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促神经细胞分化
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  induce neuron differentiation
     Conclusion TPR tandem cluster D1 of CRLP are related to cell drug-resistance. TPR tandem clusters D2 and D3 have the role of inhibiting cell grouth and may induce neuron differentiation.
     结论 CRLP分子的TPR串联簇D1可提高细胞耐药性 ,TPR串联簇D2和D3有抑制细胞生长的功能 ,并可促神经细胞分化
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  “促神经细胞分化”译为未确定词的双语例句
     Screening of small molecules inducing PC12 cell differentiation
     促神经细胞分化小分子活性物质的筛选研究
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     The neuron differentiation function of different truncated mutants was observed by PC12 transient transfection assay.
     通过瞬时转染PC12细胞实验研究不同截断突变体的促神经细胞分化功能。
短句来源
     Aim To search for small molecule NGF mimetic s using a primary screening model.
     目的 建立便捷有效的高通量筛选方法用以NGF样促神经细胞分化小分子活性物质的初级筛选。
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  相似匹配句对
     Screening of small molecules inducing PC12 cell differentiation
     神经细胞分化小分子活性物质的筛选研究
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     The Effect of Nerve Growth Factor 2.5s on the Differentiation of Enbryonic Neurons in Vitro
     神经生长因子对胚胎神经细胞分化的影响
短句来源
     The neuron differentiation function of different truncated mutants was observed by PC12 transient transfection assay.
     通过瞬时转染PC12细胞实验研究不同截断突变体的神经细胞分化功能。
短句来源
     Effect of Acrylamide on Differentiation of Rat Fetal Neuron
     丙烯酰胺对大鼠胚胎神经细胞分化的影响
短句来源
     RESULTS: NGF enhanced the proliferation and differentiation of cultured embryonic spinal.
     结果:NGF可进脊髓神经细胞分化、增殖。
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  inducing cell differentiation
These data suggest that Drg-1 may suppress colon cancer metastasis by inducing cell differentiation and reversing the metastatic phenotype.
      
We suggest that Drg-1 may suppress colon cancer metastasis by inducing cell differentiation and reversing the metastatic phenotype.
      


Objective CRLP(Crn-like protein) is a novel gene that has been cloned by author's lab. The protein product of the CRLP has fifteen TPR(tetratricopeptide repeat) motifs, which can be divided into three TPR tandem clusters, named as D1, D2, D3 according to their position on the CRLP molecule. The relationship between the TPR tandem clusters and the function of CRLP is to be explored. Methods The plasmids which can express the truncated mutants of the TPR tandem clusters at different region of CRLP were constructed,...

Objective CRLP(Crn-like protein) is a novel gene that has been cloned by author's lab. The protein product of the CRLP has fifteen TPR(tetratricopeptide repeat) motifs, which can be divided into three TPR tandem clusters, named as D1, D2, D3 according to their position on the CRLP molecule. The relationship between the TPR tandem clusters and the function of CRLP is to be explored. Methods The plasmids which can express the truncated mutants of the TPR tandem clusters at different region of CRLP were constructed, stable transfected BEL7402 cell lines were established. The growth status of stable transfected BEL7402 cells and the changes of cell drug-resistance after adding chemotherapy drug adriamycin or cisplatin in the cell medium were examined by cell growth curve assay. The neuron differentiation function of different truncated mutants was observed by PC12 transient transfection assay. Results The proliferation of the BEL7402 cells stably transfected with the plasmid expressing TPR tandem clusters D2 and D3 were inhibited while the drug-resistance of the cells transfected with the plasmid expressing TPR tandem cluster D1 increased. PC12 transient transfection assay revealed that TPR tandem clusters D2 and D3 could induce PC12 differentiation. Conclusion TPR tandem cluster D1 of CRLP are related to cell drug-resistance. TPR tandem clusters D2 and D3 have the role of inhibiting cell grouth and may induce neuron differentiation.

目的 CRLP(Crn likeprotein)基因是本室克隆的新基因 ,它的蛋白表达产物具有 15个TPR(tetratricopeptiderepeat)基序 ,可按在CRLP分子上的位置把它们分为 3个TPR串联簇 ,分别命名为D1、D2、D3。本研究拟探讨这 3个TPR串联簇与CRLP功能的关系。方法 构建了不同TPR串联簇的截断突变体的表达质粒后 ,建立了稳定转染的BEL740 2细胞株。用细胞生长曲线实验检测了稳定转染细胞株的生长状况及观察在培养液中添加化疗药物阿霉素或顺铂后细胞耐药性的变化 ;通过瞬时转染PC12细胞实验研究不同截断突变体的促神经细胞分化功能。结果 稳定表达TPR串联簇D2、D3的BEL740 2细胞的生长受到了抑制 ,稳定表达TPR串联簇D1的BEL740 2细胞耐药性提高 ,瞬时表达TPR串联簇D2、D3的PC12细胞有分化现象。结论 CRLP分子的TPR串联簇D1可提高细胞耐药性 ,TPR串联簇D2和D3有抑制细胞生长的功能 ,并可促神经细胞分化

Aim To search for small molecule NGF mimetic s using a primary screening model.Methods Both rapid quantitati ve bioassay for NGF(-like) activity by measurement of neurite extension in NGF -induced PC12 cells and a following MTT technique to monitor cells alive were u sed.Results More than 1 600 compounds were tested using the se methods and several effective samples with lower cytotoxicity were found. One of them, the compound B,was in good dose-and time-effect relationship. Conclusion All above studies...

Aim To search for small molecule NGF mimetic s using a primary screening model.Methods Both rapid quantitati ve bioassay for NGF(-like) activity by measurement of neurite extension in NGF -induced PC12 cells and a following MTT technique to monitor cells alive were u sed.Results More than 1 600 compounds were tested using the se methods and several effective samples with lower cytotoxicity were found. One of them, the compound B,was in good dose-and time-effect relationship. Conclusion All above studies provide a useful model and chemical info rmation for further screen of neurotrophic mimetics and neural cell tumor induce rs.

目的 建立便捷有效的高通量筛选方法用以NGF样促神经细胞分化小分子活性物质的初级筛选。方法 采用经NGF诱导的PC12细胞,以NGF为阳性对照,通过对分化细胞百分率的测定和存活细胞的MTT染色,建立模型并对样品进行筛选。结果 所建模型定量反映NGF生物活性;应用该模型对1 600多种化合物进行筛选,发现了多个不同活性类型的样品。其中代号为B的化合物作用持续时间长,量效关系明显,且较少引起细胞死亡。结论 该工作为深入筛选促进中枢神经再生药物和神经细胞肿瘤分化诱导剂提供了模型和样品基础。

 
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