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卡介苗灌注
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  bcg perfusion
     Clinical results of BCG perfusion to prevent recurrence of bladder neoplasmas partial cystectomy (Reports of 9 cases).
     卡介苗灌注预防膀胱肿瘤术后复发的疗效观察——附9例报告
短句来源
     METHODS:clinical data of 9 cases of BCG perfusion were reviewed after the open operation of bladder tumor in Aug. 1996-Dec.
     方法 :回顾性总结 1996年 8月~ 1999年 12月共 9例开放式膀胱肿瘤切除术后卡介苗灌注的随访资料。
短句来源
     OBJECTIVE:To investigate the clinical results of BCG perfusion for the prevention of post operative recurrence of superficial bladder neoplasmas cystectomy.
     目的 :评价卡介苗灌注预防膀胱肿瘤术后复发的疗效 ,探讨其药理机理。
短句来源
     CONCLUSION: Currently the treatment of BCG perfusion is effective to preventing post operative recurrence after superficial bladder neoplasmas cystectomy in last and middle stage.
     结论 :卡介苗灌注对膀胱肿瘤切除术后预防后预防复发近中期疗效是肯定的 ,个别临床并发症经对症处理可完全治愈
短句来源
     Conclusion TURB combined with BCG perfusion produces favorable prognosis for bladder tumor patients without muscle-involved,while bladder-preserving operation is not beneficial for patients with muscle-involved bladder tumor.
     结论对于未侵及膀胱壁肌层的膀胱肿瘤,采用经尿道膀胱肿瘤电切手术,结合卡介苗灌注治疗可取得良好的预后,而对于已侵及膀胱壁肌层者,不适宜采用保留膀胱手术。
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  “卡介苗灌注”译为未确定词的双语例句
     The recurrence rate,3-year,5-year and 10-year survival rate of the patients applied to different perfusion drug were statistically different,with the lowest recurrence rate (28.2%) in patients applied Bacillus Calmette-Guerin(BCG) and the highest survival rate was in patients applied BCG(3-year: 100%,10-year: 81.7%).
     4种药物灌注后总复发率、3、5年及10年生存率有显著差异,以卡介苗灌注后的复发率最低(28.2%)、近远期存活率最高(3年为100%,10年为81.7%)。
短句来源
     The specific granulomatous prostatitis (report of 6 cases)
     卡介苗灌注后特异性肉芽肿性前列腺炎(附6例报告)
短句来源
     Intravesical Bacillus Calmette-Guerin in Ta and T_1 Bladder Cancer
     膀胱内卡介苗灌注在Ta和T_1期膀胱癌治疗中的应用
短句来源
     Results:16 trials including 1242 patients were eligible to the inclusion criteria. Of these patients 708 were treated with BCG and 534 with MMC.
     结果:共有16个研究符合标准被纳入,涉及总病例数1242例,其中进行卡介苗灌注治疗708例,丝裂霉素C治疗534例;
短句来源
     CONCLUSION:The similar immune effects and lower side effects were obtained with low dose BCG intracavitary instillation compared with the large dose.
     结论小剂量卡介苗灌注可取得与大剂量相近的免疫效果,副作用低。
短句来源
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  相似匹配句对
     Complication of Intravesical BCG Instillation for Bladder Cancer
     卡介苗膀胱灌注后的并发症
短句来源
     Intravesical Instillations of BCG for the Treatment and Prevention of Postoperative Recurrence of Bladder Cancer
     卡介苗膀胱灌注防治膀胱癌
短句来源
     Cloning of Bacillus Calmette-Guerin Genomic DNA
     卡介苗基因组的克隆
短句来源
     Treatment of drug perfusion for bladder cancer
     膀胱癌的药物灌注治疗
短句来源
     Developments and Applications of Perfusion Chromatography
     灌注色谱法的发展和应用
短句来源
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  intravesical bcg
A case of BCG sepsis with bone marrow and liver involvement after intravesical BCG instillation
      
The case described concerns a 68-year-old male patient, who received intravesical BCG instillations for non-resectable urothelial carcinoma (stage pT1, G2).
      
