AIM:To investigate the mechanism of 9-cis-RA inhibiting the growth of lung adenocarcinoma cells, and we detect the expressional changes of cyclinD1 and cdk4 in lung adenocarcinoma cells PG, A_(549), SPC-A_1 before and after being treated with 9-cis-retinoic acid(9-cis-RA).
In lung cancer cell strains, the expression levels of LCDRG in adenocarcinoma cell strains SPC A 1 and A549, big cell lung cancer cell strain H460, small cell lung cancer cell strains H446 and SH77 were decreased gradually.
Inhibition of expression of vascular endothelial growth factor and its receptors in pulmonary adenocarcinoma cell by TNP-470 in
The inhibition effects of O-(chloroacetyl-carbamoyl) fumagillol (TNP-470), an angiogenesis inhibitor, and gemcitabine, a chemotherapeutic agent, on expression of growth factors were investigated using human pulmonary adenocarcinoma cell line, A549.
Two human hepatoma cell lines, QGY-7703 and SMMC-7721, and two human pulmonary adenocarcinoma cell lines, LTEP-a-2 and SPC-A-1, were found to respond to 1 μg/mL Na2SeO3, 24 h, in-vitro treatment by decreasing its confluent saturation density.
Spontaneous pulmonary adenocarcinoma cell shows osseous metaplasia in vivo
We also evaluated potential mechanisms for the loss of Fas protein expression and Fas-mediated apoptosis in pulmonary adenocarcinoma cell lines.
Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell line A549
Taken together, the inhibition of pirh2 expression in the lung adenocarcinoma cell line A549 resulted in reduced tumor cell growth via the inhibition of cell proliferation, the activation of apoptosis and the interruption of cell cycle transition.
All-trans retinoic acid (ATRA) was used to induce lung adenocarcinoma cell line GLC-82, andRA28 was obtained by subtractive hybridization.
Restriction endonuclease analysis of mitochondrial DNA from human lung adenocarcinoma cell line SPC-A-1
Methods: single-step method was used to isolate the mtDNA from human lung adenocarcinoma cell line SPC-A-1.