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人肝纤维化
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  human liver fibrogenesis
     ROLES OF CYTOKINES TGF-β_1, PDGF-BB AND bFGF IN HUMAN LIVER FIBROGENESIS
     细胞因子TGF-β_1、PDGF-BB、bFGF在人肝纤维化中的作用
短句来源
     CONCLUSIONS This study suggests that cytokines TGF-β1,PDGF-BB and bFGF may play important regulary roles in human liver fibrogenesis.
     结论:本实验提示细胞因子TGF-β1、PDGF-BB、bFGF在人肝纤维化中起着关键的调节作用。
短句来源
     The cells which related to deposition of extracellular matrix( ECM)in human liver fibrogenesis were investigated with immunohistorhemistry(IHC )and nucleic acid hybridization。
     应用免疫组化及核酸分子杂交技术研究人肝纤维化中与细胞外基质(ECM)沉积有关的细胞。
短句来源
  human liver fibrosis
     Study on cells associated with human liver fibrosis
     人肝纤维化相关细胞的研究
短句来源
     Objective:To observe the changes of metalloproteinase-2(MMP-2)and its tissue inhibitor in human liver fibrosis from different causetive factors and at different stages,and to clarify relationship between MMP-2/TIMP-2 rate and liver pathology.
     目的 :了解基质金属蛋白酶 - 2 (MMP - 2 )及其组织抑制因子 (TIMP - 2 )在不同病因致人肝纤维化不同病理阶段中的变化 ,分析MMP - 2 /TIMP - 2与肝病理损害的关系。
短句来源
  “人肝纤维化”译为未确定词的双语例句
     It presentsed with significantly progressive tendency for the expression of CTGF in human normal tissues and liver cirrhosis(P<0.01 ) too.
     在人肝纤维化组织中,CTGF亦主要表达于HSC胞质及部分肝细胞胞质中,CTGF表达水平显著高于人正常肝组织(P<0.01)。
短句来源
     Objective To establish an enzyme-linked immunosorbent assay(ELISA) for tissue inhibitor of metalloproteinases-1(TIMP-1) in human serum,applied to the serological diagnosis of the progression of liver fibrosis.
     目的建立一种检测人血清中基质金属蛋白酶组织抑制剂-1(TIMP-1)的酶联免疫吸附方法(ELISA),用于血清学诊断人肝纤维化病程进展。
短句来源
     To explore method of establishment of the mouse model of hepatic fibrosis of mice.
     建立与人肝纤维化病变、性质及发展规律比较接近的肝纤维化动物模型 ;
短句来源
     PURPOSE To study the roles of cytokines transforming growth factor(TGF)-β1,platelet-derived growth factor (PDGF)-BB and basic fibroblast growth factor (bFGF) in human hepatic fibrosis in order to make progress in investigation of liver fibrogenesis.
     研究和探讨转化生长因子(TGF)-β1、血小板源性生长因子(PDGF)-BB、碱性成纤维细胞生长因子(bFGF)在人肝纤维化中的作用,进一步阐明人体慢性肝病纤维化发生机制。
短句来源
     It suggests that detection of MFb,marked with α-SMA in human liver,is a reliable creterion to indicate the progressing of fibrogenesis.
     因此,可籍MFb(α-SMA阳性)的定位检测来判断人肝纤维化的进展情况。
短句来源
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  相似匹配句对
     Study on cells associated with human liver fibrosis
     纤维化相关细胞的研究
短句来源
     Therapy for liver fibrosis
     纤维化的治疗
短句来源
     Relationship between tumor necrosis factorα and liver fibrosis
     肿瘤坏死因子α与纤维化关系的研究
短句来源
     Obesity and liver fibrosis
     肥胖与纤维化
短句来源
     1. Human Liver cDNA
     * CDNA
短句来源
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  human liver fibrosis
Taken together with the mouse study, these findings provide evidence that C5 has a causative role in human liver fibrosis.
      


specimens of human liver tissues with different liver diseases were studied immunohistochemically to demonstrate the relationship among α-smooth-muscle-actin(α-SMA),a marker of myofibroblast,collagen typeⅠ、Ⅲ(col Ⅰ、Ⅲ)and inflammatory cells.The results showed that the proliferation and distribution of α-SMA(+)cells were closely related to that of the inflammatory cells.In chronic liver diseases,the amount of α-SMA-positive cells,colⅠand col Ⅲ was much more greater than that in control group. Particularly in the...

specimens of human liver tissues with different liver diseases were studied immunohistochemically to demonstrate the relationship among α-smooth-muscle-actin(α-SMA),a marker of myofibroblast,collagen typeⅠ、Ⅲ(col Ⅰ、Ⅲ)and inflammatory cells.The results showed that the proliferation and distribution of α-SMA(+)cells were closely related to that of the inflammatory cells.In chronic liver diseases,the amount of α-SMA-positive cells,colⅠand col Ⅲ was much more greater than that in control group. Particularly in the chronic active diseases,the quantity of col Ⅲ was more than that of col Ⅰ as well.However,in chronic nonactie disease. the of colⅠis more than that of col Ⅲ The variations of distibution and the quantity of α-SMA(+)cells among different groups were basically similar to those col Ⅲ.It suggests that detection of MFb,marked with α-SMA in human liver,is a reliable creterion to indicate the progressing of fibrogenesis.

