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口服给药     
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  oral administration
    Studies on pharmacokinetics of pefloxacin by oral administration
    培氟沙星口服给药的药物动力学研究
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    Determination of total coenzyme Q_(10) in plasma following dose oral administration of 50 mg coenzyme Q_(10) sustained release tablets and regular tablets in healthy volunteers
    多剂量口服给药后辅酶Q_(10)缓释片和普通片在健康人体内的血药浓度
短句来源
    Study on LHRH-loaded solid lipid nanoparticles for oral administration
    LHRH固体脂质纳米粒口服给药系统的研究
短句来源
    (2)Comparison of pharmacokinetics: 48 rabbits were randomly divided into oral administration group and rectal administration group.
    (2)药动学的比较研究:大白兔共48只,随机分为直肠给药组和口服给药组。
短句来源
    Preliminary results showed that compounds Ⅲ_2, Ⅲ_4 and Ⅲ_7 exhibited notable antimalarial activity against chloroquine-sensitive strain of P. berghei in mice at 6.25mg/kg after oral administration.
    动物筛选的初步结果表明:口服给药6.25mg/kg,化合物Ⅲ_2、Ⅲ_4和Ⅲ_7能完全抑制感染伯氏鼠疟原虫氯喹敏感株(Plalmodium berghei)小白鼠的原虫血症;
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  oral drug
    The Study of Oral Drug Delivery System with Insulin-Adsorbed Porous Microspheres
    胰岛素-多孔羟基磷灰石微球口服给药系统的研究
短句来源
    Preclinical Safety Evaluation of Oral Drug of Human Granulocyte-Macrophage Colony-Stimulating Factor Expressed in Silkworm Pupae As Bioreactor
    利用家蚕蛹生物反应器生产的人粒细胞/巨噬细胞集落刺激因子口服给药的临床前安全性评价(英文)
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  “口服给药”译为未确定词的双语例句
    CONCLUSION Tymopentin can be administered orally in the form of Tp5-TMC-SM.
    结论Tp5-TMC-SM可实现胸腺五肽口服给药
短句来源
    Methods A single oral dose of A771726(3, 6, 12 mg/kg)was performed in SD rats, then the corresponding pharmacokinetic parameters based on the time process of blood drug concentration were calculated.
    方法单剂量口服给药3个剂量的A771726,根据大鼠体内血药浓度经时过程,计算相应的药代动力学参数。
短句来源
    The concentrations of ciprofloxacin in serum samples were determined by RP-HPLC, and the bioequivalence were evaluated. RESULTS: The main pharmacokinetic parameters of the test and reference in volunteers were as follows, AUC0-t were 10.889±1.385 μ g ·h ·ml-1 and 12.406±1.384 μ g ·h ·ml-1;
    结果单剂口服给药试验制剂和参比制剂环丙沙星时间-浓度曲线下面积(AUC0-t)分别为10.889±1.385 μg ·h·ml-1和12.406±1.384 μg ·h ·ml-1;
    RESULTS The plasma concentration-time curves of olmesartan were fitted to a one-compartment model after a oral olmesartan medoxomil tablet in single dose(20, 40, 80 mg). The main pharmacokinetic parameters of olmesartan were as follows: Tmax were (2.7±1.4), (2.6±0.8) and (2.8±0.8) h;
    结果奥美沙坦的体内经时过程符合有滞后时间的一室模型,低、中、高三个剂量组单剂量口服给药后血浆中奥美沙坦的Tmax分别为(2.7±1.4),(2.6±0.8)和(2.8±0.8)h;
    Studies on the properties and application to the oral insulin delivery of a pH-sensitive hydrogel
    一种pH敏感水凝胶的性质及用于胰岛素口服给药的研究
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  oral administration
5-FU-PT was given to rats by oral administration at a dosage of 22.5?mg kg-1.
      
Specific immune response to this recombinant strain was evaluated by oral administration of the recombinant live bacteria pBO1/S.
      
