plays an important role in mediating selective uptake of high-density lipoprotein (HDL)-derived cholesterol and cholesteryl ester in liver and steroidogenic tissues.
      
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The rats were first given gossypol acetate (30 mg/kg/day for 11 days), on day 15 of ageand received daily subcutaneous injection of 10 IU hCG from the 21st to the 25th day oflife. After these treatments the histological and histochemical changes of the interstitialcells were observed. The results indicated gossypol could partly interfere with the responseof the testicular interstitial cells of prepubertal rats to exogeneous hCG. The inhibitionwas found mainly in two aspects: (1) checking the hyperplasia of the...

The rats were first given gossypol acetate (30 mg/kg/day for 11 days), on day 15 of ageand received daily subcutaneous injection of 10 IU hCG from the 21st to the 25th day oflife. After these treatments the histological and histochemical changes of the interstitialcells were observed. The results indicated gossypol could partly interfere with the responseof the testicular interstitial cells of prepubertal rats to exogeneous hCG. The inhibitionwas found mainly in two aspects: (1) checking the hyperplasia of the cells in the interstitialtissue, including the Leydig cells and precursor fibroblast-like cells, (2) histochemically weak-ening the activity of the steroidogenic enzymes(e.g. 3β-hydroxysteroid dehydrogenase andnon-specific esterase). The morphology of the seminiferous epithelium and Leydig cells atlight microscope level seemed to be changed. It is suggested that gossypol may inhibitthe function of the interstitial cells in the rat testis.

本实验给15日龄大鼠每日灌服醋酸棉酚30mg/kg,共11天;同时从21天龄起每日皮下注射hCG 10IU,共5天后,观察了睾丸间质细胞的组织学及组织化学变化,并进行了定量及半定量测定。结果表明,棉酚可部分地抑制幼龄大鼠睾丸间质细胞对外源性hCG刺激的反应。主要表现在两方面:间质细胞和成纤维细胞样前体细胞(简称前体细胞,下同)数目减少;以及同质细胞内与类固醇合成有关的酶类(如3β-羟固醇脱氢酶、非特异性酯酶)活性减弱。但光镜下生精上皮及间质细胞的形态在本实验条件下未见明显异常。结果提示,棉酚对睾丸间质细胞的功能有抑制性作用。

The present study revealed the effect of prolactin (PRL) on steroidogenesis of the domestic hen theca cells in the serum free 199 medium supplemented with EGF, insulin (Ins) and transferrin (Tf), PRL with or without LH/FSH were added the serum free medium containing hen theca cells. The results showed that theca cells in serum free medium response to increasing dose of LH, the testosterone (T) and estradiol (E 2) content of the media significantly increased in a dose dependent manner. PRL alone had no effect...

The present study revealed the effect of prolactin (PRL) on steroidogenesis of the domestic hen theca cells in the serum free 199 medium supplemented with EGF, insulin (Ins) and transferrin (Tf), PRL with or without LH/FSH were added the serum free medium containing hen theca cells. The results showed that theca cells in serum free medium response to increasing dose of LH, the testosterone (T) and estradiol (E 2) content of the media significantly increased in a dose dependent manner. PRL alone had no effect on steroidogenesis of theca cells, but when add together with FSH (100 μg/L) or LH (50 μg/L) it effectively suppressed the production of E 2 or E 2 and T which were stimulated by FSH or LH. The results suggested that PRL may have a direct inhibitory effect on gonadotropin stimulated steroidogenesis of theca cells in the domestic hen.

利用无血清培养的鸡卵泡(F3)膜细胞模型研究了催乳素(PRL)对卵泡膜细胞类固醇激素合成的作用。用不同剂量的PRL、黄体生成素(LH)及促卵泡激素(FSH)分别或共同处理在无血清培养液中培养了48h的鸡卵泡膜细胞,24h后收集培养液,测定培养液中睾酮(T)和雌二醇(E2)含量。结果表明,LH能明显刺激膜细胞合成T和E2,并具有剂量依赖关系;PRL单独对膜细胞类固醇合成无明显作用,但可抑制LH诱导的T和E2合成,以及FSH刺激的E2合成。本研究证明PRL能作用于鸡卵泡膜细胞,并能抑制促性腺激素LH和FSH诱导的类固醇激素的合成

Objective To explore the characteristics of the gene expression in Cushing′s adrenal corticoadenoma and its associated molecular mechanism. Methods cDNA libraries of human normal adrenal and the adenoma were constructed. Large scale sequencing and bioinformatics were used. Results From the tumor library, 2089 expressed sequence tags (ESTs) were obtained with a successful rate of 98.9%. The functional distribution of the known genes in the tumor coincided with that in normal adrenal. Some synthases such as...

Objective To explore the characteristics of the gene expression in Cushing′s adrenal corticoadenoma and its associated molecular mechanism. Methods cDNA libraries of human normal adrenal and the adenoma were constructed. Large scale sequencing and bioinformatics were used. Results From the tumor library, 2089 expressed sequence tags (ESTs) were obtained with a successful rate of 98.9%. The functional distribution of the known genes in the tumor coincided with that in normal adrenal. Some synthases such as 3bHSDⅡ and P450c17A involved in steroidogenesis were expressed more highly in the adenoma than those in normal adrenal, especially 3bHSDⅡ. By comparison with the expression abundance of genes and statistic analysis, the differences were significant in 45 genes between the tumor and normal adrenal libraries. Interestingly, some genes associated with tumorigenesis, including heat shock protein 90, metallopanstimulin (MPS1), adenine nucleotide translocators etc, were highly expressed in the adenoma. However, those genes related to apoptosis and suppressing proliferation were not found in the tumor library. Conclusion The adenoma shows exuberant activities in steroid synthesis. Not only does the tumor highly express the genes associated with tumorigenesis, but also those related to apoptosis and suppressing proliferation lowly existed in the tumor.

目的 探讨伴库欣综合征肾上腺皮质腺瘤 (简称库欣腺瘤 )的基因表达特征及与发病相关的分子机制。方法 肾上腺文库构建、大规模表达序列标签 (ESTs)测序及生物信息学分析。结果 从库欣腺瘤文库中获得 2 0 89ESTs ,成功率 98.9% ,其中已知基因的功能分类与正常肾上腺文库分布趋势基本相一致 ,类固醇激素生物合成通路中某些酶基因 ,如 3 β羟类固醇脱氢酶 (3bHSDⅡ )及P45 0c17A的表达丰度明显高于正常肾上腺 ,以 3bHSDⅡ最为突出。通过库欣腺瘤与正常肾上腺文库作基因表达丰度差异比较 ,显示 45个基因在两文库间表达的差异具有统计学意义 ,尤为引人注意的是在库欣腺瘤文库一些与肿瘤相关基因呈高表达 ,如热休克蛋白 90、金属泛调理素及腺苷酸转位因子等。而在正常肾上腺文库中表达的多种与抑制增殖或细胞凋亡相关基因在腺瘤文库未见表达。结论 该例腺瘤组织呈现旺盛的类固醇合成活性 ,肾上腺皮质腺瘤不仅有肿瘤相关基因的高表达 ,且亦存在凋亡相关及抑制增殖的基因低表达

 
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