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型前胶原肽
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  procollagen type ⅲ
     To evaluate the diagnostic significance of serum hyaluronic acid(HA), laminin(LN), collagen type Ⅳ (Ⅳ - C)and procollagen type Ⅲ (PCⅢ ) for liver cirrhosis in patients with chronic viral hepatitis.
     目的评估血清透明质酸(HA)、Ⅲ型前胶原肽(PC Ⅲ)、层粘蛋白(LN)、Ⅳ型胶原(Ⅳ-C)对病毒性肝炎肝硬化的诊断意义。
短句来源
     lndices of hepatic fibrosis including serum concelntrations of hyalurorhic acid(HA), procollagen type Ⅲ(PCⅢ), collagen type Ⅳ(CⅣ) and laminin(LN) were markedly lowered.
     肝纤维化指标血清透明质酸 (HA)、Ⅲ型前胶原肽 (PⅢP)、Ⅳ型胶原 (C Ⅳ )和层黏蛋白 (LN)浓度明显下降。
短句来源
     Objective To investigate the relations between serum hyaluronic acid(HA),laminin(LN),procollagen type Ⅲ(PCⅢ) and fibrosis of liver in patients with various types of hepatitis.
     目的 探讨各型慢性肝病中血清透明质酸 (HA)、层黏蛋白 (LN)、Ⅲ型前胶原肽 (PCⅢ )含量与肝纤维化的关系。
短句来源
     Results showed that the 319 Recipe could not only improve the clinical symptoms and liver functions, but also reduce the serum levels of monoamine oxidase B activity, tissue inhibitor of metalloproteinase I (TIMP), procollagen typeⅢN-terminal peptide, collagen type Ⅳ, hyaluronic acid and laminin, as well as increase the excretion of droxyproline markedly.
     该方不但能有效地改善肝功能及临床症状,且能降低患者显著增高的血清单胺氧化酶B(MAO-B)活性,金属蛋白酶组织抑制因子-1(TIMP)、Ⅲ型前胶原肽、Ⅳ型胶原、透明质酸及层粘蛋白(LN)的含量,提高尿羟脯氨酸(Hyp)排泄量(P<0.001~0.05)。
短句来源
     The volume of portal vein(QPV)was calculated at the same time. Measurement of liver function,kidney function and the serum makers of liver fibrosis procollagen type Ⅲ(PCⅢ),hyaluronic acid(HA)were done before and after 4-week treatment.
     治疗前后应用彩色多普勒超声诊断仪测定每例患者的肝血流动力学指标:门静脉内径(DPV)、脾静脉内径(DSV)、门静脉平均血流速度(VPV),并计算门静脉血流量(QPV),同时测定治疗前后患者的肝功能、肾功能及血清Ⅲ型前胶原肽(PCⅢ)、透明质酸(HA)。
短句来源
  “型前胶原肽”译为未确定词的双语例句
     The expression of TGFβ 1 protein in liver tissues were detected by immunohistochemical methods in 45 cases with viral hepatitis and cirrhosis,and the serum level of TGFβ 1,hyaluronic acid (HA),laminin(LN),collagen type Ⅳ(Ⅳ-C) and precollagen type Ⅲ(PⅢP)were measured in 21 of these 45 cases.
     对 45例慢性病毒性肝炎病人肝组织进行了TGFβ1免疫组织化学检测 ,同时检测其中 2 1例血清TGFβ1及血清透明质酸 (HA)、层粘蛋白 (LN)、Ⅳ型胶原 (Ⅳ -C)、Ⅲ型前胶原肽 (PⅢP)水平。
短句来源
     RESULTS Serum levels of typeⅢ procollagen peptide)pⅢp)and hyaluronic acid)HA)were significantly lower comparedto oretreatment)P<0.01).
     结果:血清Ⅲ型前胶原肽(PⅢP)及血清透明质酸(HA)含量与治疗前相比明显降低(P<0.01);
短句来源
     Before treatment. the average values of HA and P P were 245. 89 148. 49 ng/ml and 261. 89 134. 42 g/L respectively ; and afer treatment decreased to 125. 43=85. 46 ng,/ml and 144. 04 83. 99 g/L (P = 0. 000 ), respectively.
     结果显示改良小柴胡汤治疗可使血清透明质酸(HA)和Ⅲ型前胶原肽(PⅢP)由治疗前的245.89±148.49 ng/ml和261.89±134.42μg/L分别降至125.43±85.46 ng/ml和144 04±83.99μg/L(P=0.000),均优于对照组;
短句来源
     Dynamic Detection of Serum Type Ⅲ Procollagen Peptide in Patients with Viral Hepatitis
     病毒性肝炎患者血清Ⅲ型前胶原肽的动态检测
短句来源
     30 and 45 days after treatment, the serum HA, PⅢP, LN and Ⅳ -C were al so decreased significantly (P<0.05 or 0.01).
     血清透明质酸 (HA)、Ⅲ型前胶原肽 (PⅢP)、层粘蛋白 (LN)、Ⅳ型胶原 (Ⅳ -C)在治疗 3 0、45d后也明显降低 (P <0 .0 5或 0 .0 1)。
短句来源
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  相似匹配句对
     Detection of serum procollagen Ⅲ peptide in tubercu-lous patients
     肺结核患者血清Ⅲ前胶原的检测分析
短句来源
     Dynamic Detection of Serum Type Ⅲ Procollagen Peptide in Patients with Viral Hepatitis
     病毒性肝炎患者血清Ⅲ前胶原的动态检测
短句来源
     (3)D shape.
     D
短句来源
     (2)C shape;
     C ;
短句来源
     Diagnostic significance of serum type Ⅲ procollagen Naminoterminal peptide(P Ⅲ P) in liver fibrosis
     血清Ⅲ前胶原对肝纤维化的诊断价值
短句来源
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The present study is concerned with the fibronectin(Fn) distribution,the formation character and its source in atherosclerotic lesi- ons using immunohistochmical and immunoelectronic microscopy.The resu- lts showed that large amount of Fn was localized in fatty streaks,gelati- nous lesions and early atherosclerotic plaques.The smooth muscle cells of intima synthesize more Fn in atherosclerotic lesions.It is likely that Fn represents a new marker of smooth muscle cell modulating from “contrac- tile”to“synthetic”state.With...

