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肝纤维化逆转
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  “肝纤维化逆转”译为未确定词的双语例句
     Activation and characteristics of MAPK/ERK signal pathway during spontaneous resolution of hepatic fibrosis
     肝纤维化逆转中MAPK/ERK信号转导通路的活化及其特征
短句来源
     Conclusion: ZBC is good at protecting liver cells, improving liver function, adjusting the metabolism of extracellular matrix(LCM), reversing hepatic tissue pathological change and reversing HF, it's mechanism is probably inhibiting the expression of gene.
     抑制Ⅲ型胶原mRNA的表达。 结论:枳鳖胶囊有较好的保护肝细胞,改善肝功能和调节细胞外基质的代谢的作用,并能使肝纤维化大鼠肝组织病理改变逆转,抑制胶原基因表达,从而使肝纤维化逆转,其机制可能与抑制胶原基因的表达有关。
短句来源
     ECM degradation was mainly regulated by matrix metalloproteinases (MMPs) and its inhibitors (Tissue inhibitor of metalloproteinases, TIMPs). MMPs degrade ECM and reverse fibrosis,TIMPs restrain MMPs' enzyme activity and accelerate the development of fibrosis.
     ECM降解与调控主要由基质金属蛋白酶(MMPs)及其抑制剂(TIMPs)介导,MMPs降解ECM,阻抑肝纤维化发生,促进肝纤维化逆转;
短句来源
     Meanwhile, MMP-2, MT-MMP2, MMP-2mRNA, MT-MMP2mRNA firstly increased for a period, then decreased gradually.
     此后逐渐减弱; 肝纤维化逆转过程中MMP 2及其lint-n A、*lMMP 2及其nutNH表达呈先强后弱的趋势。
短句来源
     After confirmed by RT-PCR, the differentially expressed were associated with metabolic enzymes, ion channels, transcription factors, gastrointestinal hormones and their receptors, mitogen-activated protein kinase (MAPK) and PI3k/Akt signaling pathway.
     筛选所得的肝纤维化逆转相关基因主要涉及代谢相关酶、脂肪代谢相关蛋白、离子通道、转录因子、胃肠激素及受体、MAPK及PI3k/Akt信号转导通路等.
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     Therapy for liver fibrosis
     纤维化的治疗
短句来源
     Incidence rate of liver hepatic fibrosis was added up.
     统计纤维化的发生率。
短句来源
     the toxic action of PZA on liver is greater than that of other antitubercular drugs.
     ?
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     The Household Registering System Reform Reverse
     户籍改革逆转
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     THE REVERSE ON CAUCHY INEQUALITY
     关于柯西不等式的逆转
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The effect of a herbs mixture, Liver-clearing and Stasis-eliminating mixture(LCSEM) on CCl4-induced hepatic fibrosis of rats was investigated and compared with controlgroup, colchicine group,model group and nontreatment group. Immunohistochemical staining ofⅠ、Ⅲ、Ⅳ、Ⅴ collagen and desmin, computer imaging analysis and electronic microscopy were usedto study the effect. Hepatocyte degeneration and inflammatory reaction were distinctivelyinhibietd,and deposition of type Ⅰ、Ⅲ、Ⅳ、Ⅴ collagen and desmin was significantly...

The effect of a herbs mixture, Liver-clearing and Stasis-eliminating mixture(LCSEM) on CCl4-induced hepatic fibrosis of rats was investigated and compared with controlgroup, colchicine group,model group and nontreatment group. Immunohistochemical staining ofⅠ、Ⅲ、Ⅳ、Ⅴ collagen and desmin, computer imaging analysis and electronic microscopy were usedto study the effect. Hepatocyte degeneration and inflammatory reaction were distinctivelyinhibietd,and deposition of type Ⅰ、Ⅲ、Ⅳ、Ⅴ collagen and desmin was significantly decreasedwhile sinusoid microcirculation was restored after LCSEM treatment. This indicates LCSEM hasdissolvent and absorbent efficacy to collagenous fiber which has deposited in the liver. Therefore,hepatic fibrosis might be reversed. The antifibrosis of LCSEM is more effective than colchicine(P <0.01 ). Additionally, CCl4-induced fibrosis of rats could somewhat restore. It suggestedthat LCSEM could significantly reduce CCl4-induced fibrosis of rats.

