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肿瘤诱导分化
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  antitumor differentiation
     The present study was conducted to define the effect of 4-PA,a new antitumor differentiation inducer, on the proliferation and apoptosis of BEL-7402 cells was studied.
     应用MTT、流式细胞术研究了新型肿瘤诱导分化剂4- PA 对人肝癌细胞系BEL- 7402 细胞的生长调控、诱导凋亡作用。
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  “肿瘤诱导分化”译为未确定词的双语例句
     Theoretical Study of Radioprotective Agents DMSO, As_2O_3 as Differentiation-inducing Agent and Apoptotic Agent for Tumor Cells
     辐射防护剂DMSO、As_2O_3及其作为肿瘤诱导分化剂、凋亡剂的研究
短句来源
     With the unceasing progression of realization to induction differentiation recently, the experimental result of animal solid tumor suggests that induction differentiation therapy may turn into another breach to the treatment of human solid tumor.
     随着对肿瘤诱导分化认识的不断深化,尤其是诱导分化在实体瘤动物实验中的治疗结果,提示该方法可能会成为人实体肿瘤治疗的又一突破点。
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     [Objective] Differentiation therapy against tumor was initiated fromexperimental therapy on leukemia.
     [目的]肿瘤诱导分化治疗研究始于白血病,我国陈氏在该领域的研究处于国际领先地位,然而在实体瘤诱导分化治疗方面的研究相对滞后,迄今仍以体外研究为主。
短句来源
     Thus, it is a key to search for non-toxic and natural origin substances that can induce the differentiation of cancer cells efficiently, especially for the therapy of solid tumor, which needs futher studies and researches to resolve.
     因此,寻找低毒高效的肿瘤诱导分化剂对实体肿瘤诱导分化治疗具有十分重要的实用价值和意义。
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     Subtraction hybridization of cDNA libraries prepared from untreated and treated melanoma cells identified a novel melanoma differentiation-associated (mda) cDNA, mda-7, which displayed elevated expression in treated melanoma cells.
     他们将体外肿瘤诱导分化治疗模型—黑色素瘤细胞,经人成纤维细干扰素(IFN-β)和蛋白激酶C的激活剂mezerein(MEZ)共同处理后,诱导其生长抑制并引发了终末分化,将未处理和处理后黑色素瘤细胞的cDNA文库进行减数杂交,从而首次发现了后者有一新的黑色素瘤分化相关基因(mda-7)。
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  相似匹配句对
     THE MODEL OF HUMAN TUMOR-CELL-INDUCING DIFFERENTIATION
     人类肿瘤细胞诱导分化模型的建立
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     Inducing Differentiation Effect of Gambogic Acid on Tumor Cells
     藤黄酸对肿瘤细胞诱导分化作用的探讨
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     Objectives: The induction of differentiation therapy for cancer is a new field in the research of tumor treatment.
     目的:肿瘤诱导分化疗法是肿瘤治疗学研究的新领域。
短句来源
     Microcalorimetric Study on Induced Differentiation of Tumour Cells by Drug
     微量热法研究药物对肿瘤细胞的诱导分化作用
短句来源
     Objective To set up a cell model of human tumor cell inducing differentiation.
     ①目的 建立肿瘤细胞诱导分化的模型。
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The present study was conducted to define the effect of 4-PA,a new antitumor differentiation inducer, on the proliferation and apoptosis of BEL-7402 cells was studied. The IC50 of 4-PA on the proliferation of BEL-7402 ranges from 4 to 9mmol/L and increases with time going on. The effect of 4-PA is as short as 0.5 hour versus 12hours of 5-FU and DDP. The inhibitory rate increases with time and 4-PA concentration, and gets saturated after reaching the maximum. It indicates that 4-PA has cell circle speciality...

The present study was conducted to define the effect of 4-PA,a new antitumor differentiation inducer, on the proliferation and apoptosis of BEL-7402 cells was studied. The IC50 of 4-PA on the proliferation of BEL-7402 ranges from 4 to 9mmol/L and increases with time going on. The effect of 4-PA is as short as 0.5 hour versus 12hours of 5-FU and DDP. The inhibitory rate increases with time and 4-PA concentration, and gets saturated after reaching the maximum. It indicates that 4-PA has cell circle speciality on cell proliferation. The rapid effect is related to its molecule small in site, easy to penetrate cell membrane and affecting gene expression. The results of cell circle and apoptosis by flow cytometry show that 4-PA has a strong inhibition and reversal effect on the cell proliferating phases(S and G2 phases),and makes the cells stop mainly in G1 phase.The percentage of cell apoptosis increases with treating time and 4-PA concentration. The apoptosis cells comes mainly from cell proliferating phases(S and G2 phases).

