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肝细胞     
相关语句
  hepatocyte
    TREATMENT EXPERIMENTAL LIVER DAMAGES OF MOUSE AND RAT WITH THE HEPATOCYTE GROWTH FACTOR
    用肝细胞生长因子治疗鼠实验性肝损伤
短句来源
    STUDY ON ACETAMINOPHEN-INDUCED RAT HEPATOCYTE INJURY AND ITS MECHANISM
    醋氨酚大鼠肝细胞损伤及其机制的研究
短句来源
    The level of TNF-α in serum was tested with ELISA,while the expression of TNFR1 protein in hepatocyte was detected with Western Blot,and the distribution and expression of Fas/FasL in hepatocyte were determined with immunohistochemistry.
    采用ELISA法检测各组大鼠血清中TNF-α含量,Western blot法测定肝细胞TNFR1的表达量,免疫组化法检测Fas/FasL在各组肝细胞中分布的趋势及表达强度。
短句来源
    Objective: To investigate the effects of shenshuai xiezhuo decoction on hepatocyte growth factor (HGF), transforming growth factorβ1(TGFβ1) in renal interstitial fibrosis mouse.
    目的:观察中药复方肾衰泄浊汤对肾间质纤维化小鼠肾组织肝细胞生长因子(HGF)、转化生长因子β1(TGFβ1)蛋白表达的调节作用,探讨其抗肾间质纤维化的机制。
短句来源
    The animal number of happening hepatocyte necrosis in group 0.25 g/kg was lowered, the degree of pathobiological changes was lightened,compared with the CCl4 control group,the hepatocyte necrosis evaluation was decreased significantly (P<0.05).
    0.25g/kg剂量组发生肝细胞坏死的动物例数减少,病变程度减轻,肝细胞坏死评分降低,与CCl4对照组比较,差异亦有显著性(P<0.05)。
短句来源
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  liver cell
    Study on Molecular Mechanisms of Schisandrins in the Repair of CCl_4 Poisoned Rat Liver Cell
    五味子对CCl_4中毒大鼠肝细胞修复作用分子机理的研究
短句来源
    The Influences of Fetal Liver Cell(FLC)Transplantation on the Survival Rates of IHS Mice
    移植胎肝细胞对环磷酰胺处理小鼠存活率的影响
短句来源
    Influence of Cultured Cordyceps sinensis and Cordyceps militaris on Energy Charge of Isolated Rat Liver Cell
    虫草及蛹虫草对大鼠离体肝细胞能荷的影响
短句来源
    Effects of Jinlida Oral Liquor(津力达口服液) on Insulin Receptor of Liver Cell Membrane in Experimental Diabetic Rats
    津力达口服液对糖尿病大鼠肝细胞膜胰岛素受体的影响
短句来源
    Experimental Study on the Effect of Mangan Mixture(慢肝合剂) on Promoting Liver Cell Regeneration in Rats
    慢肝合剂促进大鼠肝细胞再生实验研究
短句来源
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  hepatic cell
    Conclusion: Pue can improve IR of the Experimental diabetes by decrease blood sugar and serum insulin level to protect β cell and hepatic cell, as well as lower TG, TC, TNF- α , Leptin and adjust NO synthesis, reduce the expression of IDE gene to improve the insulin sensitivity of hepatic and periphery tissue.
    结论:Pue可明显改善实验性糖尿病胰岛素抵抗,其作用机制主要是:一方面通过降低血糖和血清胰岛素水平来保护胰岛β细胞及肝细胞的功能,另一方面通过降低血浆TG、TC、TNFa、Leptin水平,调节肝细胞NOS的活性和NO的合成,降低IDE的基因表达,改善肝脏及外周组织对胰岛素的敏感性而实现的。
短句来源
    Conclusion Fructus lycii has an action to protect animal′s hepatic cell from injury caused by CCl4.This experiment provides certain basis for the clinical treatment of hepatitis and fatty liver with fructus lycii.
    结论枸杞具有抗CCl4所致的动物肝细胞损伤作用,本实验为枸杞在临床上治疗肝炎、脂肪肝提供了一定的实验依据。
短句来源
    METHOD Hepatic cell activities were detected by MTT at different doses of caffeic acid, caffeic acid phenethyl ester, quercetin, rutin, naringenin, diomin, and were compared with the results detected by 3H-TdR. .
    方法 测定咖啡酸、咖啡酸苯酯、槲皮素、芦丁、橙皮苷和香叶木素等几种多酚类化合物在不同浓度条件下 ,对MTT法测定肝细胞活性的影响 ,并与3 H TdR测定结果进行比较。
短句来源
    Results The isola- ted cells not only expressed stem cell marker c-kit,but also expressed embryonic hepatic cell markerα-fetoprotein, cholangiocyte marker OV6 and CK19,as well as mature hepatic cell marker albumin,which were thought to be rats' hepatic oval cells.
    结果所分出的细胞既表达干细胞标志物c-kit,也表达胚胎肝细胞标志物甲胎蛋白、胆管细胞标志物OV6和CK19,此外还表达成熟肝细胞标志物白蛋白,认为它们是大鼠肝卵圆细胞。
短句来源
    The effects of rhubarb on the function of mitochondria of hepatic cell in posttrauma sepsis
    大黄对创伤后脓毒症大鼠肝细胞线粒体功能的影响
短句来源
更多       
  hepatic cells
    The Influence of Reinforcing Body Resistance and Eliminating the Stagnant Chinese Drugs on Albumin Synthesis and Secretion of Hepato - fibrosis Rat's Hepatic Cells
    扶正化瘀中药体外对大鼠纤维肝肝细胞白蛋白合成、分泌的影响
短句来源
    Objective To study the effect of grape procyanidins (GPC) on the protein kinase C(PKC) and proliferative cell nuclear antigen (PCNA) expression in mice hepatic cells.
    目的观察葡多酚(GPC)对小鼠肝细胞蛋白激酶C(PKC)和增殖细胞核抗原(PCNA)表达的影响。
短句来源
    Conclusion GPC could promote the PKC protein expression and improve the proliferative activity of the mice hepatic cells.
    结论葡多酚可促进小鼠肝细胞PKC的表达,提高肝细胞增殖活性。
短句来源
    CONCLUSION : Qinkai Granule alleviates endotoxin induced liver injury and hepatic cells apoptosis and delays caspase-3 mRNA expression.
    结论:清开颗粒能减轻内毒素肝损伤小鼠肝细胞凋亡和下调及延迟肝细胞caspase-3mRNA的表达。
    Objective:1) To study the effects of thermal injury and two-hit, induced by endotoxin on the expression of TNFR1, and TNFR2 in hepatic cells;
    目的:观察烫伤和内毒素二次打击后肝细胞表达肿瘤坏死因子受体TNFR1(p55)和TNFR2(p75)的情况;
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  hepatocyte
Synthesis of lactosylated piperazinyl porphyrins and their hepatocyte-selective targeting
      
