The level of TNF-α in serum was tested with ELISA,while the expression of TNFR1 protein in hepatocyte was detected with Western Blot,and the distribution and expression of Fas/FasL in hepatocyte were determined with immunohistochemistry.
Objective: To investigate the effects of shenshuai xiezhuo decoction on hepatocyte growth factor (HGF), transforming growth factorβ1(TGFβ1) in renal interstitial fibrosis mouse.
The animal number of happening hepatocyte necrosis in group 0.25 g/kg was lowered, the degree of pathobiological changes was lightened,compared with the CCl4 control group,the hepatocyte necrosis evaluation was decreased significantly (P<0.05).
Conclusion: Pue can improve IR of the Experimental diabetes by decrease blood sugar and serum insulin level to protect β cell and hepatic cell, as well as lower TG, TC, TNF- α , Leptin and adjust NO synthesis, reduce the expression of IDE gene to improve the insulin sensitivity of hepatic and periphery tissue.
Conclusion Fructus lycii has an action to protect animal′s hepatic cell from injury caused by CCl4.This experiment provides certain basis for the clinical treatment of hepatitis and fatty liver with fructus lycii.
METHOD Hepatic cell activities were detected by MTT at different doses of caffeic acid, caffeic acid phenethyl ester, quercetin, rutin, naringenin, diomin, and were compared with the results detected by 3H-TdR. .
方法 测定咖啡酸、咖啡酸苯酯、槲皮素、芦丁、橙皮苷和香叶木素等几种多酚类化合物在不同浓度条件下 ,对MTT法测定肝细胞活性的影响 ,并与3 H TdR测定结果进行比较。
Results The isola- ted cells not only expressed stem cell marker c-kit,but also expressed embryonic hepatic cell markerα-fetoprotein, cholangiocyte marker OV6 and CK19,as well as mature hepatic cell marker albumin,which were thought to be rats' hepatic oval cells.
The Influence of Reinforcing Body Resistance and Eliminating the Stagnant Chinese Drugs on Albumin Synthesis and Secretion of Hepato - fibrosis Rat's Hepatic Cells
Objective To study the effect of grape procyanidins (GPC) on the protein kinase C(PKC) and proliferative cell nuclear antigen (PCNA) expression in mice hepatic cells.
Synthesis of lactosylated piperazinyl porphyrins and their hepatocyte-selective targeting
It is suggested that such novel lactosylated piperazinyl porphyrins, as potential hepatocyte-selective targeting drugs, thus show promising activity in photodynamic therapy.
And we used this two-hybrid library to screen FOXA3, a hepatocyte nuclear factor, and found out an interacting protein: complement component C3.
Relationship between expression of hepatocyte grow factor and apoptosis of trophoblasts in hypertensive disorder complicating pr
Hepatocyte ballooning was observed in 94.6% of all 130 cases.
A hypothetical mechanism of adaptation of rat liver cell metabolism to a deficiency of glucose as the main energy substrate is proposed.
After repeated injections of DNA-poly(L-Lys)Gal complexes, the level of human ApoA-I in rat serum increases, probably, due to accumulation of functional human apoA-I gene in the liver cell nuclei.
The OAT-dependent suppression proved to be associated with a decrease in the DNA-binding activity of HNF3 in liver cell extracts.
Expression of different liver cell markers during the early prenatal human development
The expression of the liver cell markers, vimentin, desmin, cytokeratins 7, 18, 19, and stem cell markers CD34 and Bcl-2 in the early stages of the human prenatal development was studied.
Hepatic cell apoptosis was triggerred by HBx accumulation and independent on verapamil
In order to study the roles of HBx and calcium inhibitor verapamil in apoptosis of human normal hepatic cells, L02-off, a pTet-off stably integrated human hepatic cell line was established, in which HBx expression was tightly induced by Doxycycline.
This research testified the feasibility of targeting Asor complex delivery to hepatocyte mediated by ASGP-Rin vivo, and provided foundation for the genetic diagnosis and gene therapy of hepatic cell-related diseases.
Studies on the radioprotective efficacy of cysteamine against 500 r from the measurement of hepatic cell protein
It is concluded that biguanides primarily suppressed hepatic cell respiration, which led to an accumulation of reducing equivalents inside the mitochondria.
Hydrocortisone acetate was administered daily by intramuscular injection (2.5mg/ 100gm body weight) to 14 adulat rats.Another 6 rats were used as controls.The ex- perimental animals were divided into 3 groups of which the first group were sacrificed 24 hours after 3 injections,the second group 24 hours after 6 injections and the third group 9 days after 6 injections.The liver of both the experimental and control animals were studied with routine histological and histochemical methods. After the hydrocortisone...
