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i型前胶原mrna
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  type i procollagen mrna
     III procollagen mRNA expression was increased in the acute alveolitis phrase of pulmonary fibrosis induced by Bleomycin, the expression of type I procollagen mRNA was mainly increased in the chronic stage of pulmonary fibrosis.
     在肺间质纤维化形成中,I型和III型前胶原mRNA表达呈动态变化,早期肺泡炎以III型前胶原mRNA大量增生为主,晚期纤维化期以I型前胶原mRNA增生为主。
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     METHODS: The keloid derived fibroblasts were used as the subjects and normal skin fibroblasts as the control. The effects of different contents of chitosan on the collagen synthesis and secretion of keloid derived fibroblasts and content changes of their corresponding type I procollagen mRNA were detected.
     方法:以瘢痕疙瘩成纤维细胞为研究对象,正常皮肤成纤维细胞为对照,观察不同含量几丁糖对瘢痕疙瘩成纤维细胞合成分泌胶原量及其相应I型前胶原mRNA量的变化。
短句来源
     And the type I procollagen mRNA of keloid derived fibroblasts decreased significantly.
     其相应I型前胶原mRNA量显著下降。
短句来源
  procollagen i mrna
     Gene transfection using lipid mediated TGFβ1 sense and antisense gene expression vectors and its effects on TGFβ1 and procollagen I mRNA expression in~(60) Co-irradiated human embryo lung fibroblasts
     TGFβ1正、反义基因转染~(60)Co照射HELF对TGFβ1及I型前胶原mRNA表达调控影响
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     Objective To study the molecular mechanism of fibrosis in the patients with severe viral hepatitis by detecting the expressions of procollagen I mRNA and platelet-derived growth factor-1 (PDGF-1) mRNA and type Ⅰ ,Ⅳ collagen.
     目的 了解重症病毒性肝炎患者肝组织I型前胶原mRNA、血小板衍生生长因子-1(PDGF-1)mRNA及Ⅰ、Ⅳ型胶原蛋白的表达情况,探讨重症病毒性肝炎纤维化发生的分子机制。
短句来源
     RESULTS: This polypeptide could significantly inhibit the TGFβ1 induced collagen synthesis and down regulate the expression of procollagen I mRNA in the fibroblasts from scar.
     结果该短肽可以明显抑制TGFβ1所诱导的增生性瘢痕成纤维细胞的胶原合成量及细胞内I型前胶原mRNA的表达。
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  “i型前胶原mrna”译为未确定词的双语例句
     After 6 weeks of treatment, the rats were killed and liver samples were obtained for observing the histopathological changes and investigating content of hydroxyproline(HYP) , the mRNA levels of procollagen I (procol-I) and tissue inhibitor of metalloproteinase-1(TIMP-1).
     6周后,处死大鼠,取肝组织进行病理学观察并测定肝组织匀浆中的羟脯氨酸(HYP)含量,检测I型前胶原mRNA(procol-ImRNA)和组织金属蛋白酶抑制因子1mRNA(TIMP-1mRNA)的表达水平。
短句来源
     Methods The normal rats were fed on cordyceps mycelium and salvia mitiorrnizae respectively, then the rat sera were collected and incubated with subcultured hepatic stellatecells (HSC). HSC α-SM actin (SMA) expression, [3H]TdR and [3H]Proline incorporation, mRNA and protein production of type I collagen, mRNA and protein production of Transforming Growth Factor β1(TGFβ1) were observed.
     方法虫草菌丝与丹参流浸膏分别给大鼠经口灌胃给药后分离药物血清,观察药物血清对体外传代活化的大鼠肝星状细胞α-平滑肌肌动蛋白(SMactin,SMA)表达、[3H]TdR及[3H]脯氨酸掺入,TGFβ1、I型前胶原mRNA表达及其蛋白生成量的影响。
短句来源
     Results Human (α 1) Ⅲ procollagen mRNA expression in portal hypertensive patients were higher than control group(P<0.01), however, Human (α 1) I procollagen mRNA expression in portal hypertensive patients shows a non-significant difference pattern with control group(P>0.05).
     结果门脉高压症时脾静脉壁 (α1)Ⅲ型前胶原mRNA表达明显增高 (P <0 .0 1) ,但门脉高压症病人脾静脉壁 (α1)I型前胶原mRNA表达与非门脉高压症病人相比差异无显著性意义 (P >0 .0 5 )。
短句来源
     The expression of I procollagen mRNA was highest at 42 day, and there is a significant difference between Q1 and H1 group Q2 and H2 group at 28 day(P<0.05), but there is no significant difference between Q2 and H2 at 42 day.
     I型前胶原mRNA的表达在28天时芪丹1组和氢可1组及芪丹2组和氢可2组组间均有显著性差异,但在42天时,芪丹2组与氢化可的松2组其表达无显著差异(P<0.05)。
短句来源
     On the other hand, within the low-COL1A1 mRNA-producing subpopulations, they had a dramatically smaller proportion of cells(14.33 % ?4.91%) than normal fibroblasts(62.33% ?.53%).
     继而,采用RT一PCR方法分析了SSc组和正常组I、111型前胶原基因表达的差别,SSc组I型前胶原mRNA表达约是对照组的2倍,m型约是对照组的
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  type i procollagen mrna
The levels of TβRII and type I procollagen mRNA in human dermal fibroblasts were measured by quantitative real-time RT-PCR, and TβRII protein levels were assayed by western blotting.
      
