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人膀胱癌相关蛋白
相关语句
  homo sapiens bladder cancer associated protein gene
     Objective: To identify the single nucleotide polymorphisms (SNPs) in the regulatory and coding regions of homo sapiens bladder cancer associated protein gene (BLCAP) and to assess their potential effect on the function of BLCAP.
     目的:检测人膀胱癌相关蛋白(BLCAP)基因编码区及调控区的单核苷酸多态性(SNPs),并初步探讨其可能对人BLCAP基因功能的影响以及与宫颈癌发病易感性的关系。
短句来源
  sapiens bladder cancer associated protein
     Objective: To investigate the relationship between two single nucleotide polymorphisms (SNPs) within Homo sapiens bladder cancer associated protein (BLACP) gene and cervical carcinoma.
     目的 :检测人膀胱癌相关蛋白 (BLACP)基因调控区的单核苷酸多态性 (SNP)及其基因型在宫颈癌高发区———湖北省五峰县土家族人群中的分布情况 ,并分析其不同基因型与原发性宫颈癌的相关性。
短句来源
     To analyze the cervical carcinoma specimen with an oncogene and anti-oncogene cDNA microarray. We found that Homo sapiens bladder cancer associated protein(BLCAP) gene down-expressed.
     人膀胱癌相关蛋白 (BLCAP)基因是本研究室从细胞原癌、抑癌基因分类芯片中筛选并克隆的宫颈癌候选抑癌基因。
短句来源
     Objective: To identify the single nucleotide polymorphisms (SNPs) in the regulatory and coding regions of homo sapiens bladder cancer associated protein gene (BLCAP) and to assess their potential effect on the function of BLCAP.
     目的:检测人膀胱癌相关蛋白(BLCAP)基因编码区及调控区的单核苷酸多态性(SNPs),并初步探讨其可能对人BLCAP基因功能的影响以及与宫颈癌发病易感性的关系。
短句来源
  “人膀胱癌相关蛋白”译为未确定词的双语例句
     Structural and Functional Prediction of BLCAP Gene and Its Encoded Protein
     人膀胱癌相关蛋白基因及其编码蛋白质的结构及功能预测
短句来源
  相似匹配句对
     Human Telomeric Protein
     端粒相关蛋白
短句来源
     EXPRESSION OF MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN GENE IN HUMAN BLADDER CANCER
     膀胱癌多药耐受相关蛋白基因表达的意义
短句来源
     Human Protein C Development and Correlated Study
     蛋白C的研制及其相关研究
短句来源
     Structural and Functional Prediction of BLCAP Gene and Its Encoded Protein
     膀胱癌相关蛋白基因及其编码蛋白质的结构及功能预测
短句来源
     Identification of Tumor-associated Proteins in Human Gastric Carcinoma
     胃癌癌变相关蛋白分子的筛选
短句来源
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Objective: To investigate the relationship between two single nucleotide polymorphisms (SNPs) within Homo sapiens bladder cancer associated protein (BLACP) gene and cervical carcinoma. Methods: These two single nucleotide polymorphisms (SNPs) within BLACP gene were studied in this experiment, by means of dynamic allele specific hybridization (DASH) in 30 unrelated case subjects and 60 control subjects which matched to the cervical carcinoma cases in age and residence. Results: Significant results were obtained...

Objective: To investigate the relationship between two single nucleotide polymorphisms (SNPs) within Homo sapiens bladder cancer associated protein (BLACP) gene and cervical carcinoma. Methods: These two single nucleotide polymorphisms (SNPs) within BLACP gene were studied in this experiment, by means of dynamic allele specific hybridization (DASH) in 30 unrelated case subjects and 60 control subjects which matched to the cervical carcinoma cases in age and residence. Results: Significant results were obtained for one SNP site (rs3795147), which was located at 711bp down-stream of BLACP gene. SNP rs3795147 had three kinds of genotype: AA, AC and CC. The relative risk of genotype CC was 33.333 and that of genotype AC was 3.761 . Conclusion: The result has proved again that BLACP gene may play a certain role in the development of cervical carcinoma, for the SNP site rs3795147 may have influence on the expression of BLACP gene.

目的 :检测人膀胱癌相关蛋白 (BLACP)基因调控区的单核苷酸多态性 (SNP)及其基因型在宫颈癌高发区———湖北省五峰县土家族人群中的分布情况 ,并分析其不同基因型与原发性宫颈癌的相关性。方法 :采用病例 对照研究方法及动态等位基因杂交 (DASH)技术 ,对 30例原发性宫颈癌患者和 6 0例正常人BLACP基因调控区的 2个单核苷酸多态性 (SNP)位点进行检测。结果 :位于BLACP基因下游调控区的SNPrs3795 14 7位点存在AA、AC和CC 3种基因型 ,且与宫颈癌发病存在显著相关性 ,其中基因型CC和AC的相对危险度分别为 33.333和 3.76 1;位于BLACP基因上游调控区的SNPrs3795 14 8位点存在CC、CT和TT3种基因型 ,但其等位基因型频率和等位基因频率在宫颈癌患者与正常人群之间无明显差异。结论 :BLACP基因上SNP位点型别的不同 ,可能导致了个体对宫颈癌的易感性不同。