This case shows the potential of a life-threatening systemic side effect after intravesical BCG instillation.
      
At day 1 after the sixth intravesical BCG administration, the BCG treated animals showed a significantly higher lymph node induction of LAK cell activity compared to placebo treated animals.
      
Our data indicate that, with the exception of the BCG antigen specific reaction, the immunological responses after intravesical BCG administration in the guinea pig are mainly limited to the regional draining (iliac) lymph nodes.
      
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OBJECTIVE:To investigate the clinical results of BCG perfusion for the prevention of post operative recurrence of superficial bladder neoplasmas cystectomy. METHODS:clinical data of 9 cases of BCG perfusion were reviewed after the open operation of bladder tumor in Aug. 1996-Dec. 1999. RESULTS: All cases have been followed up for 8 months to 4 years, the mean was 31 6 months. Pathological reports and cystoscopy have observed no recurrence. CONCLUSION: Currently the treatment of BCG perfusion is effective to...

OBJECTIVE:To investigate the clinical results of BCG perfusion for the prevention of post operative recurrence of superficial bladder neoplasmas cystectomy. METHODS:clinical data of 9 cases of BCG perfusion were reviewed after the open operation of bladder tumor in Aug. 1996-Dec. 1999. RESULTS: All cases have been followed up for 8 months to 4 years, the mean was 31 6 months. Pathological reports and cystoscopy have observed no recurrence. CONCLUSION: Currently the treatment of BCG perfusion is effective to preventing post operative recurrence after superficial bladder neoplasmas cystectomy in last and middle stage.

目的 :评价卡介苗灌注预防膀胱肿瘤术后复发的疗效 ,探讨其药理机理。方法 :回顾性总结 1996年 8月~ 1999年 12月共 9例开放式膀胱肿瘤切除术后卡介苗灌注的随访资料。结果 :本组随访 8月~ 4年 ,平均 3 1 6月。卡介苗灌注后均做膀胱镜检及病理活检 ,无 1例肿瘤复发。结论 :卡介苗灌注对膀胱肿瘤切除术后预防后预防复发近中期疗效是肯定的 ,个别临床并发症经对症处理可完全治愈

Objective To observe therapeutic effects of intravesical instillation of mitomycin C (MMC) immediately after TUR added with low dose BCG maintenance therapy to prevent recurrence of superficial bladder cancer. Methods 83 patients with superficial bladder cancer were randomly divided into two groups, 50 cases were managed with intravesical instillation of mitomycin C immediately after TUR added with low dose BCG maintenance therapy (group A), 33 cases were treated with traditional method of MMC therapy (group...

Objective To observe therapeutic effects of intravesical instillation of mitomycin C (MMC) immediately after TUR added with low dose BCG maintenance therapy to prevent recurrence of superficial bladder cancer. Methods 83 patients with superficial bladder cancer were randomly divided into two groups, 50 cases were managed with intravesical instillation of mitomycin C immediately after TUR added with low dose BCG maintenance therapy (group A), 33 cases were treated with traditional method of MMC therapy (group B) to prevent recurrence of superficial bladder cancer. Results After 12-66 months (mean 32 months) following up, 3 patients had tumor recurrence in the group A and 7 patients in the group B, the rate of tumor recurrence of the group A was 6 0% (3/50) and that of the group B was 21.2%(7/33), and there was a significantly difference between two groups ( P<0.05). Side effects of the group B were obviously more than that of the group A. Conclusion Intravesical instillation of MMC immediately after TUR added with low dose BCG maintenance therapy is effective to prevent patients with superficial bladder cancer from recurrence.

