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tgfβ    
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  tgf beta
    Effects of drug serum of Ganzheng Solution(肝癥口服液) on TGF beta receptor of SMMC-7721 cell line
    肝癌患者肝癥口服液含药血清对SMMC-7721肝癌细胞TGFβ受体表达的影响
短句来源
    EFFECTS OF GANZHENG SOLUTION ON THE TRANSDUCTION OF TGF BETA 1/SMADS SIGNALING PATHWAY IN SMMC-7721 CELL LINE
    肝癥口服液含药血清对SMMC-7721肝癌细胞TGFβ1/Smads信号转导通路的影响
短句来源
    Objective To clone rat transforming growth factor (TGF) beta1 cDNA, and to investigate TGF beta1 gene expression in transfected osteoblasts.
    目的 克隆鼠转化生长因子 β1(TGF β1)基因并研究其在转染的成骨细胞中表达情况。
短句来源
    Results Rate TGF beta1 gene expression could be detected 48 h later in the transfected osteoblasts.
    结果  48h后转染的成骨细胞具有明显鼠TGF β1基因的表达产物。
短句来源
    Conclusion After rat TGF beta1 was cloned into expression vector pcDNA, TGF beta1 gene could be expressed effectively in transfected osteoblasts by pcDNA-TGF beta1 plasmid 48 h later.
    结论 将构建的TGF β1表达载体转入鼠成骨细胞 ,48h后可获得TGF β1的高效表达。
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  tgf-beta
    Smad7 overexpressing cells showed upregulation of c-myc expression and downregulation of p15 and p21 expression, which contributed to the loss of TGF-beta responses in these cells.
    RT PCR结果表明 ,在稳定转染Smad7基因的细胞中 ,c myc表达上调 ,p15表达降低 ,对TGF β刺激的应答丧失 ,p2 1表达降低。
短句来源
    Objective To determine the relation between transforming growth factor β1 (TGF-beta1)in allograft and long-term renal function.
    目的 :探讨移植肾内转化生长因子β1(TGF β1)的表达与远期肾功能的关系。
短句来源
    Results:Blood TGF-beta1 concentrations in the two groups were not different significantly;
    结果:两组患者血TGFβ1浓度没有明显差异;
短句来源
    Objective To study the relationship between the expression of transforming growth factor-beta 1 (TGF-beta1) and proliferative cell nuclear antigen (PCNA) in human glioma.
    目的探讨胶质瘤中转化生长因子β1(TGFβ1)蛋白与增殖细胞核抗原(PCNA)蛋白在胶质瘤中的表达及相互关系。
短句来源
    Objective To investigate the effects of transfection of the pcDNA3+TGF-β1 with or without pAT_ 153+IGF-1 on rabbit chondrocytes proliferating and synthesizing TGF-beta1,IGF-1 and collagen Ⅱ.
    目的探讨重组大鼠转化生长因子β1基因(pcDNA3+TGFβ1)单独转染及其与重组大鼠胰岛素样生长因子1基因(pAT153+IGF1)共转染兔软骨细胞后细胞增殖及所分泌的TGFβ1因子、IGF1因子、Ⅱ型胶原的变化。
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  tgf
Efficient bioinformatic analysis has fundamentally determined that KIAA0372 is an extracellular protein which may be involved in TGF-β signaling.
      
We studied the effect of extractive substances (ES) and total glycoside fraction (TGF) from Panax ginseng on plant cell growth.
      
Such are the suggested effects on telomerase of Myc, p53, Waf1, protein kinases B and C, Wnt5A, TGFβ, WT1, and estrogens.
      
However, Myc, p53, WT1, estrogens, protein kinases B and C, and TGFβ can also directly influence telomerase independently of the G1-S checkpoint mechanism.
      
The aim of this study was to evaluate how growth factors (PDGF-BB, EGF, and TGF-1β) modulate hyaluronan synthase (HAS) activities in normal or stressed cultured human skin fibroblasts.
      
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  tgf beta
Bone morphogenetic protein 7 (BMP?7) is a member of the transforming growth factor (TGF) beta superfamily and is involved in regeneration, repair, and development of specific tissues, for example kidney, gut, lens, and skeleton.
      