To analyze the cervical carcinoma specimen with an oncogene and anti-oncogene cDNA microarray. We found that Homo sapiens bladder cancer associated protein(BLCAP) gene down-expressed. After a series of experiments, we ascertained that BLCAP gene was a candidate tumor suppressor gene for cervical carcinoma. In order to definitude the function of BLCAP gene in the development of human cervical carcinoma, we studied two single nucleotide polymorphisms (SNPs) within BLCAP gene in this experiment. We analysed 30...

To analyze the cervical carcinoma specimen with an oncogene and anti-oncogene cDNA microarray. We found that Homo sapiens bladder cancer associated protein(BLCAP) gene down-expressed. After a series of experiments, we ascertained that BLCAP gene was a candidate tumor suppressor gene for cervical carcinoma. In order to definitude the function of BLCAP gene in the development of human cervical carcinoma, we studied two single nucleotide polymorphisms (SNPs) within BLCAP gene in this experiment. We analysed 30 unrelated cervical carcinoma cases and 60 control subjects, which matched to the cervical carcinoma cases in age and residence, by means of dynamic allele specific hybridization (DASH). Significant results were obtained from one SNP site (rs3795147), which was located at 711bp down-stream of BLCAP gene. SNP rs3795147 had three kinds of genotype:AA,AC and CC, and results of χ 2 test showed that the frequencies of different genotypes resulted in cervical carcinoma cases and control subjects were significantly different(P<0.01). The result proves again that BLCAP gene plays a certain role in the development of cervical carcinoma, for the SNP site rs3795147 may influence the expression of BLCAP gene.

人膀胱癌相关蛋白 (BLCAP)基因是本研究室从细胞原癌、抑癌基因分类芯片中筛选并克隆的宫颈癌候选抑癌基因。为检测该基因调控区的单核苷酸多态性 (SNP)及其不同基因型与宫颈癌的相关性 ,采用病例 对照研究方法及动态等位基因杂交 (DASH)技术 ,对 30例原发性宫颈癌患者和 6 0例正常人BLCAP基因调控区的 2个SNP位点进行了检测。结果显示 :位于BLCAP基因下游调控区的SNPrs3795 14 7位点存在AA、AC和CC 3种基因型 ,且与宫颈癌发病存在显著相关性 (P <0 0 1)。SNPrs3795 14 7处在BLCAP基因下游调控区域 ,其多态类型可能在某种程度上影响BLCAP基因的表达调控 ,从而进一步支持了 :BLCAP基因与宫颈癌的发生、发展可能存在密切关系。

Objective: To identify the single nucleotide polymorphisms (SNPs) in the regulatory and coding regions of homo sapiens bladder cancer associated protein gene (BLCAP) and to assess their potential effect on the function of BLCAP. Methods: Seven SNPs were identified by the means of sequencing and dynamic allele specific hybridization (DASH) in 30 unrelated case subjects and 60 control subjects that matched to the cervical carcinoma cases in age and residence. Among them, five were in regulatory region and two...

Objective: To identify the single nucleotide polymorphisms (SNPs) in the regulatory and coding regions of homo sapiens bladder cancer associated protein gene (BLCAP) and to assess their potential effect on the function of BLCAP. Methods: Seven SNPs were identified by the means of sequencing and dynamic allele specific hybridization (DASH) in 30 unrelated case subjects and 60 control subjects that matched to the cervical carcinoma cases in age and residence. Among them, five were in regulatory region and two in coding region. Results: One SNP site (rs3795147) that was located in the down-stream of BLCAP gene has three kinds of genotype as AA, AC and CC. The relative risk of genotype AA was 33.333 and that of genotype AC was 3.761. Conclusion: BLCAP gene may play a certain role in the development of cervical carcinoma, for the SNP site rs3795147 may influence on the expression of BLCAP gene.

目的:检测人膀胱癌相关蛋白(BLCAP)基因编码区及调控区的单核苷酸多态性(SNPs),并初步探讨其可能对人BLCAP基因功能的影响以及与宫颈癌发病易感性的关系。方法:采用病例对照研究、直接测序及动态等位基因杂交(DASH)技术检测该基因的7个SNP位点其中包括调控区5个、编码区2个,以确定人群中BLCAP基因SNP的类型。结果:位于BLCAP基因下游调控区的SNPrs3795147位点基因型频率和等位基因频率在癌症组和正常对照组间差异有显著性,其中基因型AA和AC的相对危险度分别为33.333和3.761。结论:BLCAP基因可能与宫颈癌发生的易感性密切相关。

 
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