Experiments on animals showed that native proteins may diffuse into the blood flow after oral administration of diluted protein solutions.
      
Systemic regulation of osmotic and ionic homeostasis was studied in healthy male volunteers after oral administration of desmopressin.
      
Amaranth seed oil: Effect of oral administration on energetic functions of rat liver mitochondria activated with adrenaline
      
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  oral delivery
pH-sensitive hydrogels are suitable candidates for oral delivery of therapeutic peptides, proteins and drugs, due to their ability to respond to environmental pH changes.
      
pH-sensitive hydrogels are suitable candidates for oral delivery of therapeutic peptides and proteins, due to their ability to respond to environmental pH changes.
      
A few years later, Setala introduced the concept of oral delivery of lyophilized bacteria, harvested from soil, to uremic patients, for degradation of non-protein nitrogen compounds.
      
P(MAA-g-EG) microparticles have been extensively investigated as carriers for oral delivery of proteins such as insulin.
      
Oral delivery of drugs to the small intestine is an important topic in the research and development of more effective oral dose forms.
      
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  topical drug delivery
Acceleration of wound healing by topical drug delivery via liposomes
      
A novel niosome formulation is proposed for topical drug delivery of ammonium glycyrrhizinate, a natural compound with an efficacious anti-inflammatory activity.
      
Gel formulations are often used in topical drug delivery, and the drug release is controlled by two factors, the thermodynamic activity of the drug and the microviscosity of the gel.
      
Topical Drug Delivery from Thin Applications: Theoretical Predictions and Experimental Results
      
Topical Drug Delivery in Humans with a Single Photomechanical Wave
      
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  oral drug
On the basis of this experience, we have formulated certain indications for its use, together with suggested approaches to modify patients' oral drug regimes so that apomorphine can best be deployed to improve their quality of life.
      
We investigated the efficacy of botulinum toxin A (BtxA) therapy in patients with atypical parkinsonian disorders (APD) exhibiting different types of disabling focal dystonia unresponsive to oral drug therapy.
      
Synthesis and characterization of pH-sensitive glycopolymers for oral drug delivery systems
      
The availability of atovaquone-proguanil, a safe and well tolerated oral drug, should prompt a reconsideration of current treatment recommendations that discourage empiric treatment on clinical suspicion alone.
      
Surgery is the standard of care for primary disease, and the oral drug imatinib is the standard of care for metastatic disease.
      
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1. A methed for estimation of phenelzine, based on the use of trichloroacetic acid to precipitate the protein of plasma and tissues, and the use of dimethylaminobenzaldehyde as a colour developing agent, was found to be adequate for our purpose. 2. When phenelzine was given to a mouse orally or intraperitoneally, the peak plasma level was obtained in 0.5—1 hour, which then declined gradually. The compound was distributed in the liver, brain, heart, kidney, and lung. The highest concentrations were attained...

1. A methed for estimation of phenelzine, based on the use of trichloroacetic acid to precipitate the protein of plasma and tissues, and the use of dimethylaminobenzaldehyde as a colour developing agent, was found to be adequate for our purpose. 2. When phenelzine was given to a mouse orally or intraperitoneally, the peak plasma level was obtained in 0.5—1 hour, which then declined gradually. The compound was distributed in the liver, brain, heart, kidney, and lung. The highest concentrations were attained for the first two organs, while the concentration of phenelzine for the lung was very low. The rate of disappearance of phenelzine from tissues was generally found to be slower than from the plasma. 3.In mice, the LD_(50) of phenelzine for single dose of intraperitoneal injection was 151.4 mg/kg, and that for a series of 9 daily doses was 45—50 mg/kg.In rabbits, the lethal dose of phenelzine was 75—100mg/kg. 4. In rabbit, intravenous administration of 2, 5, 10 mg/kg of phenelzine stimulated the respiration, promptly abolished respiratory depression caused by morphine and slightly elevated the blood pressure. A dose of 25 mg/kg slowed the heart rate. Atropine partially blocked this action. After given 10 mg/kg daily for a week, the plasma retention of bromosulphthalein may be elevated, and the fatty degeneration of liver tissues developed. In mice, intraperitoneal administration of 0.4 mg/kg, of phenelzine increased the anaesthetic time of the evipan. Phenelzine was not an antipyretic.

