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模拟代谢物
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  putative metabolites
     Synthesis and Antihypertensive Activity of α_1-Andrenoceptor Antagonist DDPH Putative Metabolites
     α_1受体拮抗剂DDPH模拟代谢物的合成及其降压活性
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  “模拟代谢物”译为未确定词的双语例句
     Eleven putative mitabolites of DDPH were designed and synthesized by condensation,reduction of substituted phenoxypropanone (Ⅶ 1)~(Ⅶ 3),(Ⅷ) and 3,4 substituted phenethylamine(Ⅲ 1)~(Ⅲ 3).
     设计并合成了 11个α1受体拮抗剂DDPH模拟代谢物 (Ⅰ1)~ (Ⅰ11) . 目的物以相应的醚酮 (Ⅶ1)~ (Ⅶ3 ) ,(Ⅷ )和取代苯乙胺 (Ⅲ1)~ (Ⅲ3 )经缩合、还原及成盐制得 .
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  相似匹配句对
     Statistical Simulation
     统计模拟
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     Simulation of distillation process
     精馏过程的模拟
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     (2) secondary metabolite synthesis;
     (2)次生代谢物的合成;
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     Advances in the Research of Resveratrol Metabolins
     白藜芦醇代谢物的研究进展
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     Enzyme Immunoassay of Pesticides and Metabolites.
     农药及其代谢物的酶免疫分析技术
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  putative metabolites
The retention behaviour of chlorproguanil and its putative metabolites chlorcycloguanil and 3,4-dichlorophenylbiguanide has been studied on a reversed phase chromatographic system incorporating sodium lauryl sulphate as hydrophobic pairing ion.
      
In the control group, 86 of the paclitaxel dose was recovered in bile as five putative metabolites, which were measured in paclitaxel equivalents, with the major metabolite.
      
Binding affinities of rimexolone (ORG 6216), flunisolide and their putative metabolites for the glucocorticoid receptor of human
      
Its pharmacological effects at a molecular level in comparison to structurally related neuroleptics and putative metabolites are reviewed.
      
To study the reaction of artelinic acid with chemical model systems of cytochrome P-450 as a means of obtaining authentic samples of the putative metabolites necessary for identification of the mammalian metabolites of artelinic acid.
      
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Eleven putative mitabolites of DDPH were designed and synthesized by condensation,reduction of substituted phenoxypropanone (Ⅶ 1)~(Ⅶ 3),(Ⅷ) and 3,4 substituted phenethylamine(Ⅲ 1)~(Ⅲ 3).The compounds (Ⅶ 1)~(Ⅶ 2) were prepared by nitration,reduction,diazotization,hydrolytic action of 2,6 dimethylphenoxypropane.The compound (Ⅶ) was prepared from 2 methylphenol via hydroxymethylation and then condensation with bromoacetone.The structures of the target compounds and imprortant intermediated products were...

Eleven putative mitabolites of DDPH were designed and synthesized by condensation,reduction of substituted phenoxypropanone (Ⅶ 1)~(Ⅶ 3),(Ⅷ) and 3,4 substituted phenethylamine(Ⅲ 1)~(Ⅲ 3).The compounds (Ⅶ 1)~(Ⅶ 2) were prepared by nitration,reduction,diazotization,hydrolytic action of 2,6 dimethylphenoxypropane.The compound (Ⅶ) was prepared from 2 methylphenol via hydroxymethylation and then condensation with bromoacetone.The structures of the target compounds and imprortant intermediated products were certified by elemental analysis,IR, 1H NMR and MS.The compounds (Ⅰ 1)~(Ⅰ 8 ) were tested for the antihypertensive activity in rats and the results showed that (Ⅰ 5) had mardedly antihypertensive activities.

