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|  | | 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。 | |
Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity
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Betulinic acid derivatives were synthesized to enhance the anti-HIV activity.
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The side chain at position 28 is critical for the antifusion activity of the betulinic acid derivatives.
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| | Betulinic acid, a natural product, is an anti-HIV and antitumor agent with novel structure and new mechanism of action. Not only it is found abundantly in the nature, but also its semi-synthesis approach has been successful. Betulinic acid is a perfect lead-compound. A lot of betulinic acid derivatives have been synthesized. The structure-activity relationships of Betulimic acid, The mechanisms and the effects of YK-FH312, RPR103611 and IC9564 derivated from Betulinic acid were reviewed in the paper. | | 对白桦酸衍生物的构效关系及其中的YK FH312、RPR10 36 11和IC95 6 4等的作用机制及活性进行述评。天然产物白桦酸是有抗HIV和抗肿瘤活性 ,且具有新型结构和新型作用机制的化合物 ,其天然来源广泛 ,半合成方法成熟 ,是寻找抗HIV和抗肿瘤药物的优秀的先导物。通过对白桦酸的结构修饰 ,大量白桦酸衍生物已被合成。 | | 文摘来源 | |   |
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