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迹象
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    There are many manners for tumor metastasis, such as direct dissemination, lymph node metastasis and blood metastasis.
    肿瘤转移的方式包括淋巴道转移、直接播散、血道转移和种植转移,其中淋巴道转移是最常见的方式,也是肿瘤转移的早期迹象,因此及早发现微小的淋巴结转移灶是控制肿瘤转移的关键。
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    And no recurrence was found by physical examination and B-ultrasonography in 15 patients(21 lesions) during follow up period for 6~21(13.5±4.0) months.
    15例 (2 1处 )经术后 6~ 2 1(13 .5± 4.0 )个月的随访 ,临床及B超复查均无复发迹象
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    Lymph node metastasis often represents the first step in the metastasis process and occurs before blood metastasis. Inhibiting lymphatic metastasis is a key step to control tumor.
    其中淋巴道转移是最常见的方式,也是肿瘤转移的早期迹象,因此及早发现微小的淋巴结转移灶是控制肿瘤转移的关键。
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    There is no tumor found for 6 months after completed operation and chemotherapy, and then there is a tumor again found in abdomen or the blood markers increasing again.
    复发标准:完成手术及化疗后无肿瘤迹象6个月以上,又出现盆腔或腹腔包块,或血清肿瘤标志物又上升。
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    It was initially proposed that dural tails resulted from direct tumor invasion, but many later investigators were able to show little or no direct tumor involvement. It was therefore proposed that dural tails represented non-neoplasm reactive changes to the dura mater, including local reactive hyperemia, tissue hyperplasia, vascular hyperplasia, vascular permeability enhancement, dural vascular dilatation and others.
    起初,脑膜尾征被认为是脑膜瘤直接浸润邻近硬脑膜的结果,但后来的研究发现部分脑膜瘤脑膜尾征组织中并没有肿瘤组织直接浸润的迹象,而被认为是非新生物性的反应性变化,包括局部反应性充血、组织增生、血管增生、血管渗透性增强和脑膜血管扩张等。
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Based on the concept that cancer is possibly a disease related to immunological disorder, corynebacterium anaerobic vaccine was used in combination with cryosurgery in 10 cases of disseminated cancer in the period between April and October 1978. The vaccine was injected into the tumor (intratumoral, I.T.) and started before, during or after cryosurgery, with a dosage of 4 mg I.T. once every week for 3 months, followed by 4 mg I.T. biweekly for a period of 1-2 years. All the patients were followed for 7-14 months...

Based on the concept that cancer is possibly a disease related to immunological disorder, corynebacterium anaerobic vaccine was used in combination with cryosurgery in 10 cases of disseminated cancer in the period between April and October 1978. The vaccine was injected into the tumor (intratumoral, I.T.) and started before, during or after cryosurgery, with a dosage of 4 mg I.T. once every week for 3 months, followed by 4 mg I.T. biweekly for a period of 1-2 years. All the patients were followed for 7-14 months and were alive, with 7 of them free of cancer clinically. In 2 cases, surgical operation was done during vaccine therapy. Pathological features in the resected specimens after intratumoral injection of vaccine were as follows: (1) marked necrosis of tumor tissue especially in the area where vaccine was injected. (2) remarkable white cell infiltration (including plasma cells and macrophages) at the site of necrosis. (3) residual tumor cells at the area of vaccine injection undergoing degenerative changes. It is postulated that combined cryosurgery and vaccine treatment may enhance both specific and non-specific immunity against cancer.

本文报道应用国产厌气棒状杆菌菌苗局部注射和冷冻手术综合治疗晚期肿瘤10例,经过7~10个月随访,疗效显著。从切除标本的病理组织学检查,可见到癌肿坏死,癌巢周围有大量白细胞浸润,显示局部用药后明显地消除肿瘤的迹象。提示了这种方法能增强免疫作用,有效地控制肿瘤。

The immune status of 80 miners,44 smelters and another 18miners(suffering from lung cancer)has been studied in detail.There aretwo control groups:one group including 50 workers from other units in thesame district;the another group including 18 workers from the groundsurface of this mine.In 1972,the average radon concentration in the air of this undergroundmine was about 750 pCi/1.The ores of this mine contain various kinds of elements,in which thecontent of inorganic arsenic is 0.5%.The arsenic concentration...

