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染色单体
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  chromatid
     Lymphocytes of mothers and their newborn infants were treated with varying concentrations of diethylstilbestrol (10-6M, 10-5M and 10-4M) and mito mycin C (0.003, 0.009 and 0.03 μg/ml), and the incidence of sister chromatid exchange (SCE) was determined.
     在母亲及其新生儿外周血液中加入不同浓度的己烯雌酚(10~(-6)M,10~(-5)M和10~(-4)M)和丝裂霉素C(0.003,0.009和0.03μg/ml),测定其姊妹染色单体交换(SCE)率。
短句来源
     The rate of chromatid aberration(2.30 VS1.56%,P<0.05),sister chromatid exchange(SCE)frequencies(5.3±1.5 VS4.1±0.6 per cell,P<0.05),and hypodiploid(8.88 VS6.78%,P<0.05)were significautly different be- tween the longevous persons and the adults.
     结果表明,染色单体畸变率、姐妹染色单体互换(SCE)频率和亚二倍体细胞百分率长寿组均明显高于对照组(分别为2.3VS1.56/每100个细胞、5.3±1.5/细胞 VS 4.1±0.6/细胞和8.88%VS 6.78%,P<0.05),认为上述指标可作为衰老指标。
短句来源
     Results: Sodium arsenite caused more chromosomal aberrations(8%,10.5%,15%) and more sister chromatid exchanges(11%,15%,21%)than the control did (2.5%,2%).
     结果 不同浓度NaAsO2 处理的淋巴细胞 ,出现的染色体畸变率 (8%、10 .5 %、15 % )、姊妹染色单体互换率 (11%、15 %、2 1% )显著高于对照组 (2 .5 %、2 % )。
短句来源
     Study on Sister Chromatid Exchange of Human Diploid Cell 2BS Strain
     2BS细胞姐妹染色单体互换研究
短句来源
     Sister chromatid exchange (SCE) rates in peripheral lymphocytes of 51 normal women in Xi'an area were observed. The mean SCE/cell was 8.39 ± 1.44 (5.50-11.90) with no significant difference among different age groups (P>0.05).
     作者对西安地区正常女性51例进行了外周血淋巴细胞姊妹染色单体互换(SCE)观察,其平均SCE/细胞为8.39±1.44(5.50~11.90),各年龄组间无显著性差异(P>0.05).
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  chromatids
     THREE SIMPLIFIED METHODS FOR DIRECT DIFFERENTIAL STAINING OF SISTER CHROMATIDS
     三种姊妹染色单体直接染色分化方法
短句来源
     Nondisjunction was found in 22(18%) oocytes, unbalanced predivision of chromatids in 15(12%) oocytes, balanced predivision of chromatids in 45(36%) oocytes.
     结果  4 7%的卵细胞核型正常 ,5 3%的卵细胞为异常核型 ,其中 18%为同源染色体不分离 ,12 %为姐妹染色单体非平衡性过早分离 ,36 %为姐妹染色单体平衡性过早分离 ;
短句来源
     Those of the c-myc were positioned on 5L and 3S; their percentage distances were 75.90±6.62 and 47.63±5.20 respectively. For the tested heterogeneus single copy genes, over 30% of the detected cells, which appeared signals simultaneously on sister chromatids of the barley, were obtained by technique improvement of FISH.
     c myc有2个位点被检出,分别位于5L和3S上,百分距离相应为75.90±6.62和47.63±5.20.利用改进的荧光原位杂交技术,使异源单拷贝或低拷贝基因在大麦姐妹染色单体上,同时出现信号的检出率达到了30%以上.
短句来源
     THE PATTERNS OF SISTER CHROMATIDS DIFFERENTIAL STAINING ARE INFLUENCED BY THE PRETREATMENT
     预处理对姐妹染色单体分化染色形式的影响
短句来源
     Cytological observation in AT04 showed that sister chromatids in at least one pair of somatic chromosomes were delayed obviously in separation at late metaphase.
     细胞学研究发现,AT 04在有丝分裂的中后期至少有1对染色体的姊妹染色单体分离明显滞后。
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  “染色单体”译为未确定词的双语例句
     The natural SCE value is 14.10±0.90, and the micronucleus test is 24.60 ‰.
     自发的姐妹染色单体互换(SCE)值为14.10±0.90,微核率24.60‰;
短句来源
     Sister Chromosome Separation Correlative Genes' Expressions in the A549,SPC-A-1 Tumor Cell Lines
     姐妹染色单体分离相关基因在肿瘤细胞A549、SPC-A-1中的表达
短句来源
     Mice were abdominally injected with a adaptive dose of 3.7×10~2--3.7×10~5 Bq/gbw HTO, and then exposed to a challenge dose of 1.5 Gy of~(60)Coγ-rays. In bone marrow cells that received both the adaptive and challenge doses.
     小鼠腹腔注射3.7×10~2—3.7×10~5Bq/gbw HTO(氚水)作为适应剂量,随后全身照射1.5Gy~(60)Coγ射线作为激发剂量,观察对骨髓细胞染色单体畸变率的影响。
短句来源
     BALB/c mice were radiated by microwave of different pov/er density (10 and 20mW/cm2) for 30 and 60 days respectively.
     用功率密度为10mW/cm~2和20mw/cm~2的微波照射BALB/c小鼠30和60d,其中20mW/cm~2照射60d组的骨髓细胞姊妹染色单体互换有明显增高(6.93±8.46vs.57±1.08)。
短句来源
     ②Comparison between b/c value induced by combined SARB with BLM and only BLM was performed: The b/c value of former is significantly lower than the latter (0.48±0.14,0.15±0.08,0.42±0.12, 0.17±0.11,P< 0.01).
     ②应用五加皮和博来霉素后与单纯应用博来霉素所致每细胞染色单体断裂率的比较:患者组及一级亲属组均显著降低(0.48±0.14,0.15±0.08,0.42±0.12,0.17±0.11,P<0.01)。
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  chromatid
By destroying anaphase inhibitors it promotes sister chromatid separation, and by destroying B-type cyclins it promotes cytokinesis and removes the replication block.
      