This process involves transforming growth factor beta-1 (TGF beta1), which stimulates production of the extracellular matrix proteins, including laminin (LN).
      
The aim of the study was to assess LN and TGF beta1 concentration according to VUR grade.
      
LN and total TGF beta1 concentrations in serum and urine were determined by the immunoenzymatic (EIA) method.
      
To assess total serum TGF beta1 levels, we used a solid-phase enzyme-linked immunosorbent assay (ELISA).
      
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  tgf-beta
Transforming growth factor beta1 (TGF-beta1) has antagonistic effects on TNF-alpha and IL-1-mediated processes.
      
TGF-beta 1 gene-activated matrices regulated the osteogenic differentiation of BMSCs
      
TGF-beta1 transgenic mouse model of thoracic irradiation: Modulation of MMP-2 and MMP-9 in the lung tissue
      
Ex vivo supplementation of TGF-beta1 enhances the fibrous tissue regeneration effect of synovium-derived fibroblast transplantat
      
In Group C, we transplanted autologous fibroblasts, which had been cultured with supplementation of TGF-beta1, into the tendon defect.
      
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  tgf gene
Analysis of TGF gene expression at protein and mRNA levels was performed in thyroid specimens from eight patients with autoimmune thyroid disease.
      
Thus, these changes in the level of neu and TGF gene expression may accompany malignant progression rather than cause it.
      
  其他


The serum TGF3,, I -C and, -Cconcentrations were determined by ELISA in ll8patients with chronic hepatitis and cirrh0sis, rela-tionships between TGF5,, I -C and, -C and sever-al indices renecting liver function were analyzed.The result sh0wed that the patients with HC hadsignificantly higher serum TGF9,, l -C and, -Clevels than those with CAH, who had significantlythose with CPH. The patients with NC had l0werserum TGF9,, I -C and 1 -C c0ncentrati0ns.Serum TGF5, levels had a p0sitive c0rrelati0n withI -C, 1...

The serum TGF3,, I -C and, -Cconcentrations were determined by ELISA in ll8patients with chronic hepatitis and cirrh0sis, rela-tionships between TGF5,, I -C and, -C and sever-al indices renecting liver function were analyzed.The result sh0wed that the patients with HC hadsignificantly higher serum TGF9,, l -C and, -Clevels than those with CAH, who had significantlythose with CPH. The patients with NC had l0werserum TGF9,, I -C and 1 -C c0ncentrati0ns.Serum TGF5, levels had a p0sitive c0rrelati0n withI -C, 1 -C, ALT and n0 significant c0rrelationwith A/G. STB. These suggest that TGF8, mightbe a pr0mising serum mark f0r hepatic fibr0sis, theassay 0f serum TGFP, and I -C would be valuablefor clinic.

应用酶免疫技术对118例慢性肝炎、肝硬化患者进行血清转化生长因子β1(TGFβ1)、Ⅰ、Ⅲ型胶原(Ⅰ-C、Ⅲ-C)含量测定,分析三者与肝功能指标间相关关系。结果表明,患者血清TGFβ、Ⅰ、Ⅲ型胶原含量均高于正常对照组,且随慢迁肝→慢活肝→肝硬化逐渐递增,组间差异显著。血清TGFβ1与Ⅰ-C、Ⅲ-C、谷丙转氨酶呈正相关,与白/球比值、血清总胆红素不相关。提示TGFβ1可能是一种很有前途的肝纤维化血清学标志物,与Ⅰ、Ⅲ型胶原的联合检测可能有重要的临床意义。

To study the role of transforming growth factor β1 (TGF β1) in the pathogenesis of hepatic fibrosis, serum TGF β1 activity of 108 patients with viral hepatitis were analysed by the modified MV1LU cell growth inhibitory assay, serum procollagen type Ⅲ (PCⅢ),hyaluronic acid (HA) and laminin (LN) concentrations were likewise measured by radioimmunoassay. The results showed the TGF β1 activity was significantly higher in various types of viral hepatitis as compared with the normal controls (P<0 01). The TGF...