应用MTT、流式细胞术研究了新型肿瘤诱导分化剂4- PA 对人肝癌细胞系BEL- 7402 细胞的生长调控、诱导凋亡作用。结果表明: 4 - PA 对BEL- 7402 细胞增殖抑制的IC50 为4 -9m mol/L,随着作用时间的增加,IC50 增加。作用效果迅速,在0 .5 小时就有效地抑制了细胞增殖,抑制率随4- PA 浓度的增加和作用时间的延长而增加,在达到最大抑制率后出现饱和。流式细胞仪对细胞周期和细胞凋亡的分析发现:4 - PA 对细胞增殖期(S期、G2 期) 有较强的抑制和逆转作用,使细胞群截止在G1 期。随着作用时间的延长和4 - PA 浓度的增加,细胞凋亡的比例增加,凋亡细胞多来自于细胞增殖期(S 期、G2 期) 。诱导凋亡和使细胞截止于细胞静息期是4 - PA 抑制细胞增殖的主要途径。

Objective To investigate the relationship between induction of differentiation of T24 cell lines and alteration of telomerase activity.Methods T24 cell lines were induced by all trans retinoic acid (ATRA);Telomerase activity was measured by Polymerase Chain Reaction Enzyme Linked Immunosorbent Assay(PCR ELISA) after induction of T24 cell lines;Cell cycle was detected by flow cytometry (FCM).Results The cell cycle dynamics of T24 cell lines was changed signifiacntly after induction of differentiation with...

Objective To investigate the relationship between induction of differentiation of T24 cell lines and alteration of telomerase activity.Methods T24 cell lines were induced by all trans retinoic acid (ATRA);Telomerase activity was measured by Polymerase Chain Reaction Enzyme Linked Immunosorbent Assay(PCR ELISA) after induction of T24 cell lines;Cell cycle was detected by flow cytometry (FCM).Results The cell cycle dynamics of T24 cell lines was changed signifiacntly after induction of differentiation with ATRA:the ratio of stage S cells decreased gradually,while the ratio of stage G 0/G 1 cells increased gradually;telomerase activity was significantly inhibited with the inhibitory ratios of telomerase activity being 10.9%,34.7%,81.2%,92.5% respectively after treated with ATRA for 1,3,5,7 day,which were compared with control group.Telomerase activity wasn't inhibited by differentiation inducing agents directly,which indicated that the inhibition of telomerase activity responded to the induction of differentiation and the loss of telomerase activity was colsely associated with the state of the celluar differentiation.Conclusion The cell cycle dynamics was changed and the telomerase activity was inhibited after T24 cell lines induced by ATRA,which could provide the theoretical basis of bladder carcinoma differentiation inducing therapy.

目的 探讨人膀胱肿瘤T2 4细胞诱导分化治疗与端粒酶活性改变的关系。方法 用全反式维甲酸 (ATRA)诱导分化人膀胱肿瘤T2 4细胞 ,用聚合酶链反应 酶联免疫吸附试验(PCR ELISA)法检测T2 4细胞诱导分化后端粒酶活性变化 ,用流式细胞术检测细胞周期动力学改变。结果 T2 4细胞经ATRA诱导分化后 ,细胞周期动力学发生改变 :S期细胞所占比例逐渐降低 ,G0 /G1 期细胞所占比例逐渐增加 ;端粒酶活性被明显抑制 ,与对照组比较 ,ATRA处理后 1、3、5、7d端粒酶活性抑制率分别为 1 0 .9%、34 .7%、81 .2 %、92 .5 % ;端粒酶活性的高低与细胞所处的分化状态有关。结论 人膀胱肿瘤T2 4细胞诱导分化后 ,其细胞周期动力学发生改变 ,端粒酶活性被抑制 ,这可能为膀胱肿瘤的诱导分化治疗提供理论依据。

BACKGROUND &OBJECTIVE: Up to now, searching for non toxic and natural origin substances that induced the differentiation of cancer cells is a key for anticancer therapy. Ginseng is one of the most widely used natural tonics in oriental countries for thousands of years and has been reported to have various biological effects. Ginsenosides are thought to be the major effective ingredients in ginseng. Among them, ginsenoside Rh2(G Rh2) has been suggested to have a cell growth suppressive effect on various cancer...