It is suggested that such novel lactosylated piperazinyl porphyrins, as potential hepatocyte-selective targeting drugs, thus show promising activity in photodynamic therapy.
      
And we used this two-hybrid library to screen FOXA3, a hepatocyte nuclear factor, and found out an interacting protein: complement component C3.
      
Relationship between expression of hepatocyte grow factor and apoptosis of trophoblasts in hypertensive disorder complicating pr
      
Hepatocyte ballooning was observed in 94.6% of all 130 cases.
      
更多          
  liver cell
A hypothetical mechanism of adaptation of rat liver cell metabolism to a deficiency of glucose as the main energy substrate is proposed.
      
After repeated injections of DNA-poly(L-Lys)Gal complexes, the level of human ApoA-I in rat serum increases, probably, due to accumulation of functional human apoA-I gene in the liver cell nuclei.
      
The OAT-dependent suppression proved to be associated with a decrease in the DNA-binding activity of HNF3 in liver cell extracts.
      
Expression of different liver cell markers during the early prenatal human development
      
The expression of the liver cell markers, vimentin, desmin, cytokeratins 7, 18, 19, and stem cell markers CD34 and Bcl-2 in the early stages of the human prenatal development was studied.
      
更多          
  hepatic cell
Hepatic cell apoptosis was triggerred by HBx accumulation and independent on verapamil
      
In order to study the roles of HBx and calcium inhibitor verapamil in apoptosis of human normal hepatic cells, L02-off, a pTet-off stably integrated human hepatic cell line was established, in which HBx expression was tightly induced by Doxycycline.
      
This research testified the feasibility of targeting Asor complex delivery to hepatocyte mediated by ASGP-Rin vivo, and provided foundation for the genetic diagnosis and gene therapy of hepatic cell-related diseases.
      
Studies on the radioprotective efficacy of cysteamine against 500 r from the measurement of hepatic cell protein
      
It is concluded that biguanides primarily suppressed hepatic cell respiration, which led to an accumulation of reducing equivalents inside the mitochondria.
      
更多          
  hepatic cells
The colonies formed from bone marrow and hepatic cells of rat differed from the murine ones by a higher proportion of fibroblasts.
      
Synthesis and study of the effect of uracil and theophylline derivatives on the glucose transport into rat hepatic cells
      
These findings suggest that the pathogenetic processes in MND may involve not only motor neurons but also hepatic cells.
      
These findings were interpreted as a consequence of Pb toxicity on toad hepatic cells, the kidney and some components of the immune system.
      
Glucagon can keep adrenergic receptors stable on hepatic cells and muscular cells of blood vessels in the rat liver.
      
