Objective It is known that dementia is a multi-factorial disorder, but the etiological factors other than aging remain to be explored, hence we sought to investigate the risk factors of dementia and Alzheimer' s disease (AD).
We describe a patient who was clinically diagnosed with familial early-onset Alzheimer disease (AD) carrying both the E318G substitution in presenilin 1 (PSEN1) and an insertion of 7 octapeptide coding repeats in the prion protein gene (PRNP).
A variety of therapeutic modalities have been employed in the treatment of Alzheimer disease (AD).
Special emphasis is placed on studies of anticholinergics in patients with Alzheimer disease (AD).
Alzheimer disease (AD) is the most common cause of dementia.
In order to investigate the pathogenesis of Alzheimer disease (AD) and study the enzymatic progress of amyloid precursor protein (APP), the fluorescent eukaryotic expression plasmid of C99 was constructed containing APP717 mutation.