Hydrocortisone acetate was administered daily by intramuscular injection (2.5mg/ 100gm body weight) to 14 adulat rats.Another 6 rats were used as controls.The ex- perimental animals were divided into 3 groups of which the first group were sacrificed 24 hours after 3 injections,the second group 24 hours after 6 injections and the third group 9 days after 6 injections.The liver of both the experimental and control animals were studied with routine histological and histochemical methods. After the hydrocortisone treatment,the rats decreased in body weight,but the liver weight/body weight percentage increased.The parenchymal cells showed a marked de- pletion of eosinophil granules,protein and ribonucleic acid,but the content of glycogen and the activity of phosphorylase increased.There was a drop in the activity of non- specific esterase. The change of alkaline phosphatase was not consistent.The content of desoxyribo- nucleic acid and lipids and the activity of acid phosphatase and succinic dehydrogenase did not show any distinct changes.
Forty-nine adult male albino rats, weighing between 140--210 gms were selectedfor study. Among them, 9 served as controls and the rest were injected daily with 25 mgof cortisone or hydrocortisone into the gluteal muscles and they were sacrificed after 1,2, 3, and 6 injections and 4, 5, and 9 days after the 6th injection. Liver blocks fromboth experimental and control groups were taken immediately after death and were pro-cessed with routine histological and histochemical techniques. After the administration...
Forty-nine adult male albino rats, weighing between 140--210 gms were selectedfor study. Among them, 9 served as controls and the rest were injected daily with 25 mgof cortisone or hydrocortisone into the gluteal muscles and they were sacrificed after 1,2, 3, and 6 injections and 4, 5, and 9 days after the 6th injection. Liver blocks fromboth experimental and control groups were taken immediately after death and were pro-cessed with routine histological and histochemical techniques. After the administration of cortisone, the eosinophilic granules, protein-bound tyro-sine, histidine and tryptophan, sulfhydryl and disulfide groups, and ribonucleic acid con-spicuously decreased in amount in liver cells. Hence these cells were filled with clearvacuoles of various sizes in the cytoplasm and assumed the name of "balloon cells." Cortisone caused an immediate rise of liver glycogen and phosphorylase activity. The activity of acid and alkaline phosphatases increased in the liver tissues in thecarly stages of treatment and the change of the latter enzyme was more apparen.Later, it was reduced and did not recover to the normal level even on the 9th day afterthe last injection. The activity of adenosine triphosphatase and 5-nucleotidase, elevatedat the beginning of the treatment, returned to normal afterwards. The activity of nonspecific phosphatase in the liver tissues of all the animals of theexperimental group was kept at a lower level than in the normal controls. Nonspecificesterase reacted in the same but more exaggerated manner. Cytochrome oxidase activity in the liver cells apparently decreased after the adminis-tration of cortisone, but it gradually recovered after the injection was suspended. The influence of cortisone and hydrocortisone upon glycogen, ribonucleic acid, andvarious enzymes was the same, but they showed different actions on proteins and pro-tein-bound sulfhydyl and disulfide groups. Maximum depletion of the latter substanceswas attained after a single injection of cortisone, it required 6 injections of hydrocor-tisone to get a similar effect apparently the action of the former compound is more im-mediate and more pronounced than that of the latter.
Effects of total saponin extracted from aerial parts of Ginseng on the biosynthesis of nucleic acids and protein were studied by radioisotope tracers.Results showed that the process of DNA,RNA, and protein synthesis in bone marrow cells of mice were promoted when total saponin was administered orally in the dose of 70mg/kg body weight every day for one week. The stimulating effects could be observed 4 hrs. after a single intraperitoneal injection. Total saponin stimulated the incorporation of labelled precursor(~3H-Leu)...
Effects of total saponin extracted from aerial parts of Ginseng on the biosynthesis of nucleic acids and protein were studied by radioisotope tracers.Results showed that the process of DNA,RNA, and protein synthesis in bone marrow cells of mice were promoted when total saponin was administered orally in the dose of 70mg/kg body weight every day for one week. The stimulating effects could be observed 4 hrs. after a single intraperitoneal injection. Total saponin stimulated the incorporation of labelled precursor(~3H-Leu) into mouse serum protein and could promote the process of RNA and protein synthesis in mouse liver and kidney, However, it did not show any influence on DNA synthesis when total saponin extracted from aerial parts of Ginseng was administered orally 70mg/kg body weight every day for one week.
肝细胞
hepatocyte 
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