These expression patterns were essentially coupled with those of type I procollagen mRNA and PDGF-Rβ protein.
      
Type I procollagen mRNA expression was spatially co-distributed with PDGF-A-expressing interstitial cells.
      
Both PDGF-A and type I procollagen mRNA increases correlated with morphological features of tubulointerstitial damage.
      
When another 4 strains of dermal fibroblasts were treated with IGF-1, a significant increase (16.94±1.13 vs 10.87±1.79, p>amp;lt;0.01, N=4) in the expression of type I procollagen mRNA was found.
      
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  procollagen i mrna
After 9 days of expansion, increased levels of procollagen I mRNA were found, while after 16 days increased levels of procollagen III mRNA were evident.
      


The effect of ligustrazine and 764-3 on type I and type Ⅲ collagen mRNA expression incuitured fibroblasts was sttidied.The results showed that ligustrazine at a final concentra-tion of 30μg/ml for 24 hours could inhibit type I and type Ⅲ collagen mRNA expression;764-3 at a final concentration of 15μg/ml for 24 hours conld stimulate type I collagen mR-NA expression,but exerted no effect on type Ⅲ collagen expression.The possible mecha-nism of 764-3 action was discussed.

川芎嗪和764-3均有抑制纤维化的作用。本工作观察了川芎嗪和764-3对体外培养的成纤维细胞Ⅰ、Ⅲ型前胶原mRNA表达的影响结果表明,加入川芎嗪(终浓度30μg/ml)24h对I、Ⅲ型前胶原mRNA表达均有明显抑制作用;加入764-3(终浓度为15μg/ml)24h对Ⅲ型前胶原mRNA表达无明显作用,对I型前胶原mR-NA表达非但不抑制反而有明显促进作用。作者对764-3这种作用的可能原因做了初步讨论。

Background/Aims: To study the effects of taurine on proliferation and collagen gene expression of rat lipocytes and hepatocytes in vitro. Methods: Rat lipocytes and hepatocytes were isolated and cultured, cell proliferation and collagen syntheses were assessed by mesuring the incorporation of 3H-TdR and 3H-proline: type Ⅰ and type Ⅲ procollagen mRXA levels were determinded by in situ hybridization technique. Results: Taurine (5-80mmol/L) markedly inhibited lipocyte. hepatocyte proliferation and collagen syntheses...

Background/Aims: To study the effects of taurine on proliferation and collagen gene expression of rat lipocytes and hepatocytes in vitro. Methods: Rat lipocytes and hepatocytes were isolated and cultured, cell proliferation and collagen syntheses were assessed by mesuring the incorporation of 3H-TdR and 3H-proline: type Ⅰ and type Ⅲ procollagen mRXA levels were determinded by in situ hybridization technique. Results: Taurine (5-80mmol/L) markedly inhibited lipocyte. hepatocyte proliferation and collagen syntheses in a dose- and time-dependent manner. 20mmol L taurine significantly suppressed the type Ⅰ and type Ⅲ procollagen mRNA expression. Conclusions: Taurine has an antifibrotic effect and it could be of clinical significance and prospective for application in liver fibrosis.

目的:研究牛磺酸对大鼠贮脂细胞、肝细胞增殖及胶原基因表达的影响,为应用牛磺酸防治肝纤维化提供实验依据。方法:分离、培养大鼠贮脂细咆和肝细胞:采用~3H-胸腺嘧啶和~3H-脯氨酸掺入测定细胞增殖及胶原合成:用原位杂交检测I、Ⅲ型前胶原mRNA含量:结果:在5~80mmol/L浓度范围内。牛磺酸能显著抑制贮脂细咆、肝细胞的增殖及胶原合成,并呈时间、剂量依赖性关系:20mmol/L牛磺酸可显著抑制I、Ⅲ型前胶原mRNA的表达。结论:牛磺酸在体外具有抗肝纤维化作用,其对于防治肝纤维化可能有一定的临床意义和应用前景。

Background Aims: To observe the effect of glycyrrhetinic acid on proliferation, expression of procollagen type I Ⅲ procollagen mRNA and desposition of collagen type I Ⅲ in fibrotic liver of rat. Methods: The liver fibrosis model of rat was induced by CCl4. The rats was classified as normal control group, model control group and glycyrrhetinic acid treated group. Each group contained early, middle, late stage subgroup. After using drugs for 2, 6 and 9 weeks, the rats were killed respectivly. The Ito cells were...

