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前列腺癌cap
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     Objective To study the expression of hypo xi a inducible factor-1α(HIF-1α) protein in prostate cancer(CaP) and its biolog ical significance.
     目的 探讨缺氧诱导因子 1α(HIF 1α)蛋白在前列腺癌 (CaP)中的表达及意义。
短句来源
     Objective To investigate the expression of Eph tyrosine kinase receptor A2 (EphA2) and epithelial cadherin (E-cadherin) in prostate cancer (CaP) and its significance.
     目的 探讨Eph受体酪氨酸激酶A2 (EphA2) 和上皮粘连素 (E cadherin) 在前列腺癌 (CaP) 中的表达及其意义。
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     Objective This study was undertaken to investigate the relationship of some single nucleotide polymorphisms (SNPs) of estrogen receptor beta (ERβ) with the risk of prostate cancer (CaP).
     目的研究雌激素受体β(ERβ)的单核苷酸多态性(SNPs)与前列腺癌(CaP)风险的相关性。
短句来源
     a widely studied prostate cancer (CaP) associated mtAR (Ad-mtAR, T877A);
     一个被广泛研究的前列腺癌(CaP)相关的mtAR(Ad-mtAR,T877A);
短句来源
     [Objective] To study the expression and significance of Ezrin in high grade prostatic intraepithelial neoplasm(HGPIN)and prostate cancer(CaP).
     目的探讨埃兹蛋白(Ezrin)在高分级前列腺上皮内瘤(HGPIN)及前列腺癌(CaP)中的表达及意义。
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  相似匹配句对
     Radiotherapy of Prostate Cancer
     前列腺癌的放射治疗
短句来源
     Chemoprevention of Prostate Cancer
     前列腺癌的化学预防
短句来源
     p~(53) GENE MUTATION IN PROSTATE CARCINOMA
     前列腺癌p~(53)基因突变的研究
短句来源
     a widely studied prostate cancer (CaP) associated mtAR (Ad-mtAR, T877A);
     一个被广泛研究的前列腺癌(CaP)相关的mtAR(Ad-mtAR,T877A);
短句来源
     New Study Shows Garlic May Lower Risk of Prostate Cancer
     大蒜可预防前列腺癌(英文)
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  prostatic cancer (cap)
Objective: To diagnose prostatic cancer (CaP) with cDNA macroarray.
      
No simple screening test for prostatic cancer (CaP) is yet available.
      
In recent years, the value of prostatic acid phosphatase (PAP) as a tumor marker for early prostatic cancer (CaP) has been the subject of controversial discussion.
      
The manipulation caused lesions with characteristic prostatic intraepithelial neoplasia or even prostatic cancer (CaP) phenotypes within 30?days, with Hedgehog overexpression demonstrated by immunohistochemistry and Western blot detections.
      
  prostate cancer (cap)
The expression of Omi/HtrA2 was assayed by means of immunohistochemical technique in 41 prostate cancer (Cap), 20 benign prostatic hyperplasia (BPH) and 10 normal prostate (NP) specimens.
      
Background: Neuroendocrine molecules are now believed to play a significant role in the progression of human prostate cancer (CaP), especially in the androgen-independent stage.
      
Prostate cancer (CaP) cells preferentially metastasise to the bone marrow, a microenvironment that plays a substantial role in the sustenance and progression of the CaP tumour.
      
Gly-I activity was consistently more than eightfold higher in prostate cancer (CAP) specimens (n=37) than in non-cancerous (NCP) specimens (n=29).
      
Prostate-specific antigen (PSA) is a potentially useful antigen for targeted T-cell immunotherapy of prostate cancer (CaP).
      
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From 1996 to 1997,serum PSA and PSAD of 26 cases of prostatic cancer and 56 cases ofBpH verified by pathological examination were detectecd .The results showed that PSA had a sensitivity of84. 6% and a specificity of 44. 6% with the cutoff level of 4ng/ml. If 0. 15 as the catoff level of PSAD,the specificity obvionsly reach a higher level (69.6%) but without significant change of its sensitivity(61.5%). When PSA was between 4-10ng/ml, the PSAD level of prostatic cancer group was obviouslyhigher than that of...

From 1996 to 1997,serum PSA and PSAD of 26 cases of prostatic cancer and 56 cases ofBpH verified by pathological examination were detectecd .The results showed that PSA had a sensitivity of84. 6% and a specificity of 44. 6% with the cutoff level of 4ng/ml. If 0. 15 as the catoff level of PSAD,the specificity obvionsly reach a higher level (69.6%) but without significant change of its sensitivity(61.5%). When PSA was between 4-10ng/ml, the PSAD level of prostatic cancer group was obviouslyhigher than that of BpH group(p<0. 05), whatmore the positive rate of prostatic cancer detected by PSADwas higher than by PSA .So we think that when PSA rise slightly with PSAD higher than 0. 15, prostatepuncture biopsy should be undertaken to promote the detective rate of prostatic cancer.

