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远曲肾小管细胞
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  “远曲肾小管细胞”译为未确定词的双语例句
     Conclusion TMP can treat CRF through reduce the production of oxygen radical and increase the content of cAMP in cells.
     结论提示川芎嗪治疗慢性肾功能衰竭的机理与其增加肾皮质SOD活性、降低肾皮质的脂质过氧化、并增加近曲肾小管细胞和远曲肾小管细胞cAMP含量有关。
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     A lot of lysosomes were seen in the cytoplasm of the renal proximal convoluted tubule cells.
     管细胞的胞质内有大量溶酶体。
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     Results In control,the shape of renal proximal tubule epithelial cell is regular.
     结果对照组管细胞形态规则;
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     The THP excretion was not correlated with thyroid function and patients with AITD may complicated with the immunological damage of the distal convoluted tubule of kidney.
     提示:AITD患者可伴有管细胞的免疫损伤.
短句来源
     THE CULTURE OF PROXIMAL TUBULE CELLS OF RABBIT KIDNEY
     兔近端管细胞的培养
短句来源
     Advances of the mechanisms of renal tubular cell injury
     管细胞损伤机制的研究进展
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  distal convoluted tubules
Pigmented casts in distal convoluted tubules, mild interstitial inflammatory infiltrate and mesangial enlargement of some glomeruli were observed in kidney biopsies.
      
In the distal convoluted tubules an increase in the fractional fluid and sodium reabsorption could be established using a recollection technique.
      
No further inhibition of fluid and sodium reabsorption in the distal convoluted tubules could be detected after the drug using a free flow recollection technique.
      
Silver grains were rather homogeneously distributed to both proximal and distal convoluted tubules, with no specific glomerular localization.
      
A single, large, toxic dose of lithium chloride (LiCl) caused necrosis of the distal convoluted tubules, which was visible by light microscopy in 30?min, had fully developed in 1?h, and had disappeared by the next day.
      
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and Methods In order to understand the mechanism of PTH in regulating cytosolic free calcium concentration ([Ca2+]i), we differentiated rat renal proximal and distal convoluted tubules (PCT&DCT) by Percoll density gradient centrifugation, and successfully gauged the effect of hPTH(1-84), dibutyryl cAMP (db cAMP, a kind of cAMP activator) and prostaglandin E2(PGE2) on [Ca2+]i of DCT using fluorescent Ca2+indicator Fluo 3-AM. We found that PTH, db cAMP and PGE2 all could increase [Ca2+]i. Results The results suggest...

and Methods In order to understand the mechanism of PTH in regulating cytosolic free calcium concentration ([Ca2+]i), we differentiated rat renal proximal and distal convoluted tubules (PCT&DCT) by Percoll density gradient centrifugation, and successfully gauged the effect of hPTH(1-84), dibutyryl cAMP (db cAMP, a kind of cAMP activator) and prostaglandin E2(PGE2) on [Ca2+]i of DCT using fluorescent Ca2+indicator Fluo 3-AM. We found that PTH, db cAMP and PGE2 all could increase [Ca2+]i. Results The results suggest that the rise in [Ca2+]i induced by PTH in DCT was through activation of cAMP, and PGE, might be also involved in regulation of [Ca2+]i as a messenger of PTH.

本实验以Percoll密度梯度离心法分离出大鼠肾皮质的近曲肾小管细胞(proximalconvolutedtubules,PCT)和远曲肾小管细胞(distalconvolutedtubules,DCT),应用荧光指示剂Fluo3-AM成功测定了人甲状旁腺激素[hPTH(1-84)]、双丁酰环磷酸腺苷酸(dbCAMP,系一种可进入细胞内的CAMP激动剂)及前列腺素E2(PGE2)对DCT细胞内钙浓度([Ca2+]i的影响,发现PTH、dbcAMP和PGE2均可引起[Ca2+]i的增加。提示:(1)cAMPP在DCT细胞中可能与PTH所致的[Ca2+]i的升高有关;(2)PGE2可能在PTH对[Ca2+]的调节作用中充当某种信使物质。

Objective To study treatment effects of tetramethylpyrazine(TMP) on chronic renal failure (CRF). Methods The CRF animal model of rats were established by 5/6 of kidney mass were removed through operation.Results In the TMP treating grops, the urea nitrogen and creatinin in blood serum were significantly decreased (P<0.01). In the renal cortex the contens of malondialdehyde(MDA) were reduced and the activity of superoxide dimutase were increased. Meanwhile the content of cAMP in proximal tubular cells and...

Objective To study treatment effects of tetramethylpyrazine(TMP) on chronic renal failure (CRF). Methods The CRF animal model of rats were established by 5/6 of kidney mass were removed through operation.Results In the TMP treating grops, the urea nitrogen and creatinin in blood serum were significantly decreased (P<0.01). In the renal cortex the contens of malondialdehyde(MDA) were reduced and the activity of superoxide dimutase were increased. Meanwhile the content of cAMP in proximal tubular cells and distal tubular cells were increased in the TMP treating grops.Conclusion TMP can treat CRF through reduce the production of oxygen radical and increase the content of cAMP in cells.