To study the role of transforming growth factor β1 (TGF β1) in the pathogenesis of hepatic fibrosis, serum TGF β1 activity of 108 patients with viral hepatitis were analysed by the modified MV1LU cell growth inhibitory assay, serum procollagen type Ⅲ (PCⅢ),hyaluronic acid (HA) and laminin (LN) concentrations were likewise measured by radioimmunoassay. The results showed the TGF β1 activity was significantly higher in various types of viral hepatitis as compared with the normal controls (P<0 01). The TGF β1 activity as well as serum PCⅢ. HA and LN levels increased gradually with the progress of the diseases. The difference was significant among various groups (P<0 01), except for the hepatocelluar carcinoma group. There existed possitive correlation between the serum TGF β1 activity PCⅢ、HA and LN levels (r=0 65, 0 65, 0 60, respectively, P<0 01). The results suggested that TGF β1may be an important modulating factor in the process of hepatic fibrosis and might be used as an index for evaluating the progress of liver fibrosis.

为了探讨转化生长因子 -β1( TGF-β1)在肝纤维化发病机制中的作用 ,采用 MV1LU细胞生长抑制 MTT法 ,检测 10 8例病毒性肝炎患者血清 TGF-β1活性 ,同时用放免法检测血清前 型胶原( PC )、透明质酸 ( HA)、层粘蛋白 ( LN)的含量 ,结果表明各型肝炎患者 TGF- β1活性较正常对照都明显增高 ( P<0 .0 1)。随病情的发展 ,TGF- β1活性逐渐增高 ,PC 、HA、LN含量也明显增加 ,各组间差异均有显著性 ( P<0 .0 1)。除肝癌组外 ,TGF- β1活性与 PC 、HA、L N含量间呈正相关 ( r分别为 0 .65、0 .65、0 .60 ,P<0 .0 1)。提示 TGF- β1活性较好地反映肝纤维化进展状况 ,是调控肝纤维化的重要因子

AIM To measure TGFβ1 levels and HBV protein positive rate in the sera or patients with hepatitis B. METHODS The serum samples from 24 patients with acute hepatitis B (AHB) and 24 patients with chronic hepatitis B(CHB) were measured for TGF β1 by using Promega's kit and HBX protein by anti HBX antibody produced in our laboratory. RESULTS The serum TGFβ1 levels (μg/L) in AHB and CHB patients were 23 6±7 7 and 19 7±8 9 respectively and both were significantly higher than those in normal controls (8...

AIM To measure TGFβ1 levels and HBV protein positive rate in the sera or patients with hepatitis B. METHODS The serum samples from 24 patients with acute hepatitis B (AHB) and 24 patients with chronic hepatitis B(CHB) were measured for TGF β1 by using Promega's kit and HBX protein by anti HBX antibody produced in our laboratory. RESULTS The serum TGFβ1 levels (μg/L) in AHB and CHB patients were 23 6±7 7 and 19 7±8 9 respectively and both were significantly higher than those in normal controls (8 0±3 4, P <0 01). And HBX protein was present in 25 0% of the serum samples from patients with AHB, but 50% of those from patients with CHB. The TGFβ1 were higher than median value in 83% of the HBX positive serum from CHB patients. CONCLUSION The serum levels of TGFβ1 were significantly increased in patients with AHB or CHB. Fifty percent of the serum samples from CHB patients were HBX protein positive and 83% of these patients show higher serum TGFβ1 level.

目的分析急性乙型肝炎(AHB)和慢性乙型肝炎(CHB)患者血清中有生物活性的TGFβ1蛋白水平和HBX蛋白阳性率.方法AHB和CHB患者各24例,用Promega免疫分析试剂盒检测血清中TGFβ1浓度,并用自产的抗HBX单克隆抗体ELISA检测血清中HBX蛋白的存在.结果AHB组和CHB组的TGFβ1水平(μg/L)分别为236±77和197±89,均明显高于对照组80±34,P<001),但两组之间区别不大.血清中HBX阳性率AHB组为250%,CHB组达500%,HBX阳性的慢性肝炎患者15例中有10例(83%)TGFβ1血清水平高于中位值.结论AHB和CHB患者血清中TGFβ1水平明显升高,CHB组有半数患者血清呈HBX蛋白阳性,而这些HBX阳性患者中83%显示有较高的TGFβ1血清水平

 
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