为了评价前列腺特异抗原密度(PSAD)在前列腺癌(CaP)诊断中的作用以及在对前列腺癌和前列腺增生(BpH)的鉴别诊断中的价值。我们于1996年3月-1997年4月对经病理学诊断的26例CaP和56例BpH患者的PSA和PSAD进行了检测研究。结果显示:PSA对CaP诊断的敏感性高,而特异性低;以0.15为界值,PSAD可提高诊断的特异性,而敏感性无明显降低;对于PSA在4-10ng/ml时,CaP组的PSAD值显著高于BpH值(P<0.05),而且在此区间,PSAD对CaP的检出率大于PSA。故认为当PSA轻度升高时,若PSAD>0.15,考虑行前列腺穿刺活捡,可以提高CaP的早期诊断率。

Objective To study the effect of AR and sex hormones as well as change with age on prostatic disease. Methods AR was expressed by dot blot.Sex hormones contents(testosterone?LH?cortisone?estradiol)were determined by radioimmune method. Results A progressive declines of serum testosterone levels and increase of serum LH levels with age were found.Serum cortisol contents were found increased with age.Serum estradiol levels in surveyed men over 40 were higher than that of the men in control group.The estradiol...

Objective To study the effect of AR and sex hormones as well as change with age on prostatic disease. Methods AR was expressed by dot blot.Sex hormones contents(testosterone?LH?cortisone?estradiol)were determined by radioimmune method. Results A progressive declines of serum testosterone levels and increase of serum LH levels with age were found.Serum cortisol contents were found increased with age.Serum estradiol levels in surveyed men over 40 were higher than that of the men in control group.The estradiol concentration did not change more in the men over 50.Dot blot:AR hybrid signal of prostate cancer was stronger than that prostate hyperplasia and prostate tissues. Conclusion Testosterone levels was negatively correlated with age(r=-0.45,P<0.000?1),Chang of LH was opposite.Cortisol contents was positively correlated with age.Analysis of dot blot showed that ARmRNA expression in CaP tissues was higher than that of controls,and that ARmRNA expression in BPH tissues was no difference compared with controls.

目的 研究雄激素受体mRNA的表达和性激素随增龄的变化 ,探讨性激素与增龄对前列腺的影响。方法 通过放射免疫分析、核酸印迹分析 (Dotblot) ,检测性激素 (睾酮、促黄体生成激素、皮质醇、雌二醇 )的含量 ,表达雄激素受体。结果 血清睾酮含量随增龄下降 ,对照组 (2 0~ 39岁 )睾酮含量为 (8 6 7± 3 2 5 )ng/ml,>4 0岁各组均明显降低。血清促黄体生成激素含量随年龄增长而增高。血清皮质醇含量进行性增高 ,4 0~ 4 9岁组增高尤为明显。血清雌二醇的含量以 4 0~ 4 9岁组增高最为明显 ,>5 0岁人群均波动于同一水平上。前列腺癌 (CaP)杂交信号强于前列腺增生 (BPH)与正常前列腺 (NP)组织。结论 血清睾酮含量与年龄呈显著的负相关 (r=- 0 4 5 ,P <0 0 0 0 1) ,促黄体生成激素的变化亦相反。皮质醇含量与年龄呈正相关。前列腺癌组织的ARmRNA高表达 ,而良性前列腺增生的杂交信号与对照组接近 ,

Objective To study the expression of hypo xi a inducible factor-1α(HIF-1α) protein in prostate cancer(CaP) and its biolog ical significance. Methods The expression of HIF-1α wa s assayed by means of immunohistochemical technique in 42 prostate cancer,12 pr ostatic imtraepithelial neoplasia(PIN) and 9 normal prostate tissue(NP) specimen s.Western blot was used to examine the expression of HIF-1α in prostate cancer cell line(PC-3M) induced by different oxygen tension. Results HIF-1α expression was positive in...

Objective To study the expression of hypo xi a inducible factor-1α(HIF-1α) protein in prostate cancer(CaP) and its biolog ical significance. Methods The expression of HIF-1α wa s assayed by means of immunohistochemical technique in 42 prostate cancer,12 pr ostatic imtraepithelial neoplasia(PIN) and 9 normal prostate tissue(NP) specimen s.Western blot was used to examine the expression of HIF-1α in prostate cancer cell line(PC-3M) induced by different oxygen tension. Results HIF-1α expression was positive in 33(78.6%) CaP and 9 PIN specimens , and the positive rate of HIF-1α was higher in distant metastasis patients th an that in patients without metastasis of prostate cancer( P <0.05),while th ere is no expression of HIF-1α in NP.The level of HIF-1α in PC-3M significa ntly increased with the decrease of oxygen tension( P <0.01). Co nclusions Overexpression of HIF-1α is the preliminary incident of the formation of CaP,which may induce carcinoma into malignant phenotype.Thus it may be the early diagnosis parameter and the novel target for CaP treatment.

目的 探讨缺氧诱导因子 1α(HIF 1α)蛋白在前列腺癌 (CaP)中的表达及意义。 方法 应用免疫组化SP法检测 42例CaP和相应癌旁组织 ,12例高分级前列腺上皮内瘤 (PIN )以及 9例正常前列腺组织 (NP)中HIF 1α的表达 ,免疫印迹技术分析不同氧浓度诱导下CaP细胞株PC 3M的HIF 1α蛋白水平。 结果  3 3例 (78.6% )CaP和 9例PIN组织HIF 1α蛋白表达阳性 ,有远处转移的CaP组织中HIF 1α表达显著高于无转移者 (P <0 .0 5) ,癌旁组织及正常前列腺组织中无阳性表达 ;PC 3M细胞株中HIF 1α表达水平随氧浓度减小而明显升高 ,差异有显著性意义 (P <0 .0 1)。 结论 HIF 1α表达是CaP形成的早期事件 ,其水平升高可能导致肿瘤向恶性发展表型 ,HIF 1α可作为CaP的早期诊断指标和治疗新靶点

 
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