助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   凋亡信号调节激酶 的翻译结果: 查询用时:0.487秒
图标索引 在分类学科中查询
所有学科
基础医学
更多类别查询

图标索引 历史查询
 

凋亡信号调节激酶
相关语句
  apoptosis signal regulating kinase
     Cotransfection of apoptosis signal regulating kinase 1 (ASK1) and GSTπ cDNA was performed to elucidate the impact of GSTπ on ASK1 activity, as well as on its downstream signals, MKK7 and JNK, and to elucidate the potential protection of GSTπ on 293 cell death induced by serum depletion.
     用凋亡信号调节激酶 (apoptosissignal regulatingkinase 1,ASK1)和GSTπcDNA转染 2 93细胞 ,来研究GSTπ对ASK1激酶活性及其对下游激酶MKK7和JNK活性的影响及对细胞死亡的保护作用 ;
短句来源
     Objective To study the effect of apoptosis signal regulating kinase 1(ASK1) protein expression in hypertrophic myocardium in rat models of hypertension.
     目的研究凋亡信号调节激酶(apoptosis signal regu lating k inase 1,ASK1)在高血压心脏肥大中的作用。
短句来源
  apoptosis signal-regulating kinase
     Regulatory Effects of Apoptosis Signal-Regulating Kinase 1 on Apoptosis
     凋亡信号调节激酶1对细胞凋亡的调节作用
短句来源
     Apoptosis signal-regulating kinase1 (ASK1) is an upstream kinase of MAPK,and participates in cell growth,differentiation and apoptosis. A close relationship has been discovered between apoptosis signal-regulating kinase1 and cardiac hypertrophy in many research studies.
     凋亡信号调节激酶1是有丝分裂原激活蛋白激酶的上游激酶,参与细胞的生长、分化、凋亡,近年来研究发现它与心脏肥大的发生也存在密切关系。
短句来源
  “凋亡信号调节激酶”译为未确定词的双语例句
     Advances in Research into Relationship Between ASK1 and Cardiac Hypertrophy
     凋亡信号调节激酶1与心脏肥大研究进展
短句来源
     Apoptosis signal\|regulating kinase 1(ASK1) is one member of the mitogen\|activated protein(MAP) kinase kinase kinase family and activates both the SER1\|JNK and MKK3/MKK6\|p38 signaling cascades,plays a critical role in signal transduction of cytokines\| and stress\|induced apoptosis.
     凋亡信号调节激酶 1 (ASK1 )是促分裂原活化蛋白激酶激酶激酶家族的成员之一 ,它分别激活SER1 JNK和MKK3 MKK6 p38途径 ,在细胞因子及应激诱导细胞凋亡过程中起着关键作用。
短句来源
     The results of this study indicate that the abnormal expression of 18 genes related to cell cycle and apoptosis might play a key role in the
     凋亡信号调节激酶1(apoptosissignal-regulationg kinase 1,ASK1)则呈表达增强趋势。 本实验在AAA中发现了45条与信号传导系统有关的异常表达基因,这些基因的异常表达在AAA的发生过程中起重要作用。
短句来源
  相似匹配句对
     Regulatory Effects of Apoptosis Signal-Regulating Kinase 1 on Apoptosis
     凋亡信号调节激酶1对细胞凋亡调节作用
短句来源
     Regulation of metabolism and apoptotic signal by ceramide
     神经酰胺代谢及凋亡信号调节
短句来源
     Advances in Research into Relationship Between ASK1 and Cardiac Hypertrophy
     凋亡信号调节激酶1与心脏肥大研究进展
短句来源
     adjustment of protein kinase C;
     调节蛋白激酶C;
短句来源
     Expression of Extracellular Signal-regulated Kinase in Epithelial Ovarian Cancer
     细胞外信号调节激酶在卵巢肿瘤的表达
短句来源
查询“凋亡信号调节激酶”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  apoptosis signal-regulating kinase
Recent studies have indicated that activation of apoptosis signal-regulating kinase 1 (ASK1) is involved in polyQ-induced apoptosis.
      
Apoptosis signal-regulating kinase 1 (ASK1) is an upstream regulator of the stress-activated MAPK cascades and has been shown to play critical roles in ROS-mediated cellular responses.
      
