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肝细胞     
相关语句
  hepatocyte
    INDUCTION OF HEPATOCYTE MICROSOMAL CYTOCHROME P-450 BY SCHIZANDRIN B IN MICE
    五味子乙素对小鼠肝细胞微粒体细胞色素P-450的诱导作用
短句来源
    Effects of TNT on Ca2+ ATPase and protein-thiol of rat hepatocyte plasma membrane
    三硝基甲苯对大鼠肝细胞质膜Ca(2+)-ATP酶和蛋白质巯基含量的影响
短句来源
    The Effects of Diverse Doses of Rifapentine on Mouse Hepatocyte Structure and the Activites of 10 Enzymes
    不同剂量利福喷丁对小鼠肝细胞结构和10种酶活性的影响
短句来源
    INHIBITORY EFFECT OF 2 ( N ACETYL METHYL AMINO) 3′,4′ METHYLENEDIOXYACETYL AMINOPHENE(SY 640) ON COVALENT BINDING OF CARCINOGENIC BENZO(a)PYRENE WITH MOUSE HEPATOCYTE NUCLEAR DNA
    N-甲基(3,4-亚甲二氧基苯甲酰)甲基-乙酰胺(SY-640)对化学致癌剂苯并芘与小鼠肝细胞核DNA共价结合的抑制作用
短句来源
    Study on Pharmacokinetics of Hepatocyte Promoting-growth Factor in Human in Vivo
    促肝细胞生长素人体内药代动力学的研究
短句来源
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  liver
    The Long Term Effect of Hepatic Stimulating Substances on Kinetic Change of Liver Cells
    肝细胞刺激物质长期使用与肝脏细胞动力学变化
短句来源
    STUDY ON ANTAGONISM OF TRACE ELEMENT ON Cd-INDUCED DAMAGE OF PREGNANT RAT'S HEPATIC CELLS──Ⅰ. PROTECTIVE ACTION OF VARIOUS DOSES COMPOUND ZINC PREPARATION ON LIVER FROM Cd-INDUCED DAMAGE
    锌、硒拮抗镉致妊娠大鼠肝细胞损伤的研究──Ⅰ.不同剂量的复方锌对镉致妊娠大鼠肝细胞损伤的保护作用
短句来源
    Study on Regeneration of Liver Cell with Soft liver Pill
    软肝丸对肝细胞再生作用的研究
短句来源
    Effects of Mifepristone on the Ultrastructure of Human Fetal Liver Cells
    米非司酮对人胎肝细胞超微结构的影响
短句来源
    PROTECTIVE EFFECT OF IL-1β ON ACETAMINOPHEN-INDUCED LIVER DAMAGE IN MICE AND ITS RELATIONSHIP WITH SUPEROXIDE DISMUTASE
    IL-1β抗醋氨酚引起的小鼠肝细胞损伤作用及其与超氧化物歧化酶的关系
短句来源
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  liver cells
    The Long Term Effect of Hepatic Stimulating Substances on Kinetic Change of Liver Cells
    肝细胞刺激物质长期使用与肝脏细胞动力学变化
短句来源
    Effects of Mifepristone on the Ultrastructure of Human Fetal Liver Cells
    米非司酮对人胎肝细胞超微结构的影响
短句来源
    These apoA-I have activities of combining with SMMC-7721、HepG2 2.2.15、Wister rat liver cells with dot blotting and 125I analysis.
    这些apoA-I经Dot blotting 和125I放射法测定均具有与SMMC-7721肝细胞、HepG2 2.2.15 肝细胞和大鼠肝脏细胞结合的生物活性。
短句来源
    12-0-tetradecanoyl-phorbol-13-acetate (TPA)-induced release of arachidonic acid from 3H-arachidonic acid prelabelled rat liver cells was also inhibited by cyclosporin A.
