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复制叉
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  replication fork
     When DNA was damaged or DNA replication fork halted by ionization radiation or ultra-violet radiation, Chk1 was activated, which induced cell cycle arrest, DNA repair or cell apoptosis.
     当电离辐射、紫外线等引起细胞DNA损伤或者DNA复制叉停滞时Chk1活化,诱导细胞产生细胞周期阻滞、DNA修复或细胞凋亡等特征。
短句来源
     Single-Stranded Oligonucleotide-mediated Gene Repair Is Enhanced by Slowing Replication Fork Progression
     复制叉抑制提高寡核苷酸介导的基因定点修复效率(英文)
     Topotecan,a new agent for SCLC treatment,is a topo is onerase inhibitor. It can induce the fragmentation of DNA replication fork,theref ore it is not easy to produce drug resistance.
     小细胞肺癌 (SCLC)治疗新药盐酸拓扑替康 (topotecan)属喜树碱类 ,为拓扑异构酶Ⅰ抑制剂 ,它能导致DNA复制叉断裂 ,该作用方式决定其不易产生耐药性。
短句来源
  “复制叉”译为未确定词的双语例句
     Chromosomal DNA replication starts at the sites called Origins by forming replication forks.
     染色体DNA的复制是由许多复制起点处形成的起始复制叉开始的。
短句来源
  相似匹配句对
     THE REPLICATION OF CHROMOSOME
     染色体的复制
短句来源
     BEAUTIFUL COPY
     完美复制
短句来源
     Single-Stranded Oligonucleotide-mediated Gene Repair Is Enhanced by Slowing Replication Fork Progression
     复制抑制提高寡核苷酸介导的基因定点修复效率(英文)
     KNIFE & FORK
     刀与
短句来源
     Chromosomal DNA replication starts at the sites called Origins by forming replication forks.
     染色体DNA的复制是由许多复制起点处形成的起始复制开始的。
短句来源
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  replication fork
Nonhomologous cohesion of sister chromosomes and unequal crossing over were assumed to take place when the replication fork stops.
      
Historical observations have suggested that establishment of cohesion is roughly coincident with replication fork passage.
      
Emerging evidence now indicates that replication fork components, such as PCNA, a novel DNA polymerase, Trf4p/Pol σ (formerly Trf4p/Pol κ), and a modified clamp-loader complex, actively participate in the process of the cohesion establishment.
      
Replication fork structures were found in both circular and linear mtDNA molecules.
      
From the results obtained, the time required for a DNA replication fork to traverse the chromosome from origin to terminus (C period) was calculated.
      
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  replicating fork
A consideration of the kinetics of formation of the 26S component indicates that is may contain the replicating fork.
      
A model for SCE induction is proposed involving a single-strand break or gap as the initial requirement for SCE initiation at the replicating fork.
      
The β-irradiation source is therefore most effective in inducing SCEs when present in the replicating fork and considerably less effective when it is just behind the fork (SCE 1) and/or in the surrounding chromosomes in the cell.
      
The same preference is found for the cI gene inserted in the genome in the inverse orientation, so the differential effect is not caused by the direction of motion of the DNA replicating fork.
      


Why are there 4 bases in the genetic code is discussed and a model of helix unwinding of DNA is introduced.

讨论了遗传密码为什么总由四种碱基组成的原因。从密码的稳定性和变异的可能性证明了“字母”数为4。给出了DNA双螺旋解链的一个物理模型,指出复制叉移动速度决定于酶的反应扩散速率,而解链过程的高度有序性则系由于其实质为量子的构象变换,利用四能级跃迁的非平衡特征解释解链的稳定性和复制的忠实性。

Purified plasmid PSMGH and PBR322 (circular or linear ) were coinjectedwith biotinylated dATP into fertilized eggs of Medaka fish at the one cell stage. The injected eggs were kept at 25C to the stage of blastpore closure. Then DNA was extracted from cytoplasm of the embryonic cells and analyzed. Newly synthesized biotinylatedDNA was found in cytoplasm. No detectable biotinylated DNA was found in the cytoplasm of the controls, into which only biotinylated dATP was injected. The DNA sample from the cytoplasm,...

Purified plasmid PSMGH and PBR322 (circular or linear ) were coinjectedwith biotinylated dATP into fertilized eggs of Medaka fish at the one cell stage. The injected eggs were kept at 25C to the stage of blastpore closure. Then DNA was extracted from cytoplasm of the embryonic cells and analyzed. Newly synthesized biotinylatedDNA was found in cytoplasm. No detectable biotinylated DNA was found in the cytoplasm of the controls, into which only biotinylated dATP was injected. The DNA sample from the cytoplasm, into which PSMGHDNA was injected, was applied to transmission electron microscopy investigation. Some types of replicating molecules were found,including the Y,B and rolling circle forms. The premature and poly fork replications werealso found.

利用显微注射技术将外源DNA与标有生物素的dATP一起导入处于1细胞期的青鱼(Medaka)受精卵细胞质中,鱼卵在25℃孵化一天至胚孔封闭期,从胚胎细胞质中提取DNA,经分子杂交发现外源DNA在胚胎中可进行复制。DNA样品再经核酸电镜分析,发现了几种类型的复制分子,并发现多复制叉及成熟前复制现象。由此认为外源DNA可以多种方式在青鱼早期胚胎细胞质中进行复制。

Topotecan,a new agent for SCLC treatment,is a topo is onerase inhibitor.It can induce the fragmentation of DNA replication fork,theref ore it is not easy to produce drug resistance.The dose limiting toxicity(DLT) o f it was neutropenia and diarrhea.Its maximum tolerance dose(MTD) may be reduced by elevated liver or kidney function.The usual dose for SCLC treatment is 1.5 m g·m -2 ·d -1 ×5d.Pre clinical trials indicated that the cancer killi ng effect of topotecan is as potent as 250 times of cisplatin...

Topotecan,a new agent for SCLC treatment,is a topo is onerase inhibitor.It can induce the fragmentation of DNA replication fork,theref ore it is not easy to produce drug resistance.The dose limiting toxicity(DLT) o f it was neutropenia and diarrhea.Its maximum tolerance dose(MTD) may be reduced by elevated liver or kidney function.The usual dose for SCLC treatment is 1.5 m g·m -2 ·d -1 ×5d.Pre clinical trials indicated that the cancer killi ng effect of topotecan is as potent as 250 times of cisplatin for drug resistanc e cancer strain of NCL H82rasH,and it has a synergetic effect with cisplatin or VP16.Clinical trials indicated that topotecan is an anticancer agent of first o r second choice,especially for patients who are sensitive to anticancer agent in the past and replicated now.The agent can significantly relief the symptoms and signs of brain metastasis of lung cancer.

小细胞肺癌 (SCLC)治疗新药盐酸拓扑替康 (topotecan)属喜树碱类 ,为拓扑异构酶Ⅰ抑制剂 ,它能导致DNA复制叉断裂 ,该作用方式决定其不易产生耐药性。其剂量限制毒性 (DLT)为中性粒细胞减少和腹泻 ,肝肾功能下降会降低最大耐受剂量 (MTD)。拓扑替康对SCLC最常用的有效剂量是 1.5mg·m-2 ·d-1× 5d。临床前实验发现 ,拓扑替康对耐药SCLC细胞株NCL H82rasH的杀瘤作用比单独使用顺铂的作用强 2 5 0倍 ,与顺铂或VP16有协同作用。临床试验结果亦证明 ,拓扑替康是有效的一线及二线抗肿瘤药 ,尤其对于既往化疗敏感而又复发处于进展期的患者及对颅内转移的症状和体征有明显的缓解作用。

 
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