Further study showed that knocking down of apoptosis signal-regulating kinase 1 (ASK1) by siRNA transfection in cells dramatically inhibited phosphorylation of JNK and p66Shc elicited by H2O2.
      
Involvement of p38 Mitogen-Activated Protein Kinase and Apoptosis Signal-Regulating Kinase-1 in Nitric Oxide-Induced Cell Death
      
In this study, the involvement of p38 mitogen-activated protein kinase (p38 MAPK) and apoptosis signal-regulating kinase-1 (ASK1) in NO-induced cell death was investigated in PC12 cells.
      


Glutathione S transferase π(GSTπ) protects cells from death by altering intracellular oxidative stress. In order to understand the mechanism of GSTπ protection, a cell death model induced by serum depletion as the stress was established. Cotransfection of apoptosis signal regulating kinase 1 (ASK1) and GSTπ cDNA was performed to elucidate the impact of GSTπ on ASK1 activity, as well as on its downstream signals, MKK7 and JNK, and to elucidate the potential protection of GSTπ on 293 cell death induced by serum...

Glutathione S transferase π(GSTπ) protects cells from death by altering intracellular oxidative stress. In order to understand the mechanism of GSTπ protection, a cell death model induced by serum depletion as the stress was established. Cotransfection of apoptosis signal regulating kinase 1 (ASK1) and GSTπ cDNA was performed to elucidate the impact of GSTπ on ASK1 activity, as well as on its downstream signals, MKK7 and JNK, and to elucidate the potential protection of GSTπ on 293 cell death induced by serum depletion. The dominant negative mutant of JNK was used to explore if the blocking of the JNK pathway led to cell death inhibition. It was found that GSTπ had a dose dependent inhibitory effect on activation induced by serum depletion, and also on inhibition both on MKK7 and JNK. Intracellular expression of GSTπ significantly inhibited serum depletion induced cell death. Blocking the JNK pathway by transfection of a dominant negative form of JNK (JNK APF ) brought about significant inhibition of cell death induced by serum depletion with an inhibiting rate as high as 15%. All the results suggest that the mechanism of GSTπ protection on serum depletion induced cell death works through an ASK1 MKK7 JNK pathway.

谷胱甘肽S 转移酶π(glutathioneS transferaseπ ,GSTπ)通过消除细胞内的氧化应激 (oxidativestress)来保护细胞免于死亡。为了阐明细胞内GSTπ保护细胞的机制 ,建立了血清撤离 (serumdepletion)诱导细胞凋亡的模型。用凋亡信号调节激酶 (apoptosissignal regulatingkinase 1,ASK1)和GSTπcDNA转染 2 93细胞 ,来研究GSTπ对ASK1激酶活性及其对下游激酶MKK7和JNK活性的影响及对细胞死亡的保护作用 ;使用负显性 (dominantnegative)JNK突变体转染 2 93细胞 ,来探讨阻断JNK通路对细胞死亡的抑制作用。结果发现GSTπ对血清撤离带来的ASK1激活呈剂量依赖性抑制效应 ,对MKK7和JNK也具有明显的抑制作用 ;GSTπ的细胞内表达可明显抑制血清撤离带来的细胞死亡 ;用JNK无活性突变体转染阻断JNK通路 ,对血清撤离引起的细胞死亡有明显抑制作用 ,抑制率达 15 %。表明GSTπ对血清撤离引起的细胞损伤的保护机制是通过抑制ASK1 MKK7 JNK通路而发挥作用的

The balance between cell survival and apoptosis is crucial for normal development and homeostasis of multicellular organisms.Apoptosis is a highly regulated and organized death process by various factors.Apoptosis signal\|regulating kinase 1(ASK1) is one member of the mitogen\|activated protein(MAP) kinase kinase kinase family and activates both the SER1\|JNK and MKK3/MKK6\|p38 signaling cascades,plays a critical role in signal transduction of cytokines\| and stress\|induced apoptosis.TNF receptor and Fas signaling...