应用二甲基胺苯甲醛作为显色剂,尚适用于測定血及組織內的苯乙肼。給小鼠以苯乙肼灌胃或腹腔注射,用药半小时后血浆浓度即到达最高峯,灌胃时t1/2(消除半量的时間)为3.39小时,腹腔注射时t1/2只有1.2小时。口服給药,苯乙肼主要由小腸吸收,吸收后能分布至主要脏器內,其中肝脏和脑內的浓度最高。苯乙肼給小鼠一次腹腔注射的LD_(50)为151.4毫克/公斤,連續用药9天LD_(50)为45—50毫克/公斤,兔的致死量为75—100毫克/公斤。苯乙肼小剂量具有呼吸兴奋作用及升压作用;大剂量能延长环己巴比妥鈉麻醉作用时間,損伤肝脏排泄磺溴酞鈉的功能,使肝組織产生脂肪变性,并使心率明显減慢,但无退热作用。

In this paper the antitumour action of 17 phosphoramide nitrogen mustard compounds were studied. It was found that bis-(1-aziridinyl)-[bis-(2-chloroethyl)-amino]-phosphine oxide (AT-222) possessed a marked antineoplastic activity.The main results were as follows: 1.Intraperitoneal injections of 1—2.5 mg/kg of AT-222 produced a marked inhibitory action on mouse sarcoma 180, reticulo-cell sarcoma (L-2), sarcoma AK, spindle cell sarcoma and rat Jensen sarcoma and Walker carcinosarcoma. Intragastric administration...

In this paper the antitumour action of 17 phosphoramide nitrogen mustard compounds were studied. It was found that bis-(1-aziridinyl)-[bis-(2-chloroethyl)-amino]-phosphine oxide (AT-222) possessed a marked antineoplastic activity.The main results were as follows: 1.Intraperitoneal injections of 1—2.5 mg/kg of AT-222 produced a marked inhibitory action on mouse sarcoma 180, reticulo-cell sarcoma (L-2), sarcoma AK, spindle cell sarcoma and rat Jensen sarcoma and Walker carcinosarcoma. Intragastric administration of this drug brought about a definite inhibition on the growth of Jensen sarcoma in rats. No effect on Ehrlich carcinoma (both ascitic and solid forms) was observed when the drug was injected intraperitoneally. 2.In mice, the acute and subacute LD_(50) of AT-222 were found to be 19 and 4.7mg/kg respectively. In rats the subacute LD_(50) was 2.7mg/kg (observation period= 10 days) or 1.9mg/kg (observation period=17 days) 3.In dogs, intravenous injections of AT-222 at 0.1 mg/kg/day for 10 days caused no significant change in blood picture, urinalysis, stool routine examination and body weight. In the group given 0.3 mg/kg, white cell counts were slightly decreased on the 5th day after drug administration, and gradually recovered after cessation of the drug. Pathologic studies revealed hemorrhagic spots in the intestinal mucosa and pyknotic nuclei in the granulosa cells and in the lymphocytes of the spleen.In the group of 0.9 mg/kg, white cell counts were markedly decreased and the animals died 12--14 days after drug administration, In pathologic examinations diffuse hemorrhage in the internal organs and atrophy of gastric and intestinal glands, adrenal bodies and testis were seen.

