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   大鼠原位肾移植 在 中药学 分类中 的翻译结果: 查询用时:0.41秒
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大鼠原位肾移植
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    The Purpose of this study was to address the mechanism of medicine S which has anti rejection effects of renal allografts in rats. Kidney transplantations were performed from SD to Wistar strain (allogeneic) and from Wistar to Wistar (Isograft) using the same modified technigue described by Fabre and kamada. Experimental rats were divided into five groups.
    为探索草药S抗大鼠同种异体肾移植急性排斥的作用机理,采用改进的Fabre和Ka-mada大鼠原位肾移植模型,将SD大鼠肾移植给Wistar大鼠为同种异体移植,Wistar移植给Wistar大鼠为同品系移植(空白对照),共设五个实验组,观察移植后受体鼠存活、检测移植肾功能及定量测定移植肾内MHCClasⅡ抗原分子的表达。
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The Purpose of this study was to address the mechanism of medicine S which has anti rejection effects of renal allografts in rats. Kidney transplantations were performed from SD to Wistar strain (allogeneic) and from Wistar to Wistar (Isograft) using the same modified technigue described by Fabre and kamada. Experimental rats were divided into five groups. Group Ⅰ (Isograft group) and group Ⅱ (allograft group)as controls were not treated with medicine. The others were allograft groups which received medicine...

The Purpose of this study was to address the mechanism of medicine S which has anti rejection effects of renal allografts in rats. Kidney transplantations were performed from SD to Wistar strain (allogeneic) and from Wistar to Wistar (Isograft) using the same modified technigue described by Fabre and kamada. Experimental rats were divided into five groups. Group Ⅰ (Isograft group) and group Ⅱ (allograft group)as controls were not treated with medicine. The others were allograft groups which received medicine S, Cyclosporine A, and low dose Cyclosporine combined with medicine S, respectively. Renal function and resultant morphology changes were assessed 2, 4 weeks after transplantation. All sections of kidney grafts were stained with monoclonal antibody class Ⅱ MHC (OX6), and then the surface densities of positive staining were quantified by computer image analysis. The level of molecular expression in group Ⅱ was significantly increased (7.61±0.57 vs 0.51±0.2 of group Ⅰ, P<0.01) . In groups Ⅰ and Ⅳ, the molecule of expression was reduced, compared with the groups Ⅱ, Ⅲ and Ⅴ ( P<0.05 ). The results suggest that medicine S decreases the level of class Ⅱ MHC expression and medicines combined with lowe dose cyclosporine is more effective than cyclosporine alone.

为探索草药S抗大鼠同种异体肾移植急性排斥的作用机理,采用改进的Fabre和Ka-mada大鼠原位肾移植模型,将SD大鼠肾移植给Wistar大鼠为同种异体移植,Wistar移植给Wistar大鼠为同品系移植(空白对照),共设五个实验组,观察移植后受体鼠存活、检测移植肾功能及定量测定移植肾内MHCClasⅡ抗原分子的表达。结果表明,草药S能延长受体鼠存活时间,并抑制MHCClasⅡ在移植肾内的表达(与不用药物组比较P<0.01),S药加小剂量环孢素A(cyclosporineA,CsA)治疗组与同系组相比差异无显著性(P>0.05)。这些结果提示,移植肾内MHCClassⅡ表达水平的高低与其排斥的强弱有相关性。

Objective:To study immune inhibitory effect of Sinomenine(SIN)and provide experimental gist for application of SIN in organic transplantation.Methods:48acute rejection reaction models(Wistar-SD)of orthotopic renal transplantation of rat were established and randomly divided into4groups(12rats each group):respectively abdominal injection of0.9%sodium chloride solution(1ml/(kg·d));Sinomenine(SIN)(30mg/(kg·d));Cyclosporin A(CsA)(2.5mg/(kg·d));SIN(30mg/(kg·d))+CsA(2.5mg/(kg·d)).6rats randomly se-lected from each...

Objective:To study immune inhibitory effect of Sinomenine(SIN)and provide experimental gist for application of SIN in organic transplantation.Methods:48acute rejection reaction models(Wistar-SD)of orthotopic renal transplantation of rat were established and randomly divided into4groups(12rats each group):respectively abdominal injection of0.9%sodium chloride solution(1ml/(kg·d));Sinomenine(SIN)(30mg/(kg·d));Cyclosporin A(CsA)(2.5mg/(kg·d));SIN(30mg/(kg·d))+CsA(2.5mg/(kg·d)).6rats randomly se-lected from each group were killed on the postoperative sixth day(acute rejection reaction stage),sampling of blood from inferior vena cava for test of creatinine(Cr)and urea nitrogen(BUN)in blood.Tissue of trans-planted kidney was gotten for pathological test.Affection of pathological changes of SIN combined with CsA on survival time of renal recipient,kidney function index BUN,Cr in renal transplantation of rat and patho-logical changes of transplanted kidney were analyzed.Results:SIN(30mg/(kg·d))might prolong survival time of recipient rat to(9.67±0.52)day,combined application of CsA(2.5mg/(kg·d)might markedly prolong sur- vival time of recipient rat to over18day(25.00±4.65);SIN might protect kidney function and improve patho-logical changes of transplanted kidney.Conclusions:SIN has definite inhibition effect on acute rejection reac-tion in renal transplantation,and a cooperation effect with sub-treatment dosage of Cyclosporin A(CsA).SIN is a natural drug with good exploitation future in immune inhibition.

目的探讨青藤碱免疫抑制作用,为其在器官移植免疫抑制治疗上的应用提供实验依据。方法建立48个大鼠原位肾移植急性排斥反应模型(Wistar-SD)分为四组分别于腹腔注射生理盐水(1ml/(kg.d))、青藤碱(30mg/(kg.d))、环孢菌素A(2.5mg/(kg.d))、青藤碱(30mg/(kg.d))+环孢菌素A(2.5mg/(kg.d)),每组12例,随机抽取6例观察受者存活时间,另6例于术后第六天处死,取腔静脉血测尿素氮及肌酐,取移植肾组织标本病检。分析青藤碱协同环孢菌素A对大鼠肾移植受者存活时间、肾功能指标BUN、Cr以及对移植肾组织病理变化的影响。结果青藤碱[30mg/(kg·d)]可延长受体鼠存活时间至(9.67±0.52)d,与环孢菌素A[2.5mg/(kg·d)]联用后可明显延长受体鼠存活时间至18天以上(25.00±4.65)d;青藤碱对移植肾的功能表现出保护作用并改善移植肾组织的病理变化。结论青藤碱对大鼠肾移植的急性排斥反应起到一定的抑制作用,并与亚治疗剂量的环孢菌素A产生协同作用,青藤碱是一种从自然药物中提取的具有开发前景的免疫抑制药物。

 
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