更多          
  其他


Hydrocortisone acetate was administered daily by intramuscular injection (2.5mg/ 100gm body weight) to 14 adulat rats.Another 6 rats were used as controls.The ex- perimental animals were divided into 3 groups of which the first group were sacrificed 24 hours after 3 injections,the second group 24 hours after 6 injections and the third group 9 days after 6 injections.The liver of both the experimental and control animals were studied with routine histological and histochemical methods. After the hydrocortisone...

Hydrocortisone acetate was administered daily by intramuscular injection (2.5mg/ 100gm body weight) to 14 adulat rats.Another 6 rats were used as controls.The ex- perimental animals were divided into 3 groups of which the first group were sacrificed 24 hours after 3 injections,the second group 24 hours after 6 injections and the third group 9 days after 6 injections.The liver of both the experimental and control animals were studied with routine histological and histochemical methods. After the hydrocortisone treatment,the rats decreased in body weight,but the liver weight/body weight percentage increased.The parenchymal cells showed a marked de- pletion of eosinophil granules,protein and ribonucleic acid,but the content of glycogen and the activity of phosphorylase increased.There was a drop in the activity of non- specific esterase. The change of alkaline phosphatase was not consistent.The content of desoxyribo- nucleic acid and lipids and the activity of acid phosphatase and succinic dehydrogenase did not show any distinct changes.

1.本实验用成年雄雌性大白鼠20只,体重为100—200克。其中六只动物作为对照。其余动物经臀部肌肉注射氢化可的松2.5毫克/100克体重,每日一次,分为注射三次、六次和注射六次后生活9日三组。大部分动物(16只雄性动物)经绝食24小时后杀死取材,分别进行组织学及组织化学观察。2.注射氢化可的松后动物体重下降,肝重略有增加,肝重/体重百分比也随之升高。3.实验动物肝细胞中,嗜伊红性颗粒、核糖核酸以及蛋白质均显著的减少。与此相反,肝糖原合量急剧增加。与其相伴,磷酸化酶的活性也趋于增强。非特异性酯酶的活性明显的降低。4.碱性磷酸酶的变化不一致。酸性磷酸酶、三磷酸腺苷酸酶的活性以及脱氧核糖核酸的含量均无变化。脂类含量及琥珀酸脱氢酶的活性也无改变。

Forty-nine adult male albino rats, weighing between 140--210 gms were selectedfor study. Among them, 9 served as controls and the rest were injected daily with 25 mgof cortisone or hydrocortisone into the gluteal muscles and they were sacrificed after 1,2, 3, and 6 injections and 4, 5, and 9 days after the 6th injection. Liver blocks fromboth experimental and control groups were taken immediately after death and were pro-cessed with routine histological and histochemical techniques. After the administration...

Forty-nine adult male albino rats, weighing between 140--210 gms were selectedfor study. Among them, 9 served as controls and the rest were injected daily with 25 mgof cortisone or hydrocortisone into the gluteal muscles and they were sacrificed after 1,2, 3, and 6 injections and 4, 5, and 9 days after the 6th injection. Liver blocks fromboth experimental and control groups were taken immediately after death and were pro-cessed with routine histological and histochemical techniques. After the administration of cortisone, the eosinophilic granules, protein-bound tyro-sine, histidine and tryptophan, sulfhydryl and disulfide groups, and ribonucleic acid con-spicuously decreased in amount in liver cells. Hence these cells were filled with clearvacuoles of various sizes in the cytoplasm and assumed the name of "balloon cells." Cortisone caused an immediate rise of liver glycogen and phosphorylase activity. The activity of acid and alkaline phosphatases increased in the liver tissues in thecarly stages of treatment and the change of the latter enzyme was more apparen.Later, it was reduced and did not recover to the normal level even on the 9th day afterthe last injection. The activity of adenosine triphosphatase and 5-nucleotidase, elevatedat the beginning of the treatment, returned to normal afterwards. The activity of nonspecific phosphatase in the liver tissues of all the animals of theexperimental group was kept at a lower level than in the normal controls. Nonspecificesterase reacted in the same but more exaggerated manner. Cytochrome oxidase activity in the liver cells apparently decreased after the adminis-tration of cortisone, but it gradually recovered after the injection was suspended. The influence of cortisone and hydrocortisone upon glycogen, ribonucleic acid, andvarious enzymes was the same, but they showed different actions on proteins and pro-tein-bound sulfhydyl and disulfide groups. Maximum depletion of the latter substanceswas attained after a single injection of cortisone, it required 6 injections of hydrocor-tisone to get a similar effect apparently the action of the former compound is more im-mediate and more pronounced than that of the latter.