The roles of cohesins and of the SC proteins in meiotic sister-chromatid cohesion are considered.
      
The chromoneme elements in a stabilized chromatin of the mitotic chromosome preserved specific interconnection and the general pattern of their packaging in the chromatid was also preserved.
      
Aluminum has a genotoxic effect causing genome, chromatid, and chromosome aberrations in apical root meristem cells.
      
The mutagen sensitivity was inferred from the number of sister chromatid exchanges (SCEs), which was used to characterize the structural alterations of the chromosomes in workers' lymphocytes before and after administration of retinol for a month.
      
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  chromatids
A New Protein Complex (meiCohesin) Regulating Cohesion of Sister Chromatids in Meiosis in Saccharomyces cerevisiae
      
The SMC proteins enter into the composition of complexes responsible for cohesion of sister chromatids, formation of mitotic chromosomes, recombination, DNA repair, and regulation of gene expression.
      
rDNA genes are unequally distributed among nucleolus organizing chromosomes and nucleolus organizing regions of sister chromatids.
      
It may also be involved in the morphogenesis of leg imaginal disks, and it is necessary for condensation and separation of sister chromatids during mitosis.
      
Chiasmata, i.e., physical crossovers of nonsister chromatids, are preserved in bivalents until metaphase I due to local cohesion of sister chromatids in the remaining SC fragments.
      
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In this study,the karyotype and Giemsa banding pattern of the chromosomes of cultured peripheral blood lymphocytes in R.r.roxellanae were investigated.The chromosome number of this species is 44 in both sexes.In R.r.raxellanae,as in other monkeys,sex is determined by specific sex chromosomes,i.e.the male is XY and the female is XX.The 21 pairs of autosomes consist of 7 pairs of metacentric chromosomes,13 pairs of submetacentric ones,1 pair of acrocentric ones.Chromosome measurements were made from highly enlarged...

In this study,the karyotype and Giemsa banding pattern of the chromosomes of cultured peripheral blood lymphocytes in R.r.roxellanae were investigated.The chromosome number of this species is 44 in both sexes.In R.r.raxellanae,as in other monkeys,sex is determined by specific sex chromosomes,i.e.the male is XY and the female is XX.The 21 pairs of autosomes consist of 7 pairs of metacentric chromosomes,13 pairs of submetacentric ones,1 pair of acrocentric ones.Chromosome measurements were made from highly enlarged photographic prints.Table II lists the results obtained including the relative length,arm ratio and centromere index of each chromosome.Both chromosomal and the chromatid aberrations were observed.They were 0.67% and 2%,respectively.Finally,Giemsa banding pattern analysis of chromosomes of R.r.roxellanae were carried out.The results show that each homologous pair has its own special banding pattern,so that each of them is easily recognizable.Idiograms of chromosome complements with the Giemsa banding pattern were constructed.