本文研究了17种磷酰胺氮芥类化合物,发現N-双(2-氯乙基)-N'-N"-二乙撐基磷酰胺(以下均簡称AT-222)具有較强的抗癌作用。主要結果如下:(1)腹腔注射AT-2221—2.5毫克/公斤对小白鼠肉瘤180,网織細胞肉瘤,AK肉瘤,梭形細胞肉瘤,大白鼠Jensen肉瘤和Walker癌肉瘤都有明显的抑制作用,口服給药时对Jensen肉瘤也有一定的疗效。但对Ehrlish癌固体型和腹水型則无明显的影响。(2)AT-222对小白鼠的急性和亚急性LD_(50)分別为19和4.7毫克/公斤,大白鼠的亚急性LD_(50)为2.7毫克/公斤(停药后观察3天)和1.9毫克/公斤(停药后观察10天)。(3)給狗靜脉注射AT-222 0.1毫克/公斤,其血象、大小便和体重均无明显改变。在0.3毫克/公斤組,給药第5天时白血球稍有下降,停药后逐渐恢复,解剖发現腸粘膜有出血点,脾淋巴細胞核和卵巢顆粒細胞核有固縮現象。0.9毫克/公斤組,于給药后第5天时白血球卽明显下降,停药后2—4天动物相继死亡,解剖检查发现各脏器均有弥蔓性出血,腸、胃腺体、腎上腺和睾丸均有明显萎縮。

The absorption, distribution and elimination of carbon-14 labelled daidzein(~(14)C-daidzein) were studied in rats using filter paper-liquid scintillation counting method.The radioactivity began to appear in the blood 30 min after oral administration of ~(14)G-daidzein, reached its peak in 6~8 hrs, and then decreased steadily. It was estimated that about 64.6% of the radioactivity was absorbed from the gastrointestinal tract within 24 hrs.After intravenous injection of ~(14)C-daidzein, the blood level of radioactivity...

The absorption, distribution and elimination of carbon-14 labelled daidzein(~(14)C-daidzein) were studied in rats using filter paper-liquid scintillation counting method.The radioactivity began to appear in the blood 30 min after oral administration of ~(14)G-daidzein, reached its peak in 6~8 hrs, and then decreased steadily. It was estimated that about 64.6% of the radioactivity was absorbed from the gastrointestinal tract within 24 hrs.After intravenous injection of ~(14)C-daidzein, the blood level of radioactivity was found to decrease in two phases, namely the distribution phase and the elimination phase, with the T1/2 of 13 rain and 42 rain respectively. The level of radioactivity was highest in the kidney and liver, moderate in the plasma, lung and heart, and low in the skeletal muscle, spleen, testis and brain.After intravenous injection of ~(14)G-daidzein, the majority (71.2%) of the radioactivity was excreted in the urine 24 hrs after administration, while only 17.4% was recovered from the faeces. However, after oral administration, the amount excreted in the urine and faeces was about equal, namely 34.3% and 33.1%, respectively.About 47.4% or 39.1% of the dose could be recovered from the bile 24 hrs after intravenous or oral administration, indicating that biliary excretion was one of the main routes of elimination.Gomparison of the results presented above with those reported in the previous paper using chemical method for the determination provides evidence that the radioactivity recovered from the gastrointestinal tract, urine and bile was mainly metabolites of daidzein. It implies that daidzein is metabolized rapidily in the body.

本文采用纸片液体闪烁计数法研究了~(14)C-黄豆甙元在大鼠体内的吸收、分布和消除。大鼠口服~(14)C-黄豆甙元30分钟,血液即可测出放射性,6~8小时达高峰,以后缓慢下降。口服给药吸收不完全,由实验推论约有64.6%放射性可被吸收。静脉注射后,血放射性消失曲线分为快、慢两个时相,其生物半衰期分别为13分钟和42分钟。放射性在肾、肝含量最高,血浆、肺、心次之,肌肉、脾、睾丸、脑较低。静脉注射后,~(14)C主要自尿排出(24小时可排出剂量的71.2%),自粪排出17.4%。口服后24小时可自尿排出34.3%,自粪排出33.1%。胆汁也是一条重要排泄途径,静脉注射后24小时可自胆汁排出剂量的47.4%;口服后相应时间内排出39.1%。 本文所得结果与前文应用化学方法所得结果进行比较,表明自消化道、尿、胆汁所回收的放射性主要是黄豆甙元的代谢产物,说明该药在体内的代谢很旺盛。

 
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