应用清肝化瘀口服液治疗小剂量CCl_4诱导的肝纤维化大鼠,并与正常对照组、CCl_4模型组、自然恢复组、秋水仙碱治疗组对照。对各组肝脏Ⅰ、Ⅲ、Ⅳ、Ⅴ型胶原及结蛋白进行免疫组化染色和计算机图像分析,并用电镜观察肝脏超微结构的变化。结果发现,清肝化瘀口服液可抑制肝细胞变性坏死,减轻炎症反应,改善微循环,抑制Ⅰ、Ⅲ、Ⅳ、Ⅴ型胶原及结蛋白在肝内的沉积,并可使已形成的胶原重新溶解和吸收,使肝纤维化逆转,效果优于秋水仙碱(P<0.01);同时,CCl_4诱导的大鼠肝纤维化可有一定程度的自然恢复。表明清肝化瘀口服液对大鼠肝纤维化有显著的治疗作用。

To investigate MT 1 MMP mRNA expression in the development of liver fibrosis and during the reversal of liver fibrosis ,we undertook a dynamic observation by situ hybridization. Liver fibrosis model was established by intraperitoneal injection with CCl 4 in Wistar rats, then allowed them fo recover spontaneously to observe the reversal of liver fibrosis .The results showed that MT 1 MMP mRNA was expressed mainly in mesenchymal cells(such as hepatic stellate cell), also in a part of hepatocytes.The...

To investigate MT 1 MMP mRNA expression in the development of liver fibrosis and during the reversal of liver fibrosis ,we undertook a dynamic observation by situ hybridization. Liver fibrosis model was established by intraperitoneal injection with CCl 4 in Wistar rats, then allowed them fo recover spontaneously to observe the reversal of liver fibrosis .The results showed that MT 1 MMP mRNA was expressed mainly in mesenchymal cells(such as hepatic stellate cell), also in a part of hepatocytes.The levels of MT 1 MMP mRNA expression were increased gradually in the development of liver fibrosis and decreased gradually during reversal of liver fibrosis. These results suggest that the expression of MT 1 MMP may have an important role in the development of liver fibrosis and its reversal.

应用原位杂交观察基质金属蛋白酶 (MT1 MMP)mRNA在肝纤维化形成及逆转过程中的动态表达。采用CCl4 皮下注射Wistar大鼠建立肝纤维化模型 ,并让其自然恢复以使纤维化逆转。结果显示 ,MT1 MMPmRNA主要表达在间质细胞 (肝星状细胞等 ) ,部分肝细胞也有表达 ;随着肝纤维化的进展 ,MT1 MMPmRNA表达逐渐增强 ;而在肝纤维化的逆转过程中 ,MT1 MMPmRNA表达逐渐减弱。提示MT1 MMP在肝纤维化形成及逆转过程中可能具有较重要的作用

Objective To observe the inhibition of asON phosphorothioate to the TIMP-1 gene and protein expression in the liver tissue of immune- induced hepatic fibrosis rats. Methods According to the analysis of modulator, structure protein, encoding sequence of TIMP-1 genome, we designed four different groups of asONs. These asONs were injected into the hepatic fibrosis rat models through coccygeal vein. The results were observed by RT-PCR, immunohistochemistry and in situ hybridization with collagen Ⅰ、Ⅲ, special...

Objective To observe the inhibition of asON phosphorothioate to the TIMP-1 gene and protein expression in the liver tissue of immune- induced hepatic fibrosis rats. Methods According to the analysis of modulator, structure protein, encoding sequence of TIMP-1 genome, we designed four different groups of asONs. These asONs were injected into the hepatic fibrosis rat models through coccygeal vein. The results were observed by RT-PCR, immunohistochemistry and in situ hybridization with collagen Ⅰ、Ⅲ, special staining of collagen fiber, electron microscope. Results The asON phosphorothioate of TIMP-1 could be expressed in vivo, and could block the TIMP-1 gene and protein expression in the liver of immune- induced hepatic fibrosis rats on the level of mRNA, which could promote the degradation of collagen Ⅰ、Ⅲ(P<0.01) and had certain effect on the reverse of hepatic fibrosis. The electron microscopic observation and pathologic classification of hepatic fibrosis models proved this result.Conclusions The asON of TIMP-1 has a good anti-hepatic fibrosis effect. The result lays the groundwork for the development of a new gene therapy drug of anti-hepatic fibrosis.

目的 观察硫代反义寡核苷酸 (asON)对实验性免疫性肝纤维化大鼠肝组织中TIMP 1基因和蛋白表达的抑制作用。方法 根据TIMP 1二级结构基因组的调控序列、结构蛋白、编码区序列等分析 ,设计 4组不同的asON。利用尾静脉注射将其导入肝纤维化大鼠模型体内 ;通过逆转录 聚合酶链反应 (RT PCR)、Ⅰ型胶原和Ⅲ型胶原的免疫组化、原位杂交法、胶原纤维特殊染色及电镜等观察asON对大鼠肝纤维化的影响。结果 针对TIMP 1设计的asON经硫代修饰后在活体内能确切表达并能在mRNA水平上封闭实验性肝纤维化大鼠肝组织中TIMP 1的基因和蛋白表达 ,其结果可促进肝脏中Ⅰ、Ⅲ型胶原的降解 (P <0 .0 1)。肝纤维化病理学分级和电镜观察结果显示asON对肝纤维化的逆转具有一定效果。结论 针对TIMP 1设计的硫代asON在动物体内具有良好的抗肝纤维化效应 ,从而为研制新一代抗肝纤维化基因治疗药物奠定了基础。

 
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