    对于~3H-花生四烯酸标记的大鼠肝细胞,环孢霉素A可抑制12-0-十四脂酰佛波-13-乙酸(TPA)诱发的放射性物质的释放。
短句来源
    GTE decreased the frequency of SCE induced by oxygen radical in IAR 20 liver cells treated with hypo-zanthine and xanthine oxydase.
    次黄嘌呤和黄嘌呤氧化酶反应产生的含氧自由基可以引起IAR20肝细胞SCE增高,而GTE可明显抑制这种自由基对细胞SCE的诱导作用.
短句来源
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  primary hepatocyte
    Rat primary hepatocyte UDS assay showed that MTBE could damage DNA.
    大鼠肝细胞UDS试验显示,MTBE具有轻微的DNA损伤作用。
短句来源
    Objective: To observe the effect of itraconazole on the activity of cytochromeP450 isoenzyme 1A2(CYP1A2) and 3A4 (CYP3A4) of health adult human primary hepatocyte microsome, exploring the influencing mechanism of itraconazole to pharmacokinetics of combinactive applying medicine.
    目的:观察伊曲康唑对健康成年人肝细胞微粒体细胞色素P450同功酶1 A2、3A4活性的作用,探讨伊曲康唑对合用药物药代动力学影响的机制,为临床上安全有效的联合用药提供实验依据。
短句来源
    Methods: The health adult human primary hepatocyte microsome was randomly divided into 12 groups for control and itraconazole with different concentrations in the range of clinical drug blood concentration, each group have 10 samples. Control groups were added culture fluid, itraconazole groups were added itraconazole with different concentration respectively, after cultured 30 minutes, substrates (phenacetin for CYP1A2, testosterone for CYP3A4) were added and cultured for another 40 minutes.
    方法:采用健康成人肝细胞微粒体,分为对照组和不同浓度的伊曲康唑组,共12组,每组10个样本,伊曲康唑组分别加入血药浓度范围内不同对应浓度的伊曲康唑,对照组仅加入培养液,孵育30min 后,再加入CYP450同工酶1A2和3A4的相应底物(分别为非那西丁和睾酮)再孵育40 min。
短句来源
    Conclusion: In the range of maximum clinical blood concentration, itraconazole can not inhibit the activity of CYP1A2 of health adult human primary hepatocyte microsome, but can inhibit the activity of CYP3A4, so that itraconazole can influence the blood concentration and half life of combinactive applying medicines that metabolized by CYP3A4.
    结论:伊曲康唑在临床应用血药浓度范围内,对健康成年人肝细胞微粒体细胞色素P450酶同功酶1A2的活性无显著影响,然而对细胞色素P450同功酶3A4的活性有抑制作用,直接影响经3A4代谢的合用药物的血药浓度、半衰期等药代动力学参数。
短句来源
    AIM To observe the effect of itraconazole on the activity of cytchrome P450(CYP) 1A2 and 3A4 of health adult human primary hepatocyte microsome.
    目的观察伊曲康唑对健康成人肝细胞微粒体细胞色素P450同工酶1A23、A4活性的作用,为临床上安全有效地联合用药提供实验依据。
短句来源
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      hepatocyte
    Synthesis of lactosylated piperazinyl porphyrins and their hepatocyte-selective targeting
          