目的观察丝裂霉素C加卡介苗灌注预防浅表性膀胱癌术后复发的疗效。方法将 83例行经尿道膀胱镜下肿瘤电切术 (TUR)的浅表性膀胱癌患者随机分为丝裂霉素C加卡介苗 (BCG)组 (5 0例 )和单纯丝裂霉素 (MMC)组 (3 3例 ) ,前者术后即刻采用MMC灌注加小剂量BCG维持 ,后者单用传统MMC灌注。观察两组患者的肿瘤复发和毒副反应情况。结果经 12— 66个月 ,平均 3 2个月随访 ,BCG组 3例患者肿瘤复发 ,MMC组 7例患者肿瘤复发 ,两组复发率间的差异有显著性意义 (P <0 .0 5 ) ;BCG组患者毒副反应发生率为 10 % ,MMC组为 66.7%。结论TUR术后即刻膀胱灌注MMC加小剂量BCG维持预防浅表性膀胱癌术后复发疗效较好 ,不良反应少 ,临床使用安全可靠。

Objective:To compare the prophylactic efficacy and toxicity of intravesical bacillus Calmette-Guerin (BCG) versus mitomycin C (MMC) on recurrence of Chinese bladder cancer.Methods:We retrieved published Chinese comparative studies on intravesical BCG versus MMC for bladder cancer of Chinese people, and pooled the data from eligible studies (Meta-analysis).Results:16 trials including 1242 patients were eligible to the inclusion criteria. Of these patients 708 were treated with BCG and 534 with MMC. Within the...

Objective:To compare the prophylactic efficacy and toxicity of intravesical bacillus Calmette-Guerin (BCG) versus mitomycin C (MMC) on recurrence of Chinese bladder cancer.Methods:We retrieved published Chinese comparative studies on intravesical BCG versus MMC for bladder cancer of Chinese people, and pooled the data from eligible studies (Meta-analysis).Results:16 trials including 1242 patients were eligible to the inclusion criteria. Of these patients 708 were treated with BCG and 534 with MMC. Within the maximum follow-ups, 23.4% (166/708) of the patients treated with BCG and 30.7%(164/534)of those with MMC had recurrence of bladder tumor. Pooling data of a meta-analysis indicated that BCG was statistically significantly superior to MMC in the prophylaxis of tumor recurrence (OR 0.63, 95% CI 0.48~ 0.83, P= 0.001). 9 studies reported comparative data on toxicity mainly cystitis, combined result of these studies showed that the incidence of cystitis were significantly higher in BCG group than MMC group (OR 4.52, 95% CI 1.11~ 18.36, P= 0.03).Conclusions:The results of this meta-analysis suggest the significant superiority of intravesical BCG therapy compared with MMC for the prevention of tumor recurrence. However, the toxicity of BCG therapy, especially the incidence of cystitis, is significantly higher than that of MMC therapy.

目的:比较卡介苗与丝裂霉素C膀胱灌注预防国人膀胱癌复发的疗效及毒性。方法:检索国内已公开发表的关于卡介苗与丝裂霉素C膀胱灌注治疗国人膀胱癌复发的比较性研究资料,对纳入研究的资料进行统计学综合(Meta分析)。结果:共有16个研究符合标准被纳入,涉及总病例数1242例,其中进行卡介苗灌注治疗708例,丝裂霉素C治疗534例;最大随访期内分别有23.4%(166/708),30.7%(164/534)出现复发。Meta分析结果提示卡介苗组预防肿瘤复发作用统计学上显著优于丝裂霉素C组(OR0.63,95%CI0.48~0.83,P=0.001);9个研究报道了治疗毒性主要是膀胱炎的比较,Meta分析结果提示卡介苗组膀胱炎发生率明显高于丝裂霉素C组(OR4.52,95%CI1.11~18.36,P=0.03)。结论:卡介苗膀胱灌注预防国人膀胱癌复发作用优于丝裂霉素C,但其毒性(膀胱炎发生率)较丝裂霉素C高。

 
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