设计并合成了 11个α1受体拮抗剂DDPH模拟代谢物 (Ⅰ1)~ (Ⅰ11) .目的物以相应的醚酮 (Ⅶ1)~ (Ⅶ3 ) ,(Ⅷ )和取代苯乙胺 (Ⅲ1)~ (Ⅲ3 )经缩合、还原及成盐制得 .化合物 (Ⅶ1) ,(Ⅶ2 )是以 2 ,6 二甲苯氧丙酮经硝化、还原、重氮化、水解制得 .化合物 (Ⅷ )以 2 甲苯酚为原料 ,经羟甲基化并与溴丙酮缩合制得 .目的物及重要中间体的结构经元素分析、红外光谱、核磁共振谱和质谱确证 .目的物的急性降压试验表明 :部分目的物有不同程度的降压活性 ,其中 (Ⅰ5)尤为明显

AIM To study the phase I metabolites of phenoprolamine hydrochloride (DDPH) in rat bile. METHODS DDPH was administered ip to bile duct cannulated rats. Bile samples were collected before administration and up to 12 h after administration. After being treated with β glucuronidase, the bile samples were purified and enriched with C 18 SPE columns, and then were analyzed by LC/DAD/MSD. The samples containing synthesized reference standards of DDPH metabolite 1 (2,6 dimethylphenoxy) 2 (3 methoxy 4 hydroxyphenylethylamino)...

AIM To study the phase I metabolites of phenoprolamine hydrochloride (DDPH) in rat bile. METHODS DDPH was administered ip to bile duct cannulated rats. Bile samples were collected before administration and up to 12 h after administration. After being treated with β glucuronidase, the bile samples were purified and enriched with C 18 SPE columns, and then were analyzed by LC/DAD/MSD. The samples containing synthesized reference standards of DDPH metabolite 1 (2,6 dimethylphenoxy) 2 (3 methoxy 4 hydroxyphenylethylamino) propane (M 1), 1 (2,6 dimethyl 3 hydroxyphenoxy) 2 (3,4 methoxy phenylethylamino) propane (M 2), 1 (2,6 dimethyl 4 hydroxyphenoxy) 2 (3,4 methoxyphenylethylamino) propane (M 3), 1 (2,6 dimethyl 4 hydroxyphenoxy) 2 (3 hydroxy 4 methoxyphenylethylamino) propane (M 4), 1 (2,6 dimethyl 3 hydroxyphenoxy) 2 (3 hydroxy 4 methoxyphenylethylamino) propane (M 5) and 1 (2,6 dimethyl 4 hydroxyphenoxy) 2 (3 methoxy 4 hydroxyphenylethylamino) propane (M 6) were analyzed by LC/DAD/MSD under identical conditions. RESULTS The retention times, UV spectra, molecular weights and production spectra (obtained by collision induced dissociation)of the apparent ions of peak A, B, C, D, E and F in the total ion chromatogram of DDPH treated rat bile sample were consistent with those of M 1, M 2, M 3, M 5, M 4 and M 6, respectively. CONCLUSION M 1, M 2, M 3, M 4, M 5 and M 6 were identified as the phase I metabolites of DDPH in the rat.

目的 研究大鼠服药后胆汁中盐酸非洛普 (DDPH)I相代谢物。方法 大鼠做胆管插管 ,分别收集ipDDPH之前的空白胆汁及服药后 12h内的服药胆汁 ,将大鼠胆汁以葡糖醛酸酶水解后进C 18SPE小柱进行纯化富集 ,再进行LC/DAD/MSD分析 ;同时将合成的 6个DDPH模拟代谢物M1-M6的对照品混合液按相同条件进行LC/DAD/MSD分析对照。结果 大鼠服药胆汁色谱图中峰A ,B ,C ,D ,E和F分别与M1,M2 ,M3,M5,M4 和M6的保留时间、紫外吸收光谱、分子量及碎片离子完全一致。结论 M1,M2 ,M3,M4 ,M5和M6为大鼠ipDDPH后产生的体内I相代谢物

 
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