For over a decade, the area of micro total analysis systems, also called “lab on a chip”, has been growing rapidly. The numerous advantages of incorporating several previously distinct processes into a miniaturized format include faster analysis time, decreased cost and waste production, portability, disposability.
在过去的十几年中，微全分析系统(μ-TAS) 或芯片实验室(lab on a chip)已经发展成为当今世界上最前沿的研究领域之一，它的主要特点是：分析速度快、信息量高、操作费用低、试样消耗小、污染小。
Conventional method for viable pathogen detection typically relies on the culture-based assays, which is generally time-consuming and replies on laboratory facilities, In recent years, with the dramatic development of micromachining technologies, more and more biological analyses have been successfully demonstrated in miniaturized analysis systems (lab on a chip or micro total analysis system, μTAS).
传统的病原微生物活性检测依赖于以细菌培养为基础的分析手段,但这样的方法通常都比较耗费时间,同时还必须依赖于实验室特有的设备,难以达到便携化现场监测的要求。 而近些年随着微器件加工技术的飞速发展,已经有越来越多的生物分析过程可以成功地在微型分析系统(芯片实验室lab on a chip或微全分析系统micro total analysis system,μTAS)上演示。
Biochip technology contains three fields which is genechip 、 proteinchip and chip laboratory. Biochip brings a tremendous revolution on modern biotechnology .
In recently years, the chip-based capillary electrophoresis (CCE) has achieved great progress and becomes essential technique of the miniaturized total chemical analysis system(μTAS or Lab-On-a-chip).
最近几年,以毛细管电泳为核心技术、以芯片为操作平台的芯片毛细管电泳技术迅速崛起,并成为微全化学分析系统(miniaturized total chemical analysis system,μTAS,又称芯片实验室,Lab—On—a—chip)的主流技术。
In recent years, microfluidic chip-based microanalytical systems have emerged as a main area of development in the field of micro total analysis systems (μTAS) or Labchips, the ultimate objective of which is to integrate all main analytical functions, including sample introduction, pretreatment, reaction, separation and detection operations on a single chip.
Furthermore the fabrication process of pH-responsive-actuated micro-valve arrays using PDMS is simple and its performance is suitable for a disposable lab-on-a-chip.
The underlying principles and application of these biosensors are discussed with special emphasis on new biorecognition elements, nanomaterials, and lab on a chip technology.
Brief introduction to microsystems.2)Discussions on the developments of microsystem technologies.3)Applications of electrochemistry in microsystem:Confined Etchant Layer Technique (CELT) for the complex 3D pattern micromachining;Focusing Electrophoresis and the application of microsystem in (bio) chemistry (μTAS or Lab on A Chip);Smart Electro Osmosis pump——a reasonable choosing for microfluidic network.4)Concluding remark.
Bio-chip is a molecular micro-array,which is composed of some biological message codes (e.g.oligonucleotides,cDNA,genome DNA,protein,and so on) arranged on solid surfaces in light of a engineering design in advance.There are three kinds of Bio-Chips,i.e.,nucleic acid chip,protein chip,and chip “lab”.The essence of Bio-Chip technology is a parallel analysis for biology message.It is based on the principle of nucleic acid molecule hybridization or protein immunochemistry.The occurrence of hybridization/immuno...
The development of DNA detecting technique promotes the in-depth research of DNA structure and function . The structure principle of DNA biosensor, DNA chip, DNA sequencing technique, pooled DNA, Laboratory on chip (LOC) are introduced in this paper.
芯片实验室
lab on a chip
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