本研究通过外周血淋巴细胞培养的方法,对二只金丝猴的染色体组型和染色体带型进行了分析。现已确证,金丝猴的2倍体细胞的染色体数目为2n=44。雄性为XY,雌性为XX。在染色体组型分析中,测量和计算了每一染色体的相对长度,臂比和着丝点指数。染色体和染色单体的“自发”畸变率分别为0.67%和2%。从姬姆萨(Giemsa)氏带型分析表明,每一对同源染色体都有自己的特殊带型,因此所有的染色体都能予以识别,并能准确无误的配对。

Studies on 5,500 metaphase plates from 103 members of 5 high risk cancer families and 1,567 metaphase plates from 30 members of 4 low risk cancer families were carried out. The investigated individuals of both groups lived in close proximity. Although the modal number and Karyotype were normal diploid (2n = 46), many more cells from members of high cancer families were found to show aneuploid and various types of structural aberrations than those from members of low risk families. In the high risk group, 1.6%...

Studies on 5,500 metaphase plates from 103 members of 5 high risk cancer families and 1,567 metaphase plates from 30 members of 4 low risk cancer families were carried out. The investigated individuals of both groups lived in close proximity. Although the modal number and Karyotype were normal diploid (2n = 46), many more cells from members of high cancer families were found to show aneuploid and various types of structural aberrations than those from members of low risk families. In the high risk group, 1.6% of the cells showed numerical aberrations and 3.25% structural aberrations, while the corresponding figurs for the low risk group were 0.5% and 0.72% respectively (p < 0.01). The 101 chromatid breaks found in the high risk cancer families were mostly distributed among chromosomes of A, B and C groups and occurred more frequently in long arms (q) than in short arms (p). During karyo-typing it was found that chromosomes A2 could not be matched with each other in 10 cells out of 300. The interaction between genetic and environmental factors in the carcinogenesis of esophageal cancer in Linxian County was briefly discussed.

从林县5个食管癌高癌家族成员103名及与之毗邻的4个低癌家族成员31名的淋巴细胞所作的染色体对比分析结果表明:高癌和低癌家族成员淋巴细胞染色体众数及其核型均属正常二倍体(2n=46)。但在高癌组中查到1.6%和3.25%具有染色体数目和结构异常的细胞,与低癌组比较有非常显著的差别(P<0.01)。核型分析发现有少数假二倍体、G组三体性和第2号染色体不配对现象。101个染色单体断裂主要集中在A、B、C三组,断裂部位长臂比短臂为多。对肿瘤发生中遗传和环境(内因和外因)因素的相互作用进行了讨论。

A diploid cell strain (KIZ-7901) of red muntjac (Muntiacus muntjak) has been established in our laboratory. The diploid chromosome number of red muntjac( = 7 , = 6 ) is the lowest among all vertebrates, so it is a good assay system for the testing of chemical mutagens.

研究环境化学物质(农药、药物、食品添加剂,工业毒物、化妆品、大气和水的污染物等等)对人类遗传的潜在危害以及这种危害的定量估价和对策即遗传毒理学工作,是当前环境科学的一项重要内容。其中,建立灵敏可靠的环境致癌—诱变剂检测系统又有特别重要的意义(施立明等,1979)。姐妹染色单体交换率(SCEs)测定,由于操作简单,观察客观又具有高度的灵敏性,是近年来颇受重视的一项新的检测指标(施立明,1979)。赤麂(Muntiacus muntjak)是迄今已知染色体数目最少的脊椎动物(2n=♂7,♀=6)其核型特点适合于遗传毒理学测定的需要。本工作以离体培养的赤麂二倍体细胞株为材料,结合姐妹染色单体交换这一新指标,旨在探讨这一新的检测系统对于研究化合物诱变活力的价值。

 
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