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胆囊鳞癌
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  squamous cell carcinoma of gallbladder
     Squamous cell carcinoma of gallbladder (with 6 cases report)
     胆囊鳞癌6例报告
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  “胆囊鳞癌”译为未确定词的双语例句
     Squamous cell carcinoma and adenosquamous carcinoma of the gallbladder:a clinicopathologic analysis of 7 cases
     胆囊鳞癌、腺鳞癌7例临床病理分析
短句来源
     Squamous cell carcinoma and adenosquamous carcinoma of gallbladder: An analysis of 9 cases
     胆囊鳞癌腺鳞癌9例临床分析
短句来源
     Clinical analysis of squamous cell carcinoma and adenosquamous carcinoma of gallbladder in 12 cases
     胆囊鳞癌和腺鳞癌12例临床分析
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     ABSTRACTOrthotoplc liver transplantation for liver cancer.
     胆囊鳞癌1例
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     Objective To investigate the clinicopathologic characteristics and histogenesis of squamous cell carcinoma and adenosquamous carcinoma of the gallbladder.
     目的 观察胆囊鳞癌、腺鳞癌 ,探讨其组织起源及发病机制。
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  相似匹配句对
     ABSTRACTOrthotoplc liver transplantation for liver cancer.
     胆囊1例
短句来源
     Squamous cell carcinoma of gallbladder (with 6 cases report)
     胆囊6例报告
短句来源
     Primary gallbladder carcinoma
     原发性胆囊
短句来源
     Squamous Cell Carcinoma of Gastric Cardia
     贲门
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     Primary carcinoma of the gallbladder
     原发性胆囊
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Histochemical and immunohistochemical studies were made on 89 cases of the benign and malignant lesions of the gallbladder. Normal gallbladder epithelium showed a predominance of sulphated mucosubstance Gastric—type and intestinal —type metaplasia were demonstrated in dysplastic areas of the bordering areas of the tumor and gallbladder carcinomas. The positive rates of metaplastic changes have no significant difference (P>0.05) between dysplasias and bordering areas of the carcinoma. 47 cases of 70 gallbladder...

Histochemical and immunohistochemical studies were made on 89 cases of the benign and malignant lesions of the gallbladder. Normal gallbladder epithelium showed a predominance of sulphated mucosubstance Gastric—type and intestinal —type metaplasia were demonstrated in dysplastic areas of the bordering areas of the tumor and gallbladder carcinomas. The positive rates of metaplastic changes have no significant difference (P>0.05) between dysplasias and bordering areas of the carcinoma. 47 cases of 70 gallbladder carcinoma represented metaplastic changes. The positive rate of metaplasia was lower in poor differential carcinomas (P<0.01). With gradually increasing degree of dysplastic epithilium, the quantity of mucin decreased gradually and dyspiastic epithelium contained mainly neutral mucin and nonsulphated acid mucin. This study suggested that metaplasia of gallbalder epithetium was significantly related to the development of gallbladder carcinoma. Some cases of dysplatic epithelium, bordering areas of the squamous cell carcinoma and part of squamous cell carcinoma (71.4%) represented positive reaction with monoclonal antibody K_(27) of large molecular keratin. It is suggeste that the squamous metaplastic change of gallbladder eqithelium may be the histogenesis of gallbladder squamous cell carcinoma.

作者对正常胆囊、不同程度异型增生的胆囊,癌旁组织和胆囊癌共89例活检标本进行组织化学和免疫组织化学研究.正常胆囊只含硫酸粘液,无化生改变,而异型增生胆囊、癌旁组织和胆囊癌均见有胃肠上皮化生改变,且癌旁组织与各类异型增生的各类化生出现率间的差异无显著性(P>0.05)。在70例胆囊癌中47例有化生改变,分化程度越低,其出现率越低(P<0.01)。从轻度异型增生到癌,粘液含量逐渐减少,中性粘液和非硫酸粘液相对增多,硫酸粘液相应减少或消失,作者认为胆囊癌的发生与胆囊上皮化生有重要关系。用大分子角蛋白单克隆抗体K_(27)对部分异型增生胆囊上皮、鳞癌癌旁组织和部分鳞癌作免疫组织化学染色,显示细胞质内含有大分子角蛋增白,提示胆囊上皮的鳞状上皮化生,可能是胆囊鳞癌的组织来源。

Objective To investigate the clinicopathologic characteristics and histogenesis of squamous cell carcinoma and adenosquamous carcinoma of the gallbladder. Methods Seven cases of carcinomas were analyzed with histopathologic and immunohistochemical techniqucs. Results There were 5 female and 2 male with range of agc from 47 to 79 years.Histologically,2 cases were classified as squamous cell carcinoma and 5,adenosquamous carcinoma.The tumors showed an invasive growth pattern, significant necrosis,inflammation...