The balance between cell survival and apoptosis is crucial for normal development and homeostasis of multicellular organisms.Apoptosis is a highly regulated and organized death process by various factors.Apoptosis signal\|regulating kinase 1(ASK1) is one member of the mitogen\|activated protein(MAP) kinase kinase kinase family and activates both the SER1\|JNK and MKK3/MKK6\|p38 signaling cascades,plays a critical role in signal transduction of cytokines\| and stress\|induced apoptosis.TNF receptor and Fas signaling play significant role in mediating pro and anti\|apoptotic cellular events,including TNF receptor Ⅰ associated death domain protein(TRADD),Fas\|associated death domain\|containing protein(FADD),and many protein factors.Cytochrome C is mitochondrial dependent death signals and is regulated by Bcl\|2 family proteins.Reactive oxygen species induce oxidative stress,which oxidizes thioredoxin(Trx).The oxidation of Trx results in the dissociation of ASK1 form the ASK1\|Trx complex,and ASK1 is activated and apoptosis is induced.Thus,the complicated and antagonistic machineries are composed of many pro\| and anti\|apoptosis factors.The balancing effects of these factors at various checkpoints of signal transduction culminate in a final decision to die or to live.\;

细胞存活与凋亡之间的平衡是多细胞生物正常发育与稳态的关键。细胞凋亡是受多种因素高度调控的细胞程序性死亡过程。凋亡信号调节激酶 1 (ASK1 )是促分裂原活化蛋白激酶激酶激酶家族的成员之一 ,它分别激活SER1 JNK和MKK3 MKK6 p38途径 ,在细胞因子及应激诱导细胞凋亡过程中起着关键作用。TNF受体和Fas信号转导系统在抗凋亡与促凋亡过程中发挥重要作用 ,其中包括TNF受体Ⅰ相关死亡域蛋白 (TRADD)、Fas相关死亡域蛋白 (FADD)等多种蛋白因子。细胞色素C是线粒体依赖性死亡信号 ,受Bcl 2家族蛋白的调节。反应性氧化合物的氧化激活使硫氧还蛋白 (Trx)氧化 ,并与ASK1分离 ,从而激活ASK1造成细胞凋亡。总之 ,许多促凋亡与抗凋亡因子组成复杂的、相互拮抗的机制。在信号转导的各种不同的关卡上 ,这些因子的平衡作用最终决定细胞的生与死。

Objective To study the effect of apoptosis signal regulating kinase 1(ASK1) protein expression in hypertrophic myocardium in rat models of hypertension.Methods The rat model of hypertension was established by abdominal aortic constriction.Six weeks later,the reactive oxygen species(ROS) level and ASK1 protein expression in myocardium of left ventricle were detected respectively by color matching and Western blotting.Results The left ventricular mass index,ROS level and ASK1 protein expression all increased significantly...

Objective To study the effect of apoptosis signal regulating kinase 1(ASK1) protein expression in hypertrophic myocardium in rat models of hypertension.Methods The rat model of hypertension was established by abdominal aortic constriction.Six weeks later,the reactive oxygen species(ROS) level and ASK1 protein expression in myocardium of left ventricle were detected respectively by color matching and Western blotting.Results The left ventricular mass index,ROS level and ASK1 protein expression all increased significantly in hypertensive rats as compared with those underwent sham operation.Conclusion Under chronic pressure overload,the activated ASK1 with the increasing ROS may play an important role in signal transduction pathway of myocardial hypertrophy.

目的研究凋亡信号调节激酶(apoptosis signal regu lating k inase 1,ASK1)在高血压心脏肥大中的作用。方法复制腹主动脉缩窄高血压大鼠模型,用比色法测定假手术组和高血压组左心室活性氧(reactive oxygen spec ies,ROS)水平,用免疫印迹法测定ASK1蛋白表达。结果高血压大鼠左心室质量指数、ROS水平、ASK1蛋白表达均显著高于假手术组(P<0.05)。结论压力超负荷下随着ROS的升高,激活的ASK1可能在心脏肥大信号传导途径中发挥重要作用。

 
<< 更多相关文摘    
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关凋亡信号调节激酶的内容
在知识搜索中查有关凋亡信号调节激酶的内容
在数字搜索中查有关凋亡信号调节激酶的内容
在概念知识元中查有关凋亡信号调节激酶的内容
在学术趋势中查有关凋亡信号调节激酶的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社