BACKGROUND &OBJECTIVE: Up to now, searching for non toxic and natural origin substances that induced the differentiation of cancer cells is a key for anticancer therapy. Ginseng is one of the most widely used natural tonics in oriental countries for thousands of years and has been reported to have various biological effects. Ginsenosides are thought to be the major effective ingredients in ginseng. Among them, ginsenoside Rh2(G Rh2) has been suggested to have a cell growth suppressive effect on various cancer cells, but the mechanism is unclear.This study was to investigate the induced differentiative effects of G Rh2 on SMMC 7721 hepatocarcinoma cells. METHODS: Effects of G Rh2 on cell viability was analyzed by MTT assay. Cell morphology was examined by a light and electronic microscope. Alpha fetoprotein (AFP) in plasma was determined qualitatively and quantitatively with immunohistochemistry and ELISA. The specific activities of alkaline phosphatase (ALP) and heat resistant ALP in plasma were assayed by ALP kit based on Bessey method. The specific activity of γ glutamyltranspeptidase (γ GT) was measured with γ GT kit.The secretory amount of AFP or albumin was detected with radioimmunoassay kit. RESULTS: G Rh2 inhibited the proliferation of SMMC 7721 cells in dose and time dependent manners. The inhibition rate was 50.87%after 6 day treatment with 10 μg/ml G Rh2 while 46.84%after 4 day treatment with 20 μg/ml G Rh2. Twenty μg/ml G Rh2 induced the mature and normality of morphology and ultrastructure in SMMC 7721 cells. After treated with 10 μg/ml or 20 μg/ml G Rh2, the production of AFP was significantly reduced (P< 0.05), and the secretory amount of AFP was reduced from 6.60±0.30 to 2.35±0.06 (P< 0.01), and the specific activities of γ GT and heat resistant ALP were remarkably declined (P< 0.01); while the secretory amount of albumin and ALP activity were remarkably enhanced (P< 0.01). CONCLUSION: G Rh2 could induce the SMMC 7721 cell differentiation tending to normal.

背景与目的目前寻找低毒高效的分化诱导剂是肿瘤诱导分化治疗的关键。人参具有抗肿瘤、抗衰老、抗辐射等多种生物学活性,其主要的活性有效成分人参皂甙Rh2(ginsenosideRh2,G-Rh2)具有较强的抗癌活性,但其抗肿瘤机制还不十分清楚。因此,本研究探讨G-Rh2对人肝癌细胞株SMMC-7721的生长抑制作用及抗癌机制。方法以MTT法、光镜、电子显微镜观察G-Rh2对SMMC-7721细胞增殖、形态、超微结构的影响。用免疫组化染色和ELISA法检测细胞浆中甲胎蛋白(alpha-fetoprotein,AFP)合成情况,酶促反应试剂盒检测细胞浆中碱性磷酸酶(alkalinephosphatase,ALP)和γ-谷氨酰转肽酶(γ-glutamyltranspeptidase,γ-GT)活性,放射免疫法检测细胞AFP和白蛋白(albumin,Alb)分泌量,并观察G-Rh2对以上指标的影响。结果G-Rh2以时间依赖性和浓度依赖性抑制SMMC-7721细胞增殖,10μg/mlG-Rh2作用6天抑制率达50%;而20μg/mlG-Rh2作用4天抑制率近50%。经20μg/mlG-Rh2作用4天,肝癌细胞形态...

背景与目的目前寻找低毒高效的分化诱导剂是肿瘤诱导分化治疗的关键。人参具有抗肿瘤、抗衰老、抗辐射等多种生物学活性,其主要的活性有效成分人参皂甙Rh2(ginsenosideRh2,G-Rh2)具有较强的抗癌活性,但其抗肿瘤机制还不十分清楚。因此,本研究探讨G-Rh2对人肝癌细胞株SMMC-7721的生长抑制作用及抗癌机制。方法以MTT法、光镜、电子显微镜观察G-Rh2对SMMC-7721细胞增殖、形态、超微结构的影响。用免疫组化染色和ELISA法检测细胞浆中甲胎蛋白(alpha-fetoprotein,AFP)合成情况,酶促反应试剂盒检测细胞浆中碱性磷酸酶(alkalinephosphatase,ALP)和γ-谷氨酰转肽酶(γ-glutamyltranspeptidase,γ-GT)活性,放射免疫法检测细胞AFP和白蛋白(albumin,Alb)分泌量,并观察G-Rh2对以上指标的影响。结果G-Rh2以时间依赖性和浓度依赖性抑制SMMC-7721细胞增殖,10μg/mlG-Rh2作用6天抑制率达50%;而20μg/mlG-Rh2作用4天抑制率近50%。经20μg/mlG-Rh2作用4天,肝癌细胞形态及亚细胞结构向正常肝细胞方向逆转。10μg/ml、20μg/mlG-Rh2作用SMMC-7721细胞后,AFP合成明显下降(P<0.05),分泌量从6.60±0.30下降到2.35±0.06(P<0.01);γ-GT及耐热型ALP活性显著降低(P<0.01);ALP活性及Alb分泌量显著升高(P<0.01)。结论G-Rh2具有诱导人

 
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