The present study is concerned with the fibronectin(Fn) distribution,the formation character and its source in atherosclerotic lesi- ons using immunohistochmical and immunoelectronic microscopy.The resu- lts showed that large amount of Fn was localized in fatty streaks,gelati- nous lesions and early atherosclerotic plaques.The smooth muscle cells of intima synthesize more Fn in atherosclerotic lesions.It is likely that Fn represents a new marker of smooth muscle cell modulating from “contrac- tile”to“synthetic”state.With the maturation of atherosclerotic plaque, Fn does not fill the whole plaque but is concentrated only in the fibrous cap surface and basocentral atheroma.We also prove that proeollagen Ⅲ peptide(PⅢP)distribution in atherosclerotic plaque is similar to Fn.

应用免疫组织化学和免疫电镜技术,研究人体动脉粥样硬化病灶纤维连接蛋白的分布、形态特征和来源,结果发现在脂纹、胶样病变及早期斑块的内膜上有大量纤维连接蛋白沉积。纤维连接蛋白主要由内膜平滑肌细胞合成,平滑肌细胞表达纤维连接蛋白的能力也可能是反映其表型改变的一个标志。随着斑块的成熟、纤维化,纤维连接蛋白则减少。动脉粥样硬化斑块Ⅲ型前胶原肽的分布与纤维连接蛋白具有一致性。

Serum procollagen,Ⅲ peptide (PⅢ p) concentrations were measured by RIA in 38 patients with hepatolenticular de-generation(HLD).The mean level in HLD (18.34±12.42ng/ml) was significantly higher than that in control group(7.49±0.81ng/ml,P<0.001).In some mild patients serum PⅢP contents could decrease to normal range 2 years after pe-nicillamine treatment.The results suggested that serum PⅢP level of HLD might reflect not only the activity and degree of liver fibrosis,but also hepatocelluar necroinflammation.The...

Serum procollagen,Ⅲ peptide (PⅢ p) concentrations were measured by RIA in 38 patients with hepatolenticular de-generation(HLD).The mean level in HLD (18.34±12.42ng/ml) was significantly higher than that in control group(7.49±0.81ng/ml,P<0.001).In some mild patients serum PⅢP contents could decrease to normal range 2 years after pe-nicillamine treatment.The results suggested that serum PⅢP level of HLD might reflect not only the activity and degree of liver fibrosis,but also hepatocelluar necroinflammation.The determination of PⅢP levels may have clinical values in estimating the tendency of cirrhosis and medicine therapeutic effectiveness.

本文用放射免疫分析法测定了38例HLD患者血清Ⅲ型前胶原肽(PⅢP)的含量,其均值为18.34±12.42ng/ml,较正常对照组7.49±0.81ng/ml明显增高,经青霉胺治疗后的部分轻症患者血清PⅢP水平可恢复正常。认为HLD患者血清PⅢP的检测为反映肝纤维化活动性、程度及肝细胞炎症、坏死的灵敏指标,定期监测对肝硬化的趋势及药物疗效的评估均具有临床价值。

The levels of serum PⅢP were measured in 14 patients with chronic active hepatitis (CAH) and 6 patients with liver cirrhosis (Cir). The results showed that the levels of serum PⅢP of both CAH and Cir group were significantly higher than the normal value, but there is no difference between CAH group and Cir group; the levels of serum PⅢP was not in parallel with the severity of CAH or Cir. It is suggested that using PⅢP as an index for judging the severity of CAH or Cir is not recommendable.

以放射免疫法测定了14例慢性活动性肝炎(CAH)和6例肝硬化(Cir)患者的血清Ⅲ型前胶原肽(PⅢP)水平。结果发现CAH和Cir两组患者的血清PⅢP水平均明显高于正常值(P<0.05),但两组间无明显差异:血清PⅢP水平与肝组织炎症及纤维化程度无相关性。提示不能以血清PⅢP为指标来判断肝组织炎症及纤维化的严重程度。

 
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