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移植肾
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     Data Bank Management System for Renal Transplantation
     移植数据库管理系统
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     Nierentransplantation bei Kindern
     儿童移植
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  cadaveric kidney transplantation
A 45-year-old man with end-stage renal disease underwent a cadaveric kidney transplantation.
      
It may be concluded that cadaveric kidney transplantation can be performed safely in patients older than 60 years of age.
      
Those who presented with interstitial fibrosis declined to endstage renal failure after 13 months requiring chronic hemodialysis treatment or cadaveric kidney transplantation.
      
The effect of α-human atrial natriuretic peptide on the incidence of acute renal failure in cadaveric kidney transplantation
      
Fifty-one pediatric patients undergoing a first cadaveric kidney transplantation were followed for at least 2 years after grafting.
      
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The main targets of acute rejection (AR) in transplanted kidneys had been proved to be vascular endothelial cells and tubular epithelial cells (TEC) in clinical and animal experiments during the last 14 years. The easiness of technique, harmless to the transplanted kidneys and fastness to report the results (2 hours) by counting TEC in 10—15 cc urine sediment provide a better method for its rapidity and realiability for the diagnosis of AR than biopsies of the transplanted kidneys.

14年来移植肾急性排异(AR)的靶位经临床和动物试验研究已明确为脉管内皮细胞和肾小管上皮细胞(TEC)。在10~15毫升尿沉渣做TEC计数是一种简便、无害且在2小时可出结果的技术,此法较移植肾活检安全、快速且可靠是其优点。从1977年10月至1978年9月尿TEC研究结果如下:(1)23例健康人都无TEC,13例移植前尿毒症仅0~5 TEC;(2)在移植后病人尿TEC数少于15为阴性,15~25为可疑,26及以上为阳性;(3)移植直后,肾如受急性肾小管坏死损伤TEC阳性时并非AR;(3)一年间共测知54次AR,其中51次在TEC阳性前3天至后2天出现临床AR;有三次AR未被TEC测知。故此TEC所诊断的AR率为94%。

From September 1975 to May 1978, 20 uremic patients were transplanted with cadaveric kidneys There were 15 males and 5 females, and their age 17 to 56 years old. Their primary causes of renal failure were chronic glomerulonephritis in 15 cases, chronic pyelonephritis in 2 cases, and renal tuberculosis, polycystic kidneys and irreversible compressive symdrome each in 1 case Before transplanlat(?)or(?) 10 cases were suffered from severe cardiac failure and their symptoms were nol improved even under adequate bemodialysis....

From September 1975 to May 1978, 20 uremic patients were transplanted with cadaveric kidneys There were 15 males and 5 females, and their age 17 to 56 years old. Their primary causes of renal failure were chronic glomerulonephritis in 15 cases, chronic pyelonephritis in 2 cases, and renal tuberculosis, polycystic kidneys and irreversible compressive symdrome each in 1 case Before transplanlat(?)or(?) 10 cases were suffered from severe cardiac failure and their symptoms were nol improved even under adequate bemodialysis.

从1975年9月至1978年5月对15名男性、5名女性尿毒症病人做了尸体肾移植。年龄17到56岁。他们的肾衰原因有15例为慢性肾小球肾炎、2例为慢性肾盂肾炎,1例肾结核、1例多囊肾和1例不可逆的挤压综合征,移植前有10例患严重心衰而且在适当的血透析下心衰症状仍不能改善。从这20例尸体肾移植我们取得的主要经验是移植肾的初始功能对移植肾的后果是很重要的。在我们这组最初20例的尸体肾移植,至1980年1月有8例仍以有功能肾存活,故此2年的有功能肾存活率为40%尚优于日本。

From March 1979,hypertonic citrate adenine solution(HC-A),composed of K~+80 mM/L,Na~+ 80 mM/L,MgSO_4 41 mM/L,citrate 55 mM/L,mannitol 30.2 g/L andadenine 0.38 mM/L,was used for preservation of kidneys in dog experiments.Usinghypothermic HC-A solution for single flushing and storage,the canine kidneys weresuccessfully preserved for 12,24,48 and 72 hr before autotransplantation,the onemonth survival rate being over 71%.From Dec.1979 to May 1980,this method was applied clinically in 7 cases.The cadaveric kidneys,after...

From March 1979,hypertonic citrate adenine solution(HC-A),composed of K~+80 mM/L,Na~+ 80 mM/L,MgSO_4 41 mM/L,citrate 55 mM/L,mannitol 30.2 g/L andadenine 0.38 mM/L,was used for preservation of kidneys in dog experiments.Usinghypothermic HC-A solution for single flushing and storage,the canine kidneys weresuccessfully preserved for 12,24,48 and 72 hr before autotransplantation,the onemonth survival rate being over 71%.From Dec.1979 to May 1980,this method was applied clinically in 7 cases.The cadaveric kidneys,after HC-A preservation for 12hr 38 min to 30 hr 38 min,averaging 23 hr 22 min,were transplanted without post-operative acute renal failure.The patients' serum creatinine value returned to normaland all kidneys were functioning well one month after transplantation.

本文报道犬肾保存12~72小时后自体移植术71次,总的1月以上存活率为62%,无一只死于术后急性肾功能衰竭,术后同位素检查、肾动脉造影及肾组织活检均正常。临床应用7例,肾保存时间平均为23小时22分钟,无一例发生术后急性肾功能衰竭,血清肌酐于术后1个月内降至正常范围,术后1个月移植肾有功能者为100%。

 
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