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老年原发性肾病综合征
相关语句
  aged primary nephrotic syndrome
     Expression and significance of CD62P in peripheral blood and renal tissue in patients with aged primary nephrotic syndrome
     老年原发性肾病综合征患者肾组织和外周血CD62P的表达及意义
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  “老年原发性肾病综合征”译为未确定词的双语例句
     Objective:To study the changes of CD62P expression in peripheral blood and renal tissue in aged patients with primary nephrotic syndrome(APNS) and to explore its effects on APNS.
     目的 :研究老年原发性肾病综合征 (APNS)患者外周血和肾组织CD62P表达水平的变化 ,并探讨CD62P在APNS病理过程中的作用。
短句来源
     Changes of blood and urine endothelin levels in the elderly patients with primary nephritic syndrome
     老年原发性肾病综合征患者血、尿内皮素的变化
短句来源
     Objective To investigate the changes of blood and urine endothelin levels in the aged patients with primary nephrotic syndrome(PNS) and their clinical significance.
     目的 探讨血、尿内皮素在老年原发性肾病综合征 (PNS)患者中的变化及临床意义。
短句来源
  相似匹配句对
     Das nephrotische Syndrom
     肾病综合征
短句来源
     Changes of blood and urine endothelin levels in the elderly patients with primary nephritic syndrome
     老年原发性肾病综合征患者血、尿内皮素的变化
短句来源
     Molecular portrait of primary nephrotic syndrome
     原发性肾病综合征的分子肖像(英文)
短句来源
     Clinical and Pathological Analysis of Primary Nephrotic Syndrome
     原发性肾病综合征的临床及病理分析
短句来源
     Risk factors for infection in primary nephrotic syndrome
     原发性肾病综合征并发感染的危险因素
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Objective:To study the changes of CD62P expression in peripheral blood and renal tissue in aged patients with primary nephrotic syndrome(APNS) and to explore its effects on APNS.Methods:Peripheral blood samples and renal tissues of 36 APNS patients were collected.The number of platelets expressing CD62P was counted by flow cytomerty.Renal frozen sections were coated with fluorescent isothiocyanate conjugated monoclonal anti CD62P antibody.Results:Compared with the healthy control subjects,the number of platelets...

Objective:To study the changes of CD62P expression in peripheral blood and renal tissue in aged patients with primary nephrotic syndrome(APNS) and to explore its effects on APNS.Methods:Peripheral blood samples and renal tissues of 36 APNS patients were collected.The number of platelets expressing CD62P was counted by flow cytomerty.Renal frozen sections were coated with fluorescent isothiocyanate conjugated monoclonal anti CD62P antibody.Results:Compared with the healthy control subjects,the number of platelets expressing CD62P in APNS patients was significantly higher.CD62P staining in renal tissues was found in 32 of 36 APNS patients,while the staining in renal tissues was negative in 8 control subjects.In APNS patients,the level of CD62P expression of peripheral blood was correlated with that of renal tissue and both of the levels of CD62P expression in peripheral blood and in renal tissue were correlated with 24 h urine protein respectively.Conclusion:The expressions of CD62P in APNS patients increase both in peripheral blood and in renal tissue;CD62P involes in the pathological course of APNS;The levels of CD62P expression of peripheral blood and renal tissue can reflect the condition severity of APNS patients,thus they have important value in clinic.

目的 :研究老年原发性肾病综合征 (APNS)患者外周血和肾组织CD62P表达水平的变化 ,并探讨CD62P在APNS病理过程中的作用。方法 :采用流式细胞术和直接免疫荧光法 ,对 3 6例APNS患者外周血和肾活检组织CD62P的表达进行研究。结果 :APNS患者外周血CD62P的表达明显高于正常对照组 ,有显著性差异 (P <0 0 1) ;肾组织CD62P的表达 3 2例( 88 89% ) ,表达部位主要在肾小球系膜区和毛细血管袢 ,与常规肾脏病理检查所观察到的病变部位及其病变程度相一致。正常对照组肾组织中无CD62P表达。结论 :CD62P在APNS患者外周血和肾组织中表达增强 ,CD62P可能参与了APNS的病理过程 ,外周血和肾组织CD62P的变化可反映APNS的病情严重程度 ,具有重要的临床价值。

Objective To investigate the changes of blood and urine endothelin levels in the aged patients with primary nephrotic syndrome(PNS) and their clinical significance. Methods The levels of blood and urine endothelin were measured by radioimmunoassay at different stages(active and alleviated stages) in 40 elderly and 40 non elderly patients with PNS and 40 elderly healthy controls(control group). The levels of endothelin in blood and urine of the aged patients with PNS, and serum creatinine(Scr), endogenous...