Background Aims: To observe the effect of glycyrrhetinic acid on proliferation, expression of procollagen type I Ⅲ procollagen mRNA and desposition of collagen type I Ⅲ in fibrotic liver of rat. Methods: The liver fibrosis model of rat was induced by CCl4. The rats was classified as normal control group, model control group and glycyrrhetinic acid treated group. Each group contained early, middle, late stage subgroup. After using drugs for 2, 6 and 9 weeks, the rats were killed respectivly. The Ito cells were isolated from liver and cultured in DMEM medium. The effect of glycyrrhetinic acid on proliferation and collagen synthesis of Ito cells were determined with H-TDR. H-proline incoperating test After culturing two weeks, total RNA of Ito cells were etracted. The cDNA of procollagen typeI Ⅲ and interstitial collagenase were labeled using Dig High Primer technique. The level of procollagen type I Ⅲ and interstitial collagenase mRNA were measured by Northern blot. Desposition of collagen type I Ⅲ in fibrotic liver was evaluated with Dot blot. Results: At 4h, 24h, 48h, glycyrrhetinic acid inhibited the intake of H-TDR. H-prolme by Ito cells significantly. The inhibition rate was 15% , 21%,31%, respectively. When the concentration of glycyrrhetinic acid ≥0.125μg/ml, the intake of H-prohne by Ito cells was inhibited obviously. Only the concentration of glycyrrhetinic acid≥0.25μg ml. it showed inhibition to H-TDR The level of procollagen type I Ⅲ mRNA in glycyrrhetinic acid treated group was significantly lower than model controle group in all stage of fibrosis. At 2. 6 week groups, the desposition of collagen type I Ⅲ in glycyrrhetinic acid treated group was decreased significantly than model control group. No difference was found in 9 week groups. There was no difference in expression of collagenase mRNA between glycyrrhetinic acid treated group and model control group. Conclusions: Glycyrrhetimc acid inhibited the proliferation and collagen synthesis of Ito cells. Downregulated expression of procollagen type I Ⅲ mRNA and reduced desposition of collagen type I Ⅲ in fibrosis liver There was no effect of collagenase

目的:观察甘草酸对鼠肝纤维化时Ito。细胞增殖和IⅢ型前胶原mRNA表达和肝脏胶原沉积的影响。方法:以CCl_4复制肝纤维化模型,动物分组为止常对照组,模型对照组及甘草酸治疗组三个大组,各组又包括早(2周),中(6周)。晚(9周)期组,分别于用药后第2、6、9周处死动物,分离提取肝Ito细胞,培养两周后提取总RNA,以DIG High-Prlmer去标记IⅢ型前胶析和间质胶原酶cDNA探针,Northern杂交分析IⅢ型前胶原和间质胶原酶mRNA表达.鼠肝IⅢ型胶原沉积用Dot blot测定,用~3H-TDR~3H-脯氨酸观察甘草酸对培养的Ito细胞增殖和胶原合成的影响 结果,甘草酸对Ito细胞H-TDR和H-脯氨酸的掺入在4h、24h、48h与空白对照比呈明显抑制作用(P<0.05),其抑制率分别为15%、21%、31%,在甘草酸浓度≤0.125μg/ml时,对Ito细胞~3H-TDR掺入抑制不明显,而≥0.25μg/ml时呈现明显抑制作用(P<0.05),对H脯氨酸掺入,在甘草酸浓度≥0.125μg/ml时,则出现明显抑制作用(P<0.05),且随浓度增加而抑制作用加强。在鼠肝纤维化早、中、晚各期,模型对...

目的:观察甘草酸对鼠肝纤维化时Ito。细胞增殖和IⅢ型前胶原mRNA表达和肝脏胶原沉积的影响。方法:以CCl_4复制肝纤维化模型,动物分组为止常对照组,模型对照组及甘草酸治疗组三个大组,各组又包括早(2周),中(6周)。晚(9周)期组,分别于用药后第2、6、9周处死动物,分离提取肝Ito细胞,培养两周后提取总RNA,以DIG High-Prlmer去标记IⅢ型前胶析和间质胶原酶cDNA探针,Northern杂交分析IⅢ型前胶原和间质胶原酶mRNA表达.鼠肝IⅢ型胶原沉积用Dot blot测定,用~3H-TDR~3H-脯氨酸观察甘草酸对培养的Ito细胞增殖和胶原合成的影响 结果,甘草酸对Ito细胞H-TDR和H-脯氨酸的掺入在4h、24h、48h与空白对照比呈明显抑制作用(P<0.05),其抑制率分别为15%、21%、31%,在甘草酸浓度≤0.125μg/ml时,对Ito细胞~3H-TDR掺入抑制不明显,而≥0.25μg/ml时呈现明显抑制作用(P<0.05),对H脯氨酸掺入,在甘草酸浓度≥0.125μg/ml时,则出现明显抑制作用(P<0.05),且随浓度增加而抑制作用加强。在鼠肝纤维化早、中、晚各期,模型对照组Ito细胞IⅢ型前胶原mRNA表达均高于正常对照组(P<0.05),甘草酸组各期Ito细胞IⅢ型前胶原mRNA表达与模型对照组比均显著降低(P<0.05).Ito细胞间质胶原酶mRNA表达.在早、中期模型对照组均高于正常对照组(P<0.05

 
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