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时间-剂量效应
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  time-dose effect
     Time-dose Effect on Esophagus Cancer with Radiotherapy Alone
     食管癌放射治疗时间-剂量效应的临床研究
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     Objective To probe the time-dose effect on esophagus cancer with radiotherapy alone.
     目的 探讨食管癌单纯放射治疗的时间 -剂量效应。
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  “时间-剂量效应”译为未确定词的双语例句
     【Results】①1~8μmol/L As_2O_3 significantly inhibited the proliferation of NB4 cells in a time and dose dependent manner in vitro.
     【结果】①1~8μmol/L As2O3能显著抑制NB4细胞增殖,且这些变化呈明显的时间和浓度依赖关系(时间-剂量效应);
短句来源
     Cell cycle was examined by PI fluoresence. Results 1~8? μmol/L As_2O_3 could induce NB4 cell in a time-and-dose dependent manner in vitro.
     结果1~8μmol/L As2O3能显著抑制NB4细胞增殖,且这些变化呈明显的时间和浓度依赖关系(时间-剂量效应)。
短句来源
     THE TIME DOSE EFFECT OF THE ENTOMOPHTHORALEAN FUNGUS, ZOOPHTHORA ANHUIENSIS AGAINST THE GREEN PEACH APHID, MYZUS PERSICAE, IN BIOASSAY
     安徽虫瘟霉对桃蚜的生物测定与时间-剂量效应分析
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     AT has remarkable time-dosage effects on the cell growth and ap- optosis.
     AT对BmN细胞增殖和凋亡的影响有明显的时间-剂量效应
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     Conclusions The results suggest that CDDP had the cytotoxicity on ovarian granulosa cells and genistein may relieve the cytotoxicity induced by CDDP in dose and time manner.
     结论CDDP对大鼠颗粒细胞具有明显的毒性作用,GEN对其引起的细胞毒性有保护作用,呈时间-剂量效应
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  相似匹配句对
     Time-dose Effect on Esophagus Cancer with Radiotherapy Alone
     食管癌放射治疗时间-剂量效应的临床研究
短句来源
     their physiological effects correlate with dosage used and time.
     其生理效应与其剂量时间相关联。
短句来源
     PV) in dose-dependent and time-dependent manners.
     Tet的这种效应剂量时间依赖性。
短句来源
     Apoptosis of these cells showed a time-dose relationship.
     而且其诱导凋亡作用呈现剂量时间效应
短句来源
     X ray Dose Enhancement Effects *
     X射线剂量增强效应
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  time-dose effect
It is still unknown whether the effects of pulse therapy are due to the peak concentration or the time-dose effect of the high-dose steroid.
      


Liver damage induced by perfusing formate into the portal vein of isolated mice livers

本文采用流过式灌流装置,以小鼠门静脉插管操作,对小鼠肝损害进行了观察。结果:灌注甲酸前的LDH活力与蛋白质含量均保持在稳定的水平。当灌注毒物后LDH活力开始持续增加,停止给毒酶活力迅速恢复到灌注前的水平。经统计处理(方差分析F=0.38 p>0.05)不存在明显的时间-剂量的效应关系。蛋白质含量在给毒以后有明显的增加趋势,停止给毒后蛋白质含量仍较高。病理学检查肉眼均有肝的肿胀、苍白;镜下均有肝细胞变性、坏死、炎症细胞浸润的变化。

URPOSE To detect radiation-induced HL-60 apoptosis and explore the relationship between apoptosis and loss of clonogenicity.METHODS Light microscope, electron microscope, agarose gel electrophoresis and flow cytometry (FCM) were used to detect both qualitatively and quantitatively radiation-induced HL-60 apoptosis. Limiting dilution assay was performed to determine the HL-60 cell colony forming efficiency (CPE).RESULTS The irradiated HL-60 cell exhibited condensation of the cytoplasm, chromatin condensation,...