The immune status of 80 miners,44 smelters and another 18miners(suffering from lung cancer)has been studied in detail.There aretwo control groups:one group including 50 workers from other units in thesame district;the another group including 18 workers from the groundsurface of this mine.In 1972,the average radon concentration in the air of this undergroundmine was about 750 pCi/1.The ores of this mine contain various kinds of elements,in which thecontent of inorganic arsenic is 0.5%.The arsenic concentration in theatmosphere of this mine's surrounding environment is greater than theproposed MPC of arsenic in the air.Morbidity for lung cancers among the miners of this mine is quite high.The results showed that the total and differential counts of leucocytes,serum levels of IgG,IgA,IgM and numbers of circulating T cells and B cellsfrom the above-mentioned miners and smelters Were normal,but a signifi-cant depression of proliferative responses of peripheral blood lympbocytesto PHA in vitro.The level of seCretory IgA in Sputa and positive inciden-Ces of autoantibodies(nuClear,smooth muscle and parietal cell antibodies,andrheumatoid factors)were elevated.The longer the duration of employment,the more the changes of the am-beoventioned indices were taken place.Immunoepidemiological investigation showed that the imparied blasto-genie response to PHA by peripheral blood T cells the injuries of respira-tory tract involvements and other body tissues were observed in the above-mentioned miners and smelters,who have had a duration of exposure for 20years or more.It was suggested that the immune status of these miners is a phenomenaof premature senility,which is similar to that of the lung cancer patients.

某矿山矿体中含有0.5%砷,1972年测得氡气平均浓度约为7.5×10~(-10)居里/升。矿工肺癌发病率显著增高。本文对80名矿工、44名冶炼工、18名肺癌工人和两个对照人群进行了较全面的免疫状态观察。结果表明矿工及冶炼工淋巴细胞对 PHA 的增殖反应显著低下。痰中分泌性 IgA含量有增高趋势,抗各种组织的自身抗体(抗细胞核、抗平滑肌、抗胃壁细胞抗体和类风湿因子)阳性率明显上升,免疫流行病学分析表明,矿工和冶炼工在上述作业环境中工作,工龄20年时,可能发生细胞免疫功能低下,呼吸道及全身其他组织损伤。这是免疫状态早衰的迹象,在某些方面与肺癌患者相似。

Two derivatives of Tc-99m-labeled iminodiaoetio acid (Tc-99m-IDAs) were used as the imaging agents. 2 m Ci of either one of the Tc-99m-IDAs was administered intravenously to the subject after fasting overnight. Serial sointisoans including the hepatobiliary and gastric areas were taken immediately after the injection was completed and then at intervals of about 15 minutes for an hour or longer when necessary. In normal state, the liver, biliary tract, gallbladder, duodenum and jejunum were visualized successively,...

Two derivatives of Tc-99m-labeled iminodiaoetio acid (Tc-99m-IDAs) were used as the imaging agents. 2 m Ci of either one of the Tc-99m-IDAs was administered intravenously to the subject after fasting overnight. Serial sointisoans including the hepatobiliary and gastric areas were taken immediately after the injection was completed and then at intervals of about 15 minutes for an hour or longer when necessary. In normal state, the liver, biliary tract, gallbladder, duodenum and jejunum were visualized successively, while no radioactivity was detectable in the stomach region.All the 6 normal controls, who showed no enterogastrie (EG) reflux under fiberogastroseopy, ha'd normal scintiscans. Of the 34 patients showing EG reflux under fiberogastroscopy, 26(76.47%) showed radioactivity in stomach region. All the remaining 8 who exhibited no evidence of reflux on the sointiscans had vigorous nausea during the fiberogastroscopic examination. We believe that this method was non-traumatic and accurate in detecting EG reflux of bile.

在34例经纤维胃镜检查发现肠-胃胆汁反流的患者和作为对照组的6名纤维胃镜检查无胆汁反流的健康人中使用~(99m)Tc-IDA类药物进行放射性核素动态显象以探测肠-胃胆汁反流,并试与纤维胃镜检查结果相比较。静脉注射~(99m)Tc-IDA类药物后,依次显现肝脏、胆管、胆囊和肠道。对照组6人胃部始终未检得放射性,而纤维胃镜检查见肠-胃胆汁反流的34例患者中,26例在示踪剂排入肠道之早期即可观察到胃部出现放射性并逐渐增加;另8例放射性核素显象未显示反流迹象,此8例在纤维胃镜检查时都有剧烈的(口恶)心和反胃。作者认为本核医学检查方法没有创伤性,不需插管,在接近正常生理状况下施行,因而较习用的其他检测方法更为准确。

 
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