Objective To investigate the changes of blood and urine endothelin levels in the aged patients with primary nephrotic syndrome(PNS) and their clinical significance. Methods The levels of blood and urine endothelin were measured by radioimmunoassay at different stages(active and alleviated stages) in 40 elderly and 40 non elderly patients with PNS and 40 elderly healthy controls(control group). The levels of endothelin in blood and urine of the aged patients with PNS, and serum creatinine(Scr), endogenous creatinine clearance rate(Ccr), 24 hour urinary protein and urinary retinal binding protein(uRBP) were determined. Results The contents of endothelin in blood and urine of the aged PNS patients in the active stage were (229±81) ng/L and (143±58)ng/24 h,which were apparently higher than those in the alleviated stage 〔(60±11) ng/L, (53±13)ng/24 h〕 and the healthy control group〔(53±9) ng/L, (50±14 ng)/24 h, P <0 01〕. But there was no significant difference between the alleviated stage group and normal healthy control group in the endothelin level. In the same period, the contents of blood and urine endothelin of the aged PNS active stage and alleviated stage showed no obvious difference as compared with the non aged PNS. The level of urine endothelin in active stage of the aged PNS was positively correlated with Scr, 24 hour urinary protein and uRBP( r =0 48-0 67, P <0 01), and showed negative correlation with Ccr and plasma albumin( r =-0 56,-0 47, P <0 01). The level of blood endothelin in the active stage of the aged PNS was not positively related to Scr, Ccr, 24 hour urinary protein, plasma albumin,uRBP ( r =-0 23, -0 21, P >0 05). Conclusions Endothelin may be involved in the pathogenesis of the aged PNS. The increased urine endothelin level may be an important factor in glomerulus and tubular damage in the elderly PNS patients.

目的 探讨血、尿内皮素在老年原发性肾病综合征 (PNS)患者中的变化及临床意义。 方法 采用放射免疫法对健康老年、非老年人 (对照组 )和不同病期老年、非老年PNS患者的血、尿内皮素含量进行测定 ,并对老年PNS患者血、尿内皮素水平与血肌酐 (Scr)、内生肌酐清除率 (Ccr)、2 4h尿蛋白定量、尿视黄醇结合蛋白 (uRBP)等指标进行分析。 结果 老年PNS活动期组血、尿内皮素含量分别为 (2 2 9± 81)ng/L、(14 3± 5 8)ng/ 2 4h ,显著高于缓解期组的 (6 0± 11)ng/L、(5 3± 13)ng/2 4h及老年对照组的 (5 3± 9)ng/L、(5 0± 14 )ng/ 2 4h(均为P <0 0 1) ,而缓解期组与老年对照组比较差异无显著性。老年PNS活动期组、缓解期组血、尿内皮素含量与非老年PNS组间差异无显著性。老年PNS活动期尿内皮素水平与Scr、2 4h尿蛋白定量、uRBP呈正相关 (r=0 4 7~ 0 6 7,均为P<0 0 1) ,与Ccr、血浆白蛋白呈显著负相关 (r =- 0 5 6 ,- 0 4 7,P <0 0 1...

目的 探讨血、尿内皮素在老年原发性肾病综合征 (PNS)患者中的变化及临床意义。 方法 采用放射免疫法对健康老年、非老年人 (对照组 )和不同病期老年、非老年PNS患者的血、尿内皮素含量进行测定 ,并对老年PNS患者血、尿内皮素水平与血肌酐 (Scr)、内生肌酐清除率 (Ccr)、2 4h尿蛋白定量、尿视黄醇结合蛋白 (uRBP)等指标进行分析。 结果 老年PNS活动期组血、尿内皮素含量分别为 (2 2 9± 81)ng/L、(14 3± 5 8)ng/ 2 4h ,显著高于缓解期组的 (6 0± 11)ng/L、(5 3± 13)ng/2 4h及老年对照组的 (5 3± 9)ng/L、(5 0± 14 )ng/ 2 4h(均为P <0 0 1) ,而缓解期组与老年对照组比较差异无显著性。老年PNS活动期组、缓解期组血、尿内皮素含量与非老年PNS组间差异无显著性。老年PNS活动期尿内皮素水平与Scr、2 4h尿蛋白定量、uRBP呈正相关 (r=0 4 7~ 0 6 7,均为P<0 0 1) ,与Ccr、血浆白蛋白呈显著负相关 (r =- 0 5 6 ,- 0 4 7,P <0 0 1) ,老年PNS患者活动期血浆内皮素水平与Scr、血浆白蛋白、Ccr、2 4h尿蛋白定量、uRBP无相关性。 结论 内皮素参与了老年人PNS的发病过程 ,尿内皮素的变化可能在一定程度上反映老年PNS患者肾小球和肾小管功能受损情况

 
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