URPOSE To detect radiation-induced HL-60 apoptosis and explore the relationship between apoptosis and loss of clonogenicity.METHODS Light microscope, electron microscope, agarose gel electrophoresis and flow cytometry (FCM) were used to detect both qualitatively and quantitatively radiation-induced HL-60 apoptosis. Limiting dilution assay was performed to determine the HL-60 cell colony forming efficiency (CPE).RESULTS The irradiated HL-60 cell exhibited condensation of the cytoplasm, chromatin condensation, chromosal clumping and margination, apoptotic body and the nuclear DNA degradation with characteric “DNA ladder” subjected to electrophoresis. Radiation-induced HL-60 apoptosis showed a time-dose response curve with most apparent apoptosis at 4h after irradiation. The induced apoptotic cell number increaed with dose. However, HL-60 cell were much more sensitive to radiation-induced loss of clonogenicity than to induction of apoptosis at 6h, e.g. 8Gy radiation reduced the surviving fraction to 0.0016 in a clonogenic assay, wheras the irradiation induced apoptotic cell number was nearly the same as the control.CONCLUSIONS Our data show irradiation can induce HL-60 apoptosis, but the apoptotic cell number is not able to account for its radiation-induced loss of clonogenicity.

目的研究放射诱导的HL-60细胞凋亡及其与放射后细胞克隆存活率的关系。方法应用电子显微镜、琼脂糖电泳、流式细胞术和TdT介导的缺口和末端标记法(TUNEL)等方法分析放射诱导HL-60细胞凋亡,应用有限稀释法测定放射后细胞克隆形成率。结果放射后HL-60细胞表现出细胞体积缩小、染色质固缩致密化、边缘化、染色体断裂、出现凋亡小体、细胞膜保持完整和电泳时DNA“梯谱”等典型的细胞凋亡特征。放射诱导HL-60细胞凋亡有明显的时间剂量效应,照射后4h细胞凋亡已比较明显,放射诱导HL-60细胞凋亡随着照射剂量增加而增加。但是,放射引起HL-60细胞克隆存活率的减少比放射诱导HL-60细胞凋亡更敏感,如8Gy照射后克隆存活率减少到0.0016,而此剂量时的细胞凋亡水平几乎与对照组水平相同。结论放射能诱导HL-60细胞凋亡,并有明显的时间剂量效应关系。但是,放射诱导HL-60细胞凋亡并不能解释HL-60细胞克隆存活率的减少。

Purpose To investigate retinoic acid (RA) induced apoptosis in retinal pigment epithelial (RPE) cells. Methods 10 5 、10 6 、10 7 RA mol/L were added to cultured RPE cells.Aridine orange fluorescence and TdT mediated dUTP nick end labelling(TUNEL)techniques were used to observe apoptotic changes. Results 10 -5 、10 -6 、10 -7 mol/L RA induced apoptosis in RPE cells.Cell shringkage,chromatin condensation and nuclear DNA fragmentation of RPE cells were...

Purpose To investigate retinoic acid (RA) induced apoptosis in retinal pigment epithelial (RPE) cells. Methods 10 5 、10 6 、10 7 RA mol/L were added to cultured RPE cells.Aridine orange fluorescence and TdT mediated dUTP nick end labelling(TUNEL)techniques were used to observe apoptotic changes. Results 10 -5 、10 -6 、10 -7 mol/L RA induced apoptosis in RPE cells.Cell shringkage,chromatin condensation and nuclear DNA fragmentation of RPE cells were observed by TUNEL technique.When 10 7 、10 6 、10 5 mol/L RA treated RPE cells for 5 days,apoptotic index(AI)was 36.9%、44.9% and 61.4% respectively,and 48.0%、59.9%、74.2% for 6 days.At the same concentration of RA,AI increased when time prolonged.At the same day,AI increased when the concentration of RA rose.There was significant difference in the results(P<0.05). Conclusion Our results showed that RA induced apoptosis in RPE cells was detected with a good dose and time response.

目的研究维甲酸(rentinoicacid,RA)诱导的视网膜色素上皮(retinalpigmentepithlium,RPE)细胞凋亡特征。方法体外培养的RPE细胞中加入10-5、10-6、10-7mol/LRA,应用吖啶橙荧光染色和核苷酸末端转移酶介导的dUIP末端标记法(TdT-mediateddUTPnickendlabelingmethod,TUNEL法)观察凋亡细胞。结果10-5、10-6、10-7mol/LRA诱导RPE细胞凋亡,凋亡细胞表现为细胞固缩,染色质凝聚。TUNEL法显示凋亡细胞DNA片断化。10-7、10-6、10-5mol/LRA作用5天时,凋亡指数分别为36.9%、44.9%、61.4%。作用6天时,凋亡指数分别为48.0%、59.9%、74.2%。经统计学处理,同一RA浓度时,随作用时间延长凋亡指数增加;同一作用时间时,随RA浓度增大凋亡指数增加,差异有显著性(P<0.05)。结论RA能诱导RPE细胞凋亡,且有很好的时间剂量效应

 
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