Objective To investigate the clinicopathologic characteristics and histogenesis of squamous cell carcinoma and adenosquamous carcinoma of the gallbladder. Methods Seven cases of carcinomas were analyzed with histopathologic and immunohistochemical techniqucs. Results There were 5 female and 2 male with range of agc from 47 to 79 years.Histologically,2 cases were classified as squamous cell carcinoma and 5,adenosquamous carcinoma.The tumors showed an invasive growth pattern, significant necrosis,inflammation and gall stones,with involvement in the liver and other adjacent tissues.All the cases existed proliferation,metaplasia, dysplasia, and carcinoma in situ in the neoplastic tissues.There also was a transition from benign to malignant components.Immunohistochemically,both glandular and squamous elements were stained strong positivities for EMA,AE 1,AE 3 and ER,but only glandular clement was positive for CA19-9.Adenocarcinoma element was much stronger stained for CEA and AFP than that of squamous cell carcinoma.Ki-67 staining sbowed positive in the moderate or low-differentiated carcinomas and negative in the well-differentiated ones. Conclusions The incidence of the carcinomas is higher in women than in men.Chronic choleocytitis and gallstones may play an important role in carcinogenesis of the gallbladder.The transition between atypical hyperplasia or dysplasia or carcinoma in situ and invasive carcinoma in adjacent mucosa of the tumors suggests that the lesions mentioned above are closely relative to the carcinogenosis.Ki-67,ER and AFP can be used to evaluate the degrees of the differentiation,malignancy and prognosis.

目的 观察胆囊鳞癌、腺鳞癌 ,探讨其组织起源及发病机制。方法 全部病例做常规石蜡切片、HE染色及CEA、EMA、AFP、ER、AE1、AE3 、CA19 9、Ki 6 7免疫组化染色。结果  7例中鳞癌 2例、腺鳞癌 5例。肿瘤均浸润性生长 ,累及邻近器官 ,伴有明显坏死、炎症及结石。癌旁上皮增生、化生、不典型增生、原位癌改变 ,并与浸润性癌有过渡或移行关系。免疫组化示 7例EMA、AE1、AE3 强阳性 ,CEA胆囊上皮及腺鳞癌强阳性而鳞癌弱表达。ER腺鳞癌、鳞癌均表达。CA19 9胆囊上皮及腺鳞癌强阳性而鳞癌阴性。Ki 6 7在中—低分化癌中阳性 ,而高分化癌中阴性。结论 本癌好发于女性。慢性炎症及胆石症在胆囊癌发生上起到一定的作用。癌旁上皮不典型增生、原位癌及与浸润癌有移行 ,提示癌旁上皮增生或化生亦为发生胆囊癌的重要因素。CA19 9在鉴别腺鳞癌与鳞癌有意义 ,Ki 6 7、ER、AFP对预测细胞增殖、分化程度、恶性程度及预后有一定帮助

Objective To investigate the expression of tumor suppressor gene PTEN protein in gallbladder carcinoma tissues and its clinicopathological significance. Methods PTEN protein expression in paraffin embedded tissues from 28 cases of gallbladder adenocarcinoma, 4 cases of gallbladder squamous cell carcinoma and their adjacent tissue was analysed by immunohistochemical method. Results Adjecent tissues of 32 carcinoma were all positive for PTEN protein. In the 32 carcinoma of gallbladder 34.4% were positive for...

Objective To investigate the expression of tumor suppressor gene PTEN protein in gallbladder carcinoma tissues and its clinicopathological significance. Methods PTEN protein expression in paraffin embedded tissues from 28 cases of gallbladder adenocarcinoma, 4 cases of gallbladder squamous cell carcinoma and their adjacent tissue was analysed by immunohistochemical method. Results Adjecent tissues of 32 carcinoma were all positive for PTEN protein. In the 32 carcinoma of gallbladder 34.4% were positive for PTEN protein, 65.6% lacked expression of PTEN protein. PTEN expression did not show correlation to sex, age and pathology type of gallbladder carcinoma, but there was a significant difference between well-differentiated carcinoma (75.0% PTEN positive) and poorly-differentiated carcinoma (25.0% PTEN positive). Conclusion There is a higher incidence of negative expression of PTEN protein in gallbladder carcinoma, which indicates that PTEN gene inactivation may play an important role in the genesis and development of gallbladder carcinoma. PTEN protein positive expression may be a feature for favorable prognosis in the patient with gallbladder carcinoma.

目的 :探讨抑癌基因PTEN蛋白在胆囊癌组织中的表达情况及其临床病理意义。方法 :应用免疫组化对 2 8例胆囊腺癌 ,4例胆囊鳞癌及其相应癌旁组织中PTEN蛋白进行检测 ,并结合患者的临床病理资料进行分析。结果 :PTEN蛋白在 32例癌旁组织中全都呈阳性表达 ,而癌组织中PTEN阳性表达率仅 34.4 %。胆囊癌组织中PTEN蛋白阳性表达与患者性别、年龄及组织类型无明显相关性 ,但与组织分化程度明显相关。结论 :PTEN蛋白在胆囊癌组织中阳性表达率较低 ,说明该基因失活可能在胆囊癌发生发展中起重要作用。PTEN阳性表达对胆囊癌患者的预后有一定意义

 
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