    It is suggested that such novel lactosylated piperazinyl porphyrins, as potential hepatocyte-selective targeting drugs, thus show promising activity in photodynamic therapy.
          
    And we used this two-hybrid library to screen FOXA3, a hepatocyte nuclear factor, and found out an interacting protein: complement component C3.
          
    Relationship between expression of hepatocyte grow factor and apoptosis of trophoblasts in hypertensive disorder complicating pr
          
    Hepatocyte ballooning was observed in 94.6% of all 130 cases.
          
    更多          
      liver
    Alcohol abuse is thought to be a risk factor for the cause of liver damage, hyperlipidemia and insulin resistance.
          
    Hepatic glutathione, lipid peroxides, glutathione peroxidase, alcohol dehydrogenase, aldehyde dehydrogenase, glycogen and total protein in liver were also significantly altered.
          
    glutamate cysteine ligase (GCL) and γ-glutamyl transpeptidase (γ-GT) from bovine filarial worms Setaria cervi and their counterparts from mammalian liver to known inhibitors i.e.
          
    Antioxidant activity of melatonin and some new melatonin analogue indole derivatives were investigated, using lipid peroxidation and superoxide anion radical scavenger activity assays, in rat liver tissue homogenate.
          
    The anticancer properties were evaluated using ras transformed liver epithelial cells.
          
    更多          
      liver cells
    Conversion of L-Cystine and L-Cysteine to Taurine by the Enzyme Systems of Liver Cells
          
    The kinetics of the conversion of the sulfur-containing amino acids L-cystine and L-cysteine to taurin by the enzyme system of cattle liver cells was studied and a mathematical model was developed.
          
    Bone marrow and fetal liver cells formed colonies in vitro including fibroblasts as well as a considerable proportion of macrophages.
          
    Ultrastructural study of liver cells from rooks living in ecologically unfavorable areas
          
    The ultrastructure of liver cells was studied in rooks (Corvus frugilegus) living in radioactive and chemical contamination areas.
          
    更多          
      primary hepatocyte
    Studies on the metabolism of metallothionein and alkaline phosphatase of adult rat primary hepatocyte cultures: role of fetal ca
          
    Furthermore, PVLA-coated beads were endocytosed by primary hepatocyte to a significantly higher degree than asialofetuin-coated beads in vitro.
          
    Primary hepatocyte cultures provide a unique system for studying hepatic drug metabolism and liver toxicity from exposure to xenobiotics.
          
    Human liver tissue slices, homogenates, organ cultures, subcellular fractions and primary hepatocyte cultures represent valuable tools for analysis of metabolism, toxicity and efficacy of xenobiotics.
          
    The aim of this study was to elucidate whether serum-free conditions could be found in primary hepatocyte cultures under which the growth inducing properties of xenobiotics and hormones could be tested.
          
    更多          


    Subcutaneous injection of 40% CCl_4 dissolved in olive oil in the dose of 2cc./100gm. body weight caused an elevation of the serum transaminase (SGOT) activity on the adult normal rats (♀.♂). The value of serum transaminase is increased from 175.5 units to 924 and 908 units respectively at 24 hours and 48 hours after administration. It is believed that most of the serum transaminase comes from the liver, since the transaminase of the hepatic tissue was decreased from 159 units to 79 and 59 units respectively...

    Subcutaneous injection of 40% CCl_4 dissolved in olive oil in the dose of 2cc./100gm. body weight caused an elevation of the serum transaminase (SGOT) activity on the adult normal rats (♀.♂). The value of serum transaminase is increased from 175.5 units to 924 and 908 units respectively at 24 hours and 48 hours after administration. It is believed that most of the serum transaminase comes from the liver, since the transaminase of the hepatic tissue was decreased from 159 units to 79 and 59 units respectively under the same condition. This fact gives a strong evidence indicating that the high level of serum transaminase after CCl_4 administration is due to the injury of liver cells. Histologically, fatty metamorphosis was seen in the liver within 24 hours, especially marked at 48 hours. At the same time, the histochemical test of lipase gives a negative result, but, it is positive within the liver cells surrounding the central vein of hepatic lobules in the normal animals. So, we believe, the etiologic factor of the fatty liver after treated with CCl_4 may be accompanied by the loss of lipase. There was centralobular patchy necrosis and infiltrtaion. some liver cells at the periportal regions were swollen and vacuolated, and were found to contain neither fat, lipase, RNA nor alkaline phosphatase histochemically. We also found that the cytoplasm of some liver cells around the ihfiltrated area, owing to the absence of RNA, possesses eosinophilic property. The concentration of the alkaline phosphtase, being surrounded by the balloon cells at the periportal tracts, as demonstrated by the histochemical method in the liver at 24 hours after injection of CCl_4, was due primarily to the constriction of the sinusoid and biliary canaliculi between balloon cells.