本文以α-平滑肌肌动蛋白(α-SMA)作为肌纤维母细胞(MFb)的标志,对73例人肝组织作免疫组化研究,观察α-SMA阳性细胞与Ⅰ、Ⅲ型胶原以及炎症细胞的关系。发现在各种慢性肝病的肝组织中α-SMA、Ⅰ、Ⅲ型胶原阳性率均明显高于对照组;尤其在慢性活动性病变时,α-SMA阳性细胞数与Ⅲ型胶原量均多,而在慢性非活动性病例中Ⅰ型胶原量较多;且各组显示α-SMA阳性细胞量的曲线与Ⅲ型胶原基本一致。α-SMA阳性细胞的增生及分布与炎症细胞的浸润也密切相关。因此,可籍MFb(α-SMA阳性)的定位检测来判断人肝纤维化的进展情况。

The cells which related to deposition of extracellular matrix( ECM)in human liver fibrogenesis were investigated with immunohistorhemistry(IHC )and nucleic acid hybridization。ResuIts showed that ECMs were high in chronic liver disease(CLD)tissues,particularly collagen III and its mRNA in active-CLD。In this group,cells positive for pre-collagen III pro-peptide(PIIIP)and collagen III mRNA were markedly increased and mostly located in the area connecting interstitium and parenchyma。hese collagen producing cells...

The cells which related to deposition of extracellular matrix( ECM)in human liver fibrogenesis were investigated with immunohistorhemistry(IHC )and nucleic acid hybridization。ResuIts showed that ECMs were high in chronic liver disease(CLD)tissues,particularly collagen III and its mRNA in active-CLD。In this group,cells positive for pre-collagen III pro-peptide(PIIIP)and collagen III mRNA were markedly increased and mostly located in the area connecting interstitium and parenchyma。hese collagen producing cells were mainly the interstitial cells identified by IHC and electron microscopy as fat storing cells and associated myofibroblasts and fibroblasts。Their degree of hyperplasia was closely relat-ed to the infiltration of inflammatory cells.

应用免疫组化及核酸分子杂交技术研究人肝纤维化中与细胞外基质(ECM)沉积有关的细胞。结果显示慢性肝病组ECM均增高,尤其是活动性慢性肝病者III型胶原及其mRNA更为突出,该组III型胶原前肽(PIIIP)的免疫组化及原位杂交阳性细胞亦明显增多,主要位于间质与实质交接处。免疫组化及电镜证明这些胶原生成细胞主要是与贮脂细胞相关的间质细胞,其增生程度与炎症细胞浸润密切相关。

PURPOSE To study the roles of cytokines transforming growth factor(TGF)-β1,platelet-derived growth factor (PDGF)-BB and basic fibroblast growth factor (bFGF) in human hepatic fibrosis in order to make progress in investigation of liver fibrogenesis.METHODS Human liver tissue including active chronic liver diseases(ACLD), non-or mild-ACLD and considerably normal tissues were detected for TGF-β1 mRNA by Northern blot hybridization and localized for PD GF-BB,bFGF and their relateted cells by immunohistochemistry...

PURPOSE To study the roles of cytokines transforming growth factor(TGF)-β1,platelet-derived growth factor (PDGF)-BB and basic fibroblast growth factor (bFGF) in human hepatic fibrosis in order to make progress in investigation of liver fibrogenesis.METHODS Human liver tissue including active chronic liver diseases(ACLD), non-or mild-ACLD and considerably normal tissues were detected for TGF-β1 mRNA by Northern blot hybridization and localized for PD GF-BB,bFGF and their relateted cells by immunohistochemistry (IHC).RESULTS Northern Blot hybridization analysis showed that the amount of TGF-β1 mRNA was higher in chronic liver disease particularly in the ACLD. IH C revealed that PDGF-BB and bFGF positive staining were strong in ACLD, and their number and localization was associated with Lz and CD3 (markers for monocytes/macrophages and Pan T lymphocyte respectively) positive cells. The quantity and distribution of PDGF-BB and bFGF positive cells were coincided with extracellular matrix-producing cells (marked by desmin,a-smooth muscle actin and procollagen Ⅲ peptide), and as well as the Collagen Ⅰ and Collagen Ⅲ.CONCLUSIONS This study suggests that cytokines TGF-β1,PDGF-BB and bFGF may play important regulary roles in human liver fibrogenesis.

研究和探讨转化生长因子(TGF)-β1、血小板源性生长因子(PDGF)-BB、碱性成纤维细胞生长因子(bFGF)在人肝纤维化中的作用,进一步阐明人体慢性肝病纤维化发生机制。外科切除的肝细胞标本按病变活动程度分为活动性、非活动性或轻度活动性以及对照组,以Northern分子杂交法测肝组织TGF-β1mRNA,以免疫组化法显示组织原位PDGF-BB,bFGF及其相关细胞,并作半定量分析。结果:(1)肝病组织内TGF-β1mRNA含量随肝病活动程度而增高(P<0.01);(2)组织原位PDGF-BB、bFGF多肽定位及阳性细胞半定量显示,活动性肝病时两者均增高,阳性细胞所在部位与单核巨噬细胞以及胶原生成细胞一致,与Ⅰ、Ⅲ型胶原沉积也有密切关系。结论:本实验提示细胞因子TGF-β1、PDGF-BB、bFGF在人肝纤维化中起着关键的调节作用。

 
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