1.实验用49只成年雄性大白鼠,体重为140—210克。其中9只作为对照。实验动物分别经臀部肌肉注射可的松或氢化可的松25毫克/每日一次。分注射一次、三次、六次以及注射六次后恢复4、5和9日四组。取材后,按组织学及组织化学常规处理,进行观察。 2.注射可的松后,肝细胞中嗜伊红性颗粒和含酪氨酸、组氨酸及色氨酸的蛋白貭、结合-SH和结合-S-S-化合物以及RNA的含量均显著减少。因此胞貭中出现大小不等的明亮空泡,或称之为气球样细胞。 3.可的松促使肝糖原急剧增加,与其相伴磷酸化酶的活性也增强。 4.ACP和ALP的活性在注射初期增强,ALP更加明显。之后酶的活性下降,到注射停止后9日尚未完全恢复。ATP酶和5-核甙酸酶的活性在注射初期略有升高,以后则逐渐恢复正常。非特异性磷酸酶的活性,在实验动物中,始终低于正常。而酯酶活性则显著下降,注射停止后9日,仍未恢复正常。注射后肝细胞中细胞色素氧化酶的活性显著降低,注射停止后则逐渐恢复。 5.实验结果表明可的松和氢化可的松对肝糖原和RNA的含量以及对各种酶的影响是一致地。然而对蛋白貭、结合-SH和结合-S-S-化合物含量的影响却不完全相同。注射可的...

1.实验用49只成年雄性大白鼠,体重为140—210克。其中9只作为对照。实验动物分别经臀部肌肉注射可的松或氢化可的松25毫克/每日一次。分注射一次、三次、六次以及注射六次后恢复4、5和9日四组。取材后,按组织学及组织化学常规处理,进行观察。 2.注射可的松后,肝细胞中嗜伊红性颗粒和含酪氨酸、组氨酸及色氨酸的蛋白貭、结合-SH和结合-S-S-化合物以及RNA的含量均显著减少。因此胞貭中出现大小不等的明亮空泡,或称之为气球样细胞。 3.可的松促使肝糖原急剧增加,与其相伴磷酸化酶的活性也增强。 4.ACP和ALP的活性在注射初期增强,ALP更加明显。之后酶的活性下降,到注射停止后9日尚未完全恢复。ATP酶和5-核甙酸酶的活性在注射初期略有升高,以后则逐渐恢复正常。非特异性磷酸酶的活性,在实验动物中,始终低于正常。而酯酶活性则显著下降,注射停止后9日,仍未恢复正常。注射后肝细胞中细胞色素氧化酶的活性显著降低,注射停止后则逐渐恢复。 5.实验结果表明可的松和氢化可的松对肝糖原和RNA的含量以及对各种酶的影响是一致地。然而对蛋白貭、结合-SH和结合-S-S-化合物含量的影响却不完全相同。注射可的松一次后上述成分减少的最明显,而氢化可的松,则以注射六次后改变的最显著,就是说,前者较后者对蛋白貭、结合-SH和-S-S-化合物的作用迅速而强烈。

Effects of total saponin extracted from aerial parts of Ginseng on the biosynthesis of nucleic acids and protein were studied by radioisotope tracers.Results showed that the process of DNA,RNA, and protein synthesis in bone marrow cells of mice were promoted when total saponin was administered orally in the dose of 70mg/kg body weight every day for one week. The stimulating effects could be observed 4 hrs. after a single intraperitoneal injection. Total saponin stimulated the incorporation of labelled precursor(~3H-Leu)...

Effects of total saponin extracted from aerial parts of Ginseng on the biosynthesis of nucleic acids and protein were studied by radioisotope tracers.Results showed that the process of DNA,RNA, and protein synthesis in bone marrow cells of mice were promoted when total saponin was administered orally in the dose of 70mg/kg body weight every day for one week. The stimulating effects could be observed 4 hrs. after a single intraperitoneal injection. Total saponin stimulated the incorporation of labelled precursor(~3H-Leu) into mouse serum protein and could promote the process of RNA and protein synthesis in mouse liver and kidney, However, it did not show any influence on DNA synthesis when total saponin extracted from aerial parts of Ginseng was administered orally 70mg/kg body weight every day for one week.

本实验采用氚标记的胸腺嘧啶核苷、氚标记的尿嘧啶核苷、氚标记的亮氨酸,观察人参地上部分总皂甙对标记前体参入骨髓细胞、肝细胞、肾细胞中DNA、RNA、蛋白质合成的影响,同时观察氚标记的亮氨酸参入血清蛋白的影响。结果表明,人参地上部分总皂甙连续给药一周70mg/k8和单次腹腔给药后4小时均能促进小白鼠骨髓细胞内DNA、RNA、蛋白质的合成。同样剂量连续给药一周也能促进血清蛋白质和肝脏、肾脏的RNA、蛋白质的合成,而对肝脏、肾脏DNA合成无明显影响。

 
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