目的探讨川芎嗪对大鼠实验性慢性肾功能衰竭的治疗作用。方法采用改良方法制造大鼠慢性肾功能衰竭模型 :一次手术切除左侧全部肾脏及右侧 2 / 3肾脏 ,二周后测定大鼠血清肌酐和尿素氮含量 ,建立大鼠慢性肾功能衰竭模型。给予川芎嗪 6 0mg/kg ,1次 /日口服 ,连续治疗 10 0天。结果川芎嗪可明显改善实验动物的肾功能 ,降低该模型肾皮质丙二醛含量并明显增加肾皮质SOD活性 ,还可增加该模型近曲小管细胞及远曲小管细胞cAMP含量。结论提示川芎嗪治疗慢性肾功能衰竭的机理与其增加肾皮质SOD活性、降低肾皮质的脂质过氧化、并增加近曲肾小管细胞和远曲肾小管细胞cAMP含量有关。

To identify human homologue gene of collectrin, which is a kidney-specific novel gene cloned in 5/6 ablated mouse kidney, rapid amplification of cDNA end PCR (RACE-PCR) with human collectrin homologous primers were performed and its distribution and expression were further investigated. The full-length cDNA of human collectrin (GenBank No. AF229179) is 1345 bp, and it encodes 222 amino acid residues. The sequence is conserved in mouse and human, which shares 86.9% identity in nucleotide and 87.4% in amino acid...

To identify human homologue gene of collectrin, which is a kidney-specific novel gene cloned in 5/6 ablated mouse kidney, rapid amplification of cDNA end PCR (RACE-PCR) with human collectrin homologous primers were performed and its distribution and expression were further investigated. The full-length cDNA of human collectrin (GenBank No. AF229179) is 1345 bp, and it encodes 222 amino acid residues. The sequence is conserved in mouse and human, which shares 86.9% identity in nucleotide and 87.4% in amino acid between mouse and human. Bioinformatical analysis demonstrates that collectrin contains a signal peptide and a trans-membrane domain with a predicted molecular mass of 25 kD. It has 47.8% homology with ACE2, which was recently identified as a novel member of ACE gene family. Multiple tissue Northern blot reveals that collectrin was only detectable in the kidney. In situ hybridization and immunohistochemical staining show that human collectrin exists in renal collecting ducts, as well as in distal tubules. Human collectrin is a kidney-specific novel gene expressed in collecting ducts and distal tubules. The result implied that human collectrin might be a novel member of ACE gene family with its sequence highly homologue with ACE2.

为探讨collectrin在人类疾病中的作用 ,利用人类collectrin同源性引物 ,经末端cDNA快速扩增法分离获得人collectrin基因全长序列并对collectrin进行生物信息学分析及定位表达研究 .结果发现 ,人类collectrin(GenBank登录号为AF2 2 9179)基因全长含 1345bp ,开放阅读框架编码 2 2 2个氨基酸 .在核苷酸和氨基酸水平 ,与小鼠collectrin序列分别有 86 9%和 87 4 %同源性 .生物信息学分析结果提示 ,collectrin为一个 2 5kD的具有一个信号肽和一个跨膜区的跨膜糖蛋白 .人类collectrin与人类血管紧张素转换酶相关的羧基肽酶 (ACE2 )具有 4 7 8%高度同源性 .人多组织Northern杂交结果显示 :collectrin基因为人类肾脏特异性表达基因 .原位杂交及免疫组化证实 ,与小鼠collectrin特异表达于集合管细胞不同 ,人collectrin基因mRNA及其蛋白产物除位于肾脏集合管细胞外 ,远曲肾小管细胞也有表达 .由此推论 ,人类collectrin基因为肾脏特异性表达基因...

为探讨collectrin在人类疾病中的作用 ,利用人类collectrin同源性引物 ,经末端cDNA快速扩增法分离获得人collectrin基因全长序列并对collectrin进行生物信息学分析及定位表达研究 .结果发现 ,人类collectrin(GenBank登录号为AF2 2 9179)基因全长含 1345bp ,开放阅读框架编码 2 2 2个氨基酸 .在核苷酸和氨基酸水平 ,与小鼠collectrin序列分别有 86 9%和 87 4 %同源性 .生物信息学分析结果提示 ,collectrin为一个 2 5kD的具有一个信号肽和一个跨膜区的跨膜糖蛋白 .人类collectrin与人类血管紧张素转换酶相关的羧基肽酶 (ACE2 )具有 4 7 8%高度同源性 .人多组织Northern杂交结果显示 :collectrin基因为人类肾脏特异性表达基因 .原位杂交及免疫组化证实 ,与小鼠collectrin特异表达于集合管细胞不同 ,人collectrin基因mRNA及其蛋白产物除位于肾脏集合管细胞外 ,远曲肾小管细胞也有表达 .由此推论 ,人类collectrin基因为肾脏特异性表达基因 ,与人类血管紧张素转换酶相关的羧基肽酶具有高度同源性 ,可能为血管紧张素转换酶 (ACE)基因家族的新成员 .

 
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