    大白鼠皮下注射一定剂量的CCl_4(2C.C./100克体重40%的CCl_4)后24及48小时出現显著的肝脂肪病变,此时血內轉氨酶活力由正常时的175.5单位上升至924与908单位,同时肝組織內轉氨酶活力則由正常时的159单位分別下降至79及59单位。因此我們认为,由CCl_4引起的这样肝病变时血內轉氨酶的上升可能系由中毒的肝組織而釆。在注射CCl_4后的动物肝組織中有某些数量的肝细胞由于肿胀而成气球细胞,此类细胞用一般組織学及組織化学方法观察,无脂肪的积聚,亦无脂肪酶、核糖核酸及硷性磷酸酶的存在;由于此类細胞的出現,致使肝血变狭窄,影响了肝細胞的血液供应,而使肝小叶中央細胞坏死。我們也观察到,在肝病变过程中,靠近中央靜脉周围单核浸澗細胞較多,此类細胞中的核糖核酸及硷性磷酸酶均呈阴性反应。在浸潤細胞间有小型肝細胞的存在,此种細胞形状較小,其細胞質的嗜伊紅性較强,其中硷性磷酸酶及核糖核酸則呈阴性反应;致使核糖核酸及硷性磷酸酶在病变后臂由正常分布形式而集中于肝門管附近的肝細胞及肝胆管周围。我們認为,硷性磷酸酶的集小于肝门管区是由于气球細胞的胀大阻塞了血,而胆毛細管的收縮又妨碍了磷酸酶由肝至胆道的去...

    大白鼠皮下注射一定剂量的CCl_4(2C.C./100克体重40%的CCl_4)后24及48小时出現显著的肝脂肪病变,此时血內轉氨酶活力由正常时的175.5单位上升至924与908单位,同时肝組織內轉氨酶活力則由正常时的159单位分別下降至79及59单位。因此我們认为,由CCl_4引起的这样肝病变时血內轉氨酶的上升可能系由中毒的肝組織而釆。在注射CCl_4后的动物肝組織中有某些数量的肝细胞由于肿胀而成气球细胞,此类细胞用一般組織学及組織化学方法观察,无脂肪的积聚,亦无脂肪酶、核糖核酸及硷性磷酸酶的存在;由于此类細胞的出現,致使肝血变狭窄,影响了肝細胞的血液供应,而使肝小叶中央細胞坏死。我們也观察到,在肝病变过程中,靠近中央靜脉周围单核浸澗細胞較多,此类細胞中的核糖核酸及硷性磷酸酶均呈阴性反应。在浸潤細胞间有小型肝細胞的存在,此种細胞形状較小,其細胞質的嗜伊紅性較强,其中硷性磷酸酶及核糖核酸則呈阴性反应;致使核糖核酸及硷性磷酸酶在病变后臂由正常分布形式而集中于肝門管附近的肝細胞及肝胆管周围。我們認为,硷性磷酸酶的集小于肝门管区是由于气球細胞的胀大阻塞了血,而胆毛細管的收縮又妨碍了磷酸酶由肝至胆道的去路。CCL_4注射48小时后大白鼠肝內的核糖核酸集中于肝門管区,被認为是肝細胞的再生現象。本实驗观察到,CCl_4中毒后肝脂肪的产生与肝細胞內脂肪酶的阴性反应,这可能与肝細胞內脂肪酶的减低有关,是由于CCl_4破坏了肝內脂肪酶的活性所致。

    It is well known that schizandra can markedly reduce the SGPT activity both in patients with hepaticdisease and in experimental animals, but the mechanism remains obscure.Our preliminary study in rabbits reveals that:Schizandra does not directly inactivate the SGPT activity to any significant degree nor does it reduce the permeability of the liver cell membrane for GPT release. In addition, schizandra does not markedly increase the SGPT clearance nor does it significantly protect the liver cell from CGl_4 intoxication....

