Results: The median toxic concentration(TC_(50)),~()median inhibition concentration(IC_(50)) and therapeutic index(TI) of the monomeric hypericin solution were(195.96 mg/L,) 19.15 mg/L and 10.23 respectively.
The 50% concentration doses of Adefovir dipivoxil, Covilagin, ACV andα-IFN were 0.67 M, 0.49 g/L, >0.75 g/L and >10×10 8 IU/L, and the treatment index (TI) on HBsAg and HBeAg were respectively 2.79, 4.47;
RESULTS: The 50% inhibitory concentration (IC 50) of Astragalus and Thoroughfare decoction against HBsAg, HBeAg, and extracellular HBV DNA was 1.35, 1.92 and 2.19 g/L respectively, and treatment index (TI)>3.56-5.79. α-IFN had weak inhibitory effects against HBV. CONCLUSION: Astragalus and Thoroughfare decoction can inhibit HBV replication in vitro to some extent.
Results: Ribavirin was an effe ctive antiviral agent for parainfluenza viruses(Ⅲ) in a concentration-dependent manner and its median toxic concentration(TC 50), median efficacious conce ntration(EC 50) and treatment index(TI) was 1783.86μg/ml,11.53μg/ml and 154.71, respectively.
Conclusion:The treatment indices(TI) of the direct virucidal activity,the inhibition effects on the multiplication and infection of HSV -2 333 strain of this combination ratio are 726,525,1 400 times of ACV TIs respectively,it is the most excellent combination ratio.
Median infective concentration(IC 50 )of sp to HBeAg and HBsAg secretion equaled 2 62±0 25 mg/ml and 2 90±0 18 mg/ml,respectively,with therapeutic indices more than 1 53 and 1 38.Sp also inhibited HBV DNA.
Results The active principle of Styelec plicate was shown to have a relatively prominent inhibitory effect on the secretion of both HBsAg and HBeAg. The toxicity of the principle to the cells was low and its therapeutic indices were all greater than 10. Conclusion The active principle of Styelec plicata was shown to have an evident anti HBV effect in vitro.
Quantitative trait loci (QTL) for growth traits and water-use efficiency have been identified in two water regimes (normal and drought-treated) and for a treatment index.
QTL specific for each treatment and for the treatment index were found, but QTL common across the treatments and the treatment index were also detected.
Common QTL identified between treatments and treatment index in the complex trait dry weight can be useful tools in the breeding and selection for drought stress tolerance in Salix.
A treatment index (TI) was formulated from the total number of patients (NTOT), the number of stone free patients (NSF), the number of patients with retreatment (NRE), auxiliary procedures (NAUX) and general or regional anaesthesia (NANE).
The average treatment index was 95 (range 53-191) days per 1 cm of elongation.
This review highlights the results of current approaches for improvement of the therapeutic indices of these agents.
Newer agents with improved therapeutic indices are in various stages of development, including some which have been designed on the basis of recent progress in understanding immune mechanisms.
The therapeutic indices of the effective chelators were: 25.4 (deferoxamine mesylate), 35.7 (citric acid), 42.3 (succinic acid), 52.2 (malic acid) and 111.1 (oxalic acid).
The therapeutic indices and therapeutic effectiveness of the most effective chelators were, respectively: EDTA (5.0, 7.0), DTPA (7.3, 13.7), CDTA (8.6, 6.3), d-PA (4.6, 1.9), DMPS (1.3, 1.0), DMSA (3.2, 5.4).
Moreover, mitoxantrone possessed much higher therapeutic indices than ADM against IP implanted P388 (optimal dose/ILS40; >amp;gt;128 versus 15.2) and L1210 (optimal dose/ILS25; 72.7 versus 4.8) leukemias.