Objective To investigate the influence of recombined human growth hormone(rHGH) on the growth hormone(GH) and insulin-like growth factor(GH-IGF) axes in the patients with chronic severe viral hepatitis(CSVH).
目的研究重组人生长激素(rHGH)对慢性重型病毒性肝炎(chronic severe viral hepatitis,CSVH)患者生长激素(growth hormone,GH)-胰岛素样生长因子(insulin-like growth factor,GH-IGF)轴的变化以及其影响。
Methods A retrospective survey was made on 118 dead cases of severe viral hepatitis who had been discharged from hospital from Jan 1999 to Dec 2002.Results Antibiotic use rate was 95.7% in the 118 cases,of the percentile 68.3% belonged to therapeutic use (nonhospital infectoin 60.2%,and hospital infection 29.8%),and 31.7% belonged to preventive use;
Study on FAS/FAS-L expression in liver tissue and hepatocyte apoptosis in patients with hepatitis gravis
It was found that in the 20 patients with clinical hepatitis gravis, Fas in hepatocytes showed strong expression and Fas-L also showed intensive expression in infiltrating lymphocytes and scattering hepatocytes.
It was suggested that the overexpression of Fas/Fas-L could cause the death of hepatocytes and thus the occurrence of hepatitis gravis.
The apoptosis caused by Fas might be one of the important pathogeneses of hepatitis gravis.
Among the detected samples, apoptosis and necrosis coexisted, indicating that both two types of cellular death were closely associated with the pathogenesis of hepatitis gravis.