    It is well known that schizandra can markedly reduce the SGPT activity both in patients with hepaticdisease and in experimental animals, but the mechanism remains obscure.Our preliminary study in rabbits reveals that:Schizandra does not directly inactivate the SGPT activity to any significant degree nor does it reduce the permeability of the liver cell membrane for GPT release. In addition, schizandra does not markedly increase the SGPT clearance nor does it significantly protect the liver cell from CGl_4 intoxication. It was found that schizandra markedly reduced the GPT activity in the liver.The SGPT reducing effect of schizandra was found to be related to the time interval between the administration of the drug and the blood specimen collection. When the interval was 24 hours, the SGPT activity was not significantly affected; but if the interval was 2 hours, the SGPT was markedly reduced.It is concluded that schizandra is most likely a reversible enzyme inhibitor, its SGPT reducing effect is chiefly due to its reversible inhibition of the GPT activity in the liver cells. The clinicians must notice that the lowering of SGPT activity does not indicate that the lesions of the liver are restored or cured.

    通过家兔实验研究初步阐明:五味子对血清谷丙转氨酶(以下简称SGPT)无明显的直接灭活作用;没有减少肝细胞膜对GPT通透性的作用;没有明显地加速SGPT的清除作用;也不能明显地减轻CCI_4中毒所引起的肝细胞坏死。但能明显地降低肝细胞内GPT的活力,其降低程度与SGPT活性的降低程度相一致。降低SGPT活力的程度与采血的时间有关:服药后2小时采血,则明显下降,服药后24小时采血则无明显的下降。 以上结果提示,五味子很可能是一种可逆性的GPT的酶抑制剂,其降低SGPT活性的作用主要是通过对肝细胞内GPT活性的可逆性抑制,因此临床应用时应注意SGPT的下降并不代表肝脏病变的好转或恢复。

    The cotton seed meal was shown to possess marked anti-fertility effect in male rats. Its active principle was found to be gossypol. The minimal effective anti-fertility doses of gossypol for male rats were 10~12 mg/kg/day for 4~5 weeks when administered orally. The fertility of the animals recovered 4~5 weeks after cessation of the medication. Gossypol neither altered the mating behaviour and the function of accessory glands in rats, nor changed the plasma testosterone levels in rats and rhesus monkeys. It did...

    The cotton seed meal was shown to possess marked anti-fertility effect in male rats. Its active principle was found to be gossypol. The minimal effective anti-fertility doses of gossypol for male rats were 10~12 mg/kg/day for 4~5 weeks when administered orally. The fertility of the animals recovered 4~5 weeks after cessation of the medication. Gossypol neither altered the mating behaviour and the function of accessory glands in rats, nor changed the plasma testosterone levels in rats and rhesus monkeys. It did not affect the growth rate and the fertility of the offsprings. After long-term administration of gossypol to rats, no obvious abnormalities were found in the electrocardiogram. In some of these treated rats, the levels of serum glutamicpyruvic transaminase and gammaglobulin were raised slightly but restored to normal after cessation of the medication. The histological examinations of the liver tissues of a few treated rats showed that there were pathological changes in the hepatic cells. Since d-gossypol did not possess any significant anti-fertility effect or toxicity, it was suggested that these actions of gossypol were related to its levo-rotatory substance only. When the-CHO and-OH groups in the structure of gossypol were replaced by other groups, the anti-fertility effect was lost.

    棉籽粉对雄性大鼠有抗生育作用,其有效成份为棉酚。棉酚对雄性大鼠的抗生育作用最低有效剂量为10~12mg/kg,连续给药4~5周。停药后4~5周生育力能可逆恢复。棉酚对大鼠的交配行为及副性腺的功能均无明显的影响;亦不改变大鼠及猴血浆中睾丸酮的含量。棉酚对子代生长及生育力均无不良影响。大鼠长期服用棉酚后,心电图未见有异常变化。部分大鼠的血清谷丙转氨酶及γ球蛋白值稍有升高,停药后恢复正常。个别大鼠肝组织切片显于肝细胞有病理性改变。右旋棉酚既无明显的抗生育作用,亦无显著的毒性反应,提示棉酚的抗生育作用及毒性反应与左旋体有关。棉酚结构上的CHO基与OH基,一旦用其它基团取代,即失去抗生育作用。

     
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